• Journal of The Korean Society of Inherited Metabolic disease
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• v.17 no.2
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• pp.55-62
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• 2017

Gaucher disease (GD) is an autosomal recessive lysosomal storage disorder caused by beta-glucosidase deficiency. An 18 month-old male with hepatosplenomegaly, anemia, thrombocytopenia, and growth retardation referred to our hospital. The patient showed neurological symptoms, such as supranuclear gaze palsy and developmental delay. Bone marrow biopsy performed to rule out malignancy and the results revealed no malignant cell; however, abnormal histiocytes suggesting storage disease was noted. Based on hepatosplenomegaly, bicytopenia and unexplained neurologic manifestations, enzyme activity and genetic analysis were conducted emergently with a strong suspicion of GD. Beta-glucosidase activity in leukocyte was decreased. GBA sequencing to confirm the diagnosis revealed compound heterozygous pathogenic variants (i.e., c.754T>A, c.887G>A), both previously reported as the cause of neuronopathic GD. Under the diagnosis of type 3 GD, the patient immediately received enzyme replacement therapy (ERT). After 17 months of ERT, the size of spleen decreased, and hemoglobin and platelet count returned to normal. In addition, the activity of chitotriosidase and angiotensin converting enzyme decreased. However, myoclonic movement and generalized seizure occurred at the age of 19 months and antiepileptic drug was started. Other neurological deterioration including supranuclear gaze palsy and developmental delay also persisted. A new therapy to overcome neurologic problems should be developed for patients with type 3 GD.

• The Journal of Engineering Geology
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• v.19 no.1
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• pp.15-23
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• 2009

The site effects relating to the amplification of ground motion under earthquake loading are strongly influenced by both the subsurface soil condition and geologic structure. In this study, the site effects at the Hongseong area in Korea were examined by both the site investigation including borehole drilling and in-situ seismic tests and the site visit for acquiring geologic information of ground surface. Subsurface of Hongseong area with a major instrumental earthquake event in 1978 is composed of weathered layers of a maximum of 45 m thickness overlying bedrock. A geotechnical information system based on GIS framework was implemented to effectively find out spatial geologic structure of study area and it indicated Hongseong is a shallow and wide shaped basin. Two-dimensional finite element (FE) analyses for a representative cross-section of the Hongseong area were performed to evaluate seismic site responses. From the results of seismic responses, it was observed that the ground motions were amplified during the propagation of shear waves through the soil layer overlying the bedrock and the duration of shaking near the basin edges was prolonged due to the surface waves generated by interactions of shear waves with basin geometry. Furthermore, one-dimensional FE seismic response analyses were additionally conducted for soil sites selected in the basin, and it gives similar results to the two-dimensional seismic responses at most locations in the basin with the exception of the locations near the basin edges, because the basin in this study is very shallow and wide.

• Journal of the Korean Society of Hazard Mitigation
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• v.10 no.2
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• pp.61-68
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• 2010

Korea is constructing the disaster management system to prevent various disasters and minimize damages. In spite of these efforts, however, Korea lately suffered from a number of diverse disasters. These disasters once again lead to the questions and criticisms concerning the effectiveness of the disaster management system. So research into how to quantify the disaster management system is very significant in securing the right of the people to lead a safe life, keeping human life and properties from being injured. The purpose of this study is to prioritize policies which can be considered for establishing and operating disaster management system. To do that, this study conducts a questionnaire survey, targeting for 282 fire man. The survey includes various factors according to four stages in disaster management process: prevention, preparedness, response and recovery. The method used is AHP(Analytic Hierarchy Process) technique using expertchoice 2000. Results of the analysis are as follows. At the first stage of analysis, prevention is found as the most significant factor. The other significant factors are response, preparedness, and recovery factor in order. At the second stage of analysis, share of role among disaster facilities is the most significant factor. Reorganization of disaster facilities and connection of law are significant in order.

• Journal of the Earthquake Engineering Society of Korea
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• v.15 no.5
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• pp.35-44
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• 2011

PGA (Peak Ground Acceleration) is the parameter which indicates the peak value for strong ground motion and is mainly due to the intensity of the seismic wave. Usually, seismic waves can consist of different characteristics and can have different effects on structures. Therefore, it may be undesirable that the effects of a seismic wave are evaluated only based on the PGA. In this study, time history analysis was executed with a single degree of freedom model for inelastic seismic analysis. The numerical model was assumed to be a perfect elasto-plastic model. Input accelerations were made with El Centro NS (1940), other earthquake records and artificial earthquakes. The displacement ductility demand and cumulative dissipated energy, which were calculated from other artificial earthquakes, were compared. As a result, different responses from other seismic waves which have the same PGA were identified. Therefore, an index which could reflect both seismic and structural characteristics is needed. The SI (Spectrum Intensity) scale which could be obtained from integration by parts of the velocity response spectrum could be an index reflecting the inelastic seismic response of structures. It can be possible to identify from correlation analysis among the SI scale, displacement ductility demand and cumulative dissipated energy that the SI scale is sufficient to be an index for the inelastic response of structures under seismic conditions.

