• (The)Study of the Eastern Classic
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• no.33
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• pp.231-252
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• 2008

This study is to investigate on focus of his political position change to build up his the real form about Park je sang(朴堤上) who had taken an active part within Shila nulgi king(訥祗王) period on base of previous park je sang' study results. that is, this study took attention about excellent capability by diplomat who had shown his diplomatic ability in complicated and international fields of three countries, and about process of entrance on central political fields by private capability in sap lang(?良) district in relation with building up the real form of park je sang. As result, by means of few investigations about park je sang who had taken an active part, we looked into process how local power man in sap lang(?良) district had built up his position to jin-gol(眞骨) status with strategic location of sap lang(?良) district on shila history within Shila nulgi king period. I think that we found valuable means from figures of a district society in process how Shila had grown with a country of centralizing power.

• Journal of Life Science
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• v.25 no.10
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• pp.1184-1195
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• 2015

The zebrafish is an emerging vertebrate model organism in reproductive biology. The oocyte maturation of zebrafish is triggered by maturation inducing hormone (MIH, 17α,20β-Dihydroxy-4-pregnen-3-one). In almost all animals, the oocyte maturation is governed by activation of pre-MPF which consists of cyclinB and inactive Cdk1. In the oocyte of Xenopus and mice, the activity of Cdk1 is regulated in two ways, one is the interaction with cyclinB and the other is phosphorylation/dephosphorylation of T14/Y15 residues on the Cdk1 by Wee1 and Cdc25. Unlike Xenopus and mice that have a sufficient amount of pre-MPF, pre-MPF is absent in GV oocyte of most teleost including zebrafish. Therefore, the activation of MPF during zebrafish oocyte maturation might totally depend on de novo synthesis of cyclinB proteins. It is reported that the translation of maternal mRNA is regulated by combination of several RNA binding proteins such as CPEB, Dazl, Pum1/Pum2, and insulin-like growth factor2 mRNA-binding protein 3 in the zebrafish oocytes. However, the definitive mechanism of these proteins to regulate the translation of stored maternal mRNAs remains to be elucidated. Therefore, the investigation of the maturation process of the zebrafish oocyte will provide new information that can help identify the role of translational control in early vertebrate oocyte maturation.

• Proceedings of the Korean Society for Agricultural Machinery Conference
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• 2017.04a
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• pp.100-100
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• 2017

2016년부터 중국에 수출한 진공포장 쌀이 진공이 풀려 중국 현지 소비자들에게 품질에 대한 신뢰저하로 외면 받아 판매에 어려움을 겪었다. 진공풀림 원인은 주로 포장재의 모양, 과열 열접착 및 운송 중 부주의 등을 들 수가 있다. 따라서 본 연구에서는 쌀 진공포장 후 진공 풀림현상이 발생되는 원인을 분석하고, 진공포장에 적절한 포장재 및 취급조건에 대해 구명하여, 중국 쌀 수출 시 품질신뢰도 및 경쟁력 제고로 쌀 수출 확대를 위해 진공 포장재, 진공포장기술 및 운송 취급 방법을 제시하고자 하였다. 미곡종합처리장에서 사용하고 있는 플라스틱 필름 포장재의 적합 여부를 살펴보기 위하여 산소투과도 및 투습도를 산소투과도 측정장치(OX-Tran Model 2/61, Mocon, USA), 투습도 측정장치(Permatran-W Model 3/33, Mocon, USA)를 이용하여 측정하였다. 적정 열접착 온도를 구명하기 위하여 열접착 작업시간 간격 3, 5, 10초 3수준으로 하고 가열시간을 0.2초~2초까지 9수준으로 설정하여 포장필름을 열접착한 후 접착상태를 조사하였다. 진공 포장된 쌀을 골판지상자에 2차 포장하여 운송할 때 진공풀림 현상이 발생 여부를 조사하기 위해 가상 운송시험을 진동시험 장치를 이용하여 수직 및 수평으로 진동시험을 수행하였으며, 또한 취급조건에 따라 진공풀림을 조사하기 위하여 골판지 상자단위, 비닐포장 단위로 50, 70, 90cm 높이에서 낙하 시험을 하고 진공풀림여부를 조사하였다. 유통 중인 쌀 진공 포장재는 나이론(nylon)+선형저밀도폴리에틸렌(LLDPE) 복합필름으로 산소투과도가 $30{\sim}70cc/m^2{\cdot}day$, 투습도가 $2{\sim}4.5g/m^2{\cdot}day$로 산소투과도 및 투습도가 충분히 낮아 진공포장재로 적합했으며, 적정 열접착온도 조건은 $130{\sim}150^{\circ}C$에서 1~1.5초가량 가열해야 되는 것으로 조사되었다. 진동시험 및 낙하시험결과, 골판지박스 포장 시 완충재를 사이에 넣은 경우 진골풀림이 적었고, 상자단위나 비닐포장단위 모두 가능한 50cm보다 높은 곳에서 낙하충격을 받지 않도록 취급해야 할 것으로 판단되었다.

