• Journal of Nutrition and Health
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• v.51 no.3
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• pp.228-241
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• 2018

Purpose: The health risk of women increases after menopause. This study evaluated the effectiveness of a public health center-based nutrition education program for hypertension in women older than 50 years of age. Methods: The program included 8-week nutrition education and 8-week follow-up with keeping a health diary and nutrition counseling. The program was evaluated three times: before and after the nutrition education, and after the follow-up. The subjects were classified into hypertensives (n = 44) or normotensives (n = 71). Results: The rate of taking antihypertensive drugs in the hypertensive group was 86.4%. The systolic blood pressure decreased in the hypertensive and normotensive groups after nutrition education (p < 0.05). The body weight (p < 0.001), BMI (p < 0.001), waist circumference (p < 0.001), and percent body fat (p < 0.01) were also decreased after nutrition education in both groups. The hypertensive group showed an increase in HDL-cholesterol level (p < 0.001) and decreases in triglycerides (p < 0.01) and LDL-cholesterol (p < 0.05) levels after completion of the program. The normotensive group also displayed significant changes in HDL-cholesterol (p < 0.001) and triglycerides (p < 0.01). The dietary habits and nutrition knowledge on sodium and hypertension were improved in both groups (p < 0.001). The total score of dietary behavior related to the sodium intake was improved in the normotensive group (p < 0.001). The total score of the high sodium dish frequency questionnaire decreased in both groups after nutrition education and completion of the program compared to that before the program. Decreases in the consumption frequencies of noodles, pot stews and stews, Kimchi, and beverages were significant. The total self-efficacy score was increased in both groups by the program (p < 0.001). In particular, the hypertensive group showed improvement in all items. Conclusion: This public health center-based nutrition education program may contribute to the prevention and management of hypertension and chronic diseases in women over 50 years of age.

• Journal of Nutrition and Health
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• v.32 no.5
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• pp.533-539
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• 1999

The effects of capsaicin, a pungent principle of hot red pepper, on body fat gain, balance serum lipid values were investigated in rats fed a high-fat(30%) diet. Administration of capsaicin by dietary administration caused a complete cessation of increased in body weight and fat gain induced by the high-fat diet. However, energy intake and body protein gain were not affected by capsaicin. Therefore, the suppression of body fat gain by capsaicn was believed due to an increased in energy expenditure. Simultaneous administration of capsaicin and a $\beta$-adrenergic blocker, propranolo, resulted in the inhibition of changes in body fat gain by capsaicin without remained unchanged, indicating an increase in the number of mitochondria in brown adipose tissue. Therefore, it appears that capsaicin possesses potent body fat suppressive effects mediated by $\beta$-adrenergic stimulation in which brown adipose tissue may be involved. On the other hand, capsaicin had no effects on serum triglyceride, total cholesterol or HDL-cholesterol levels. These results are in contrast to those reported by other investigators. Perhaps expression of the effects of capsaicin on plasma lipids is a rather complicated process, dependent on the type of diet administered, fat content of the diet, period and route of capsaicin administration, and species and strain of animals used.

• Journal of the Korean Society of Food Science and Nutrition
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• v.29 no.3
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• pp.460-465
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• 2000

본 연구는 여성 갱년기장애에 대한 홍삼의 효과를 조사할 목적으로 수행하였다. 홍삼의 효과는 자연적으로 갱년기 장애가 유도되었다고 생각되는 자성 노령흰쥐를 사용하여 홍삼 조사포닌 분획을 투여(20mg/kg,b.w./day) 한 후 그 효괴를 조사하였다. 홍삼조사포닌 분획은 노령쥐의 체지방 축적으로 야기되는 체중 증가를 다소 감소시키는 것으로 관찰되었다. (p<0.01). 노령쥐는 젊은 쥐에 비해 혈중 당, 총콜레스테롤, BUN 함량이 증가하였는데 조사포닌 분획의 투여는 혈당, 총콜레스테롤 함량 및 BUN 함량증기를 유의하게 억제하는 것으로 나타났다. (p<0.05, p<0.01). 노령쥐는 노령화에 따른 간기능의 저하로 GOT 및 GPT 활성이 증가하였으나 사포닌의 투여는 GOT 및 GPT 활성증가를 억제하여 간기능을 젊은 쥐의 수준으로 회복시킴을 알 수 있었다. (p<0.01). 노령쥐의 대퇴골은 사포닌투여와 관계없이 현저한 무게차이가 관찰되자 않았으나 대퇴골중 무기이온 Na+ 함량은 사포닌 투여시 약 2배 증가하는 것으로 나타났다. 이러한 사실로부터 홍삼 조사포닌 분획은 노령쥐의 혈당, 총콜레스테롤, BUN 함량증가를 억제하는 효과를 나타내며 또한 노령화에 따른 간기능 관련 생화학 지수를 개선하는 것으로 사료된다.

