• Journal of the Korean Institute of Traditional Landscape Architecture
• /
• v.41 no.3
• /
• pp.47-58
• /
• 2023

This study was conducted through reviewing Aspects of Design and Construction in Entrance Space of the World Heritage Royal Tombs of the Joseon Dynasty, which is equipped with parking lots, ticket offices, toilets, exhibition halls, information boards, and rest facilities for the convenience of visitors and the purpose of this study was to propose a direction for improvement. The results of the study are as follows: First, the reduced area of Royal Tombs of the Joseon Dynasty was unable to fully accommodate the ritual movement line, and as a result, the location of the entrance space in the current royal tomb was decided to accommodate minimal convenience functions. In the meantime, the entrance space of the royal tombs has been relocated or renovated in order to achieve its integrity as a World Heritage Site, rational arrangement of movement lines and spatial utility. Second, the size of the entrance space ranges from 1,000 square meters in Jeongneung in Seoul to 16,000 square meters in Hongyuneung in Namyangju, and the number of annual users varies greatly from 12,000 in Onneung in Yangju to 410,000 in Seonjeongneung in Seoul. Considering the conditions of the 16 royal tombs, the entrance space should be provided at an appropriate scale, reflecting the surrounding land use and accessibility that affect the influx of users, the size of the site, and the king's awareness and preferences. Third, the location of the parking lot, the presence or absence of an outer courtyard and an internal courtyard bordering the ticket and check offices, and the location of the Historical and Cultural Museum made it possible to know the aspects of entrance space of the Joseon Royal Tombs, where the spatial configuration is determined Fourth, according to the royal tombs, it was found that the entrance space should have essential parking, access control, information, and convenience functions, and that support, exhibition, passage, and recess functions should be optional. At this time, the management office and the Historical and Cultural Center are in charge of support and exhibition functions. The function of passage can be a strategy that provides a sense of entry and the function of recess which has been introduced in only four royal tombs requires an appropriate location and landscape access.

• The Korean Journal of Medicine
• /
• v.99 no.1
• /
• pp.37-49
• /
• 2024

Background/Aims: In Korea, the incidence of primary diffuse large B-cell lymphoma of the central nervous system (PCNSL) is increasing and autologous stem cell transplantation (ASCT) has improved the survival of younger patients. We explored our real-world experience with PCNSL at Asan Medical Center (AMC). Methods: We used the AMC lymphoma registry to collect patient data prospectively. We analyzed 279 patients diagnosed from 2002 until August 2019. Results: The PCNSL incidence at AMC increased progressively and comprised 7.4-8.9% of new non-Hodgkin lymphoma patients annually during the most recent 4 years. The median age was 60 years (range, 17-85) and males comprised 55%. Patients under 65 years of age (n = 183) had no significant differences in characteristics compared to those aged 65 years or over, with the exception of less occipital lobe involvement and lower beta-2 microglobulin levels. Rituximab, methotrexate, procarbazine, and vincristine (R-MPV) combination induction had the best overall response, of 95%. The median overall survival was 3.8 years with 5- and 10-year survival rates of 41.5% and 30.2%, respectively. Survival was better in younger patients and those treated with ASCT. Thiotepa, busulfan, and cytoxan (TBC) conditioning chemotherapy had better survival than other combinations. The International Extranodal Lymphoma Study Group and Memorial Sloan Kettering Cancer Center prognostic score systems were valid in this cohort. Age and performance status were independent prognostic factors. Exclusive extra-central nervous system failure occurred in six patients (5.6%) among 107 failures. Conclusions: The incidence of PCNSL is rising. R-MPV induction therapy followed by ASCT with TBC has improved the survival of young, fit PCNSL patients.

