• Journal of the Korean Society of Food Science and Nutrition
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• v.45 no.10
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• pp.1391-1397
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• 2016

We investigated the hepatoprotective effects of Angelica keiskei Koidzumi extract (AK) in HepG2-overexpressing cytochrome P4502E1 (CYP2E1) and C57BL/6J mice. In HepG2 cells expressing CYP2E1, cell viability and catalase activity in the ethanol-AK co-treated group significantly increased compared to those in the ethanol-treated group. In the in vivo study with C57BL/6J mice, the AK-supplemented group with ethanol liquid diet showed significantly reduced hepatic markers, including serum aspartate aminotransferase, alanine aminotransferase, and ${\gamma}$-glutamyl transferase, compared to the ethanol group without AK supplementation. AK supplementation (20 mg/kg BW/d) also significantly attenuated reactive oxygen species generation and malondialdehyde level. Notably, a low dose of AK supplementation (20 mg/kg BW/d) suppressed expression of hepatic CYP2E1 and inhibited CYP2E1 enzyme activity. These data indicate that a low dose of AK supplementation could restrain alcohol-induced hepatic damage mediated by CYP2E1.

• Journal of Chest Surgery
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• v.31 no.1
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• pp.1-6
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• 1998

Total body water is increased after cardiopulmonary bypass resulting in tissue edema and organ dysfunction. Ultrafiltration has been used to reduce this accumulation of water. We have carried out a prospective randomized study in 17 children undergoing open heart surgery, comparing modified ultrafiltration(MUF) with nonfiltered controls. MUF was carried out for about 10 minutes after completion of cardiopulmonary bypass to a hematocrit 36∼42%. Blood loss, blood transfused, hemodynamics, and laboratory data were recorded for 24 hours postoperatively. The results were analyzed using Mann-Whitney U test, comparing controls(n=7) to ultrafiltered(n=10). There was no death in each group. The mean filtrate volume(ml/kg) was 42(30∼68). Blood loss(ml/kg/24hr) was 14.5 mean(4.0∼26.6) in controls versus 12.1 mean(6.0∼21.5) in MUF(P＞0.05) ; blood transfused(ml/kg/24hr) was 9.4 mean (6.0∼36.3) in controls versus 3.4 mean(0∼11.4) in MUF(P<0.05). There was rise in arterial blood pressure during MUF. Percent rise of systolic blood pressure was 4.2(0∼11.7) in controls versus 19.8(7.0∼36.9) in MUF(P=0.001). Percent rise of diastolic blood pressure was 10.0(1.6∼20.8) in controls versus 30.6(5.8∼73.3) in MUF(P<0.05). Platelet count, fibrinogen, and oncotic pressure rose after MUF. No complications directly attributable to the ultrafiltration were observed. Conclusively, MUF is safe, effective means of removing body water and beneficial to hemodynamics.

• Journal of Korean Elementary Science Education
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• v.18 no.2
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• pp.65-77
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• 1999

The purpose of this study was to find out the effectiveness of metacognitive instruction model on the changes of science concepts, when it was applied to 6th grade students. To do this, students were tested with the achievement of molecules and molecular motion concepts and metacognitive self-regulation test as a pretest Based upon metacognitive instruction model and student's conception, instruction program were developed. This metacognitive strategy Program was applied to the experimental group and expository teaching was applied to the comparison group (followed the order and method in authorized science textbook and teachers handbook). When planned lessons were finished, students were given a post-test to find conceptual change. After six months students were given a test again to find retention effect. There was a significant difference in conceptual change and retention between comparison group and experimental group by treatment at p< .05 level, The difference between comparison group and experimental group was especially significant, when the situation of test item wasn't similar to that of the textbook Metacognitive instruction model was more effective to high group than low group in metacognitive self-regulation level on conceptual change and retention. So the metacognitive strategy Played an important role in conceptual change and retention. And we can recognize that the students who take part in the metacognitive lesson can apply the corrected concept to the other concrete situation because they can understand new concept accurately by metacognitive strategies. And we can guess that high group in metacognitive self-regulation level can team metacognitive strategy easily but relatively low group student have some trouble in learning new strategy.

• Journal of Korean Society of Forest Science
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• v.104 no.1
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• pp.67-75
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• 2015

This research is to investigate the four years growth mountain-cultivated ginseng ripened twenty-two weeks into four years fermented persimmon vinegar (tentatively: Sansamcho) ingestion on obese-related factors during dietary control. The Sansamcho was ingested orally, two times a day, after every meal for six weeks to the male rats. Groups were divided into the control (CON), the restricted diet (RD), and the weight cycling (WC). And, each groups has its own sub-groups as the -control (-CON), 2.5 times diluted Sansamcho ingestion (-MPV2.5), and 5.0 times diluted Sansamcho ingestion (-MPV5.0) groups, respectively. The number of rat was consisted of seven in each group. After six weeks rearing periods was done, abdominal fats (retroperitoneal fat, mesentery fat, and epididymal fat) and energy metabolic-related protein (AMPK: AMP-activated protein kinase; PPAR-${\alpha}$: peroxisome proliferator-activated receptor-${\alpha}$; and CPT-1: carnitine palmitoyltransferase-1) were weighed and analyzed. Amount of stored fat was significantly or tended to decrease by Sansamcho ingestion. In addition, sum of fats increasing were suppressed by the material. On the contrary, energy metabolism-related protein expression was significantly increased or tended to increase by Sansamcho ingestion. This results suggested that increased energy metabolism using Sansamcho was restrained effectively visceral fat store by high-fat diet and/or dietary control. In other words, it has a good function to suppress weight cycling which is the most insoluble problem. Therefore, the fusion material, Sansamcho, may expect to utilize as the obese-suppression-food.

