• Journal of the Society of Cosmetic Scientists of Korea
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• v.44 no.1
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• pp.73-79
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• 2018

The primary cilium protrudes from the cell body like a bio-antenna that has many receptors, channels and signaling molecules to sense and response to external stimuli. The external environment such as ultraviolet irradiation, temperature, humidity, gravity and shear stress always influences skin. Skin responds to external stimuli and differentiates by making melanin, collagen and horny layer. Ciliogenesis participates in developmental processes of skin, such as keratinocyte differentiation and hair formation. And it was reported that skin pigmentation was inhibited when ciliogenesis was induced by sonic hedgehog-smoothened-GLI2 signaling. When skin is exposed to ultraviolet irradiation, alpha-melanocyte stimulating hormones (${\alpha}$-MSH) increase melanin synthesis through activation of the cAMP pathway in melanocytes. We observed that ${\alpha}$-MSH and cAMP production inducers inhibited ciliogenesis of melanocytes. Therefore, we thought that regulation of ciliogenesis is potential candidate target for the development of agents to treat undesirable hyperpigmentation of skin. As a result, we found out that an ethanol extract of Glycyrrhiza glabra (EGG) root and 3,4,5-trimethoxy cinnamate thymol ester (TCTE, Melasolv) significantly inhibit melanin synthesis of normal human melanocyte by inducing primary cilium formation. This study proposed new theory to regulate skin pigmentation and cosmetic components for skin whitening.

• Journal of Ginseng Research
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• v.31 no.2
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• pp.79-85
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• 2007

Compound K (CK) is a final metabolite of panaxadiol ginsenosides. Although panax ginseng is known to have anti-diabetic activity, the active ingredient is not yet fully identified. Therefore, it would be interesting to know whether and how CK has an anti-diabetic activity. First, insulin secretion-stimulating activity of CK was examined using RIN-m5F cell line and primary cultured islets. CK enhanced the insulin secretion in a concentration dependent manner. This effect, however, was almost completely abolished in the presence of diazoxide, $K^+$ channel opener, indicating that the insulin secretion-stimulating activity of CK is presumably due to blockade of ATP sensitive $K^+$ channel. In addition, effects of CK on gene expressions of hepatic enzymes (phosphoenolpyruvate carboxykinase[PEPCK], glucose-6-phos-phatase[G6Pase]) and on adipocyte differentiation in H4IIE and 3T3-Ll cells, respectively, were examined. CK suppressed the induction of PEPCK and G6Pase mRNA expressions under the dexamethasone/cAMP stimulation condition. CK also reduced the $PPAR-{\gamma}$ mRNA expression and triglyceride accumulation in a dose dependent manner as compared to the control. The present study suggests that CK deserves to examine whether it shows an anti-diabetic activity in animal and human studies.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.30 no.4A
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• pp.336-344
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• 2005

Discrete Wavelet Transform(DWT) is the oncoming generation of compression technique that has been selected for MPEG4 and JEPG2000, because it has no blocking effects and efficiently determines frequency property of temporary time. In this paper, we propose an efficient bit-serial architecture for the low-power and low-complexity DWT filter, employing two-channel QMF(Qudracture Mirror Filter) PR(Perfect Reconstruction) lattice filter. The filter consists of four lattices(filter length=8) and we determine the quantization bit for the coefficients by the fixed-length PSNR(peak-signal-to-noise ratio) analysis and propose the architecture of the bit-serial multiplier with the fixed coefficient. The CSD encoding for the coefficients is adopted to minimize the number of non-zero bits, thus reduces the hardware complexity. The proposed folded 1D DWT architecture processes the other resolution levels during idle periods by decimations and its efficient scheduling is proposed. The proposed architecture requires only flip-flops and full-adders. The proposed architecture has been designed and verified by VerilogHDL and synthesized by Synopsys Design Compiler with a Hynix 0.35$\mu$m STD cell library. The maximum operating frequency is 200MHz and the throughput is 175Mbps with 16 clock latencies.