• Proceedings of the KSR Conference
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• 2010.06a
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• pp.880-894
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• 2010

The Grout injected precast pile is widely used in rapid-transit railway bridge recently. The existing portland cement of well used filling at injected precast method that with low strength and environmental pollution, unstable in which ground water contamination by cement flow out, ground relaxation by water down, decrease of horizontality resistance and durability and load transfer divide etc. In particular, as in rapid-transit railway bridge need to secure safety from different angle with vibration of high speed train, horizontal force when train stop and earthquake. Works of foundation construction consider to requirements of the times to coal yard green growth. Together, new green foundation method for possible economics and securing of reduce the term of works are material to developments. Therefore, we carried out study that it is using and development new concept environment - friendly filling include durability and earthquake resistance, for secure safety and minimize environment pollution. To achieve this, we carried out difference tests that new green fillings of underwater concrete, high liquidity, high viscosity, early stiffness as compared to existing portland cement fillings. As results, new green filling have outstanding application at precast pile method and micropile construction method with vertical bearing capacity, horizontal bearing capacity and many case. From now on we will be looking forward to development of new environment-friendly foundation method from various further studies.

• Progress in Medical Physics
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• v.26 no.1
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• pp.1-5
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• 2015

The C-band compact linear accelerator (linac) is being developed at Dongnam Institute of radiological & Medical Sciences (DIRAMS) for medical and industrial applications. This paper was focused on the output measurement of the electron beam generated from the prototype electron linac. The dose rate was measured in unit of cGy/min per unit pulse frequency according to the IAEA TRS-398 protocol. Exradin-A10 Markus type plane parallel chamber used for the measurement was calibrated in terms of dose to water at the reference depth in water. The beam quality index ($R_{50}$) was determined by the radiochromic film with a solid water phantom approximately due to low energy electrons. As a result, the determined electron beam output was $17.0cGy/(min{\cdot}Hz$. The results were used to monitor the accelerator performance during the development procedure.

• The Proceeding of the Korean Institute of Electromagnetic Engineering and Science
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• v.8 no.2
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• pp.37-55
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• 1997

최근 선진국가들에서는 전자파 장애 증후군에 관심이 집중되고 있는데, 전자파에 장기 노출 되는 인구에서 뇌암이나 유방암, 백혈병 등의 발생률이 높다는 보고(Kolmodin-Hedman 등, 1988 ; Demers등, 1991)가 있어서 전자제품의 생산업체는 물론이고 사용자에 대해서도 불안한 관심사가 되 어 있다. 전자파가 생체에 미치는 영향은 열적 효과와 비열적 효과에 의한 것으로 구분된다. Microwave는 약 300MHz에서 300GHz 사이(파장 1m에서 1mm사이)의 주파수를 가지는 전자파로서 이온의 운동이나 쌍극자분자(dipole molecule)들을 진동시키므로서 조직에 열이 발생한다. 열이 과도하게 발생하면 세포 단백질이 응고하게 되는 등 일반적으로 생각할 수 있는 고열로 인한 여러 가지 유해환경이 조직 에 조성될 수 있다. 실제로 고전압의 전자파에 노출된 안구의 수정체에 백내장 등의 병변이 발생한 것 으로 보고된 바 있다(Adey,1981). 일반적으로 전자파의 생체에 대한 작용으로는 이렇듯 조직에 흡수 되는 전자파의 에너지에 의한 열작용이 지배적인 것으로 생각되어 왔다. 그러나 초저주파역대(Extre- mely low frequency, EMF)의 변조 및 펄스파 등의 영향에 관해서도 조직의 온도상승으로는 설명할 수 없는 현상이 보고된 바 있다. 이러한 비열적 효과가 신경계에 끼치는 영향에 대해서는 혈액뇌관문 의 투과성 변화(Oscar와 Hawkins, 1977), 뇌종양 발생, 칼슘대사 이상 및 신경전달물질에 대한 영향 등이 주장(Anderson, 1993)되고 있으나 아직 그 분명한 기전이 밝혀져 있지 않은 상태이다. 또한 그 영향의 평가에 서도 일정한 기준이나 지표가 정해지지 않은 실정이다. 그러므로 신경계에 대한 대체적인 소개와 더불어 전자기파의 영향에 대한 이제까지의 보고를 종합 하고 향후 연구의 방향을 소개하고자 한다.> 이온이 공동 첨가제로 더 적합하다.u(30 .angs. )/CoFe(35 .angs. )/NiO(800 .angs. ) 구조를 갖는 spin-valve 박막은 극대 MR비 6.3%, 유효자기장감응도 약 0.5(%/Oe)를 보여 spin-valve head 재료로 적합함을 알 수 있었다.다.다.다.는 각각 148 meV .angs. $^{2}$, 103.8 meV .angs. $^{2}$와 1.77 * $10^{-6}$ erg/cm, 0.67 * $10^{-6}$ erg/cm 였다.다.자 노인들을 영주권자와 귀화 시민권자의 구분없이 하나의 집단으로 간주하고 분석해 왔던 것을 볼 때, 앞으로의 연구는 이론적으로나 방법론적으로 시민권의 유무가 주거형태에 끼치는 영향도 함께 고려해야 할 것이다.에 나타난 인도의 영향은 여성복식과 남성복식에 있어서 서로 유사점과 차이점이 보이는데, 인도의 영향이 여성복식에 있어서 그 빈도가 더 높고, 종류가 더 다양함을 볼 수 있다. 여성복식에 있어서는 12가지의 다양한 인도복식스타일이 나타났으며, 그중 가장 많이 보이는 스타일은 Indian Shirt/Blouse/Smock/ Dress이며, 그 뒤를 이어 Madras, Indian lowery등을 볼 수 있다. 남성복식애 나타난 7가지의 스타일 중에는 Madras가 가장 빈도가 높으며 그외의 스타일들은 그 빈도가 매우 낮음을 볼 수 있다. 인도의 영향의 정도 (Attribution Categories) 있어서는 여성과 남성복식 모두에 있어서 인도에서 직접 수입된(originated) item이 각각 전체의 90%와 81%를 차지하여, 인도복식의 영향은 받았으나 미국내에서 제작된(attributed and connotated) item 보다 휠씬 더 많은 수를 보였다. 인도복식스타일이 가장

