• Journal of the Speleological Society of Korea
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• v.37 no.38
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• pp.26-38
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• 1994

태백산지의 내륙산간에 해당하는 태백시는 강원도의 주요 지역을 연결하는 결절지의 구실을 할 수 있는 지리적 위치에 있으며, 용연동굴 뿐만 아니라 많은 석회동굴이 산재하고 동굴의 보고 지역이다. 지금까지 이곳 주민의 주산업은 석탄광업에 의존하여 왔으나 현재는 정부의 석탄합리화 정책으로 인한 탄광의 폐광으로 마땅한 수익원이 없으므로 이촌향도 현상이 심화되어 가고 있다. 이러한 피폐를 탈피하기 위해서는 안정성이 높은 생활환경을 만드는 것이 시급한 이곳의 과제라고 하겠다.(중략)

• Proceedings of the Speleological Society Conference
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• 1994.11a
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• pp.88-89
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• 1994

태백산지의 내륙산간에 해당하는 태백시는 강원도의 주요 지역을 연결하는 결절지의 구실을 할 수 있는 지리적 위치에 있으며, 용연동굴 뿐만 아니라 많은 석회동굴이 산재하고 동굴의 보고 지역이다. 지금까지 이곳 주민의 주산업은 석탄광업에 의존하여 왔으나 현재는 정부의 석탄합리화 정책으로 인한 탄광의 폐광으로 마땅한 수익원이 없으므로 이촌향도 현상이 심화되어 가고 있다. 이러한 피폐를 탈피하기 위해서는 안정성이 높은 생활환경을 만드는 것이 시급한 이곳의 과제라고 하겠다.(중략)

• The Hankook-Saengyark Bo
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• no.255
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• pp.5-5
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• 2003

생약자원개발사업 진행 - 황분말대신 '유안' 사용 비용 덜들고 품질 향상 - 삼백초 5cm간격으로 밀식 상품성있는 잎 더욱 늘어나 - 한약재 이용 천연염색 교육 - 둥굴레 신품종 '건강백세' 개발(2005년 농가보급 계획) - 자생식물로 천연농약개발(강원도농업기술원) - 안성 죽산일대 '지황' 주산지로부상 - 자원식물학회 학술발표회

• Journal of The Korean Society of Inherited Metabolic disease
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• v.16 no.3
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• pp.141-147
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• 2016

Hypophosphatasia is caused by the mutations in ALPL, which encodes tissue-nonspecific alkaline phosphatase (TNSALP). It can be inherited either in an autosomal dominant or recessive manner. Clinically, hypophophosphatasia is characterized by skeletal findings similar to those in rickets or osteomalacia, but serum alkaline phosphatase levels are decreased in the affected patients. Hypophosphatasia can be classified into six clinical forms according to age at diagnosis and severity of symptoms: perinatal lethal, infantile, childhood, adult, odontohypophosphatasia, and perinatal benign. As being a very rare disease, only one case has been reported in Korean population. Here we describe a case with perinatal benign hypophosphatasia with recessive ALPL mutations. Bowing of lower legs was detected in prenatal period and low serum alkaline phosphatase level was noted after birth. During the follow-up evaluation for 4.5 years, bone mineralization and legs bowing were improved but the growth retardation was persistent. As the recombinant bone-targeted human TNSALP became available, the clinical improvement of the affected patients is expected including the case described here with this treatment. More efforts are needed to identify the cases affected by hypophosphatasia.

• Journal of Applied Biological Chemistry
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• v.64 no.3
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• pp.245-251
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• 2021

