• Journal of The Korean Society of Inherited Metabolic disease
• /
• v.20 no.1
• /
• pp.1-13
• /
• 2020

Purpose: Gaucher disease (GD), which is the most prevalent lysosomal storage disorder worldwide, is caused by mutations in the glucocerebrosidase gene (GBA). GD is divided into three clinical subtypes based on the appearance of neurological symptoms. Type 1 GD is a chronic non-neuronopathic disease, and types 2 and 3 are acute neuronopathic and chronic neuronopathic forms, respectively. Neuronopathic GD types 2 and 3 are characterized by increased levels of glucosylceramide (GlcCer) and glucosylsphingosine (GlcSph) in the brain, leading to massive loss of neurons. Methods: DNA damage and subsequent apoptosis of H4 cells were observed following neuroglioma H4 cell culture with GlcCer or GlcSph. Neuronal cell apoptosis was more prominent upon treatment with GlcSph. Results: When H4 cells were treated with GlcSph in the presence of tubacin, a histone deacetylase 6 inhibitor (HDAC6i), attenuation of both DNA damage and a reduction in the protein expression levels of GlcSph-induced apoptosis-associated factors were observed. Conclusion: These findings indicated that GlcSph played a prominent role in the pathogenesis of neuronopathic GD by inducing apoptosis, and that HDAC6i could be considered a therapeutic candidate for the treatment of neuronopathic GD.

• Korean Journal of Food Science and Technology
• /
• v.31 no.6
• /
• pp.1661-1666
• /
• 1999

Yungmijihwgang-Won, Yollyunggobon-Dan and Palmi-Hwan, Korea traditional prescriptions composed of oriental medical herbs, have been used successfully to improve human health and regimen. This study was designed to examine the mechanism of healthful effects of the Korea traditional prescriptions through its antioxidative potentials. Using in vitro antioxidative activity assay system such as DPPH radical quenching assay, superoxide anion radical scavenging assay and inhibition of TBARS production, three Korea traditional prescriptions were observed to have nearly the same antioxidative potentials as ascorbic acid, a well-known strong water-soluble antioxidant. Moreover, we observed reinforced antioxidative effects of these drugs in liver from mouse fed these drugs with 4 weeks. When liver homogenate was incubated with 2.2'-azobis(amidinopropane) dihydrochloride(AAPH), as a free radical initiator, we observed that oxidative damages were decreased and antioxidative potentials were increased in liver homogenate treated these drugs. However, enzymatic antioxidative system as superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase was not affected by drug administration.

• Clinics in Shoulder and Elbow
• /
• v.13 no.1
• /
• pp.92-98
• /
• 2010

Purpose: To analyze results of treating acromioclavicular injuries using clavicle hook plates. Materials and Methods: Between February 2008 and April 2010, 18 patients with acromioclavicular joint injury treated by clavicle hook plates were reviewed. Using the Rockwood classification, 7 dislocations were classified as type III injuries and 11 as type V injuries. Implant removal was done at least 3 months from initial fixation. Simple X-rays were taken for comparing the state of reduction, and clinical outcomes were evaluated by the Korean Shoulder Scoring System and the American Shoulder Elbow Society score. The average follow-up period was 9 months. Results: On weight bearing X-rays, the average coracoclavicular distance showed a 114% increase compared to the contralateral side at the time of injury. It decreased to 23% by the last follow-up. The mean Korean Shoulder Scoring System and the American Shoulder Elbow Society score were 80 and 74 at the last follow-up. Conclusion: The immediate stability these plates provide allows rapid rehabilitation. Clavicle hook plate fixation for acromioclavicular joint dislocation is considered an effective method for ensuring satisfactory results both radiologically and clinically.

