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Chemical Stability and Whitening Activity of Mixture of Functional Ingredients (미백 기능성 성분의 혼합물에 대한 미백 활성 및 안정성에 관한 연구)

  • Lee, Youn-Hee;Lim, Nam-Hoon;Joung, Min-Seok;Kim, Joong-Hoi;Sim, Sang-Soo
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.31 no.4 s.54
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    • pp.295-304
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    • 2005
  • Recently, arbutin, oil soluble licorice extact (GLY), ascorbyl glucoside (AA2G), and ethyl ascorbyl ether (EAE) have been widely used as functional whitening ingredients. To Investigate which combination between the above agents could be more effective for whitening effect, tyrosinase activity and MSH-induced melanin production in B-16 melanoma cells were investigated. Both GLY and arbutin dose-dependently inhibited purified tyrosinase activity. The inhibitory effects of GLY with AA2A or EAE on Drosinase activity were more potent than those of GLY alone, whereas that of arbutin with other ingreadients did not show those effects. In MSH-induced melanin production in B-16 melanoma cells, the mixture of Gly and EAE more significantly reduced melanin formation than Gly alone. Stability of mixture of GLY, arbutin, AA2A and EAE exposed at the temperature of $25^{\circ}C\;or\;45^{\circ}C$ for 30 days were also investigated. All of the combinations of whitening agents did not show any critical changes in their composition stability. These data suggest that the combination of GLY and vitamin C derivatives such as AA2G and EAE may be useful for the promotion of whitening effect.

Verification of the Physiological Activity of Geranium thunbergii Extract and Anti-inflammatory Activity in Raw 264.7 Cells (현지초(Geranium thunbergii) 추출물의 생리활성 및 Raw 264.7 cells에서의 항염활성 검증)

  • Seung-Mi Park;Min-Jeong Oh;Jin-Young Lee
    • Journal of Life Science
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    • v.34 no.1
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    • pp.28-36
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    • 2024
  • We evaluated the efficacy of Geranium thunbergii (GT), which has so far been understudied as a cosmetic material, and conducted anti-inflammatory-related activity studies. We measured the electron donation ability and ABTS+ radical scavenging ability to confirm the antioxidant ability of GT and found values of 91% and 94% at a concentration of 50 ㎍/ml, respectively, confirming that GT had excellent antioxidant ability. Tyrosinase inhibitory activity was measured to evaluate whitening activity, and it was found that inhibitory activity was 24.8% at the highest concentration of 1,000 ㎍/ml. Elastase and collagenase inhibitory activity were measured to determine the wrinkle improvement activity of the GT; 30.6% and 90% inhibitory activity were shown at the highest concentration of 1,000 ㎍/ml, respectively. Excellent inhibitory activity was confirmed through the measurement of collagenase inhibitory activity. Before the cell experiments were conducted, the survival rate of the macrophages Raw 264.7 according to GT treatment was determined based on the MTT assay, and the cell survival rate was greater than 83.6% at a concentration of 100 ㎍/ml. Subsequent cell-related experiments were conducted at concentrations of 100 ㎍/ml or less. The NO production inhibitory activity according to the GT treatment by NO assay was measured, and a 74.9% inhibitory rate was confirmed at a concentration of 100 ㎍/ml. Western blotting was performed to determine protein expression inhibition, and both COX-2 and iNOS factors were concentration-dependently inhibited in GT. Based on these results, GT is considered to have potential as an anti-inflammatory functional cosmetic material.

THE EFFECTS OF THERMAL STIMULI TO THE FILLED TOOTH STRUCTURE (온도자극이 충전된 치질에 미치는 영향)