• Journal of Korean Medicine for Obesity Research
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• v.1 no.1
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• pp.33-42
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• 2001

Objectives: This study was to investigate the reductive effects of oriental medicine on the body fat and abdominal obesity, Methods: The subject were selected among the patients who were treated with 4weeks total program, visited our obesity clinic from October 1999 to August 2000, We practiced combined therapy such as herbal medicine, acupuncture therapy, moxibution therapy, negative therapy, auricular acupuncture, electrolipolysis, colon hydrotherapy, heat therapy, Chuna therapy, low-calorie diet teaching, exercise teaching, and correcting life style for 4 weeks. Results and Conclusion: 1. Body weight, RBW, and BMI were significantly reduced each by 5.4kg, 10.4% and $2.2kg/m^2$ (p<0.01). 2. % Body fat was significantly reduced by 3.3%. Fat mass was reduced by 4.0kg(17.0%) and soft lean mass was reduced by 1.5kg(3.7%), thus it was acknowledged that fat mass was significantly reduced compared to soft lean mass by oriental medicine treatment for obesity. 3. WHR was significantly reduced by 0.02. Waist circumference was reduced by 6cm(6.6%) and hip circumference was reduced by 4.5cm(4.6%), thus it was acknowledged that waist fat was significantly reduced compared to hip circumference by oriental medicine treatment for obesity.

• Journal of Korean Medicine for Obesity Research
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• v.1 no.1
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• pp.13-20
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• 2001

Obesity is an excess of body fat frequently resulting from an imbalance between energy intake and expenditure, raises the risk of morbidity from chronic diseases such as hypertension, dyslipidemia, type 2 diabetes, coronary heart disease, stroke, fatty liver and osteoarthritis. Recently we experienced a 51 years old obese woman who was accompanied with hypertension, dyslipidemia and osteoarthritis. Through weight reduction program(very low calorie diet, Chegameuiintang, exercise) during 3 months, total weight loss was 17.0kg, her condition was improved.

• Journal of Korean Medicine for Obesity Research
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• v.13 no.1
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• pp.46-50
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• 2013

This study was to investigate the effects of cultivated wild ginseng pharmacopuncture and thread implantation therapy on abdominal obesity. These 5 subjects were selected among the patients who were 30 to 38 years old. We practiced combined therapy such as cultivated wild ginseng pharmacopuncture on 5 points of abdominal fat and thread implantation therapy on 10 points of abdominal fat, twice a week, totally for 2 weeks. And the other therapies and recommendations about nutrition and exercises were totally excluded for 2 weeks. Body weight was reduced by 1.0 kg. Fat mass was reduced by 1.36 kg. And waist circumference was reduced by 3.98 cm. Thus it was acknowledged that waist partial fat could be reduced only by 2 interventions within 2 weeks. It could be more effective than any other combined therapy program including 10 therapy methods of oriental medicine.

• Journal of Nutrition and Health
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• v.50 no.6
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• pp.543-551
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• 2017

Purpose: The objective of the present study was to determine whether fermentation can increase the protective effects of blueberry liquid in a high-fat diet-induced obese mice model. Methods: Male C57BL/6J mice were fed a high-fat diet (HD, 60% fat, w/w,), HD supplemented with 10 ml/kg BW/day of blueberry liquid (BHD, blueberry high-fat diet), or HD supplemented with 10 ml/kg BW/day of fermented blueberry liquid (FBHD, fermented blueberry high-fat diet) for 10 weeks. Results: There were significant decreases in the body, epididymal adipose tissue, and liver weights of blueberry-fed groups compared to HD, whereas there were no significant differences in food intake among the groups. Furthermore, blueberry liquid groups, especially fermented blueberry liquid, significantly attenuated the contents of hepatic triglycerides and total cholesterol induced by HD. Serum LDL-cholesterol was significantly lower in the BHD and FBHD-fed groups, whereas FBHD significantly increased the serum HDL-cholesterol level compared to the control. Concentrations of aspartate transaminase, alanine transaminase, and leptins in serum were also reduced by blueberry liquid supplementation. The mRNA expression of hepatic acetyl CoA carboxylase was significantly reduced in both the BHD and FBHD groups compared to HD. Furthermore, FBHD altered the mRNA expression level of hepatic lipolysis genes. Conclusion: In conclusion, these results suggest that blueberry, especially fermented blueberry liquid, may improve obesity-related abnormalities.

• Journal of Life Science
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• v.21 no.2
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• pp.211-220
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• 2011

This study tested the anti-obesity and hypolipidemic effects of red garlic extract in obese rats induced by a high fat diet over a period of 4 weeks. Red garlic extract of 15 brix was added in 1, 3, 5 and 7% ratios in diets. The obesity index and body fat content significantly decreased in rats fed a diet with over 3% red garlic extract compared to the control group. There was no significant difference in weight of visceral and epididymal fat in rats fed red garlic extract. Total lipid and triglyceride levels in serum were significantly decreased in a dose-dependent manner, and AI and CRF also fell. ALT and AST activities in groups fed red garlic extract were decreased compared to the control group. Total lipid level in liver tissue of the groups fed 5-7% red garlic extract exhibited a significant decrease compared to the control group. Total cholesterol and triglyceride levels in feces were significantly increased in rats fed a diet with over 5% red garlic extract. Lipid peroxide levels were significantly decreased in the groups fed diets with 5-7% red garlic and antioxidant activity in serum was significantly increased in the group fed a diet with 7% red garlic extract compared to the control group. Our results suggest that red garlic extract could have anti-obesity and hypolipidemic effects for suppressing obesity index and decreasing lipid profiles.