• Journal of the Korean Arthroscopy Society
• /
• v.8 no.2
• /
• pp.119-123
• /
• 2004

Purpose: The purpose of this study is to check the range of motion of shoulder and inverstigate the frequencies and patterns of partial thickness rotator cuff tear in SLAP lesions. Materials and Methods: Forty-six patients, forty-seven cases who had SLAP lesions at shoulder arthroscopy were analyzed spectively using the medical records, intra-operative arthroscopic photo & video for SLAP lesions and rotator cuff articular side partial tear. Under the interscalene anesthesia, the range of notion of foreward elevation, internal rotation and external rotation was measured on fixed scapula and 90 degree abduction of the shoulder. Results: The rang of Motion are 150 degree on foreward elevation, 65.5 degree on external rotation, 61.7 degree on internal rotation. By Snyder's classification, type ll SLAP lesion is noted in 24 cases (five cases in type 1, one case in type IV). Rotator cuff articular side partial tear is noted in 24 cases ( one case in type I, 22 cases in type II, one case in type IV SLAP). All the rotator cuff articular side partial thickness tear were located in the anterior part of the supraspinatus. Conclusion: The rotator cuff partial thickness tear is mostly noted on the articular side and frequently found in the relatively more unstable type of SLAP lesions. So we consider that SLAP lesion may be a one of the causes for partial tear of the rotator cuff articular side.

• Industry Promotion Research
• /
• v.4 no.1
• /
• pp.11-20
• /
• 2019

This study relates to a fixing device for gas piping installed in a building such as an apartment or a building. The gas piping is fixed to the inside of the housing so as to buffer the gas piping in all directions, thereby relieving vibration caused by an earthquake or an impact, Disclosed is an earthquake-proof fixing device for a gas pipeline that can minimize damages caused by damage to an earthquake and a gas pipeline by preventing damage and breakage. An apparatus for fixing a gas pipe to a bracket provided on a wall or a wall of a building, the apparatus comprising: a housing coupled to a wall or a bracket and coupled to the inside of the housing; a gas pipe penetrating through the housing to fix the gas pipe; The first plate spring includes a first plate spring formed with a plurality of concave-convex portions that are elastically supported in four directions. The first plate spring is screwed to the front surface or the rear surface of the housing. The lower plate is coupled to one end and the other end, And a pair of first adjusting screws for adjusting the elastic force of the spring. Through this study, damage and damage of gas piping due to earthquake or impact can be minimized.

• Journal of the Korean Arthroscopy Society
• /
• v.4 no.1
• /
• pp.32-37
• /
• 2000

Purpose : We performed routinely arthroscopy to diagnose and treat intra-articular soft tissue pathology and tibial condylar fractures. The purpose of this study was to evaluate clinical value of arthroscopy in the tibial condylar fractures. Materials and Methods : The 31 tibial condylar fractures was examed by routine arthroscopy, 9 treated by conservative method and 22 treated by surgery at least follow up of 12 months. The authors analysed to the cause, classification, soft tissue injuries such as ligaments and menisci, treatment and results. Results : The most common type was Schatzker classification type I in 15 cases$(18\%)$ and intra-articular lesions and associated ligament injury were in 21 cases$(67\%)$. Most common lesion was meniscal tear in 16 cases and most common type of meniscal lesions was peripheral detachment in 7 cases$(44\%)$. Schatzker I, II fracture patterns were associated with the highest frequency of soft tissue injuries, especially medial collateral ligament and meniscal injuries. Conclusion : Arthroscopic examination is useful method to evaluate the intra-articular pathology and to treat the tibial condylar fractures.

• The Journal of Internal Korean Medicine
• /
• v.35 no.1
• /
• pp.92-105
• /
• 2014