  • Baik, Byeong-Ju;Roh, Yong-Kwan;Lee, Young-Su;Yang, Jeong-Suk;Kim, Jae-Gon
    • Journal of the korean academy of Pediatric Dentistry
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    • v.26 no.2
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    • pp.339-349
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    • 1999
  • The dental structure substituted by restorative materials may produce discomfort resulting from hot or cold stimuli. To investigate the effects of this stimuli on the human teeth, thermal analysis was carried out by calculation of general heat conduction equation in a modeled tooth using numerical method. The method has been applied to axisymmetric and two-dimensional model, analyzing the effects of constant temperature $4^{\circ}C\;and\;60^{\circ}C$. That thermal shock was provided for 2 seconds and 4 seconds, respectively and recovered to normal condition of $20^{\circ}C$ until 10 seconds. The thermal behavior of tooth covered with a crown of gold or stainless steel was compared with that of tooth without crown. At the same time, the effects of restorative materials(amalgam, gold and zinc oxide-eugenol(ZOE)) on the temperature of PDJ(pulpo-dentinal junction) has been studied. The geometry used for thermal analysis so far has been limited to two-dimensional as well as axisymmetric tooth models. But the general restorative tooth forms a cross shaped cavity which is no longer two-dimensional and axisymmetric. Therefore, in this study, the three-dimensional model was developed to investigate the effect of shape and size of cavity. This three-dimensional model might be used for further research to investigate the effects of restorative materials and cavity design on the thermal behavior of the real shaped tooth. The results were as follows; 1. When cold temperature of $4^{\circ}C$ was applied to the surface of the restored teeth with amalgam for 2 seconds and recovered to ambient temperature of $20^{\circ}C$, the PDJ temperature decreased rapidly to $29^{\circ}C$ until 3 seconds and reached to $25^{\circ}C$ after 9 seconds. This temperature decreased rather slowly with stainless steel crown, but kept similar temperature within $1^{\circ}C$ differences. Using the gold as a restorative material, the PDJ temperature decreased very fast due to the high thermal conductivity and reached near to $25^{\circ}C$ but the temperature after 9 seconds was similar to that in the teeth without crown. The effects of coldness could be attenuated with the ZOE situated under the cavity. The low thermal conductivity caused a delay in temperature decrease and keeps $4^{\circ}C$ higher than the temperature of other conditions after 9 seconds. 2. The elapse time of cold stimuli was increased also until 4 seconds and recovered to $20^{\circ}C$ after 4 seconds to 9 seconds. The temperature after 9 seconds was about $2-3^{\circ}C$ lower than the temperature of 2 seconds stimuli, but in case of gold restoration, the high thermal conductivity of gold caused the minimum temperature of $21^{\circ}C$ after 5 seconds and got warm to $23^{\circ}C$ after 9 seconds. 3. The effects of hot stimuli was also investigated with the temperature of $60^{\circ}C$. For 2 seconds stimuli, the temperature increased to $40^{\circ}C$ from the initial temperature of $35^{\circ}C$ after 3 seconds of stimuli and decreased to $30^{\circ}C$ after 9 seconds in the teeth without crown. This temperature was sensitive to surface temperature in the teeth with gold restoration. It increased rapidly to $41^{\circ}C$ from the initial temperature of $35^{\circ}C$ after 2 seconds and decreased to $28^{\circ}C$ after 9 seconds, which showed $13^{\circ}C$ temperature variations for 9 seconds upon the surface temperature. This temperature variations were only in the range of $5^{\circ}C$ by using ZOE in the bottom of cavity and showed maximum temperature of $37^{\circ}C$ after 3 seconds of stimuli.

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ZAn Experimental Study on Performance Evaluation of Simplified Composite Steel I-Beam Bridge (초간편 강합성 H형강 교량의 실험 성능평가 고찰)

  • Kim, Jae-Heung;Park, Jong-Sup;Lee, Son-Ho;Choi, Seung-Ho;Lee, Young-Ho
    • Proceedings of the KAIS Fall Conference
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    • 2009.12a
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    • pp.29-32
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    • 2009
  • 본 연구는 도로교 설계 기준 바탕으로 H-형강을 사용하여 20~30m 사이의 지간장을 가진 중 소규모 교량에 적용이 가능한 초간편 교량의 모형실험 결과와 유한요소해석프로그램(ABAQUS)을 사용한 해석 결과와 비교 분석하여 초간편 교량의 성능을 평가한 것이다. 일반적으로 우리나라의 교량들은 시공과정에서 여러 단계를 거쳐 시공한다. 시공단계가 복잡할수록 공사기간은 늘어나기 때문에 기상 현상에 의한 파괴와 교량의 낙후로 인해 유지, 보수, 교체 또는 교량확장을 해야 하는 경우 교통 혼잡과 경제적 손실을 줄 수 있다. 따라서 본 연구는 이와 같은 경제적 손실을 줄일 수 있는 초간편 H형강 교량의 연구의 일환으로 기존의 연구 결과를 모형실험 수행 결과와 비교하여 최적성능을 평가하기 위해 실시하였다. 사용된 실험체는 실험장소인 건설기술연구소의 구조실험동 장소 여건에 따라 10m 안팎의 경간을 갖는 교량으로 제작하였다. 실험체의 설계 제작 과정에 대해 검토한 후 범용구조해석 프로그램을 이용하여 동일한 조건을 적용한 결과를 비교 후 최종적으로 초간편 교량의 성능에 대한 평가를 실시하여 김재흥 등(2009)의 의해 제안된 하중분배계수 값이 적용가능한지 판단하였고, 실험을 통해 응력 분포와 극한하중에 대해 검토하였다.