Codonopsis lanceolata (Deoduk) was grown in East Asia, including Korea, China, Japan, and Russia, and the roots of C. lanceolata have been used as functional foods and traditional medicine to treat symptoms of cough, bronchitis, asthma, tuberculosis, and dyspepsia. The phytochemicals of C. lanceolata have been reported such as phenylpropanoids, polyacetylenes, saponins, and flavonoids that are involved in pharmacological effects such as anti-obesity, anti-inflammation, anti-tumor, anti-oxidant, and anti-microbial activities. Selecting marker substances of the main producing area by MS-based metabolomics analysis is important to ensure the beneficial effect of C. lanceolata without side-effects because differences in cultivated areas of plants were related not only to the safety of medicinal plants but also to changes in chemical composition and biological efficacy. In our present study, ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry combined with multivariate statistical analysis was applied to recognize the main producing area of C. lanceolata in South Korea. As a result of Principal Component Analysis and loading plot analysis of three groups, Inje (Kangwon-do), Hoengseong (Kangwon-do), and Muju (Jeonlabuk-do), several secondary metabolites of C. lanceolata including tangshenoside I, lancemaside A, and lancemaside G, were suggested as potential marker substances to distinguish the place of main producing area of C. lanceolata.

• Clinical and Experimental Pediatrics
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• v.45 no.7
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• pp.855-861
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• 2002

Purpose : Thymus size can be affected by several factors and perinatal diseases can be estimated by its size. The purpose of this study was to search for a relationship between cardiothymic/thoracic(CT/T) ratio and perinatal diseases such as neonatal respiratory distress syndrome(RDS) and intrauterine growth retardation(IUGR) by measuring the width of the cardiothymic shadow at the level of the carina and dividing it by the width of the thorax at the costophrenic angles. Methods : A clinical study was conducted on newborn infants with RDS(n=51), IUGR(n=27), and premature rupture of membranes(PROM, n=48), who were admitted at NICU of Catholic University of Daegu from June 2000 to Oct. 2001. CT/T ratio was measured within six hrs of age, at 2-3 days of age, and at 5-7 days of age. Results : CT/T ratios of RDS group, IUGR group, and PROM group were $0.46{\pm}0.07$, $0.32{\pm}0.04$. $0.36{\pm}0.06$, respectively. CT/T ratios of RDS group within 6hrs of age, at 2-3 days of age, and at 5-7 days of age were $0.43{\pm}0.07$, $0.34{\pm}0.06$, $0.25{\pm}0.04$, respectively. There were statistically significances among the RDS group, the IUGR group, and the PROM group and in the RDS group at different times. Regression for gestational age among three groups was not statistically significant but correlation for gestational age in the entire groups was statistically significant. CT/T ratio between normal spontaneous vaginal delivery and c-section among three groups was not statistically significant. CT/T ratios with dexamethasone-treated group and untreated group was not statistically significant. Conclusion : We concluded that thymus size differed significantly in the perinatal diseases such as RDS and IUGR, and so can be used as an early diagnostic tool for perinatal diseases.

• Clinical and Experimental Pediatrics
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• v.45 no.12
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• pp.1503-1511
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• 2002

Purpose : Although the short- and long-term outcomes of low birth weight(LBW) neonatal intensive care unit(NICU) survivors have been extensively studied, much less information is available for normal birth weight(NBW) infants(greater than 2,500 gm) who require NICU care. Methods : We retrospectively examined the neonatal hospitalizations and one year health status of 302 NBW and 131 LBW admissions to our NICU. Information on the neonatal hospitalization was obtained from a review of medical records. Postdischarge health status was collected by using telephone surveys and medical records. Results : After initial discharge, 21.2% of the NBW infants and 23% of the LBW infants required rehospitalization during the first year of life and there was no significant difference between the two groups. The reasons for rehospitalization of the NBW infants included respiratory disorders (32.1%), G-I problems(26.2%), genitourinary problems(11.9%), surgery(10.7%), cardiac problems(7.1%), and congenital/developmental problems(1.2%). For the LBW infants, the order of frequency was the same, with the percentages slightly different. Neonatal risk factors related to the rehospitalization of the NBW infants included mechanical ventilation, duration of mechanical ventilation, and congenital anomaly. But no positive significant correlation of neonatal risk factors with rehospitalization of LBW infants was found. Conclusion : Low and normal birthweight NICU survivors were rehospitalized at similar rates. The most common cause of rehospitalization was respiratory problems. Neonatal risk factors related to rehospitalization of NBW infants were mechanical ventilation, duration of mechanical ventilation, and congenital anomaly. However, no positive significant correlation of neonatal risk factors with rehospitalization of LBW infants was found. The data suggests that NBW infant survivors, as well as LBW infant NICU survivors, require close follow up.

