• Journal of Chest Surgery
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• v.38 no.12 s.257
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• pp.835-843
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• 2005

Background: Cancer of the esophagus is one of the most malignant tumors with poor prognosis. The p53 gene alteration, over expression of Cyclin D1, and Ki67 index were thought to be the prognostic factors. However, their clinical significances in esophageal squamous cell carcinoma are controversial and p53 accumulation may not correlate with genetic mutation. The current study investigates their prognostic significance in squamous cell carcinoma of the esophagus. Material and Method: The Subjects studied were 124 esophageal squamous cell carcinoma patients who underwent esophagectomy. The mutation of p53, over expression of Cyclin D1, Ki67 labelling index, mitotic index were examined by using an immunohistochemical staining. We compared the results and investigated the correlation with the mutation of p53, overexpression of Cyclin D1, Ki67 labelling index, mitotic index and tumor size, and duration of survival. Result: There was no correlation between the results in immunohistochemical staining according to age, sex, tumor size, Iymph node status, and clinical stage of the disease. Mutant p53 protein was found in 69 cases (55.6$\%$). Median survival time was 21 months in cases with negative for mutant p53 protein and 22 months in positive cases. There was no significant difference in survival (p=0.46). Median survival time was 22 months in cases with negative for Cyclin D1 and 16 months in positive cases (p=0.18). Median and mean survival time was 22 months and 36 months when Ki67 labeling index was 40 or less (102 cases). Median and mean survival was 16 months and 23 months, when Ki67 labeling index was more than 40 (22 cases). There was significant difference in survival rate (p=0.011). Conciusion: Positivity of p53 and cyclin D1 was not useful in predicting the prognosis in our study. There was no significant correlation among mutant p53 protein accumulation, Cyclin D1 over expression, and Ki67 labeling index. However, in several studies, PCR single strand conformational polymorphism analysis of p53 showed a correlation to the prognosis. We thought that there was a significant discordance between p53 gene mutation and mutant p53 protein accumulation. When Ki67 labeling index was more than 40, prognosis was poorer, Ki67 seems to be a prognostic factor in our study. Therefore, we confirmed the possibility of using molecular markers as prognostic factors.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.25 no.2
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• pp.41-51
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• 2013

The tidal creek dependent mass transport characteristic in Gyeong-Gi Bay (west coast of Korea) was studied using field measured data and numerical model. Gyeong-Gi Bay consists of 3 main tidal channels and contains a well-developed vast tidal flat. This region is famous for its large tidal difference and strong current. We aim to study the effect of tidal creek in the tidal flat on the mass exchange between the estuary and the ocean. For numerical application, the application of unstructured grid feature is essential, since the tidal creek has complicated shape and form. For this purpose, the FVCOM is applied to the study area and simulation is performed for 2 different cases. In case A, geographic characteristics of the tidal creek is ignored in the numerical grid and in case B, the tidal creek are constructed using unstructured grid. And these 2 cases are compared with the field measured cross-channel mass transport data. The cross-channel mass transport at the Yeomha waterway mouth and Incheon harbor was measured in June, 9~10 (Spring tide) and 17~18 (Neap tide), 2009. CTD casting and ADCP cross-channel transect was conducted 13 times in one tidal cycle. The observation data analysis results showed that mass transport has characteristic of the ebb dominance Line 1 (Yeomha waterway mouth), on the other hand, a flood dominant characteristic is shown in Line 2 (Incheon harbor front). By comparing the numerical model (case A & B) with observation data, we found that the case B results show much better agreement with measurement data than case A. It is showed that the geographic feature of tidal creek should be considered in grid design of numerical model in order to understand the mass transport characteristics over large tidal flat area.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.24 no.1
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• pp.16-25
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• 2012