• Journal of Life Science
• /
• v.19 no.4
• /
• pp.520-525
• /
• 2009

Early onset of Batten disease (EBD), one of the most lethal neurodegenerative storage disorders of childhood, is caused by inactivating mutations in the Ceroid Lipofuscinosis, Neuronal (CLN1) gene. Neurogranin, a calmodulin-binding protein, is expressed in the brain and participates in the protein kinase C (PKC) signaling pathway. While oxidative stress is the suggested cause of neurodegeneration in EBD, its molecular mechanism(s) remains obscure. In this research, we examined the levels of neurogranin in the brain mRNA of wild-type (WT) mice and EBD knockout (KO) mice, as well as the proteins. We also performed neuronal cultures to measure the expression levels of neurgranin and phosphorylated-neurogranin with or without oxidative stress inducers and anti-oxidants. Results showed that neurogranin in both EBD KO mice brain mRNA and protein extracts decreased in an age dependent manner. However, high amounts of phosphorylated-neurogranin were detected in the 6-month brain. This pattern was also confirmed by cultured neurospheres samples. Moreover, neurospheres treated with $H_2O_2$, an oxidative stress inducer, showed increased phosphorylated-neurogranin patterns. Interestingly, this pattern returned to normal status when treated with N-acetyl-L-cystein, an anti-oxidant, after $H_2O_2$ treatment was performed. Our results suggest that the phosphorylation of neurogranin is affected by oxidative stress status in EBD, and appropriate anti-oxidant treatment will relieve hyper-phosphorylation of neurogranin.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.21 no.6
• /
• pp.536-544
• /
• 2020

This study provides basic data for finding a plan for future teacher education in the future society by conducting an IPA-analysis of the abilities required for early-childhood who will become talented persons of the future society and the perceptions of early-childhood teachers about the era of the 4th-Industrial-Revolution. The study was conducted with 194 childhood teachers working in early-childhood educational institutions located in Jeju. It used a questionnaire of the demand survey for teacher education development for early-education based on the 4th-Industrial-Revolution. In the era of the 4th-Industrial-Revolution, the capabilities needed for early-childhood were revised and supplemented in 2016 at the World Economic Forum "Jobs Future Report". The frequencies and percentages were calculated to analyze the characteristics of each subject's background variables, the perceptions of early-childhood teachers and teacher education needs, and a t-test was conducted for each item to analyze the difference in importance and performance of early-childhood's competence. In the importance of competence required for infants who become talents for the future, the results showed that early-childhood teachers chose to have a high level of caring-sharing and curiosity-interesting ability. In the performance, they have a high level of caring-sharing and cooperation-communication ability.

• International Commerce and Information Review
• /
• v.16 no.4
• /
• pp.79-102
• /
• 2014

A parallel importation is a non-counterfeit product imported from another country without the permission of the intellectual property owner. It is caused by price differences between countries. Therefore parallel importation are implication in issues of international trade and intellectual property rights(hereafter referred as IPR). This paper provides parallel importation issues of Korea and China under the IPR laws such as patent, trademarks, copyright and analyzes difference between two countries. In China, patent law regulates exhaustion rights which is based theory of a parallel import for the first time unlike trademark law and copyright law. On the other hands, Korea rules parallel importing under Korean customs regulations. In conclusion, two countries have no provisions that advocate a parallel import under IPR laws. This paper suggests some improvements to overcome the limitation of current regulation system and avoid trade friction between two countries. First of all, two countries should clearly make a rule about parallel import in IPR law such as definition of parallel importation, genuine goods, permission conditions, importing proses, penalty and remedy etc. Secondly, two countries should prohibit an abuse of a exclusive import agent's rights and manage a parallel importer not to cause consumer's complain about goods to expansion parallel imports. Finally, two countries should cooperate not to cause disputes about this issue with a communication channel.

• Journal of the Korean Chemical Society
• /
• v.63 no.6
• /
• pp.415-419
• /
• 2019

Fipronil is an insecticide that belongs to the N-phenylpytazole and has been used mainly for an insect pest control. However, it is known that acute poisoning of the human body causes various symptoms such as dizziness, muscle weakness, dyspnea, skin irritation, and increased heart rate. Lately, eggs containing fipronil have been distributed and toxic problems are spreading around the world. In this study, we tried to develop analytical methods to evaluate the exposure of fipronil and fipronil sulfone in animal serum samples. The differences according to mobile phase and the results of liquid - liquid extraction and solid phase extraction pretreatment method were compared. Distilled water (A) and acetonitrile (B) were selected for the mobile phase, and the pretreatment method was determined by solid phase extraction. As a result of the method validation, the intra-day / inter-day accuracies were 82.2~114.1% and the precisions were less than 20%. The detection limit was 0.027 ng/ml for fipronil and 0.087 ng/ml for fipronil sulfone. The linearity obtained was satisfying, with a coefficient of determination (r²) higher than 0.99. The concentrations in some animal sera were determined using the methods of analysis for fipronil and fipronil sulfone in animal sera developed in this study. Using the method developed in this study, it could be used as an analytical method for human bio-monitoring of fipronil and fipronil sulfone as well as animal serum.

