• Korean Journal of Clinical Pharmacy
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• v.15 no.1
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• pp.41-45
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• 2005

심바스타틴은 cholesterol 생합성 과정에서 속도 조절 효소인 HMG-CoA reductase의 강력한 상경적 길항약으로서 고지혈증 치료에 널리 쓰이는 약물이다. 심바스타틴 제제인 MSD 사의 조코 20 mg정을 대조약으로 하여 시험약인 유영 제약의 엘바스타 20mg정의 생물학적 동등성 평가를 하기 위해 22명의 건강한 지원자를 모집하였다. 지원자를 두 군으로 나누어 2정씩 투여하였고 $2{\times}2$ 교차시험을 실시하였다. 심바스타틴의 혈장 중의 농도를 정량하기 위하여 발리데이션된 LC/MS/MS를 사용하였다. 채혈 시간은 투약 전 및 투약 후 0.5, 1, 1.5, 2, 2.5, 3, 4, 6, 8, 10, 12 시간에 걸쳐 총 12시점에 걸쳐 시행하였다. 생물학적 동등성을 판정하기 위한 파라미터로 12시간까지의 혈장 중 농도곡선 하 면적 ($AUC_{12hr}$)과 최고 혈중 농도($C_{max}$)를 사용하였다. 12시간 까지의 혈중 농도 곡선 하 면적의 기하 평균은 $17.30ng{\cdot}ml/hr$(시험약)과 $17.35ng{\cdot}ml/hr$(대조약)으로 나타났다. 최고 혈중 농도의 경우 각 각 5.08 ng/ml(시험약)과 5.20 ng/ml(대조약)으로 관찰 되었다. $AUC_{12hr}$의 경우 로그변환한 평균치 차의 $90{\%}$ 신뢰구간이 log0.8510 - log1.1694이었고, $C_{max}$의 경우 log0.8176 - log1.1649로 계산되어 두 항목 모두 log0.8-log1.25이어야 한다는 식품의약품 안전청과 FDA의 기준을 모두 만족시켰다. 이상의 결과를 종합하면 시험약 엘바스타 정 20mg은 대조약 조코정 20 mg에 대하여 생물학적 동등한 것으로 판정되었다.트리머 전기비저항 탐사를 수행하였다. 이를 통해 하저에 케이블을 설치하는 방식에 비해 매우 신속하고 경제적으로 하저에 분포하는 이상대의 분포범위와 발달방향을 규명할 수 있었다.대에 대해 가장 효과적이다. 모델과 현장 적용 결과들을 통해 GRM SSM 방법을 이용하여 불규칙한 굴절면을 가진 지층들에 대해 좀 더 신뢰할 수 있는 정밀한 탄성파 속도를 산출할 수 있음을 보여주고 있다.별한 주의를 기울여야 한다.EX>$\alpha/\beta$=10인 경우 $62.0\~121.9\;Gy_{10}$ (중앙값: $93.0\;Gy_{10}$)의 분포를, ${\alpha/\beta}=3$인 경우 $93.6\~187.3\;Gy_3$ (중앙값=$137.6\;Gy_3$ )의 분포를 보였다. MD-BED $Gy_3$는 직장합병증 발생과의 관계는 통계적으로 유의하였고, 방광합병증과는 유의하지 않았다. 직장합병증과의 연관성은 MD-BED $Gy_3$보다 개별 환자의 직장전벽 총 선량 BED값인 R-BED $Gy_3$가 훨씬 더 높았다. 요도카테터 풍선의 후방지점이 대변하는 방광의 총 선량 BED값인 V-BED $Gy_3$도 방광합병증과 경향성 테스트에서 통계적 유의성을 보였다. 하지만, 어떠한 방사선선량도 골반제어율과 의미 있는 상관관계를 보이지 않았다. 본 기관에서 주치의의 선호도에 따라 강내근접치료가 외부방사선치료의 중간에 시행되는 형태인 샌드위치기법과 외부방사선치료 후반부에 시행되는 순차적 기법으로 구분하였을 때, 두 방식간 치료성적 및 합병증의 차이는 없었다. 총 치료기간에 대한 분석에서는 치료기간이 길어질수록 재발 위험이 커지는 경향을 보였으나, 나이 및 병기, 종양의 크기, MD-BED $Gy_{10}$

• Journal of KIISE:Computing Practices and Letters
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• v.6 no.3
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• pp.364-372
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• 2000

Subcategorization, defining dependency relation between predicates and their complements, is an important source of knowledge for resolving syntactic and semantic ambiguities arising in analyzing sentences. This paper describes a Korean subcategorization dictionary, particularly annotated with semantic roles of complements coupled with thesaural semantic hierarchy as well as syntactic dependencies. For annotating roles, we defined 25 semantic roles associated with surface case markers that can be used to derive semantic structures directly from syntactic ones. In addition, we used more than 120,000 entries of thesaurus to specify concept markers of noun complements, and also used 47 and 17 predicate patterns for verbs and adjectives, respectively, to express dependency relation between predicates and their complements. Using a full-fledged thesaurus for specifying concept markers makes it possible to build an effective selectional restriction mechanism coupled with the subcategorization dictionary, and using the standard predicate patterns for specifying dependency relations makes it possible to avoid inconsistency in the results and to reduce the costs for constructing the dictionary. On the bases of these, we built a Korean subcategorization dictionary for frequently used 13,000 predicates found in corpora with the aid of a tool specially designed to support this task. An experimental result shows that this dictionary can provide 72.7% of predicates in corpora with appropriate subcategorization information.

