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Submucosal CD4+ and CD8+T Lymphocyte Infiltrations in Asthma and Eosinophilic Bronchitis (천식과 호산구성 기관지염에서 CD4, CD8 림프구 침윤)

  • Lee, Sang Yeub;Lee, Sung Yong;Kim, Je Hyeong;Shin, Chol;Shim, Jae Jeong;Kang, Kyung Ho;Yoo, Se Hwa;In, Kwang Ho;Lee, Ji Hye;Jeong, Woon Yong;Kim, Han Kyeom
    • Tuberculosis and Respiratory Diseases
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    • v.55 no.5
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    • pp.459-466
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    • 2003
  • Background : Asthma and eosinophilic bronchitis(EB) are eosinophilic inflammatory diseases of the airway. However, EB differs from asthma in that there is no variable airway obstruction or airway hyper-responsiveness. Pathologically, asthma is characterized by the accumulation of eosinophils and CD4+ T lymphocytes in the submucosa. A recent study showed that there was no significant difference between asthma and EB in terms of the submucosal eosinophil and T lymphocyte count. However, it is not known whether or not an infiltration of CD4+ and CD8+ T lymphocytes occurs in the airways of EB patients. The aim of this study was to identify the difference between the two conditions by measuring the submucosal CD4+ and CD8+ T lymphocyte count. Methods : Immunohistochemical analysis of bronchial-biopsy specimens was performed in 17 subjects with asthma and 24 subjects with EB. Results : The CD4+ T lymphocytes count in the asthma subjects and the EB subjects was similar (median, 58.6 vs 50.0 $cells/mm^2$, respectively; P=0.341). In contrast, the number of CD8+ T lymphocytes in the EB subjects was higher than that in the asthma subjects (median, 46.7 vs 11.8 $cells/mm^2$, respectively; P=0.003). Conclusion : The infiltration of submucosal CD8+ T lymphocytes may be associated with the pathophysiology of EB.

Heat Flux Analysis of Lunar Lander for Potential Landing Candidate Area (달 착륙선의 착륙 후보지별 열 유입량 분석)

  • Park, Tae-Yong;Chae, Bong-Geon;Lee, Jang-Joon;Kim, Jung-Hoon;Oh, Hyun-Ung
    • Journal of the Korean Society for Aeronautical & Space Sciences
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    • v.46 no.4
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    • pp.324-331
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    • 2018
  • The thermal environment on lunar surface is more severe than that of earth's surface or low earth orbit because of the long daytime and nighttime due to 28 days of rotation cycle of moon. Thus, analyzing heat flux on lunar lander at potential landing sites is important to determine the landing site in its initial design phase. In this study, thermal model of lunar regolith that can simulate lunar surface temperature was constructed for analyzing thermal characteristics according to the potential landing sites of lunar lander. The heat flux analyses were performed various latitudes of equator, mid-latitude, polar regions, lunar mare and highland. In addition, we also investigated the heat flux of lunar lander when it is landed on adjacent area to hill.

Effect of Instruction Utilizing History of Science on the Science Achievement and Attitude of Middle School Students: In the Chapter of 'Water Cycle and Weather Change (과학사 활용 수업이 과학 학업성취도와 태도에 미치는 효과; 중학교 '물의 순환과 날씨변화' 단원을 중심으로)

  • Lee, Hyun-Sun;Yoo, Jung-Moon
    • Journal of the Korean earth science society
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    • v.25 no.7
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    • pp.565-575
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    • 2004
  • The effects of education utilizing history of science on science achievement and attitudes of the ninth grade students were investigated according to their achievement level, along with the development of teaching and ;earning materials. A total of 144 ninth grade students were divided into the experiment and control group. Instructing students using history of science was performed in the experiment group, while conventional instruction was used in the control group. The scores of both pre-test and post-test were estimated by ANCOVA. Instructions applying history of science were more effective in increasing the students' science achievement and attitude than conventional instructions. In particular, the former enhanced the achievements of the upper-level students, more than it did for the middle and lower-level students. In addition, using history of science showed a better effect on higher and middle-level students, in improving their attitudes toward science, than it did for lower-level students. This study suggests that the instruction utilizing history of science should be designed based on the students' achievement level, and that various teaching and learning materials related to the instruction were helpful.