• Korean Journal of Remote Sensing
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• v.35 no.3
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• pp.483-489
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• 2019

True color images display colors similar to natural colors. This has the advantage that it is possible to monitor rapidly the complex earth atmosphere phenomenon and the change of the surface type. Currently, various organizations are producing true color images. In Korea, it is necessary to produce true color images by replacing generations with next generation weather satellites. Therefore, in this study, visual enhancement for true color image production was performed using Top of Atmosphere (TOA) data of Advanced Himawari Imager (AHI) sensor mounted on Himawari-8 satellite. In order to improve the visualization, we performed two methods of Nonlinear enhancement and Histogram equalization. As a result, Histogram equalization showed a strong bluish image in the region over $70^{\circ}$ Solar Zenith Angle (SZA) compared to the Nonlinear enhancement and nonlinear enhancement technique showed a reddish vegetation area.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.35 no.2
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• pp.131-140
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• 2022

Installing Continuous Welded Rail (CWR) is one of the economical ways to resolve the challenges of noise, vibration, and the open-deck steel railway bridge impact, and the SSF method using the interlocking sleeper fastener has recently been developed. In this study, the method employed for determining the optimum vertical stiffness of the sleeper pad installed under the bridge sleeper, which is utilized to adjust the rail height and absorb shock when the train passes when the interlocking sleeper fastener is applied, is presented. To determine the optimal vertical stiffness of the sleeper pad, related existing design codes are reviewed, and, running safety, ride comfort, track safety, and bridge vibration according to the change in the vertical stiffness of the sleeper pad are estimated via flexible multi-body dynamic analysis,. The flexible multi-body dynamic analysis is performed using commercial programs ABAQUS and VI-Rail. The numerical analysis is conducted using the bridge model for a 30m-long plate girder bridge, and the response is calculated when passing ITX Saemaeul and KTX vehicles and freight wagon when the vertical stiffness of the sleeper pad is altered from 7.5 kN/mm to 240 kN/mm. The optimum stiffness of the sleeper pad is calculated as 200 kN/mm under the conditions of the track components applied to the numerical analysis.

• Journal of the Korean Geotechnical Society
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• v.22 no.5
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• pp.59-67
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• 2006

The centrifuge and 1-g shaking table tests were performed simultaneously to compare the dynamic behaviors of loose sands of the same geotechnical properties. The prototype soils were 10 m thick liquefiable loose sands. The geometric scaling factors were 20 for 1-g and 40 for centrifuge tests. The excess pore pressure, surface settlement, and acceleration in the soil were measured at the same locations in the 1-g and centrifuge tests. The total excess pore pressure from development to dissipation was measured. In the centrifuge test, viscous fluid was used as the pore water to eliminate the time scaling difference between dynamic time and dissipation time. In the 1-g tests, the steady state concept was applied to determine the unit weight of the model soil, and two different time scaling factors were applied for the dynamic time and the dissipation time. It is concluded that the 1-g tests can simulate the excess pore pressure of the prototype soil if the permeability of the model soil is small enough to prevent dissipation of excess pore pressure during shaking and the dissipation time scaling factor is properly determined.