• The Journal of Korean Academy of Sensory Integration
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• v.15 no.2
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• pp.35-45
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• 2017

Objective : The purpose of this study is to investigate the effect of modified Interactive Metronome (IM) program which is applicable to clinical practice based on the IM protocol on the behavioral symptoms, timing and motor function of children with Attention Deficit Hyperactivity Disorder (ADHD). Method : This study used one-group pretest-posttest research design. 13 ADHD children aged 7-12 years in Busan were participated in this study. The participants were underwent 24 sessions of 30 minutes intervention, 3 times a week. Evaluations were performed before- and after the intervention. Measurements used in this study were Korean-ADHD Rating Scale for behavior symptom, Long Form Assessment (LFA) for the timing, and second version of Bruininks-Oseretsky Test of Motor Proficiency (BOT-2) for the motor function. Results : There was a significant improvement in hyperactivity / impulsivity among the behavioral symptoms, and there was a statistically significant improvement in timing, hand coordination, and body coordination. Conclusion : Modified IM program for clinical application has significant effect on improving behavioral symptoms, timing and motor function of children with ADHD.

• Journal of Marine Life Science
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• v.5 no.1
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• pp.1-8
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• 2020

This review is about current Streptococcosis of cultured olive flounder, Paralichthys olivaceus, in South Korea. The main bacterial species are Streptococcus iniae, S. parauberis and Lactococcus garvieae. The occurrence trend has been arranged with published data and seed bank (NIFS) data that was examined with deposited strains and the number from 2002 to 2017. S. iniae and L. garvieae were collected until 2012 and 2002, respectively, but not collected any more after that year. In recent years, the dominant strain of Streptococcosis of cultured olive flounder is S. parauberis. The phenotypic and genetic characteristics of standard strains and isolated strains were examined with published paper. Notably, we describe about distinguishing gross signs and histological signs of 3 types of Streptococcosis in this report. White turbidity of eye, hemorrhage, enteritis and ascites are main signs of S. iniae infection. Darkness of body surface, hemorrhage in somatic muscle and pericarditis are predominant in occasion S. parauberis infection. In occasion of L. garvieae infection, common signs of Streptococcosis are revealed, but these are weak tendency compared with the previous two cases.

• Journal of Korean Ophthalmic Optics Society
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• v.17 no.2
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• pp.185-194
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• 2012

Purpose: The changes of phoria and subjective asthenopia before and after viewing were compared based on 2D image and two ways of 3D images, and presented for references of 3D image watching and production. Methods: Change in phoria was measured before and after watching 2D image, 3D-FPR and 3D-SG images for 30 minutes with a target of 41 university students at 20-30 years old (male 26, female 15). Paired t-test and Pearson correlation between changed phoria and subjective symptoms which were measured using questionnaires were evaluated by before and after watching each images. Results: Right after watching 2D image, exophoria was increased by 0.5 $\Delta$, in distance and near, but it was not a significant level. Right after watching 3D image, exophoria was increased by 1.0~1.5 $\Delta$, and 1.5~2.0 $\Delta$, in distance and near, respectively when compared with before watching. In the significant level, exophoria tended to increase. Changes in near was increased more by 0.5 $\Delta$, compared with those in distance. Changes based on way of 3D-FPR and 3D-SG image were less than 0.5 $\Delta$, and there was almost no difference. In terms of visual subjective symptoms, eye strain was increased in 3D image compared with that in 2D image. In addition, there was no difference depending on way of image. In terms of Pearson correlation between phoria change and eye strain, as exophoria was increased, eye strain was increased. Conclusions: Watching 3D image increased eye strain compared with watching 2D image, and accordingly exophoria tended to increase.