• Journal of fish pathology
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• v.8 no.2
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• pp.135-148
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• 1995

To elucidate the distributional pattern of macrophages within lymphomyeloid tissues according to the disease process, tilapias, teleostean fish, were intraperitoneally injected with live Edwardsiellatarda and its extracellular product(ECP) respectively. And then histopathological examination for the spleen and gead kidney were carried out for the individuals which had not any clinical signs. In the group injected with live E. tarda, macrophages were densely organized into MMC-like structures with showing some degree of recovery in histological arrangement. At the 2nd week, overall structures of the lymphomyeloid tissues became normal, accompanying the disappearance of most of macrophage groups. Also in case of ECP injection, quite similar findings were observed. Moreover, macrophage collections and hypertrophied ellipsoids were recognized at 1hour after the injection of ECP in head kidney and spleen, respectively. These results suggested that characteristic behaviors of macrophages in lymphomyeloid tissues would be used as important morphological criteria for early diagnosis of edwarsiellosis or possibly of other infectious diseases.

• Radiation Oncology Journal
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• v.19 no.4
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• pp.359-368
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• 2001

Purpose : To determine the long-term results of bladder-preserving approach by transurethral resection of the bladder (TURB), systemic chemotherapy, and radiation therapy for muscle-invasive bladder cancer Methods and materiaals : From 1991 Jan. through 1994 Dec., 25 patients with muscle invading clinical stage T2 to T4NxM0 bladder cancer were treated with induction by maximal TURB and (arm 1, n=4) three cycles of chemotherapy [MVAC(methotrexate, vincristine, adriamycin, ciplatin)] followed by 64.8 Gy of radiation with concomitant cisplatin, or two cycles of chemotherapy [MCV (methotrexate, ciplatin, vincristine)] after irradiation with concomitant cisplatin (arm 2, n=14), or concurrent chemoradiation only (arm 3, n=7). Tumor response was scored as a clinical complete response (CR) when the cystoscopic tumor-site biopsy and urine cytology results were negative. Those with less than a CR underwent cystectomy. The median follow-up of all patients was 70 months. Resulst : Most treatment toxicities were mild to moderate. Grade 3 acute hematologic toxicity and chronic cystitis were observed in only 1 and 2 patients, respectively. Overall 5 year survival was $67.3\%$. Complete remission rate was $80\%$ (20/25). Sixty-three percent of all survivors retained their bladders. In multivariate analysis, prognostic factors that significantly affect survival were T-stage (p=0.013) and Complete remission (p=0.002). Conclusion : Combined modality therapy with TURB, chemotherapy, and radiation has a $67.3\%$ overall 5 year survival rate. This result is similar to cystectomy-based studies for patients of similar clinical stages.