• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제26권5호
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• pp.437-445
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• 2000

Object This study is focused on the comparison between $CO_2$ laser and scalpel by examining the overal process of wound healing after partial glossectomy of rats so that the result from the research could be easily applied to actual clinical environment. Method and Material In this research, 2mm defect was formed on both lateral borders of the tongue of rats by using $CO_2$ laser and scalpel respectively. 4rats were sacrified each time on the 1st, 2nd, 4th, 7th, 14th and 21th day according to a general method. After fabricating $5{\mu}m$ paraffin specimen, H&E staining and MT staining were performed. Results Compared to scalpel, wound healing by $CO_2$ laser leads to a earlier initiation of vascular proliferation and re-epithelization. Therefore, some influence is exerted on the early stage of wound healing. However, the two methods seem to undergo the similar healing process.

• 한국임상수의학회지
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• 제11권1호
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• pp.427-436
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• 1994

To investigate the effect of yeast glucan on wound healing in rabbits, histopathological findings and wound contraction after topical application of glucan on the open wound were observed. Formalin fixation and embedding of tissues at wound were prepared for histopathological findings at the other day after wounding. Wound size was measured for contraction. Macrophages appeared in the deeper site under the scab at day 1 after wounding in the glucan treated group, but not in the control. A number of macrophages, fibroblasts and a small number of neutrophils were observed at day 3 after wounding In the glucan treated group as compared with the control. Histopathological findings at day 5 after wounding in control were similar with those at day 3 in the glucan treated group. Glucan like granules were scattered in the cytoplasm of macrophages at day 5 in the glucan treated group. A great portion of wound reepithelialized at day 5 in the glucan treated group but a small portion of wound in the control. The Present study indicated that the treatment of 5,000$\mu\textrm{g}$/$m\ell$ of glucan has an effect on wound heal. ins in respect to migration of macrophage into the wound site, granulation tissue formation and epithelialization.

• 한국임상수의학회지
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• 제29권4호
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• pp.331-333
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• 2012

두 살 된, 거세된 수컷, 단모종 고양이가 배뇨곤란을 주 증으로 내원하였다. 신체검사 및 방사선 검사에서 회음부 요도개구술 후 직장요도루 및 요도 협착이 발생한 것으로 진단되었다. 이 문제를 해결하기 위하여 치골 요도개구술을 실시하였다. 이후 합병증 없이 창상 치유가 잘 이루어져 정상적인 배뇨가 이루어지고 있다. 고양이에서 회음부요도개구술 후 요도 협착과 직장요도 루가 동시에 발생한 첫 번째 증례이다.

• 한국전문물리치료학회지
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• 제6권3호
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• pp.1-10
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• 1999

The purpose of this study was to determine whether high voltage pulsed current stimulation (HVPCS) would enhance wound healing in neuropathic rabbits. Ten rabbits were assigned to either an experimental or a control group. The wounded part around the peripheral neuropathy of the experimental rabbits was stimulated for two hours twice a day for six days under the following conditions: pulse frequency 80 pps, pulse duration $100{\mu}s$, and stimulation intensity 30~40 V. The results indicated that there was no difference in the wound closure between the experimental and control groups. The two groups showed similar aspects in collagen and reticulum, which were observed by colored Masson's trichome. While the rabbits in the control group had more or less thick fibers, the rabbits in the experimental group had thin and branched-shape fibers. The rabbits in the experimental group showed both strong responses in the shaping of elastic fibers and the increased aspects in fibroblast when compared with the control group.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제30권2호
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• pp.198-204
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• 2008

Behcet Disease is a multisystem inflammatory disorder of unknown orign. It is characterized by recurrent oral ulcer, genital ulcer, skin lesions and ocular inflammation, and which may involve the joints, skin, central nervous system and gastrointestinal tract. Because Behcet Disease dose not have any specific symptoms and laboratory findings, the diagnosis is made on the basis of the criteria proposed by the the International Study Group for Behcet Disease. Behcet Disease is affecting both arteries and veins, and clinically manifest large vessel involvement occurs in between 7 and 49% of patients. Superior vena cava thrombosis is a rare but well-recognized manifestation of Behcet disease. We report a case of a Behcet Disease with superior vena cava thrombosis in a patient presenting delayed facial wound healing.