• Korean Journal of Medicinal Crop Science
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• v.5 no.3
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• pp.243-248
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• 1997

Cyperus rotundus has been grown for a long time in korea to be used as medicinal crop. This study was conducted to survey the production status and economic analysis in chief producing area of Cyperus rotundus in Koryong, Korea. The Koryong area where was the major production area of Cyperus rotundus was composed of 0.6hectare cultivation size per farm household and the processes like cultivation, processing, shipping were formed unitedly. The most general management type was labor-extensive one which use the Nakdong river basin or idle land effectively. The cultivation area have been decreased gradually because the price was very low so that the income per hectare was just 3,880 thousand won and productivity per hectare was just 6,280kg. Thus, production condition was very inferior, it needs some self-help to encourage the production because it has some possibility as only regional special product.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.12
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• pp.524-535
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• 2020

This study was conducted to derive implications for the dissemination and expansion of subtropical crops in farms. To this end, the cultivation trends and main producing areas of promising subtropical crops in Korea were analyzed. Analysis results found that the cultivation area of crops, excluding mango, was stagnating or decreasing. The main producing areas of domestic subtropical crops are located on Jeju Island (mango, dragon fruit), in Gyeongsangnam-do (papaya), and in Jeollanam-do (turmeric). Guava and Yeoju could not define the main producing area. For all crops, the percentage of cultivated area in the top 10 regions was high, but only half of the regions maintained the ranking. These results imply that the introduction and abandonment of subtropical crops are frequent. The dissemination and expansion of subtropical crops are justifiable in terms of responding to climate change in the future and creating new income for farms. Therefore, government support policies and agricultural promotion agencies need to be established.

• Clinical and Experimental Pediatrics
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• v.45 no.5
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• pp.560-567
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• 2002

주산기 뇌손상은 주로 급격한 저산소-허혈 손상에 의하는데 급격한 산소 공급의 차단은 oxidative phosphorylation을 정지 시켜서 뇌대사를 위한 에너지 공급이 차단되게 된다. 에너지 공급이 차단된 뇌세포는 뇌세포막에서 세포 내외의 이온 농도 차를 유지시키던 ATP-dependent $Na^{+}-K^{+}$ pump의 기능이 정지 되고, 세포 내외의 농도 차에 따라 $Na^{+}$, $Cl^{+}$, $Ca^{{+}{+}}$의 대규모 세포 내로 이동이 일어난다. 세포 내로 calcium 이온의 이동은 glutamate 수용체의 활성화에 의해서도 일나는데, 세포 내 calcium 이온의 증가는 protease, lipase, nuclease 등을 활성화 시켜 세포를 사망에 이르게 하는 연속적이고 다양한 생화학적 반응을 일으키게 된다. Glutamate는 대표적인 신경 전달 물질인데 저산소-허혈 손상 시 glutamate 수용체의 지나친 흥분은 미성숙 뇌에 뇌손상을 유발하는데, NMDA 또는 non-NMDA 수용체와 복합체를 형성하고 있는 calcium 이동 통로를 활성화 시켜 세포 내 calcium 이온을 증가시키고, 그 외에 metabotropic recetor는 G-protein의 활성화 등을 통해 뇌손상을 유발하는 다양한 생화학적 반응을 매개한다. 저산소-허혈 손상 후 재산소화와 재관류가 일어나면서 뇌세포의 지연성 사망(secondary neuronal death)이 일어나는데 이는 초기 손상 후 뒤이어 일어나는 다양한 생화학적 반응에 의하는데 다량의 산소 자유기 발생, nitric oxide의 생성, 염증 반응과 싸이토카인, 신경전도 물질의 과흥분 등이 관여하며, 신경 세포 사망은 세포괴사(necrosis)뿐 아니라 일부는 세포 사멸(apoptosis)로 알려진 의도된 세포 사망(programmed cell death)에 의한 것으로 생각되고 있다(Fig. 2).