• Title/Summary/Keyword: 직접흡연

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Effect of Complex Extract Including Cornus officinalis on the Cimetidine/Ethanol-induced Erectile Dysfunction Model in Rats (산수유를 포함한 복합추출물이 cimetidine으로 발기부전을 유도한 동물모델에서 성기능 개선 효과)

  • Jang, Ji Hun;Kim, Tae Muk;Sim, Mi Ok;Nho, Jong Hyun;Jung, Ho Kyung;Lee, Mu Jin;Lee, Ki Ho;An, Byeong Kwan;Cho, Hyun Woo
    • Korean Journal of Plant Resources
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    • v.31 no.2
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    • pp.109-116
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    • 2018
  • Erectile dysfunction (ED), also known as impotence, is the inability to attain and sustain an erection firm enough to have sexual intercourse. Frequent ED may be a symptom of health problems including heart disease, obesity, alcoholism, stress, smoking, and depression, that need treatment. This study aimed to effect of complex extract (CPL) including Cornus officinalis on sexual function factor in the erectile dysfunction rat model. The erectile dysfuction rat model was induced by cimetidine (500 mg/kg in 5% ethanol, oral injection 2 weeks). Rats were oral administered with different concentration of CPL in rat erectile dysfunction model. As a results, sexual function factors (NO, cGMP) significantly improved in CPL treated groups (CPL-300, 600, 900 mg/kg) compared to CON group. Serum testosterone was increased in a dose-dependent manner after CPL treatment. Furthermore, administrations of CPL restored lumen areas of the prostate in the erectile dysfunction rat model. These results indicated that CPL alleviated erectile dysfunction by increasing sexual function factor and testosterone in rat model. CPL could be used to natural treatement for erectile dysfunction. However, further study is required to identify active ingredient and its mechanism of erectile dysfunction.

Correlation between Visceral Adipose Tissue and Stagnation of the Liver Qi (gan-yu, 肝鬱) in Korean Perimenopausal Women (한국 갱년기 여성의 간울과 내장비만의 상관성)

  • Hwang, Mi-Ja;Chung, Seok-Hee;Hwang, Deok-Sang;Song, Mi-Yeon
    • Journal of Korean Medicine Rehabilitation
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    • v.18 no.2
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    • pp.143-156
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    • 2008
  • 목적 : 갱년기 여성은 내장비만의 위험이 높으며 또한 심리적 변화를 겪는 시기이다. 갱년기 여성의 복부지방, 내장지방, 피하지방 및 이와 관련된 단순비만지표, 간울증, 스트레스, 우울, 자존감 등을 조사하여 갱년기 건강의 위협이 되는 신체 심리 인자를 알아보고자 이 연구를 시행하였다. 방법 : 병원공고를 통해 체질량지수 $23kg/m^2$ 이상 비흡연자인 만 45세 이상 55세 이하의 폐경 전후의 갱년기 여성 환자를 모집하여 2007년 8월 20일부터 24일까지 47명이 모집되었으며 이중 체질량지수 $25kg/m^2$ 이상이면서 복부 전산화 단층촬영 상 내장지방이 $100cm^2$ 이상인 20명의 단순비만지표, 체성분검사, 혈액검사, 복부 전산화 단층촬영 및 한방비만변증 (간울) 및 스트레스, 우울, 자존감 설문검사 결과의 상관성을 분석하였다. 본 연구는 경희대학교 동서신의학병원의 임상연구심사위원회의 승인을 받았다. 결과 : 1. 갱년기 비만여성에서 복부지방 면적, 피하지방 면적은 체질량지수, 체지방률, 허리둘레/신장비 등의 단순비만지표와 유의한 상관성을 보인 반면 (p < 0.01), 내장지방 면적은 단순비만지표와 상관성을 보이지 않았다. 2. 내장지방 면적은 사회 재적응 평가척도 (${\gamma}=0.577$, p < 0.01)와 유의한 상관성이 있었고, 선형회귀분석에서 유의한 결과를 나타냈다. $VAT(cm^2)=116.1+0.101{\times}(SRRS\;score)$ (${\gamma}^2=0.332$) 3. 피하지방은 식이태도 점수와, 총복부지방은 식이태도 점수 및 갱년기지수 중 혈관운동증상과 상관성이 있었다. 4. 간울증은 스트레스 반응척도, 우울지수, 갱년기지수 및 그 하부항목 중 혈관운동, 정신, 운동, 소화, 전신증상과 양의 상관성을, 자존감척도와는 음의 상관성을 나타냈으며, 내장지방과 직접적인 상관성을 보이지 않았다. 결론 : 간울증은 높은 스트레스, 우울, 갱년기 증상 및 낮은 자존감과 관련되는 것으로 나타났다. 폐경전후 비만여성에서 내장지방 면적은 간울증과 유의한 상관성을 보이지 않았으나, 생활 스트레스 사건이 많을수록 높아지는 것으로 나타나 갱년기 여성 내장비만에서 스트레스에 대한 대처가 중요할 것으로 사료된다. 추후 임상적 연계성 및 설문 보완에 대한 연구가 필요하리라 생각된다.