• Journal of Oral Medicine and Pain
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• 제24권2호
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• pp.137-143
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• 1999

Aucubin, the natural product, which is isolated from Aucuba japonica, has a variety of pharmacological effects such as liver-protective function, inhibition of liver RNA and protein biosynthesis, hypotensive activity and antimicrobial effect, etc. This study was performed to investigate the effects of iridoid compounds on wound healing. The author prepared 0.1% aucubin solution and 0.1% aucubin ointment as an active form, aucubigenin to which aucubin was converted by ${\beta}$-glucosidase. Artificial surgical wound was made on either 1cm lateral side of the dorsal midline along the axis of spine of Sprague-Dawley rats under sterile technique. Application of 0.1% aucubin solution or 0.1% aucubin ointment to surgical wound was done daily. Light microscopic examination was performed on the postsurgical 3 days, 5 days, and 9 days. The 0.1% aucubin solution group epithelialized earlier than the control group and the fibrosis of granulation tissue of both aucubin groups were more prominent than the control group. Collectively, this study suggests the possibility of aucubin as a topical agent. Further research should be performed on the mechanism of aucubin on wound healing and proper formulation for effective topical agents.

• 한국임상수의학회지
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• 제30권4호
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• pp.247-252
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• 2013

We compared wound healing with $CO_2$ laser incision and scalpel incision by measuring the extent of bleeding, the ease of incision, time, degrees of adhesion and histological observation in pig's stomach. Eight healthy pigs were used. Two symmetrical incisions were made in ventral aspect of the stomach between the greater curvature and lesser curvature were made with scalpel and 2 mm spot diameter $CO_2$ laser (8W, continuous wave) in eight pigs. And then each wound was closed with absorbable suture in a two-layer inverting seromuscular pattern. At 7 and 14 days after initial wounding, each wound was taken for histological observation. On surgery, the extent of bleeding, the ease of incision and incision time showed significant differences between the two groups. The $CO_2$ laser provided better hemostasis (p < 0.01) and smaller postoperative adhesion compared with the scalpel. However, the scalpel produced faster speed of incision and was easier to handle than the $CO_2$ laser group (p < 0.01). There was no considerable difference between the two groups in histological observation.

• 대한수의학회지
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• 제37권3호
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• pp.629-637
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• 1997

This study was performed to determine the optimal dose of laser energy for wound healing. The skin wound with 8mm diameter was induced over the lumbar vertebrae of the rats, and wound squares, scab hardness, hematologic findings and histopathlogic findings according to irradiation of laser energy were studied. 1. Wound square was significantly reduced at Day 1 (p<0.01), 2 (p<0.01), 3 (p<0.05), 7 (p<0.01) and 8 (p<0.05), respectively in experimental groups, especially group II, compared with control group. 2. Scab hardness was significantly increased at Day 1 (p<0.01), 2 (p<0.01), 3 (p<0.05), 5 (p<0.01) and 7 (p<0.01), respectively in experimental groups, especially group II, compared with control group. 3. In hematological findings, red blood cells and white blood cells in experimental group were increased according to the lapse of days, but they were not significant. 4. In histopathologic findings, experimental groups, especially group II, revealed early scab formation, early appearance of phagocytes and fibroblast, rapid growth of granulation tissue and collagen, and promotion of wound healing in the result.

• The Journal of Korean Physical Therapy
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• 제16권3호
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• pp.50-64
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• 2004

The studies have been designed to evaluate the effect of wound healing of pulsed ultrasound and chitosan application in diabetic incisive wound of rats. Mild diabetes mellitus was induced in rat used 30 mg/kg streptozotocin. Full thickness skin incision was made on the backs of Sprague-Dawley rats. We used 72 Sprague-Dawley rats which were divided into 4 groups; the subjects were divided into group of 6 rats each 3, 6, and 15 days. The results were summarized as follows; The rate of wound length of pulsed ultrasound with chitosan application groups more decreased than only pulsed ultrasound treatment group. The density of inflammatory cells in the experimental groups was more significantly decreased than diabetic control group(p<0.05). Historically, in the ultrasound with chitosan application groups, reepithelized epithelium was thicker and the collagen fiber were organized in a liner manner and connective tissue was matured faster those of the diabetic control group(p<0.05). From the conclusions above, in this study application of pulsed ultrasound and chitosan can be an effective way of promotion of wound healing in diabetic model.

• 한국임상수의학회지
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• 제27권4호
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• pp.382-385
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• 2010

This study was performed to investigate the wound healing effects of Allium cepa L. on Staphylococcus intermedius contaminated wound. 4 full-thickness skin wounds ($2\;cm{\times}2\;cm$) were made in the back and Staphylococcus intermedius was inoculated in seven dogs. In each dog, the wounds were treated with onion extract (experimental group) and normal saline (control group), respectively. The wound contraction rate of the experimental group was higher than that of the control group during the experimental period. The occupation rate showed that the wounds of the experimental groups contracted more vigorously than that of the control group in the early period of wound healing. The mean value of tensile strength on the 22 day after wounding was $4,741{\pm}848\;g/cm^2$ in the experimental group and $2,400{\pm}397\;g/cm^2$ in the control group. The number of S. intermedius in the experimental groups was decreased more rapidly than that of the control group. These results suggest that application of activated onion extract in like full-thickness skin wounds promote wound healing.