• Proceedings of the Zoological Society Korea Conference
• /
• 2001.10a
• /
• pp.218.2-218
• /
• 2001

• The Journal of the Korean dental association
• /
• v.38 no.1 s.368
• /
• pp.103-108
• /
• 2000

• Journal of the Korean Society of Food Science and Nutrition
• /
• v.34 no.9
• /
• pp.1325-1329
• /
• 2005

To estimate the inhibitory effect of Lithospemum erythrorhizon root extract on melanin biosynthesis, we tested its inhibitory effects on tyrosinase promoter in B16 mouse melanoma cells. Lithospermum erthrorhizon root extract had inhibitory effect above $33\%$ on tyrosinase promoter at $10{\mu}g/mL$ and exhibited no cytotoxicity under $100{\mu}g/mL$. Also, melanin biosynthesis decreased approximately $11\%$ and $24\%$ at $10{\mu}g/mL$ and $100{\mu}g/mL$, respectively. Therefore, Lithospermum erythrorhizon root extract would be considered very effective regulator of tyrosinase promoter and melanin biosynthesis.

• Journal of Convergence for Information Technology
• /
• v.10 no.7
• /
• pp.116-121
• /
• 2020

This study was undertaken to investigate the influence and related mechanisms that have yet to be clearly demonstrated of Lithospermum erythrorhizon derived-naphthoquinone (shikonin) on the anxiety, insomnia, depression in rats. We hypothesized that naphthoquinone, the primary ingredient of Lithospermum erythrorhizon, plays a role in the modulation of insomnia evoked by stress, depression evoked by forced swimming or anxiety evoked by elevated plus maze. Male ICR (Institute of Cancer Research) mice were used and the immobility or swimming time, the duration of sleep, the duration and entry frequency into open arms were measured and recorded. The administration of naphthoquinone (10, 30 and 100 mg/kg) potentiated barbiturate-induced sleep suggesting the activation of GABAA receptor. It also potentiated the time spent in open arms of the maze and decreased the immobility time in forced swimming. In conclusion, naphthoquinone has anxiolytic, hypnotic and anti-depressant properties and is a potential therapeutic for anxiety, insomnia and depression.

• Journal of Life Science
• /
• v.23 no.5
• /
• pp.643-649
• /
• 2013

In this study, we examined the antioxidative activities of ethanol extracts obtained from three plants; Lithospermum erythrorhizon Siebold & Zucc., Xanthium strumarium Linn, and Lonicera japonica, which have traditionally been used as drugs in Eastern medicine in Korea. Their extraction yields were 7.01%, 2.92%, and 7.95% in Lithospermum erythrorhizon Siebold & Zucc., Xanthium strumarium L, and Lonicera japonica, respectively. The contents of the phenolic compounds were $4.3{\pm}0.1{\mu}g/ml$, $5.4{\pm}0.1{\mu}g/ml$, and $4.6{\pm}0.1{\mu}g/ml$ in Lithospermum erythrorhizon Siebold & Zucc., and Xanthium strumarium L, respectively. Furthermore, the radical scavenging activity measured through the DPPH assay appeared highest in the Lonicera japonica's extract, and its $EC_{50}$ was 0.24 mg/ml. Compared to the control, the xanthine oxidase inhibiting activities of all extracts were effective at 0.01 mg/ml concentration. Superoxide radical scavenging activity in Lithospermum erythrorhizon Siebold & Zucc. and Lonicera japonica was more than 80%, with a concentration of 50 mg/ml. OH radical scavenging activity was 40% in the three plants, with a concentration of 50 mg/ml scavenging activity. From our results, we demonstrated that the ethanol extracts of three medicinal plants have antioxidant activities and could be potential candidates for natural antioxidants.

• Proceedings of the Korean Society of Environment and Ecology Conference
• /
• 2009.04a
• /
• pp.90-92
• /
• 2009

• Proceedings of the Korean Society of Plant Biotechnology Conference
• /
• 2002.04b
• /
• pp.141-141
• /
• 2002

• The Hankook-Saengyark Bo
• /
• no.262
• /
• pp.5-5
• /
• 2005

당귀 꽃대발생 줄이려면 신품종 '만추$\cdot$안풍' 유리 - 한약재 '굼벵이' 대량증식 성공 - 슈퍼도라지 나왔다.(기존보다 44$\%$ 증수) - 잡초발생 친환경적 억제기술 나와(농과원, 수지 살포후 물 뿌려 80이상 방제) - 무공해 한방농약 개발(고려생물약센터)

• The Journal of the Korean dental association
• /
• v.22 no.7 s.182
• /
• pp.591-606
• /
• 1984

• Korean Journal of Plant Taxonomy
• /
• v.44 no.4
• /
• pp.276-280
• /
• 2014

Two alien plants Holosteum umbellatum L. and Asperugo procumbens L., belonging to Boraginaceae and Caryophyllaceae, respectively, have been first recorded in Hongseong-gun, Chungcheongnam-do and Incheon, South Korea. This initial investigation reports to inform the importance of detection and extermination of these potential weeds in surrounding areas. Furthermore, we report the morphological characteristic features of these two alien plants.