• Journal of Nutrition and Health
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• v.56 no.5
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• pp.469-482
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• 2023

Purpose: Obesity has emerged as a critical global public health concern as it is associated with and increases susceptibility to various diseases. This condition is characterized by the excessive enlargement of adipose tissue, primarily stemming from an inequity between energy intake and expenditure. The purpose of this study was to investigate the potential of sweet pumpkin powder in mitigating obesity and metabolic disorders in leptin-deficient obese (ob/ob) mice and to compare the effects of raw sweet pumpkin powder (HNSP01) and heat-treated sweet pumpkin powder (HNSP02). Methods: Leptin-deficient obese mice were fed a diet containing 10% HNSP01 and another containing 10% HNSP02 for 6 weeks. Results: The supplementation of ob/ob mice with HNSP01 and HNSP02 resulted in decreased body weight gain, reduced adipose tissue weight, and a smaller size of lipid droplets in the adipose tissue and liver. Furthermore, the ob/ob-HNSP01 and ob/ob-HNSP02 supplemented groups exhibited lower levels of triglycerides, total cholesterol, low-density lipoprotein cholesterol, fasting blood glucose, and insulin, as well as a reduced atherogenic index in comparison with the control group. Molecular analysis also demonstrated that the intake of HNSP01 and HNSP02 resulted in a diminished activation of factors associated with fatty acid synthesis, including acetyl-CoA carboxylase and fatty acid synthase, while concurrently enhancing factors associated with lipolysis, including adipose triglyceride lipase and hormone-sensitive lipase, in the adipose tissue. Conclusion: Taken together, these findings collectively demonstrate the potential of sweet pumpkin powder as a functional food ingredient with therapeutic properties against obesity and its associated metabolic disorders, such as insulin resistance and dyslipidemia.

• Journal of the Korean Society of Food Science and Nutrition
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• v.25 no.2
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• pp.181-187
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• 1996

본 연구에서는 비타민 $B_{2}$ 결핍이 3일간 금식과 6일간 감식시 체내 저장연료 이용에 어떠한 영향을 미치는 가를 알아본 결과, -B2군은 pair-feeding을 감식시켰음에도 불구하고 +B2군에 비해 체중이 유의적으로 낮게 나타났으며 식이 이용효율도 낮았다. 모든 장기, 특히 간장 무게는 -B2군이 +B2군에 비해 무겁게 나타났으며, 감식과 금식시에도 -B2군의 장기무게가 가벼워졌으나 여전히 유의하게 무거웠으며 -B2군의 간장 중성 지방이 높게 나타나 지방간 증상으로 간장이 비대해진 것으로 추정된다. 혈장 포도당과 단백질 함량은 섭식, 금식 및 감식시 +B2군과 -B2군 사이에 유의적인 차이가 없었다. 혈장 중성지방 수준은 +B2군에 비해 -B2군이 섭식시는 높은 수준을 나타냈으나 금식 및 감식시에는 유의적인 차이를 나타내지 않았다. 간장 중성 지방도 이와 유사한 경향을 나타내었다. 혈장 유리지방산 수준은 섭식시에는 +B2군과 -B2군 사이에 유의적인 차이가 없었으나, 금식으로 인해 +B2군은 유리지방산 수준이 증가하였고 -B2군은 오히려 감소하여 -B2군이 +B2군 보다 낮게 나타났다. 그러므로 비타민 $B_{2}$ 결핍으로 인해 이 유리지방산의 유리가 원활히 일어나지 않았거나, 비타민 $B_{2}$ 결핍으로 인해 지방산화가 저해된 것이 금식으로 지방이 에저지원으로 이용되어야만 하는 상황이 발생하여 감소된 지방산 산화가 다소 회복된 것으로 추정된다. 금식 및 감식시 +B2군에 비해 -B2군이 근육단백질 수준은 높은 경향을 나타내었고 근육 글리코겐 수준은 낮은 경향을 나타내어 -B2군이 심각한 비타민 $B_{2}$ 결핍으로 저지방이나 근육단백질을 이용하지 못하게 됨에 따라 근육 글리코겐을 이용한 것으로 추정된다. 이는 +B2군에 비해 -B2군의 뇨중 총질소 배설량이 적은 것으로도 재확인되었다. 그러므로 금식이나 감식시 체지방이나 체단백질을 이용하는 에너지 보충 적응기전이 일어나야 하나 비타민 $B_{2}$ 결핍상태에서는 이러한 체내 열량공급이 지장을 받게 되며, 체단백질 이용저하로 포도당 신생이 영향을 받아 장기간의 금식 또는 감식시에는 혈장 포도당 수준도 낮아질 것으로 예상된다.