• Proceedings of the Plant Resources Society of Korea Conference
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• 2018.10a
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• pp.44-44
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• 2018

경상북도 봉화군에 위치한 각화산(1,177m)은 태백산맥에서 소백산맥으로 갈라지는 기점을 이루는 산으로 구령산, 청옥산, 옥석산 등과 함께 백두대간 일대의 중요한 산으로 인식된다. 특히 각화산은 조선왕조실록을 보관했던 태백산 사고지터(사적 제 348호)를 품고 있는 역사적인 장소이기도 하다. 본 연구는 각화산 일대 관속식물의 분포상을 파악하고자 2017년 5월부터 2018년 9월까지 진행되었다. 연구 결과 조사지 내 관속식물은 92과 291속 413종 4아종 38변종 6품종으로 총 461분류군이 확인되었다. 이는 경상북도 관속식물 1,684분류군(Korea National Arboretum, 2016)의 27.4%, 한반도 관속식물 4,499분류군(Korea National Arboretum, 2018; Http://www.nature.go.kr/kpni/)의 10.2%에 해당되는 것으로 분석되었다. 각화산 일대의 주요 식물 가운데 한국특산식물은 12분류군(할미밀망, 진범, 처녀치마, 지리대사초 등)이 확인되었고, 산림청 지정 희귀식물은 VU등급(꼬리진달래, 노랑무늬붓꽃) 2분류군, LC등급(너도바람꽃, 쥐방울덩굴, 도깨비부채) 3분류군으로 총 5분류군의 희귀식물이 분포하는 것으로 조사되었다. 또한, 식물구계학적 특정식물 IV등급 5분류군, III등급 13분류군, II등급 21분류군, I 등급 25분류군이 확인되었고, 외래식물은 총 24분류군으로 도시화지수(%) 6.8%, 귀화율은 5.2%에 해당되는 것으로 분석되었다. 조사된 식물의 유용성 분석 결과, 식용식물 348분류군(75.5%), 섬유용식물 1분류군(0.2%), 약용식물 기분류군(15.4%), 관상용식물 18분류군(3.9%), 목초용식물 102분류군(22.1%) 목재용식물 14분류군(3.0%) 등으로 확인되었다. 본 연구 결과물은 각화산의 식물 현황을 제시함과 동시에 생태축으로 연결된 백두대간 일대의 효율적인 관리 및 보전 방안을 마련하기 위한 기초자료로 활용 될 것이라 기대한다.

• Proceedings of the Korea Water Resources Association Conference
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• 2010.05a
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• pp.912-916
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• 2010

국내 통합수자원관리기술 수준은 계속되는 연구와 개발 노력으로 선진국 수준을 따라잡을 것으로 기대되나 개발된 기술의 실용성, 적용효과를 가시적으로 보여주지 못하고 있다. 따라서 본 연구에서는 통합수자원 관리 기술을 적용하고자 강원도 평창군의 평창강 유역을 대상으로 통합수자원관리 전략을 수립한다. 평창강 유역의 대부분이 평창군이라는 하나의 행정구역에 속해 있어 본 연구에서는 평창강 유역 단위로 자료의 수집이 어려운 부문은 평창군을 기준으로 수집하여 분석하였다. 이수, 치수, 환경, 조직 및 정책 부문으로 나누어 평창군의 수자원 현황을 파악하고 평창군 수자원관리의 강점, 약점, 기회, 위협 요인을 분석(SWOT 분석)하였다. 그 결과 평창군의 강점은 수자원에 대한 관심이 높고, 관련 문제를 해결하고자 하는 의지가 강하다는 것이다. 약점은 수자원관리를 위한 총괄조직이 없다는 것이고, 위협요인은 기후변화에 따른 국지성 집중 호우로 홍수피해 위험성이 증가하고 있다는 점이다. 반면, 평창군의 기회요인으로는 동계올림픽 유치를 위한 노력이 계속되고 있어 토지 및 수자원 개발 측면에서도 좋은 기회가 될 수 있다. SWOT 분석의 결과를 고려하여 통합수자원관리를 위한 전략을 제안하였다. 평창군 물문제 해결을 위한통합수자원관리 실행을 목표로 '평창물관리위원회' 설치를 제안하였다. 그리고 평창군의 통합수자원관리 기반을 조성하기 위해서는 이해당사자의 참여가 필요하며, 평창군 통합수자원관리지원시스템 구축을 제안하였다. 이러한 전략에 따라 강원도 평창군에서는 '평창군 물관리위원회 운영 조례(2009.9.11, 평창군 조례 제1919호)'가 제정되었고 평창군 물관리위원회를 이끌어갈 위원들의 구성도 마무리되었으며, 이를 지원할 평창군 통합수자원관리 지원 시스템도 구축되어 운영되고 있다. 앞으로의 계획은 2010년 4월 평창군 물관리위원회 창립총회를 시작으로 평창군 스스로 위원회를 운영하고 물관리 비전을 설정하고 실행계획을 수립할 수 있도록 지원할 계획이며;구축된 평창군 통합수자원관리지원시스템의 운영을 활성화하는 것이다. 이와 같은 통합수자원관리 적용 노력을 통합수자원관리 성공 사례로 발전시켜 나아가 국내는 물론 국외에서도 좋은 모델로 활용할 수 있을 것이다.