To calculate the total mass flux that change in dry and flood season in the Yeomha Channel of Gyeonggi Bay, the 13 hour bottom tracking observation was performed from the southern extremity. The value of the total mass flux(Lagrange flux) was calculated as the sum of the Eulerian flux value and stroke drift value and the tidal residual flow was harmonically analyzed through the least-squares method. Moreover, the average during the tidal cycle is essential to calculate the mass flux and the tidal residual flow and there is the need to equate the grid of repeatedly observed data. Nevertheless, due to the great differences in the studied region, the number of vertical grid tends to change according to time and since the horizontal grid differs according to the transport speed of the ship as a characteristic of the bottom tracking observation, differences occur in the horizontal and vertical grid for each hour. Hence, the present study has vertically and horizontally normalized(sigma coordinate) to equate the grid per each hour. When compared to the z-level coordinate system, the Sigma coordinate system was evaluated to have no irrationalities in data analysis with 5% of error. As a result of the analysis, the tidal residual flow displayed the flow pattern of sagging in the both ends in the main waterway direction of dry season. During flood season, it was confirmed that the tidal residual flow was vertical 2-layer flow. As a result of the total mass flux, the ebb properties of 359 cm/s and 261 cm/s were observed during dry and flood season, respectively. The total mass flux was moving the intertidal region between Youngjong-do and Ganghwa-do.

• Proceedings of the Korean Aquaculture Society Conference
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• 2003.10a
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• pp.138-138
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• 2003

우리나라 전남 동부 연안에서 확인된 해마 서식지를 대상으로 해마 이외의 혼재 유영 어류에 대한 생태 조사를 실시하였다. 조사는 전남 동부 연안의 해마의 서식이 확인된 수역에서 임의의 3 정점 (A, B, C)을 지정하여 채집하였다. 해마 채집 및 혼재 어류상 조사에는 소형 선박을 이용하였으며, 길이 45m, 폭 5m, 망목 크기 6~8mm의 어구를 사용하여 서식 생물을 채포하였다. 그리고 1회에 어획된 전 어종을 한 조사군으로 설정하였고 채집된 해마와 혼재 어종에 대해서는 각 어종별 분류키를 이용하여 분류하였다. 그리고 해마와 혼재 어류에 대해서는 0.1mm 범위에서 전장과 체장을 측정하였으며, 1mg 범위에서 체중을 측정하였다. 임의로 선정한 각 조사 정점별 채집된 해마와 혼재 어류상은 다음과 같다. 확인된 서식지는 전남 동부의 여수와 고흥 연안으로 각 지역별로 서식하고 있는 해마의 종류는 다소 차이가 있었는데 조사 정점 A와 B에서는 산호 해마 hippocampus sp. of. japonicus만이 관찰된 반면, 정점 c에서는 산호해마, 가시해마 Hippocampus sp. of. histrix, (참)해마 Hippocampus sp. cf. coronatus의 3종이 모두 관찰되었고 채집된 개체수도 정점 A와 B에서 1개체씩만이 관찰된 반면 정점 C에서는 5개체가 채집되어 다른 조사 정점에 비교하여 종의 수 및 개체수에서 매우 높은 결과를 나타내었다. 각 조사 정점별 관찰된 유영 어류상은 정점 A에서는 7종, 정점 B에서는 6종 그리고 정점 C에서는 12종의 어류가 관찰되었고, 이들 중 해마를 제외한 혼재 어종 수는 정점 A, B 및 C에서 각각 6종, 5종, 9종이 관찰되었다. 혼재 어종 중 감성돔, 복섬, 두줄 망둑, 실비늘치, 주둥치는 조사정점 A, B, C 모두에서 관찰되었다. 이 결과는 해마의 서식장 또는 산란장이 되는 조사 정점 C (36개체)가 다른 조사 정점 A (53개체)와 B (67개체)에 비교하여 해마의 어린 치어 또는 해마 성체를 포식할 수 있는 포식자의 개체수가 현격하게 낮기 때문인 것으로 판단된다. 그러나, 임의의 3 조사 정점에서 혼재 어종의 출현 종 수를 비교한 결과에서는 오히려 정점 A에서 6종, 정점 5에서 5종 그리고 정점 C에서 8종으로 나타나 정점 C에서 다소 높은 혼재 어종 수가 관찰되었다. 결국 해마의 서식지 주변 혼재 어종 특히, 혼재 어종의 개체수가 많을수록 해마의 서식 밀도를 감소시킬 가능성이 있는 것을 알 수 있었다. 한편, 다른 조사 정점에 비교하여 정점 C에서 출현 종 수가 높음에도 불구하고 출현 개체수가 매우 낮은 이유로 혼재 어종도 자어 또는 치어 시기에 해마 성체의 먹이로서 이용되었을 가능성도 배제할 수 없을 것으로 판단된다. 2003년 9월 (2일간)에 우리나라 전라남도 동부 연안에서 채집된 해마는 하루 오전과 오후 조석에 맞추어 4회에 걸쳐서 총 30여회 투망 작업한 결과 3종 62개체가 채집되었다.