The effect of notification disposition in the current juvenile justice system from the perspective of institutionalized children's welfare (시설보호아동의 복지 관점에서 본 소년법상 통고제도)

  • Lee, Hyung-Seob;Jung, Sun-wook
    • Journal of the Korean Society of Child Welfare
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    • no.56
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    • pp.69-99
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    • 2016
  • Taking the perspective of children's welfare, this study aimed at critically analyzing the system of notification disposition which institutionalized children have experienced. Notification disposition is a juvenile justice process that, when a child (10 th 18 years old ) has been delinquent or is at risk for delinquency, is initiated without investigation or prosecution procedures by direct notification to a judge from the caregivers, school principals, chief probation officers, or directors of child care institutions. The data used in the analysis included case records of probation offices, and court sentencing documents of juvenile protective dispositions. Results showed that notification cases were initiated by directors of child shelters/care institutions. The most common reasons of notification were theft, runaway, physical violence, drinking, and smoking. Furthermore, there were more controversial reasons, such as "bad influence on another institutionalized children", "showing no remorse", "no sense of guilt"and "challenge of rearing in institutions" Based on the results, we discussed three problematic aspects of the direct notification system by directors of childcare institutions : (1) too much reliance on the judicature judgment of juvenile court; (2) less stability of the judicial status of notified children, and (3) inadequacies of the notifying eligibility for directors of child care institutions.

Oral Health Knowledge According to Police Officers' Oral Health Behaviors (경찰공무원의 구강건강관리행태에 따른 구강보건지식)

  • Lee, Mi Hak;Lee, Hye-Jin;Oh, Han-Na
    • Journal of Convergence for Information Technology
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    • v.11 no.9
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    • pp.165-172
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    • 2021
  • This study was carried out in order to identify oral health knowledge according to police officers' oral health behaviors. The questionnaire survey was conducted targeting 237 police officers in Gwangju. A tool used general characteristics, oral health knowledge, oral health behavior and oral health education needs. The analysis was processed with descriptive statistics, t-test, Anova and regression analysis. As a result, the oral health knowledge was high in a person of using oral hygiene products and in a person of experiencing a visit to dental clinic(p<0.001). The desired the oral health education were a specialist's direct verbal explanation and the correct tooth-brushing method. Also, marital status, educational level, smoking status, using oral hygiene products and Dental visit experience were identified to have influence upon a oral health knowledge (explanatory power, 40.5%). Hence, the results of this study will be able to be applied to basic data in case of developing an oral health education program and planning a dental health project for enhancing oral health in police officers.

The Effects of Plasma Homocysteine Concentration on Upper Arm-Ankle Pulse Wave Velocity (혈장 호모시스테인 농도가 상완-발목 맥파 속도에 미치는 영향)