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Novice Elementary Teachers' Knowledge of Students' Errors on Plane Figures (평면도형에 관한 학생들의 오류에 대한 초임 초등 교사들의 교수학적 내용 지식 분석)

  • Song, Keun-Young;Pang, Jeong-Suk
    • Journal of the Korean School Mathematics Society
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    • v.15 no.3
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    • pp.429-451
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    • 2012
  • This paper examined eight novice elementary teachers' knowledge in terms of the types and sources of students' errors and teaching strategies on plane figures through a questionnaire and teachers' discussion. The teachers tended to predict students' diverse error types, but they attributed the sources of such errors mainly to their characteristics. The analysis of teachers' responses of teaching strategies revealed that they recognized the importance of the teacher's clear explanation and students' own problem-solving, while they were somewhat negative in presenting diverse examples and classifying, drawing, or constructing figures. Building on these results, this paper provides the implications for novice teachers' professional development programs.

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Latral Composition Modulation 기법으로 성장된 InP/GaP 초격자의 분광특성

  • Sin, Yong-Ho;Kim, Yong-Min;Song, Jin-Dong
    • Proceedings of the Korean Vacuum Society Conference
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    • 2013.02a
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    • pp.483-483
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    • 2013
  • Latral Composition Modulation (LCM)으로 성장한 InP/GaP 초격자(Superlattice)의 선편광된 광발광(Photoluminescence) 특성을 저온(5 K)에서 측정하였다. LCM 기법은 z-축 방향으로 InP와 GaP를 단층 초격자(monolayer supperlattice)로 성장하는 과정에서 strain에 의해 x-y 평면으로 초격자가 형성되는 특별한 경우이다. 이렇게 성장된 LCM 초격자의 경우 In-rich 영역과 Ga-rich 영역이 교차로 성장되는 구조를 가지며 가전자대역(valence band)에서 무거운 양공과 가벼운 양공의 band mixing 이 일어나게 되어 선평광된 발광특성을 가진다. 우리는 저온 발광실험에서 In-rich 영역과 Ga-rich 영역의 재결합에 의해 나타나는 두 개의 독립된 전이 피크를 측정하였다. 이 두 피크는 [110] 방향의 편광에서 발광 강도가 최대치를 가지며 [1-10] 방향에서 최소값을 가짐을 보였다. 이때 전이 에너지의 경우 [110] 방향에서 [1-10] 방향으로 편광이 바뀔 때 Ga-rich 영역의 전이의 경우 적색편이를 나타낸 반면 In-rich 영역의 경우 청색편이를 보이는 현상을 발견하였다. 이러한 상반된 편이 현상은 서로 다른 3족 물질의 영역에 따라 격자 상수가 바뀌며 tensile strss와 compressive stress에 따른 가전자 대역의 band mixing 변화에 기인하는 것으로 여겨진다.

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Study on the Way of Improving Computer Education in Elementary and Secondary Schools (초뀇중등학교 정보교과 운영 실태 추이 분석을 통한 정보교육 개선 방안)

  • Ahn, Seonghun
    • The Journal of the Korea Contents Association
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    • v.14 no.2
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    • pp.535-543
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    • 2014
  • In this paper, I proposed a way of improving computer education in elementary, middle and high schools. I firstly analyzed the importance of computer education by researching an index of a national economic condition, People's IT use frequency and the demand for computer education by students and parents. Secondly, I researched the condition of computer education in elementary, middle and high schools. Finally, I analyzed problems of current computer education and proposed three way of improving computer education in elementary, middle and high schools.