• Journal of Digital Convergence
• /
• v.16 no.5
• /
• pp.213-220
• /
• 2018

The automobile industry in Korea is a very large industrial sector. Nowadays, as the interest in low carbon green growth grows all over the world, it is time to actively secure future competitiveness of the automobile industry. Therefore, it is essential to study consumer attitudes and intentions for electric vehicles at the time when technological and social changes are expected. This study was conducted to investigate the acceptability and preference of electric vehicle for 250 people. The results are as follows. As the monthly income and the number of residents increased, the decision was made to accommodate the electric vehicle. The larger the effect of the electric vehicle on the consumers, the more the electric car decided to accommodate the electric car. In addition, three demographic characteristics (monthly income, number of residents, residence type) showed that there was a difference in satisfaction of electric vehicles. As a result of analyzing the satisfaction level of the electric vehicle, it was found that the electric vehicle has a satisfactory effect on the consumer, the electric vehicle is about 3.5 times more satisfying, and the larger the interest of the electric car is, the more the electric car is about 2.1 times.

• Management & Information Systems Review
• /
• v.34 no.4
• /
• pp.1-13
• /
• 2015

This paper presents a mathematical formulation for container slot chartering model through strategic alliance between liner shipping companies. This paper develops a solution procedure to apply the model to real world problems and its applicability is demonstrated by a numerical example. The model presented in this paper has some important features which have never been considered in the previous researches. The model is linear model and pursuits profit maximization. And also it considers slot chartering capacity selection. This paper attempts to perform sensitivity analysis and compares slot chartering model with basic non-collaborating model in which there is no alliance and collaboration. As a result of sensitivity analysis, some interesting findings are obtained; Even though freight rate is more and more decreasing, the profit by slot chartering model is always higher than the basic model but the profit gaps become smaller. But The ratio of the profit gap to the profit of basic model is more increasing.

• Resources Recycling
• /
• v.28 no.6
• /
• pp.26-35
• /
• 2019

This study aims to introduce and economical review on the possibilities of rare earth elements(REEs) recovery from coal ashes and the analysis of economical evaluation factors based on the data for securing domestic rare earth elements. The cut-off grade of REEs on recovering from coal ash was confirmed to be 1,000 ppm on total rare earth oxides(TREO) basis, and while the economic value of coal ash changed with contents and specific elements of rare earth elements. This shall be resulted in the price differences of rare earth elements required by the current industry, and it probably varies depending on the future demand of rare earth components. For developing of commercial recovery technology on REEs in coal ashes, many researches have been carried out by various analyzing methods, such as evaluation of holding value of REEs in ashes, assessment between supply and demand of industry, comparison of investment and its profitability for the REEs's production from coal ashes, and so on. Although these methods have been suggested, its recovery system with economical feasibility could not been confirmed up to present. In this reason, the process design of recovering REEs from coal ash shall be researched continuously to solve the problems of the global rare earth market. And also these researches shall be conducted actively in Korea for the purpose of securing the REEs resources and their recovering technologies.

• Journal of Korea Technology Innovation Society
• /
• v.17 no.4
• /
• pp.820-844
• /
• 2014

Various innovation theories, such as innovation system, innovation cluster, triple helix model, are different in their focus. However they all emphasize the interaction between innovation actors in order to generate, diffuse, and appropriate technological innovations successfully. This study analyzes how the interaction of innovation actors in Daedeok Innopolis has been changed since the introduction of innovation cluster policy like the designation of Daedeok Innopolis. Based on the analysis of survey data, Innopolis statistics, and patent joint-application data, we come to the conclusions that the Daedeok Innopolis has characteristics of multi-level governance structure, in which innovation cluster, i.e. Daedeok Innopolis, regional innovation system, and national innovation system directly overlap under the framework of innovation system. In addition, from the perspectives of triple helix model, we are able to verify that the inter-domain interactions between innovation actors, such as tri-lateral network, have been constantly increased in the Daedeok Innopolis. Based on our analysis, we identify some policy suggestions in order to strengthen the competitiveness of the Daedeok Innopolis as well as other innovation clusters in Korea. First, the network activities between innovation actors within innovation cluster should be strengthened based on the geographical accessibility. Second, private intermediate organizations should be established and their roles should be extended. Third, the entrepreneurial activities of universities within innovation cluster should be strengthened. In other words, the roles of universities within the Innopolis should be activated. Finally, the government should provide relevant policy supports to activate the interactions between innovation actors within innovation cluster.