Objectives : Cisplatin is a widely used cancer therapy drug. However, nephrotoxicity resulting in increased oxidative stress is a major side effect of cisplatin chemotherapy, thereby limiting its chemotherapeutic use. Lycium chinense Miller (LCM) has been used as a traditional herbal medicine in various febrile and inflammatory diseases such as night sweat, cough, nosebleed, bronchitis, pulmonary tuberculosis, etc. In this study we investigated the protective and antioxidative potential of LCM against cisplatin-induced nephrotoxicity in rats. Methods : Twenty-four 8-week-old male Wistar rats were divided into four groups: normal untreated; cisplatin treatment only; LCM 10 mg/kg plus cisplatin treatment; and LCM 30 mg/kg plus cisplatin treatment. Twenty-four hours after the last cisplatin injection, all the rats were sacrificed, and serological changes were evaluated. The levels of NF-${\kappa}B$ activity and NOX-4, $p47^{phox}$, $p22^{phox}$, COX-2, iNOS, SOD, catalase expressions were analyzed in Western blot analysis. Results : Cisplatin injection caused an increase in the BUN level, which is a reliable indicator of renal toxicity. The levels of BUN, renal ROS, and renal TBARS were significantly reduced in the LCM groups compared with the cisplatin-only groups. The levels of $p47^{phox}$ and $p22^{phox}$, which are NADPH oxidase subunits, were increased in the cisplatin-only groups, whereas they were decreased in the LCM groups. The levels of renal NF-${\kappa}B$ activity and COX-2, iNOS expressions were increased significantly in the cisplatin-only groups compared with the normal groups, whereas they were decreased in the LCM groups. Compared with the cisplatin-only groups, renal GSH and GSH/GSSG increased in the LCM groups. Also, the administration of LCM increased levels of SOD and catalase as compared with the cisplatin-only groups. Conclusions : These results suggest that LCM protects cisplatin-induced nephrotoxicity via a mechanism that may involves the inhibition of oxidative stress by the activation of antioxidants.

• Korean Journal of Heritage: History & Science
• /
• v.43 no.3
• /
• pp.4-25
• /
• 2010

This study was carried out on scientific conservation treatment based on material characteristics, provenance interpretation, and deterioration diagnosis for seven-storied Jungwon Tappyeongri stone pagoda in Chungju. As a result, main rock of the pagoda is biotite granite with magnetite-series (average $5.86{\times}10^{-3}$ SI unit), containing partly basic xenolith, pegmatite veinlet and feldspar phenocryst. As a result of the provenance presumption of the host rock, a rock around the Songgang stream was identified the same origin. Therefore the rock is appropriate for materials of the pagoda restoration. The deterioration assessment suggested that the pagoda was seriously exfoliated (2.7 to 5.5%), discolored (39.8 to 58.9), and contaminated with repair materials (3.5 to 9.4%), and bioorganisms (19.3 to 24.4%). Accordingly, conservation treatment was carried out based on preliminary investigation for stable conservation of the pagoda. Overall processes were sequentially proceeded by restoration of the replacement stone, cleaning, joining and consolidation. This study sets up an integrated conservation system from preliminary investigation to conservation treatment of the pagoda. Also, the study will contribute for establishing the future-oriented customized conservation treatment.

• Journal of Korea Ship Safrty Technology Authority
• /
• v.17
• /
• pp.24-43
• /
• 2005

최근 우리나라 어선어업은 한중일 어업협정, 연안 어업자원 감소 및 연안오염 등 사회적, 환경적 변화가 급변하고 있어 이들을 고려한 어선 선형개발이 필요로 한다. 현재 우리나라의 어선 중 연안지역에서 조업하는 5톤 미만의 소형어선은 전체 어선 중 $65\%$ 이상으로 구성되어 있으나 선박의 크기가 작고 부가가치가 낮은 관계로 지금까지 전문적인 연구는 거의 없었던 것이 현실이다. 한편, 서$\cdot$남해 연안에서 작업 및 항해하는 연안어선들의 해양사고 발생율은 전체사고의 $69.6\%$로 매년 증가하고 있는 추세이다. 전체 어선 안전사고 중 부유폐어망, 로프 등이 추진기에 감긴 사고는 전체 사고의 $10.4\%$로 매년 증가하고 있다. 이에, 추진기 손상에 의한 어선 사고와 연관하여 추진기를 보호하기 위한 장치로서 물분사 추진기(Water-Jet), 펌프제트(Pump-Jet)장치들이 있으나 이들은 고가 수입품으로서 영세한 어민들의 소형어선에 장착하기에는 한계가 있어, 본 연구에서는 폐그물, 로프 등 해상 부유물에 의한 추진기 손상이 발생되지 않는 프로펠러 보호터널 부착 추진장치를 개발을 목적으로 한다. 프로펠러 부착 추진장치는 기존 선미를 수정하여 추진기를 선체 안쪽으로 배치하며 돌출되는 부분은 덕트로 보호하고 있으며 이러한 추진기는 워터제트 추진기와는 달리 가격이 싸고 그물이나 부유물에 걸리지 않고 고장 시 신속한 대응이 쉬워 소형 연안어선에 적합할 뿐만 아니라 그물, 부유물, 갯벌이 많은 국내의 서$\cdot$남해 연안에서 작업 및 항해 시 매우 유용할 것으로 판단된다. 본 연구는 `프로펠러 보호터널 부착 연안어선의 선형개발`을 최종목표로 수행하였으며, 연구개발 내용은 기존 소형 연안어선의 분류 및 특성 조사 연구, 프로펠러 보호터널형 선미 선형 개발, 기존 선형 및 보호터널형 선형의 모형시험, 개발선의 구조강도 특성, 프로펠러 설계 및 단독시험, 보호터널 부착 추진기의 효율 검증 및 개발 대상 어선의 조선공학적 제 계산, 설계도작성 등을 실시하였다. 주요 요소 기술로서는 프로펠러 보호터널 부착 선형의 모형시험을 통하여 선미선형을 개발하며 FRP판부재의 구조강도 특성을 분석하고 그 결과를 활용하여 4톤급 연안어선의 시제선을 건조하고 시운전을 통하여 주요성능을 확인하였다.