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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• v.21 no.4
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• pp.134-143
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• 2016

This study analyzed the characteristics of emergy inputs from environmental sources that are essential in maintaining ecological processes and providing ecosystems services of the tidal flat ecosystems in Korea. Environmental sources provided a total of $4.98{\times}10^{21}sej/yr$ of emergy to the tidal flats of Korea. The emergy inputs from environmental sources were worth 1,141 billion ￦/yr. This is the value of environmental conditions that are the basis of ecosystem services provided by the tidal flat ecosystems. The emergy input per hectare to regional tidal flats decreased along the coastline from northwest to southeast, with the highest input in the Incheon-Gyeonggi area in the central western part of the Korean coast and the lowest input in the Busan area in the southeastern end. This reflects the general distribution pattern of the magnitude of tidal ranges along the Korean coast. There was no a clear-cut relationship between emergy inputs per unit area and fishery production(expressed in emergy quantity) per unit area. However, tidal flats in the west coast with higher emery inputs per unit area produced more fishery products than those in the south coast with lower emergy inputs, suggesting a possibility that the emergy inputs could be used for the rapid evaluation and comparison of the potential for ecosystem service provision by individual tidal flats.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.21 no.6
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• pp.444-452
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• 2009

Textural parameters were calculated from the surface sediments collected from Jinu-do beach in Nov. 2005 and May 2006. In Nov. 2005 and May, 2006, the grain size distribution of surface sediments shows that the mode of $3.0\phi$(i.e., 0.125 mm) dominated the west beach of Jinu-do, but in the east beach the mode of $3.0\phi$(i.e., 0.125 mm) decreased and the mode of $2.5\phi$(i.e., 0.177 mm) was apparently distinct, resulting in the more coarsening trend. Mean grain size of surface sediments also indicates little difference in the west beach between two investigations, but the increasing difference between mean grain sizes in the east beach, showing more coarsening pattern. Such seasonal pattern corresponds to the positive skewness in the east beach in May, 2006. As a result, after the winter in 2005, the surface sediments in the west beach of Jinu-do experienced a little variation, whereas the apparent coarsening of surface sediments occurred in the east beach by removal of $3.0\phi$(i.e., 0.125 mm) fine-grained sand particles. The observed seasonal change may be attributed to the different hydrographic condition and sediment delivery/removal on the surface sediments between the west beach and the east beach of Jinu-do through the increased precipitation and more freshwater discharge from the Nakdong River during the summer and the intensified wave and tide during the winter in the Nakdong River estuary.

• Korean Journal of Remote Sensing
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• v.33 no.6_3
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• pp.1215-1221
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• 2017

SeNtinel's Application Platform (SNAP) is an open source software developed by the European Space Agency and consists of several toolboxes that process data from Sentinel satellite series, including SAR (Synthetic Aperture Radar) and optical satellites. Among them, S1TBX (Sentinel-1 ToolBoX)is mainly used to process Sentinel-1A/BSAR images and interferometric techniques. It provides flowchart processing method such as Graph Builder, and has convenient functions including automatic downloading of DEM (Digital Elevation Model) and image mosaicking. Therefore, if computer memory is sufficient, InSAR (Interferometric SAR) and DInSAR (Differential InSAR) perform smoothly and are widely used recently in the world through rapid upgrades. S1TBX also includes existing SAR data processing functions, and since version 5, the processing capability of KOMPSAT-5 has been added. This paper shows an example of processing the interference technique of KOMPSAT-5 SAR image using S1TBX of SNAP. In the open mine of Tavan Tolgoi in Mongolia, the difference between DEM obtained in KOMPSAT-5 in 2015 and SRTM 1sec DEM obtained in 2000 was analyzed. It was found that the maximum depth of 130 meters was excavated and the height of the accumulated ore is over 70 meters during 15 years. Tidal and topographic InSAR signals were observed in the glacier area near Jangbogo Antarctic Research Station, but SNAP was not able to treat it due to orbit error and DEM error. In addition, several DInSAR images were made in the Iraqi desert region, but many lines appearing in systematic errors were found on coherence images. Stacking for StaMPS application was not possible due to orbit error or program bug. It is expected that SNAP can resolve the problem owing to a surge in users and a very fast upgrade of the software.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.16 no.1
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• pp.25-30
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• 1983