• Tuberculosis and Respiratory Diseases
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• v.52 no.3
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• pp.219-229
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• 2002

Background : Sepsis-induced acute lung injury (ALI) is caused by many cellular and humoral mediators induced by an endotoxin. Histamine, which is widely distributed in the lungs and has been considered as an important mediator of sepsis. It increases P-selectin expression on the endothelial cell surfaces and induces IL-8 secretion. Therefore, an endotoxin-induced histamine may be related to neutrophil-mediated ALI by inducing the migration and activation of neutrophils in the lung tissue. However, the role of endogenous histamine in endotoxin ALI has not been clarified. The purpose of this study was to investigate how endotoxin-induced ALI is influenced by endogenous histamine and to identify the possible mechanism of action. Materials and Methods : The study consisted of 4 groups using Sprague-Dawley rats : 1) control group, where the rats were infused intratracheally by normal saline, 2) an endotoxin group, where lipopolysaccharide (LPS) was administered intratracheally 3) the $H_2$ receptor antagonist-treated group ($H_2$ group) and 4) the $H_1$ receptor antagonist-treated group ($H_1$ group), where $H_2$-receptor blocker (ranitidine) and $H_1$-receptor blocker(pyrilamine) were co-treated intravenously with the intratracheal administration of an endotoxin. The lung leak index using $I^{125}$-BSA, the total protein and LDH concentration in the lung lavage fluid, myeloperoxidase(MPO) activity in the lung tissue, the pathologic score and the total number of neutrophils, TNF-$\alpha$, IL-$1{\beta}$ and IL-10 in lung lavage (BAL) fluid were measured in each group as the indices of lung injury. Results : Compared to the control group, the endotoxin group exhibited significant increases in all lung injury indices. Significant reductions in the endotoxin-mediated increases in lung leak index (p<0.05) were observed in both the $H_1$ and $H_2$ groups. In addition the total protein (p<0.05) and LDH concentration (p<0.05) in the BAL fluid were also lower in the $H_2$ group compared to the endotoxin group. However, there was no change in the MPO activity in the lung tissue, the pathologic score and the total number of neutrophils in the BAL fluid in both the $H_2$ and $H_1$ groups compared to the endotoxin group. The increases in TNF-$\alpha$ IL-$1{\beta}$ and IL-10 concentrations in the BAL fluid observed in the endotoxin group were not reduced in the $H_2$ and $H_1$ groups. Conclusion : Antihistamine attenuated the enhanced alveolar-capillary permeability induced by the endotoxin via the $H_2$ receptor. However the attenuating mechanism may not be related to the pathogenesis of neutrophil dependent lung injury.

• The Korean Journal of Food And Nutrition
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• v.16 no.1
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• pp.54-59
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• 2003

This studies were performed to functional food consisted of herb mixture having an effect on postpartum body weight control in 105 subjects(control group n=54, experimental group n=51). Mean age of control and experimental group were 29.3 and 29.1 Mean pregravida body mass index of control and experimental group were 22.8 and 21.5. Total weight gain during the period of pregnancy of control and experimental group were 19.1kg and 17.8kg. In this studies, changes in postpartum weight was measured until one year after parturition. Until 1 month after parturition, there almost had no changes in weight all of two groups. But after 2 month, change in weight loss between two groups was shown definitely. Mean weight loss of control group and experimental group were 2.3kg and 6.5kg after 2 month, 3.7kg and 9.8kg after 3 month, 5.0kg and 10.4kg after 1 year(p<0.01).