  • Kang, Ji-Hun;Shin, Sang-Yol
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.20 no.2
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    • pp.673-680
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    • 2019
  • This study was conducted to investigate the effects of plasma homocysteine concentration on the brachial-ankle pulse wave velocity between the normal homocysteine group and the asymptomatic high homocysteine group. 435 subjects who visited the general health examination center from April 1 to October 31, 2016, as well as to compare the direct correlation of the brachial-ankle pulse wave velocity, which indirectly reflects the homocysteine test and arterial stiffness, as a predictor of future cardiovascular outcome. As a result of the study, age, waist circumference, BUN, and plasma creatinine were significantly higher, and HDL was significantly lower in the high homocysteine group (> $15{\mu}mol/L$) than in the normal homocysteine group (< $15{\mu}mol/L$) (p=0.05). In addition, homocysteinemia was associated with smoking and drinking (p<0.001) and was significantly higher in males (p<0.001). The right and left brachial-to-ankle pulse wave velocities were significantly higher in the high homocysteine group (right p<0.001, left p=0.003) before calibrating the relevant variables. There was no significant difference between right and left brachial-to-ankle pulse wave velocities after calibrating the relevant variables. Therefore, further studies on the independent association of lowering homocysteine concentration and prevention of cardiovascular disease and the relationship between homocysteine and renal function are needed.

Quality of Life and Its Related Factors Among Metropolitan-dwelling Older Adults (도시지역 재택 고령자의 삶의 질(Quality of Life) 및 관련요인)

  • Ham, Seok-Pil;Kim, Beom-Ho
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.22 no.5
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    • pp.411-422
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    • 2021
  • The purpose of this study is to examine the relationships between quality of life and demographic characteristics and health-related behavioral characteristics, and their relevance to variables that represent health conditions among metropolitan-dwelling older adults. The study subjects were 380 senior citizens aged 65 or older living in the D metropolitan area, and data collection was conducted by visiting them for interviews in June 2019. A binomial logistic regression analysis was performed to examine the relationship between independent variables (demographic characteristics, health-related behavioral characteristics, health condition variables) and the dependent variable (quality of life) while controlling for gender and age. As a result, the factors related to quality of life for those surveyed were education level, spousal status, living status, bear for living expenses, average monthly allowance, satisfaction with daily life, evaluation of sleep quality, smoking and eating habits, amount of regular exercise, hobbies, subjective health status, physical disability (if any), hearing ability, visual acuity, mastication ability, urinary incontinence (present or not), and amnesia. The above results suggest that quality of life for the elderly living in urban areas is significantly related to variables that indicate demographic characteristics, health-related behavioral characteristics, and health condition.

The Impact of Late-life Poverty on Self-rated Health: A Mediated Moderation Model of Health Behaviors and Social Support (노후 빈곤이 주관적 건강상태에 미치는 영향: 건강행태와 사회적 지지의 매개된 조절효과 분석)

  • Kim, Jinhyun;Won, Seojin
    • 한국노년학
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    • v.31 no.3
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    • pp.463-478
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    • 2011
  • This study examined the impact of late-life poverty on self-rated health, focusing on the mediating and moderating effects of health behaviors and social support. Despite the significant associations among poverty, health behaviors, and health outcomes, little studies have tested complex structural pathways among them. Thus, the purpose of this study is to identify multiple causal pathways between poverty and self-rated health, mediated and moderated by health behaviors and social support. To test the structural pathways, the structural equation modeling was utilized using the 2006 Korean Longitudinal Study of Aging data. The results of this study indicated that poverty had the direct negative impact not only on the health behaviors such as smoking and lack of regular exercise but also on the self-rated health. In addition, regular exercise significantly mediated the relationship between poverty and self-rated health. Finally, informal social support from family and friends buffered the negative impact of poverty on the self-rated health. Findings suggested that providing informal social support to the low income elderly is important in addition to the economic support. It is also necessary to develop programs for promoting healthy behaviors, especially regular exercise.

The Effect of Histamine on Polymorphonuclear Leukocyte-induced Pneumocyte Injury in Vitro (다형핵구에 의한 폐포세포 손상에 Histamine이 미치는 영향)