• Journal of Life Science
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• v.31 no.3
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• pp.338-345
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• 2021

Zizania latifolia has long been used as a tea for both edible and medicinal purposes. However, research into the use of Z. latifolia as a high value-added edible material is lacking. In a previous study, we confirmed that tricin is the major component in Z. latifolia. In this study, we investigated the protective effect of a Z. latifolia extract (ZLE). Toxicity tests of ZLE or tricin on HepG2 cells revealed no toxicity due to ZLE or tricin at all concentrations used. The reduction in cell viability by tert-butyl hydroperoxide (t-BHP) was suppressed by treatment with ZLE or tricin. In addition, ZLE or tricin effectively inhibited the production of reactive oxygen species (generation of hydrogen peroxide, alkoxy free radicals, and peroxyl free radicals by t-BHP) and oxidative damage. ZLE or tricin treatments also increased the protein expression of superoxide dismutase 1 (SOD1), catalase, heme oxygenase-1 (HO-1), and nuclear factor erythroid-related factor 2 (Nrf2), which are known as antioxidant enzymes, suggesting that the protective effect of ZLE is related to activation of tricin. Taken together, the results indicate that Z. latifolia can be developed as a functional food material for improving liver function.

• 한국공간정보시스템학회:학술대회논문집
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• 2005.05a
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• pp.263-266
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• 2005

고해상도 영상은 원격탐사, 의료영상 등 다양한 분야에서 사용되며, 향후에 많은 수요가 예상된다. 초해상도 영상복원은 동일한 지역을 촬영한 여러 장의 저해상도 영상을 이용하여 고해상도 영상으로 복원하는 소프트웨어적인 영상 해상도 향상 방법이며, 공간 영역과 주파수 영역의 초해상도 영상복원으로 구분된다. 본 연구에서는 공간 영역에서 확률적 접근법을 이용하여 CCD 영상의 초해상도 영상복원을 수행하였다.

• Publications of The Korean Astronomical Society
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• v.6 no.1
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• pp.50-61
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• 1991

여러가지 초증감 처리법 중에서 굽기(baking), 쐬기(soaking)과 진공처리(evacuation)를 할 수 있는 초증감처리장치를 설계 제작하고 초증감 처리 결과 시험에 이용되는 표준감광기 (sensitometer)와 농도쐐기 (step wedge)를 제작하였다. 이를 천체사진용 건판인 103a-O와 IIIa-J에 시험적으로 사용하여 감도와 신호대 잡음비의 증가를 확인하였다.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1993.10a
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• pp.171-176
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• 1993

초정밀 공작기계의 구조물은 Sub-micron의 운동정밀도를 갖추어야 초정밀기계로서의 기능이 유지된다. 특히 가공기의 베드구조물은 구동요소간의 상대 위치를 정.동적으로 규정 해주는 중요한 기본구조물이므로 고강성, 고쇠감성,열안정성, 경년변화에 대한 치수의 안정성등의 성능이 요구되며, 이를위해 공간적인 형상 설계 및 구조재의 선정에 고도의 기술이 필요하다. 따라서 본 연구는 낮은 고유진동수의 특성을 갖으면서 하중의 설치높이의 변화에서도 고유진동수가 일정히 유지되고 또한 구조물의 중심변화에 대한 수평조절이 가능하면서 자동제어가 가능한 공기스프링을 초정밀 가공기의 방진시스템으로 활용방안에 대하여 연구하였다.

• Journal of Yeungnam Medical Science
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• v.9 no.2
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• pp.211-217
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• 1992

망막분지정맥폐쇄는 안저출혈을 일으키는 중요한 질환의 하나로서 합병성 황반부 부종 및 망막신생혈관에 의한 초자체출혈로 인하여 시력장애를 유발하는 질환으로 전신질환중 고혈압과 가장 흔히 동반되나 당뇨병 혹은 혈액성 질환과도 동반되는 것으로 알려져있다. 초자체출혈의 경우 다른 원인에 의한 경우보다 초자체절제술에 의한 시력개선의 효과가 현저한 질환으로 심한 초자체출혈이 동반된 망막분지정맥폐쇄의 경우 평면부를 통한 초자체절제술 및 안저광응고술에 의한 수술적 처치가 필요할 것으로 사료된다.

• Proceedings of the Korea Contents Association Conference
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• 2011.05a
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• pp.177-178
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• 2011

최근 우리나라의 국제화와 국제결혼 등을 통해 외국인의 활동이 많다. 따라서 대민접촉이 많은 경찰공무원에게는 어학능력은 필수라 할 수 있다. 그러므로 이 연구의 목적은 초임 경찰관들의 직무관련 어학능력을 개선하는데 있다. 연구범위는 초임 경찰관들의 어학능력 향상을 위한 교육훈련에 대한 연구이므로 초임 경찰관 교육기관의 교육훈련에 대한 연구로 한정하였다. 연구방법은 국내 외 공식현황 및 자료에 대한 분석과 경찰 내부자료를 분석하는 문헌연구를 수행하였으며 경찰공무원을 대상으로 설문조사를 실시하였다.