Development of Apparatus and Methods for Understanding the Dynamics of the Western Boundary Current (서안경계류 역학을 이해하기 위한 실험 장치 및 방법 개발)

  • Jang, Swung-Hwan;Shin, Jung-Sun;Moon, Byung-Kwon
    • Journal of the Korean earth science society
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    • v.31 no.1
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    • pp.88-94
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    • 2010
  • A simple laboratory device and methodology are developed for deep understanding of the western boundary current (WBC). The apparatus consists of a rotating (count-clockwise) rectangular tank with a sloping bottom in order to simulate the beta effect, the variation of the Coriolis parameter with latitude. We also used a clockwise rotating disk at the surface water to mimic the wind stress forcing in mid-latitude oceans. Four experiments were carried out using some combination of a bottom type and a rotation of the tank. Experiment with the beta effect clearly demonstrated the WBClike flow as well as the Sverdrup interior. However, the water in a tank gave rise to an inertial motion under the influence of a constant Coriolis force alone. We also discussed a stiffening of the rotating fluid on the basis of the Taylor-Proudman effect. We believe that the apparatus and methods developed in this study help to understand the WBC due to the beta effect.

A Simple Introduction of Extratropical Transition of Tropical Cyclone (TC) and a Case Study on the Latest Three TCs: Shanshan (0613), Yaki (0614), and Soulik (0618) (태풍의 온대성 저기압화에 대한 간단한 소개 및 최근 세 태풍의 사례분석: 산산(0613), 야기(0614), 솔릭(0618)을 중심으로)

  • Choi, Ki-Seon;Kim, Baek-Jo
    • Journal of the Korean earth science society
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    • v.28 no.7
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    • pp.947-956
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    • 2007
  • In this article, the extratropical transition (ET) of tropical cyclone (TC) was investigated based on the case study covering the latest three TCs (Shanshaa Yaki, and Soulik) associated with ET evolution (onset and completion) using the objective 37 diagnostics of Evans and Hart (2003) and Hart (2003). At 500-hPa level, on an onset of ET, all three TCs entered the baroclinic zone. In a vertical cross-section analysis, three TCs before and at an onset of ET kept warm and humid throughout all levels around the TC center. However, these TCs after ET onset became relatively cold and dry over the western part of TC as the typical characteristics of ET concept model. Although our case study was not sufficient, it is concluded that the diagnostics of the ET onset and atmospheric structure change associated with Evans and Hart (2003) and Hart (2003) will be useful in ET operational forecast.

A Robust Test for Location Parameters in Multivariate Data (다변량 자료에서 위치모수에 대한 로버스트 검정)

  • So, Sun-Ha;Lee, Dong-Hee;Jung, Byoung-Cheo
    • The Korean Journal of Applied Statistics
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    • v.22 no.6
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    • pp.1355-1364
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    • 2009
  • This work propose a robust test for location parameters in multivariate data based on MVE and MCD with the affine equivariance and the high-breakdown properties. We consider the hypothesis testing satisfying high efficiency and high test power simultaneously to bring in the one-step reweighting procedure upon high-breakdown estimators, which generally suffer from the low efficiency and, as a result, usually used only in the exploratory analysis. Monte Carlo study shows that the suggested method retains nominal significance levels and higher testing power without regard to various population distributions than a Hotelling's $T^2$ test. In an example, a data set containing known outliers does not make an influence toward our proposal, while it renders a Hotelling's $T^2$ useless.

The Ceomorphic Development of Alluvial Fans in Cheongdo Basin, Gyeongsangbuk-do( Prevince), South Korea (경북 청도분지의 선상지 지형발달)

  • Hwang Sang-Ill
    • Journal of the Korean Geographical Society
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    • v.39 no.4
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    • pp.514-527
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    • 2004
  • We investigated the distribution and geomorphic development of alluvial fans at Cheongdo- and Hweyang-eup(town) in the Cheongdo Basin, Gyeongsangbuk-do(Province) of Korea. The alluvial fans of study area are formed confluently to the E-W direction at the northern slope of the Mt. Namsan(840 m). They are classified into Higher surface, Middle surface, and Lower surface according to a relative height to a river bed. And the older alluvial fan is, the deeper gravel in the stream deposits is weathered. The magnitude of each surface composing of confluent fans is related to that of the drainage basin. So called fan-basin system of magnitude on the study area is on the positive(+) relation in the study area. The large fans over 1km in radius are found on the basin of andesite rock which is resistant to the weathering and erosion. Moreover there is no tectonic movement in the basin. It means the most important element influenced on the fan formation is not tectonic movement, but the Quaternary climatic change, which is the periglacial climate alternating glacial and interglacial stages during the Quaternary. Therefore alluvial fans would distribute in Korea overall influenced by the Quaternary climatic change.

