• Science of Emotion and Sensibility
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• v.13 no.3
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• pp.475-484
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• 2010

This study examined the influence of the SOA(stimulus onset asynchrony) between visual and auditory stimuli on the integration phenomenon of audio-visual senses. Within the stimulus integration phenomenon, the redundant target effect (the faster and more accurate response to the target stimulus when the target stimulus is presented with more than two modalities) and the visual dominance effect (the faster and more accurate response to a visual stimulus compared to an auditory stimulus) were examined as we composed a visual and auditory unimodal target condition and a multimodal target condition and then observed the response time and accuracy. Consequently, despite the change between visual and auditory stimuli SOA, there was no redundant target effect present. The auditory dominance effect appeared when the SOA between the two stimuli was over 100ms. Theses results imply that the redundant target effect is continuously maintained even when the SOA between two modal stimuli is altered, and also suggests that the behavioral results of superior information processing can only be deducted when the time difference between the onset of the auditory stimuli and the visual stimuli is approximately over 100ms.

• Annual Conference on Human and Language Technology
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• 2005.10a
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• pp.63-72
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• 2005

한자어의 처리에서 나타나는 표기중복의 효과가 표기 처리에 기인한 것인지 음운 처리에 기인한 것인지를 결정하기 위하여 두 개의 실험을 실시하였다. 실험 1에서는, 점화어-표적어의 관계를 표기불일치(음운일치), 음운불일치(표기일치), 음운-표기일치, 무 관련의 네 가지로 조작하였다 또한, 음운규칙에 따른 차이를 알아보기 위해서 유음화, 비음화, 연음화의 세 가지 규칙이 자극의 구성에 이용되었다. 점화어의 제시방식은 차폐점화와 SOA 200ms의 두 가지가 사용되었다. 음변화의 종류 및 점화어 제시방식에 관계없이, 음운불일치조건에서의 반응 양상이 음운-표기일치조건에서의 반응 양상과 유사하게 나타났다. 이것은 선행연구에서 나타난 표기중복의 효과가 음운처리에 의한 것이 아님을 시사하는 것으로 해석되었다. 실험 1에서는 표적어에 음변화 규칙이 적용되었으나 실험 2에서는 점화어에 음변화 규칙이 적용되었다. 실험 2의 결과, 음운 불일치의 효과는 나타나지 않았으나, 표기불일치의 효과는 유의하게 나타났다 실험 1과 2의 결과는 한자어 처리에서 음운정보가 아니라 표기정보의 우선성을 지지하였다.

• Journal of Genetic Medicine
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• v.6 no.2
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• pp.146-154
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• 2009

Multiplex ligation dependent probe amplification (MLPA) is a PCR-based method to detect gene dosage. Since its introduction, MLPA has been used to test a large number of genes for major deletions or duplications. Genetic testing, as a diagnostic tool for genetic disease, has been used primarily to identify point mutations, including base substitutions and small insertions/deletions, using PCR and sequence analysis. However, it is difficult to identify large deletions or duplications using routine PCR- gel based assays, especially in heterozygotes. The MLPA is a more feasible method for identification of gene dosage than another routine PCR-based methods, and better able to detect deleterious deletions or duplications. In addition to detection of gene dosage, MLPA can be applied to identify methylation patterns of target genes, aneuploidy during prenatal diagnoses, and large deletions or duplications that may be associated with various cancers. The MLPA method offers numerous advantages, as it requires only a small amount of template DNA, is applicable to a wide variety of applications, and is high-throughput. On the other hand, this method suffers from disadvantages including the possibility of false positive results affected by template DNA quality, difficulties identifying SNPs located in probe sequences, and analytical complications in quantitative aspects.

• Journal of the Korean Chemical Society
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• v.42 no.3
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• pp.306-314
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• 1998

Acetolactate synthase (ALS) is the common enzyme in the biosynthesis of branched chain amino acids, Val, Leu, and Ile in bacteria, yeast, and higher plants. The enzyme is target site of several classes of structually diverse herbicides, including the sulfonylureas, the imidazolinones, the triazolopyrimidines, and the primidyl-oxy-benzoates. We have synthesized new triazolopyrimidine (TP) derivatives, and determined their inhibitory activities on barley ALS. $lC_{50}$ values for the active compounds were 3.2 nM-0.62 mM, and some of them appeared to be potent inhibitors. The progress curves for inhibition of ALS by TP4, a representative derivative, indicated that the extent of inhibition increased with incubation time. The inhibition of ALS by TP4 showed mixed-type inhibition with respect to pyruvate. Dual inhibition analyses of TP4 versus imidazolinone Cadre and feedback inhibitor Leu suggested that three different classes of inhibitors bind to ALS in a mutually exclusive manner. Chemical modification of tyrosyl residues of ALS decreased sensitivity of ALS to TP4, while modification of tryptophan and cysteine did not affect the sensitivity.