  • Kim, Young-Kyoon;Kwon, Soon-Seog;Kim, Kwan-Hyung;Han, Ki-Don;Moon, Hwa-Sik;Sang, Jeong-Sup;Park, Sung-Hak
    • Tuberculosis and Respiratory Diseases
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    • v.39 no.3
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    • pp.228-235
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    • 1992
  • Background: Although polymorphonuclear leukocytes (PMN) are important in protecting the airways and alveolar surfaces, there is evidence that they can also injure the lung while exercising their defensive role. However it has been unclear whether PMN-induced pneumocyte injury is mediated by their direct cytotoxic effect on target cells or by PMN-derived cytotoxic mediators. On the other hand histamine was known not only to act as an important chemical mediator participated in the pathogenesis of some atotic and allegic disorders, but also to have an inhibitory effect on normal PMN functions. Method: To study the mechanism by which PMN induce pneumocyte injury, we cocultured PMN from four healthy nonsmokers or their PMN-derived supernatants (PMN-SPN) with monolayers of $^{51}Cr$-labeled human A549 pneumocytes and compared PMN-and PMN-SPN-mediated pneumocyte injuries measured by $^{51}Cr$ release assay. We also compared the effects of histamine on each pneumocyte injury. Results: 1) PMN-SPN showed more injurious effect on A549 pneumocytes than that of PMN itself regardless histamine pretreatment of PMN. 2) Pneumocyte injury by PMN with histamine pretreatment was increased or decreased compared with that by PMN without histamine pretreatment, according to histamine concentrations, and PMN stimulating agents and their concentrations. 3) Pneumocyte injury by PMN-SPN with histamine pretreatment tended to be decreased compared with that by PMN-SPN without histamine pretreatment. Conclusion: Our results suggest that PMN-SPN may play more important role in mediating pneumocyte injury than PMN itself and that histamine may partially play a protective role on PMN-induced pneumocyte injury. Alternatively we conclude that the effects of histamine on PMN-induced pneumocyte injury may be affected by microenvironment in vivo.

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Traffic Forecasting Model Selection of Artificial Neural Network Using Akaike's Information Criterion (AIC(AKaike's Information Criterion)을 이용한 교통량 예측 모형)

  • Kang, Weon-Eui;Baik, Nam-Cheol;Yoon, Hye-Kyung
    • Journal of Korean Society of Transportation
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    • v.22 no.7 s.78
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    • pp.155-159
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    • 2004
  • Recently, there are many trials about Artificial neural networks : ANNs structure and studying method of researches for forecasting traffic volume. ANNs have a powerful capabilities of recognizing pattern with a flexible non-linear model. However, ANNs have some overfitting problems in dealing with a lot of parameters because of its non-linear problems. This research deals with the application of a variety of model selection criterion for cancellation of the overfitting problems. Especially, this aims at analyzing which the selecting model cancels the overfitting problems and guarantees the transferability from time measure. Results in this study are as follow. First, the model which is selecting in sample does not guarantees the best capabilities of out-of-sample. So to speak, the best model in sample is no relationship with the capabilities of out-of-sample like many existing researches. Second, in stability of model selecting criterion, AIC3, AICC, BIC are available but AIC4 has a large variation comparing with the best model. In time-series analysis and forecasting, we need more quantitable data analysis and another time-series analysis because uncertainty of a model can have an effect on correlation between in-sample and out-of-sample.

Differences in Farmer's Syndrome between Greenhouse-Melon Farmers and Rice Farmers (시설참외 및 수도작 농작업자의 농부증 비교)

  • Park, Jong-Seop;Oh, Gyung-Jae
    • Journal of agricultural medicine and community health
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    • v.33 no.1
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    • pp.27-36
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    • 2008
  • =Objectives: This study was conducted to evaluate the diferences in Farmer's syndrome between greenhouse-melon farmers and rice farmers. Methods: The study included 160 residents, who lived in rural community. Of those subjects, 73 and 87 from June 1 to July 30, 2006. Respondents were interviewed by means of a structured questionnaire. Results: This study showed that greenhouse-melon farmers had a lower average age, shorter experience of farming, more working hours per day than rice farmers (p<0.05). n farmers was 38.4% respectively, the prevalence in rice farmers was 22.6%. There was statistically significant diference in the prevalence of Farmer's syndrome between greenhouse-melon and rice farmers (p<0.05). The most frequent symptoms among eight symptoms that constitute the Farmer's syndrome were lumbago, shoulder pain and nocturnal urination regardless of type of farming. But greenhouse-melon farmers had higher prevalence of muskuloskeletal symptoms, such as lumbago and shoulder pain, than rice farmers (p<0.05).Conclusions: These results showed that prevalence of Farmer's syndrome was more common in the tools which reduce physical burden and take a rest and exercise periodically during work in the greenhouse-melon farmers.