The concentrations of dissolved vitamin $B_{12}$, thiamine and biotin in the water of Gyokpo coast, were determined by microbiological assay methods. Also the relations between the distribution of B group vitamin and other environmental factors were studied. Vitamin $B_{12}$ was assayed with Euglena gracilis strain Z, thiamine with Cryptococous albidus and biotin with Achromo bacter sp. yH-51. It was found that the concentration of B group vitamin in the water of Gyokpo coast were normal level : vitamin $B_{12}$; 1.36-3.95 ng/l, thiamine ; u-0.4 ng/l and biotin; 1.40-14.60 ng/l. The concentration of B group vitamin was high in summer than in winter. In the water of Gyokpo coast during summer, B group vitamin occurred slightly lower level than normal, the concentration suficiently neccessary for phytoplankton development. The concentration of biotin was positively correlated with abundance of phytoplankton, but not aerobic heterotrophic bacteria. It was suggested that the concentration of biotin in water might be much more influenced with the growth of phytoplankton and any environmental factors than bacteria and the other vitamin, especially.

• Journal of the Korea Concrete Institute
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• v.13 no.5
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• pp.457-465
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• 2001

Shrinkage strains of concrete slab in multi-story building are restrained by structural members such as columns or walls, then can induce cracks due to excessive shrinkage stress over tensile strength of member. In this study, a shrinkage stress analysis method of concrete slab in multi-story building considering not only material properties such as shrinkage, creep and reinforcement effect but also construction sequence is proposed. Tensile stresses of slab due to shrinkage are calculated by converting shrinkage strains into equivalent temperature gradients, creep that can release shrinkage stress can be considered by replacing the modulus of elasticity of concrete, Ec , to the effective secant modulus of elasticity of concrete, E$\_$eff/ Reinforcements are also considered by modeling them as equivalent beam elements in FEM program. Results of step by step analysis reflecting construction sequence summed up to calculate stresses of the whole building considering that shrinkage stresses of the building come from the difference of shrinkage between i-th floor and (i-1)-th floor, named as effecitive shrinkage, and it can be varied by construction sequence. The results of 10-story example building show that shrinkage stresses of lower floors are greater than those of upper floors, that is, stresses of lower floors(1∼2FI.) exceed modulus of rupture of concrete, but stress ratios of higher floors are in the range of 27.9∼92.8%.

• Journal of Chest Surgery
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• v.39 no.5 s.262
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• pp.394-398
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• 2006

Background: Goal of the initial treatment of primary spontaneous pneumothorax is re-expansion of the lung by evacuation of air from pleural space. Authors thought small caliber catheter could reach to this goal instead of conventional large bore chest tube. This retrospective study was undertaken to assess the effectiveness of 7-French (Fr) catheter for the initial treatment of primary spontaneous pneumothorax. Material and Method: Between May 2003 and April 2005, 111 patients with primary spontaneous pneumothorax were managed with tube drainage; 7 Fr catheter for 86 patients and 24-French chest tube for 25 patients. We analyzed catheter indwelling time, use of analgesics, re-expansion of the lung, and catheter related problems by medical records. Result: Mean catheter indwelling time was $2.4{\pm}1.1$ days in 7 Fr group and $2.3{\pm}1.3$ days in chest tube group (p>0.05). All patients with 24 Fr catheter needed analgesics injection but never in 7Fr group. Complete re-expansion of the lung based on plane chest radiograph was obtained in 77% of 7 Fr group. The problem related with 7 Fr catheter was kinking, which showed in 5.6%. Conclusion: Application of the 7 Fr catheter for initial management of primary spontaneous pneumothorax was as effective as 24 Fr catheter.