• Journal of Preventive Medicine and Public Health
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• v.28 no.4 s.51
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• pp.899-910
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• 1995

This study was conducted to determine the correlation between weighted needle pinprick sensory threshold(PPT) and sensory nerve conduction tests. The subjects were 53 healthy controls, 31 diabetic patients without peripheral neuropathic symptoms(DM) and 36 diabetic patients with peripheral neuropathic symptoms(DN). PPT was measured on the index and little fingers, bilaterally, as well as under the lateral malleolus, bilaterally. In electrophysiologic assessment the left and right median, ulnar and sural nerves were studied. Each mean PPTs was high in order of controls, DM and DN. Age adjusted PPT was significantly different among three groups on right little finger(p<0.05) and left malleolus(p<0.05), but not significantly different between DN and DM on other sites. Each sensory nerve conduction velocity and amplitude was statistically significantly different among three groups(p<0.05). Correlations of PPT with sensory nerve conduction velocity and amplitude were statistically significant on each site and ranged from -0.4203(left malleolus) to -0.5649(right index finger) and from -0.3897(left index finger) to -0.6200(right index finger), respectively. When electrophysiological study is not feasible, measurement of PPT may be helpful for the assessment of peripheral sensory neurological function.

• Journal of Mushroom
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• v.11 no.2
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• pp.92-98
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• 2013

This study was carried out to evaluate the immunomodulatory capacity of edible mushrooms, including Sarcodon aspratus, Letinus edodes and Grifola frondosa in mice. BALB/c mice were administered 50, 500, and 1000 mg/kg body weight of various mushrooms five times a week over 4 weeks through oral administration. The control mice were administered distilled water. No significant changes in body weight were observed. IL-4 and $IFN{\gamma}$ production was evaluated with splenic T lymphocytes stimulated in vitro with phytohemagglutinins for 48 hr. The mice group administered Sarcodon aspratus, Grifola frondosa tend to higher ratio of $IFN{\gamma}$ versus IL-4 than the other groups. In addition, the ratio of plasma IgG2a versus IgG1 was also elevated in mice treated with Sarcodon aspratus. These results indicated that Sarcodon aspratus can enhance type-1 helper T cell-mediated cellular immunity. And also, S. aspratus seems to be one of the most useful mushrooms for immunomedicine.

• Clinical and Experimental Reproductive Medicine
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• v.33 no.3
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• pp.179-187
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• 2006

Objectives: The risk of aneuploidies of embryos increases in advanced maternal age or parental karyotype abnormality and it results in poor reproductive outcomes such as recurrent spontaneous abortion (RSA) or repeated implantation failure (RIF). Preimplantation genetic diagnosis for aneuploidy screening (PGD-AS) can be applied for better ART outcome by selecting chromosomally normal embryos. The aim of this study is to evaluate the clinical outcome of PGD-AS and which group can get much benefit from PGD-AS among the patients expected to have poor reproductive outcome. Methods: In 42 patients, 77 PGD cycles were performed for aneuploidy screening. Patients were allocated to 3 groups according to the indication of PGD-AS: group I-patients with old age (${\geq}37$) and RIF more than 3 times (n=11, mean age=42.2 yrs.), group II-patients with RSA (${\geq}3$ times) associated with aneuploid pregnancy (n=19, mean age=38.9 yrs.), group III-parental sex chromosome abnormality or mosaicism (n=18, mean age=29.6 yrs.) including Turner syndrome, Klinefelter syndrome and 47, XYY. PGD was performed by using FISH for chromosome 13, 16, 18, 21, X and Y in group I and II, and chromosome X, Y and 18 (or 17) in group III. Results: Blastomere biopsy was successful in 530 embryos and FISH efficiency was 92.3%. The proportions of transferable embryos in each group were $32.5{\pm}17.5%$, $23.0{\pm}21.7%$ and $52.6{\pm}29.2%$ (mean ${\pm}$ SD), respectively, showing higher normal rate in group III (group II vs. III, p<0.05). The numbers of transferred embryos in each group were $3.9{\pm}1.5$, $1.9{\pm}1.1$ and $3.1{\pm}1.4$ (mean ${\pm}$ SD), respectively. The clinical pregnancy rates per transfer was 0%, 30.0% and 20.0%, and it was significantly higher in group II (group I vs. group II, p<0.05). The overall pregnancy rate per transfer was 19.6% (10/51) and the spontaneous abortion rate was 20% (2/10) of which karyotypes were euploid. Nine healthy babies (one twin pregnancy) were born with normal karyotype confirmed on amniocentesis. Conclusion: Our data suggests that PGD-AS provides advantages in patients with RSA associated with aneuploidy or sex chromosome abnormality, decreasing abortion rate and increasing ongoing pregnancy rate. It is not likely to be beneficial in RIF group due to other detrimental factors involved in implantation.