• Management & Information Systems Review
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• v.39 no.3
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• pp.83-98
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• 2020

This study analyzes how investors' irrational behavior (or pessimistic sentiment) affects stock market returns and investors' market activity using mass media that delivered public information from January 1998 to December 2012 as a sample. According to pessimistic investor theory, investor pessimism leads to downward pressure on the price of equity capital, thereby making market sentiment pessimistic and lowering market yields. It also shows that investor pessimism increases transaction costs in the market, which in turn dampens investors' trading activities. In other words, pessimistic reporting on public information disseminated by mass media induces investors to act irrationally, eventually having a direct impact on the stock market. This study conducted an empirical analysis of the existing theoretical and empirical studies using domestic mass media as a sample. First, the study revealed a negative correlation between pessimistic reporting and returns as well as excess returns, while it did not show statistically significant results. Second, evidence has been suggested that pessimistic sentiment in the stock market has a negative impact on future pessimistic reporting by mass media. Third, the analysis of the impact of pessimistic reporting on investors' market activity using proxy variables for various market activities found that pessimism dampens market activity, while it did not show statistically significant results. It is assumed that low statistical significance is due to the fact that sample collection was carried out on a monthly basis. While the results of the study have low statistical significance, statistical signs support predictions of the theory.

• Journal of Digital Convergence
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• v.12 no.3
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• pp.391-397
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• 2014

This paper is concerned with medical tourism, which is expected to become the new growth engine of the 21st century. Medical tourism is a collaborative and synergistic composition of Healthcare and Tourism, and has led to a remarkable growth in 2012 since the year 2009, exhibiting huge growth potential. This paper reviews the emerging market of the medical tourism with five major hospitals in Korea from the perspective of medical tourists, and makes suggestions for the global health care and the sustainable development in Korean medical tourism as a growth market: the construction of websites for active services and transparent management of medical expenses with proper arrangement of medical consulting and advices, cooperation of the health care center and the medical tourism industry, and the activation of healthcare communication. For the smooth progress of medical tourism, this paper suggests two separate communication channels: one for the patient tourists and the other for the medical tourism coordinators. The former needs accuracy with professional knowledge on the healthcare and communication, which should be classified as medical interpreters working with disease-oriented medical tourists. The latter refers to international medical coordinators dedicated to the smooth progress of medical tourism and services. This paper also points out the creative efforts to improve the relatively poor infrastructure of tourism industry to accommodate the medical tourists, and improve the medical tourism industry.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.45 no.1
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• pp.11-21
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• 2008

In conventional video coding, the complexity of encoder is much higher than that of decoder. However, as more needs arises for extremely simple encoder in environments having constrained energy such as sensor network, much investigation has been carried out for eliminating motion prediction/compensation claiming most complexity and energy in encoder. The Wyner-Ziv coding, one of the representative schemes for the problem, reconstructs video at decoder by correcting noise on side information using channel coding technique such as turbo code. Since the encoder generates only parity bits without performing any type of processes extracting correlation information between frames, it has an extremely simple structure. However, turbo decoding errors occur in noisy side information. When there are high-motion or occlusion between frames, more turbo decoding errors appear in reconstructed frame and look like Salt & Pepper noise. This severely deteriorates subjective video quality even though such noise rarely occurs. In this paper, we propose a computationally extremely light encoder based on symbol-level Wyner-Ziv coding technique and a new corresponding decoder which, based on a decision whether a pixel has error or not, applies median filter selectively in order to minimize loss of texture detail from filtering. The proposed method claims extremely low encoder complexity and shows improvements both in subjective quality and PSNR. Our experiments have verified average PSNR gain of up to 0.8dB.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.45 no.7
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• pp.32-37
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• 2008