• Journal of Chest Surgery
• /
• v.37 no.3
• /
• pp.201-209
• /
• 2004

Extracorporeal life support (ECLS) system is a device for respiratory and/or heart failure treatment, and there have been many trials for development and clinical application in the world. Currently, a non-pulsatile blood pump is a standard for ECLS system. Although a pulsatile blood pump is advantageous in physiologic aspects, high pressure generated in the circuits and resultant blood cell trauma remain major concerns which make one reluctant to use a pulsatile blood pump in artificial lung circuits containing a membrane oxygenator. The study was designed to evaluate the hypothesis that placement of a pressure-relieving compliance chamber between a pulsatile pump and a membrane oxygenator might reduce the above mentioned side effects while providing physiologic pulsatile blood flow. The study was performed in a canine model of oleic acid induced acute lung injury (N=16). The animals were divided into three groups according to the type of pump used and the presence of the compliance chamber, In group 1, a non-pulsatile centrifugal pump was used as a control (n=6). In group 2 (n=4), a single-pulsatile pump was used. In group 3 (n=6), a single-pulsatile pump equipped with a compliance chamber was used. The experimental model was a partial bypass between the right atrium and the aorta at a pump flow of 1.8∼2 L/min for 2 hours. The observed parameters were focused on hemodynamic changes, intra-circuit pressure, laboratory studies for blood profile, and the effect on blood cell trauma. In hemodynamics, the pulsatile group II & III generated higher arterial pulse pressure (47$\pm$ 10 and 41 $\pm$ 9 mmHg) than the nonpulsatile group 1 (17 $\pm$ 7 mmHg, p<0.001). The intra-circuit pressure at membrane oxygenator were 222 $\pm$ 8 mmHg in group 1, 739 $\pm$ 35 mmHg in group 2, and 470 $\pm$ 17 mmHg in group 3 (p<0.001). At 2 hour bypass, arterial oxygen partial pressures were significantly higher in the pulsatile group 2 & 3 than in the non-pulsatile group 1 (77 $\pm$ 41 mmHg in group 1, 96 $\pm$ 48 mmHg in group 2, and 97 $\pm$ 25 mmHg in group 3: p<0.05). The levels of plasma free hemoglobin which was an indicator of blood cell trauma were lowest in group 1, highest in group 2, and significantly decreased in group 3 (55.7 $\pm$ 43.3, 162.8 $\pm$ 113.6, 82.5 $\pm$ 25.1 mg%, respectively; p<0.05). Other laboratory findings for blood profile were not different. The above results imply that the pulsatile blood pump is beneficial in oxygenation while deleterious in the aspects to high pressure generation in the circuits and blood cell trauma. However, when a pressure-relieving compliance chamber is applied between the pulsatile pump and a membrane oxygenator, it can significantly reduce the high circuit pressure and result in low blood cell trauma.