• Korean Journal of Agricultural Science
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• v.13 no.1
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• pp.17-32
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• 1986

To obtain basic information needed for developing better pearl barley varieties, a total of 148 lines of pearl barley were collected from nationwide survey except for Kangwon and Chejoo provinces and classified by principal component analysis. The results are summarized as follows : 1. Variabilities of characters for all lines except for leaf width and 100 K. Wt.(Unpolished) were high enough to indicate variation of lines. 2. Correlation coefficients among 18 characters were high enough and they showed the shape of normal distribution, more or less, inclined toward positive values. 3. The lines could be classified into four groups by correlation coefficient for 18 characters : Group I was characterized as the lines composed of grain and plant type, Group II maturity, Group III the number of tillers, and Group IV the nature of germination, respectively. 4. About 60% of the total variation could be appreciated by the first four principal components and about 89% of the total variation by the first ten principal components. 5. Contribution of characters to principal components was variable and was high at upper principal components and low at lower principal components. 6. The value of eigen vector corresponding to those which had high significant correlation coefficient between characters was almost of the same value. 7. The lines were classified into four groups by principal component analysis. 8. The lines were also classified into four groups by taxonomic distance. Group I included 79 lines, Group II 40 lines, Group III 22 lines, and Group IV 7 lines, respectively. 9. Four groups classified by taxonomic distance could be characterized as follow : Group I : medium height plant, small kernels, medium maturity, and narrow and short leaf, Group II : short height plant, small kernels, early maturity, and narrow and short leaf. Group III : tall height plant, large kernels, late maturity, and broad and long leaf. Group IV : short height plant, large kernels, medium maturity, and narrow and short leaf.

• Korean Journal of Medicinal Crop Science
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• v.9 no.4
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• pp.301-309
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• 2001

This study was conducted to provide the basic information on safflower collections and to identify the variations which could be utilized in safflower breeding programs. The agronomic characteristics was used to clarify the genetic relationships among safflower collections and to classify them into distint genetic groups. There were 21 early maturing collections with less than 80 days in number of days from planting to flowering. The number of primary and secondary branches ranged ${3.8{\sim}14.8\;and\;0{\sim}26.9}$, respectively, and two collections, IT201434 and IT202723, were found to be high branch types. The 101 safflower collections were classified into 11 groups based on the complete linkage cluster analysis using agronomic characteristics. The I, II, III, IV, IX, X and ? groups included the 25%, 33%, 14%, 8%, 2%, 1% and 1% of the collections, respectively. All the collections in the group III were Korean landraces. The collections in group X could be characterized as early emergence, late flowering and high yield components such as the number of capitula per plant, number of seeds per capitula and seed weight per plant. The number of capitula per plant and seed weight per plant, i.e., the two main yield components, had the highly significant positive correlations with stem diameter, number of the primary branches, number of the secondary branches, number of leaves and leaf length.

• Clinical and Experimental Pediatrics
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• v.45 no.10
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• pp.1204-1212
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• 2002

Purpose : Early surfactant therapy with either gentle ventilation, high-frequency ventilation or aggressive weaning of mechanical ventilation are principles for the treatment of respiratory distress syndrome(RDS). We studied to determine the accessibility of noninvasive nasal continuous positive airway pressure(CPAP) rather than mechanical ventilation by invasive intubation after early surfactant therapy. Methods : The study group consisted of 14 infants who were born and diagnosed with moderate respiratory distress syndrome and received early surfactant therapy with nasal CPAP of PEEP 5-6 cm $H_2O$ within two hours after birth in the Fatima neonatal intensive care unit for two years from January 1999 to August 2001. The control group consisted of 15 infants who were diagnosed with the disease and could be weaned from mechanical ventilator within five days after birth during the same period. Results : The characteristics, the severity of clinical symptoms and laboratory findings in the two groups at birth showed no significant difference. Neither did the interim analysis of laboratory data in two groups. Of 14 infants in the study group who received nasal CPAP after early surfactant therapy, only two infants showed weaning failure with this therapy. In the response cases, duration of CPAP was five days and mean airway pressure was $5.4{\pm}0.5cm$ $H_2O$. Two had the complication of CPAP with abdominal distension. Final complications and outcomes in the two groups showed no signifcant difference(P>0.05). Conclusion : The clinical courses in the two groups showed no significant difference. Therefore, we suggest that early surfactant therapy with noninvasive nasal CPAP is a simple and safe method rather than aggressive weaning after invasive mechanical ventilation in moderate respiratory distress syndrome.