Satellite communication systems including the DVB-S2 (Digital Video Broadcasting - Satellite Version 2) system require operations under low signal-to-noise ratio (SNR) and large frequency offset values, and the initial frame synchronization process necessitates a robust correlation method. While a variety of conventional correlation structures exist for the initial synchronization, each method has different characteristics and performance in different channel environments. In this paper, we propose new correlation methods which exhibit enhanced performance in low SNR and large frequency offsets, and analyze their performance. The proposed methods use the magnitude sum and vector sum of extended differential correlation values, to maximize the correlation between the received signal and the synchronization sequence by using the spanned differential correlation result. The magnitude sum correlation method has better performance compared to conventional methods including the approximated ML (Maximum likelihood) method for SNR values below 4 dB with or without frequency offsets. The vector sum correlation method has improved performance over the magnitude sum method for channels with relatively small frequency offsets.

• Membrane Journal
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• v.16 no.1
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• pp.31-38
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• 2006

The ceramic microfiltration system with periodic $N_2$-back-flushing was operated for treating paper wastewater discharged from a company making toilet papers by recycling milk or juice cartons. Two kinds of alumina membranes with 7 channels used here for recycling paper wastewater. The optimal filtration time interval for HC04 membrane with $0.4{\mu}m$ pore size was lower value of 4 min than 16 min for HC10 with $1.0{\mu}m$ pore size at fixed back-flushing time 40 sec, trans-membrane pressure $1.0kg_f/cm^2$ and back-flushing pressure $5.0kg_f/cm^2$. From the results of TMP effect at fixed filtration time interval and back-flushing time, the lower TMP was better on membrane fouling because high TMP could make easily membrane cake and fouling inside membrane structure. However, we could acquire the highest volume of total permeate at the highest TMP for the reason that TMP was driving force in our filtration system to treat paper wastewater. Then the permeate water of low turbidity was acquired in our microfiltration system using multi channels ceramic membranes, and the treated water could be reused in paper process.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.31 no.11A
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• pp.1076-1084
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• 2006

In this paper, we first review a concept of hybrid division duplexing (HDD) scheme, which has been proposed as a new type of duplexing scheme useful for a next generation mobile communication system and its implementation issues, including the unified radio resource management for HDD scheme. The HDD scheme maintains the advantages of both TDD and FDD at the same time while providing a useful structure to control the inter-cell interference, caused by an asymmetric traffic load of multimedia services over uplink and downlink in the TDD scheme. Employing two frequency bands, one for TDD scheme and the other for FDD scheme, uplink is operating under the TDD scheme only, while downlink is operating under the TDD or FDD scheme, depending on the location of mobile station. In the HDD scheme, therefore, it must determine a type of duplexing scheme to employ in the downlink and futhermore, a ratio of uplink and downlink duration to meet a given traffic load of asymmetric service, which requires some unified radio resource management for handling the subsequent inter-cell interference. In this paper, we propose a distributed adaptive control approach as a means of unified radio resource management for a HDD system that maximizes the overall system efficiency by fully utilizing the resource in TDD band, while minimizing the inter-cell interference.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.21 no.2
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• pp.345-352
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• 2017

In this paper, a unified potentiostat which can measure the current of both $O_2$-based and $H_2O_2$-based blood glucose sensors with low supply voltage of 1.0V has been designed and verified by simulations and measurements. Potentiostat is composed of low-voltage operational transconductance amplifier, cascode current mirrors and mode-selection circuits. It can measure currents of blood glucose chemical reactions occurred by $O_2$ or $H_2O_2$. The body of PMOS input differentional stage of the operational transconductance amplifier is forward-biased to reduce the threshold voltage for low supply voltage operation. Also, cascode current mirror is used to reduce current measurement error generated by channel length modulation effects. The proposed low-voltage potentiostat is designed and simulated using Cadence SPECTRE and fabricated in Magnachip 0.18um CMOS technology with chip size of $110{\mu}m{\times}60{\mu}m$. The measurement results show that consumption current is maximum $46{\mu}A$ at supply voltage of 1.0V. Using the persian potassium($K_3Fe(CN)_6$) equivalent to glucose, the operation of the fabricated potentiostat was confirmed.