Host Finding, Mating Behavior and Their Reproduction Model of Anagrus incarnatus Haliday (Anagrus incarnatus Haliday의 기주선택 및 교미행동과 이의 생식방법에 관한 연구)

  • 장영덕;여윤수;김용헌
    • Korean journal of applied entomology
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    • v.30 no.2
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    • pp.101-105
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    • 1991
  • The host finding, ovipostition of Anagrus incarnafus Haliday and the sex ratio of its offsprings was determined. Both male and female mate immediately after emergence and the female parasitoid search for host eggs by drumming with antenna immediately after release on the rice seedings. Time required for the host searching, drumming with antenna, tapping and inserting with ovipositor, and ovipositing of A. incarnaws takes 188.5, 17.5, 72.4 and 206.7 seconds, respectively. The time required for mating takes 16-21 seconds. The sex ratio of offsprings between female and male was about 3: 1 in mated females and all the offsprings emerged from the eggs of unmated females were males. So, A. incarnafus can reproduce zygogenetically and parthenogenetically and the mode of parthenogenetic reproduction was an arrhenotokous parasitoid.

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Experimental and Numerical Study of Smoke Movement in Tunnel Fires (터널 화재 시 연기전파에 대한 실물실험 및 수치해석적 연구)

  • Lee Seung-Chul;Lee Seung-Ho;Kim Nam-Young
    • 한국터널공학회:학술대회논문집
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    • 2005.04a
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    • pp.341-347
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    • 2005
  • 본 논문은 터널에서 화재 발생 시, 시간에 따른 연기거동에 대해 실물실험과 3차원 수치해석을 수행하고 각각의 결과를 비교,검토하였다. 실물실험을 위하여 8.8 kW의 열원과 901iter/h의 연기 발생이 가능한 연기발생장치를 자체 제작하였으며, 대상터널은 길이 570m, 단면적 $64.6m^2,$ 그리고 약 $2\%$의 구배를 가지고 있다. 실험은 외풍의 영향을 줄이기 위해 터널 입,출구에 차단막을 설치하였으며 연기발생장치로부터 20m 간격의 위치에서 20초 간격으로 연기전파, 속도 그리고 온도를 측정하였다. 연기는 60초 경과 후, 연기발생장치로부터 20m 떨어진 위치에 도달하였으며 140초, 180초 및 260초 경과 후, 각각 40m, 60m 및 80m 위치에 도달하였다. 3차원 수치해석의 결과는 터널벽면을 매끈한 표면으로 처리하였을 때, $26.3\~49.5\%$정도 과대 예측하였다. 또한 터널벽면을 일정 조도를 갖는 거친 표면으로 처리한 경우는 $-2.7\~17.6\%$ 오차로 실험결과에 보다 근접하는 결과를 보였다. 따라서 터널 내 연기거동에 대한 3차원 수치해석을 수행할 때에는 벽면조도에 대한 고려가 필요하리라 판단된다.

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A newly naturalized species in Korea: Carex scoparia Schkuhr ex Willd. var. scoparia (Cyperaceae) (한국 미기록 귀화식물: 한석사초(사초과))

  • Cheon, Kyeong-Sik;Chung, Kyong-Sook;Im, Hyoung-Tak;Yoo, Ki-Oug
    • Korean Journal of Plant Taxonomy
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    • v.44 no.4
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    • pp.247-249
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    • 2014
  • A newly naturalized plant, Carex scoparia Schkuhr ex Willd. var. scoparia, was found in Mt. Hanseok, Injegun, Gangwon-do, Korea. It belongs to sect. Ovales Kunth and had been known from North America, and was introduced into Europe and New Zealand. This species distinguished from related taxa in Asia, Carex maackii Maxim. and Carex leporina L., by pistillate scales lanceolate and having large perigynia. We propose the new Korean name, 'Han-seok-sa-cho', based on its first collecting place. We also provide descriptions for morphological characters, illustrations, photographs and keys to allied taxa.