The 40~50Day Intraseasonal Oscillation of the Geostationary Meteorological Satellite High Cloud Amount (GMS 상층운량의 40~50일 계절만 진동)

  • 하경자;서애숙
    • Journal of Environmental Science International
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    • v.5 no.5
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    • pp.619-633
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    • 1996
  • Intraseasonal variability of the tropical convection over the Indian/western Pacific is studied using the Geostationary Meteorological Satellite high cloud amount. This study is directed to find the tropical-extratropical interaction in the frequency range of intraseasonal and interannual variabilities of the summer monsoon occured over the domain of 90E-171W and 495-50N. Especially, in order to investigate the intraseasonal interaction of last Asia summer monsoon associated with the tropical convections in the high cloud amounts, the spatial and time structure of the intraseasonal oscillation for the movement-and the evolution of the large-scale connections are studied. To describe the spatial and the time evolution, the extended empirical orthogonal function analysis is applied. The first mode may be considered to a normal structure, indicating that the strong convection band over 90E-120E is extended to sastward but this mode was detected as the intraseasonal variability during summer monsoon. It is found that the dominant intraseasonal mode of the tropical convection consists of the spatial changes over a broad period range centered around 40~50days.

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El Niño-Southern Oscillation, Indian Ocean Dipole Mode, a Relationship between the Two Phenomena, and Their Impact on the Climate over the Korean Peninsula (엘니뇨-남방진동, 인도양 쌍극자 모드, 두 현상의 관련성, 그리고 한반도 기후에 대한 영향)

  • Cha, Eun-Jeong
    • Journal of the Korean earth science society
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    • v.28 no.1
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    • pp.35-44
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    • 2007
  • This paper investigated the relationship between El $Ni\widetilde{n}o-Southern$ Oscillation (ENSO) and Indian Ocean Dipole (IOD) mode events and the impacts of these two phenomena on the climate, temperature and precipitation, of the Korean Peninsula. Data gathered from 1954 to 2004 were used for analysis, which included NINO 3 index, IOD index, and monthly mean precipitation and temperature at eleven locations in Korea. Statistical results showed that the IOD and ENSO were significantly correlated in Spring and Fall. It was clearly shown that the distribution of the sea surface temperature in the Indian Ocean has seen the Southern and Northern Oscillation in El $Ni\widetilde{n}o$ year, and Eastern and Western in IOD year. On the other hand, in El $Ni\widetilde{n}o$ you, the mean temperature of the Korea Peninsula was lower than normal in Summer and higher in Winter and its precipitation was more than normal in both Summer and Winter. However, significant correlation was not found in IOD year. In addition, the global atmospheric circulations during the major IOD years are less influential, unlike those of El $Ni\widetilde{n}o$ events.

Comparative Patterns of Political Institutions and Social Policy Developments (정치제도가 사회정책의 발전에 미치는 효과에 관한 비교 연구)

  • Hong, Kyung-Zoon
    • Korean Journal of Social Welfare
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    • v.62 no.3
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    • pp.141-162
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    • 2010
  • This paper tries to provide empirical support for a formal model of social policy development which has been presented in a former paper of this study. In the direct democracy, median voter's social policy preference is critical because he is Condorcet winner in a pair-wise pure majority voting. But, in the more general setting, we should think of various political institutions as a collective choice device. For this reason, I draw a formal model which formulates three contrasting types of political institutions which are distinguished by the developments of political democracy and the differences of electoral rules. Comparative patterns of key variables which measure political institutions, social policy developments, and social policy preference provide support for my arguments. My empirical results suggest that three political institutions are associated with very different policy outcomes. Compared to other institutions, committee system entails more targeted subsidy, less universal benefit. On the contrary, proportional elections produce more universal benefit, less targeted subsidy.

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