• Journal of Chest Surgery
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• v.29 no.8
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• pp.867-874
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• 1996

This study was designed to assess the left ventricular peak systolic pressure/end-systolic volume (PSP/ESV) ratio in predicting symptomatic improvement with valve replacement in patients with aortic regurgitation and enlarged left von'lrlcular volume. We studied 21 patients (15 men and 6 women aged 15 to 60 years) with moderate or severe aortic regur- gitation, no other cardiovascular abnormalities and left ventricular end-systolic volume over 60 m11m2. In this group we assessed the preoperative variables which routinely were measured at cardiac catheterlzation to predict symptomatic improvement with valve replacement. Six months after operation, symptoms were alleviated in 13 patients(62%), and unchanged in 8()8%). By multivariate analysis, the PSP/ESV rati was a strong predictor for functional class 6 months after surgery(p=0.005) and also for change- in functional class prior to an operation to 6 months postoperatively(p=0.0)2). By 6 months after receiving valve replacement, all patients with a ratio over 1. 71 mmHglml/m'were in functional class I or II , in contrast, of those with a ratio < 1.71 mmHg/ml/m2, 40% were in functional class III. The PSP/ESV ratio may help to predict which patients with aortic regurgitation and enlarged left ven- tricular end-systolic volume will have symptomatic improvement with valve replacement.

• Journal of Digital Convergence
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• v.15 no.1
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• pp.485-495
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• 2017

This study looked into the effects of acceptance and commitment therapy(ACT) program on the premenstrual symptoms, attitudes toward menstruation and perceived stress, in females in their 20's suffering from premenstrual syndrome(PMS). Among the 263 students from 3~4 year universities, 21 were selected as participants. 7 were assigned to the acceptance and commitment therapy(ACT) group, 7 were assigned to the cognitive behavior therapy(CBT) group, and 7 were assigned to the control group. As a result, emotional factor from the premenstrual symptoms has significantly decreased more in the acceptance and commitment therapy(ACT) group, and the cognitive behavior therapy(CBT) group in comparison to the control group. In regards to attitudes toward menstruation, there were no statistical significance in the acceptance and commitment therapy(ACT) group, however there were positive changes, and the cognitive behavior therapy(CBT) group displayed significant change in the follow-up study. In perceived stress, acceptance and commitment therapy(ACT) group displayed more significant decrease than the control group and the cognitive behavior therapy(CBT) group, and that level remained unchanged until the follow-up study.

• Journal of the Korea Convergence Society
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• v.13 no.2
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• pp.55-65
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• 2022

The purpose of this paper was to investigate the relationship between cybersickness symptoms and visual function and to determine whether visual perception training is effective in reducing symptoms of cybersickness. The study subjects were healthy adult males who experienced the same virtual reality program for 15 minutes. Afterwards, the VR satisfaction score and cybersickness level were measured and classified into a comfortable virtual reality program viewer group (CVR group, 20 people) and an uncomfortable virtual reality program viewer group (UVR group, 20 people). Visual function test was performed on all subjects, and the vision therapy training program was applied to the UVR group once a week for 40 minutes 12 times, and then the visual function and SSQ questionnaire were re-evaluated. Subjects with diplopia were 55% in the UVR group and 5% in the CVR group, which was significantly higher in the UVR group, there were differences in stereopsis, exophoria, near point convergence(p<.01) and vergence function(p<.001) between the two groups. After vision therapy, changes in SSQ, stereopsis, near point convergence, and vergence function of UVR user group were positively changed(p<.01). Therefore, cybersickness symptoms are related to visual function, it seems that the vision therapy can be used as a way to alleviate the symptoms of cybersickness.

• Korean Journal of Food Science and Technology
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• v.52 no.5
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• pp.555-559
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• 2020

In order to examine the toxicity of palatinose-L (Pal-L) bioconverted from sucrose, we performed a 14-consecutive day toxicity study with male and female Sprague-Dawley (SD) rats. We recorded clinical signs of toxicity, body weight, organ weights, hematology, blood biochemical, urinalysis, histological changes in organs, such as the liver and kidneys, and clinical chemistry analysis data for all SD rats. There were no significant changes in food/water consumption, body weight, and organ weights during the experimental period. Although there were some hematologic and urinalysis alterations, these changes were not considered toxicologically significant. In addition, histopathological examination of the liver and kidneys revealed no abnormal or toxicological changes between the control and Pal-L-treated rats of both sexes. Collectively, these results suggest that Pal-L was not indicated to have any toxicity in the SD rats when it was orally administered up to a dose of 1,000 mg/kg/day for 14 days.

• Clinical and Experimental Pediatrics
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• v.52 no.12
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• pp.1348-1357
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• 2009

Purpose:The aims of this study were to identify the clinical characteristics and determine the changes in the expression of cytokines and apoptosis-related genes in children with infectious mononucleosis. Methods:Serological examinations of 15 pediatric patients diagnosed with infectious mononucleosis were performed prospectively. Peripheral blood from the patients was used to compare the composition of T cell subsets, cytokines, Epstein-Barr virus (EBV) DNA, and the expression of apoptosis-related genes with those in 10 healthy children. Results:Mean age of the patient group was $5.7{\pm}3.4$ (range, 3-9) years, and the male-to-female ratio was 1.5:1. Fever, sore throat, pharyngitis/tonsillitis, and cervical lymph node enlargement were the most common symptoms and signs. The proportions of CD3+ T cells, CD8+ suppressor cells, and CD56+ natural killer (NK) cells were higher in the patient group than in the control group (P<0.01). The IL-2, IL-6, and interferon $(INF)-{\gamma}$ levels were higher in the early symptomatic period (P<0.01). Mean amount of EBV DNA in the patients was $10^{2.38}copies/{\mu}g$, and the amount was the highest at the beginning of the symptomatic period and normalized during the convalescent phase. Bcl-2 expression increased during the initial phase, while Bax expression increased during the convalescent phase. Further, FasL expression increased 1 week after symptom presentation and decreased during the convalescent phase. There was no significant change in Fas expression. Conclusion:We analyzed the clinical characteristics and changes in the expression ofcytokines and apoptosis-related genes in the patients with infectious mononucleosis.

• Clinical and Experimental Pediatrics
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• v.50 no.7
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• pp.643-648
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• 2007

Purpose : Sepsis is a common complication in Neonatal Intensive Care Units (NICU), seen especially in low birth weight (LBW) infants. A recent study showed that fungal or gram-negative sepsis is associated with a greater degree of thrombocytopenia than is seen with gram-positive sepsis. So, this study was undertaken to examine the platelet counts and platelet indices in LBW infants during episodes of sepsis. Methods : We analyzed 36 cases with culture-proven sepsis on chart review in LBW infants admitted to the NICU at Wonkwang University Hospital from January 2001 to June 2006. Results : Patients were grouped by organism type: gram-positive bacteria ($1,521{\pm}309g$, $31.3{\pm}2.9wk$, 15/36), gram-negative bacteria ($1,467{\pm}290g,\;30.6{\pm}3.6wk$, 17/36), and fungi ($1,287{\pm}205g,\;30.0{\pm}3.9wk$, 4/36). The most common organism was Staphylococcus epidermis and the incidence of thrombocytopenia was 88.9%. When compared with infants with gram-positive sepsis, those with gram-negative sepsis had significantly higher incidences of thrombocytopenia, lower initial platelet count, lower platelet nadir, and greater mean percentage decrease in platelet count from before the onset of sepsis. Those with fungal infections were similar to gram-negative sepsis, but they were not significant because of the small number of patients. And mean platelet volume (MPV) in sepsis was increased more significantly in time of platelet nadir than before the onset of sepsis. Conclusion : We conclude that decrease in platelet count was significantly greater in gram-negative sepsis than gram-positive sepsis, and also greater than fungal sepsis-which was insignificant because of the small number of patients-in LBW infants. And elevation in MPV will be helpful in the diagnosis and treatment of sepsis in LBW infants.

• Journal of Veterinary Clinics
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• v.27 no.2
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• pp.163-169
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• 2010

To evaluate of oral toxicity of Epimedium koreanum nakai (EKN) water extract, three doses of EKN water extract (10, 100 and 1000 mg/kg/day) were administered to healthy Sprague-Dawley rats for 4 weeks. The results showed that there are no abnormal signs during the experimental period. The weights of testis and epididymis were increased dose-dependently, but seminal vesicle was decreased compared with control group. In hematology and serum chemistry, changes were observed within the normal ranges. In histological finding, slight to moderated changes were found but those were commonly or rarely encountered in the normal rats. These results suggest that no observed adverse effect level (NOAEL) of the oral application of EKN was considered to be more than 1000 mg/kg in SD rats under the conditions employed in this study.