• Journal of Mushroom
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• v.15 no.4
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• pp.254-258
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• 2017

Mushroom mites have recently caused severe damage to sawdust beds, mushroom mycelia, and fruiting bodies; therefore, they have reduced the production of the button mushroom, Agaricus bisporus, in greenhouses. There are currently no registered pesticides for mushroom mites. It is necessary to selectively control mushroom flies and mites without affecting the growth of the mushroom. We examined biological control of mushroom mites using predatory mite Stratiolaelaps scimitus in button mushroom cultivation. As a result, a three times treatment (1 treatment after water cleaning, 1 treatment after fungus inoculation, and 1 treatment before or after casing) was most effective at controlling mushroom mites, with 3.000 predatory mites (3 bottles) scattered evenly over $165-230m^2$ every 1-2 m. Predatory mite Stratiolaelaps scimitus could control mushroom flies and mites at the same time and could be used at any time during cultivation.

• Korean Journal of Cognitive Science
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• v.22 no.3
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• pp.271-298
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• 2011

The lexical semantic system should be built to grasp lexical semantic information more clearly. In this paper, we studied a semantic clustering of predicates that is one of the steps in building the lexical semantic system. Unlike previous studies that used argument of subcategorization(subject and object), selectional restrictions and interaction information of adverb, we used sense tagged definition in dictionary for the semantic clustering of predicate, and also attempted hierarchical clustering of predicate using the relationship between the generic concept and the specific concept. Most of the predicates in the dictionary were used for clustering. Total of 106,501 predicates(85,754 verbs, 20,747 adjectives) were used for the test. We got results of clustering which is 2,748 clusters of predicate and 130 recursive definition clusters and 261 sub-clusters. The maximum depth of cluster was 16 depth. We compared results of clustering with the Sejong semantic classes for evaluation. The results showed 70.14% of the cohesion.

• Journal of Korean Society of Transportation
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• v.21 no.5
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• pp.73-81
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• 2003

The Government presented improvement plans such as "Traffic Accident Frequent Point" and "Hazardous Roads" to reduce traffic accidents on the increase after 1980s. In case of the hazardous roads, they are expressed by grades which are marked by geometric elements such as width, radius, grade. sight distance. and other environmental factors. As each business for improving roads goes by only focusing on improvement of geometric elements, excessive expense can be invested too much nowadays causing economical waste. Therefore, as improvement plans approached by economic access are needed, this paper shows the cost-effective improvement of the business to keep safety related to traffic accident and economical waste. The hazardous roads which authorized by Gwang-ju National Road Preservation Office of Construction and Transportation Ministry in 1995 for business for improvement of roads, were investigated before 1999. First of all, estimating traffic accident models are presented by using existed data statistically. The models help to maximize traffic accident decrease through control of the presented factor. Secondly, optimum construction cost of improvement is presented to prevent overcapitalization. However, this paper is limited because it was difficult to sort the data with various areas and to approach various ways.

• Journal of Digital Contents Society
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• v.16 no.2
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• pp.227-234
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• 2015

Recently, there is more and more demand on broadcasting display environment that provides a sense of realism basically with high quality and high definition as in UHDTV, so various kinds of 4K cameras have been released. Super 35mm sensor 4K/UHD cameras being generally used can be usefully applied to the single camera-based system such as advertisements, dramas, nature documentaries, and culture programs. However, in the multicamera-based system such as entertaining programs, sports, and concerts, relay broadcasting may face limitations as there are restrictions of close-up or tight shots according to the distance. Besides, 4K lenses are not enough compared with the previous HD lenses' group, so there are limitations in camera photographing shots that have been realized in HD filming. Therefore, to complement this, the use of 2/3 inch sensor 4K/UHD cameras is being demanded, and it is also needed to use various lenses' groups to produce UHD image contents. Accordingly, this study used Grass Valley's LDX 4K/UHD camera to analyze its applicability based on the picture quality test at the use of HD lenses in 2/3 sensors and also the possibility of its efficient application.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.44 no.4 s.316
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• pp.26-34
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• 2007

Intelligent projection system indicates a system that displays desired images on an arbitrary screen in an arbitrary environment using projector without noticeable image distortion. In recent years, projectors have become widespread and ubiquitous due to their increasing capabilities and declining cost. Moreover, the size of projectors is getting smaller and handhold projectors are emerging. Thanks to these advances, the demand for intelligent projection system has been significantly increased and the demand has led to remarkable progress of the related techniques or technologies to intelligent projection system However, there are still some environments (or conditions, mainly dynamic ones) that intelligent projections systems cannot handle and they have limited the application area of intelligent projection systems. This paper exemplifies such environments (e.g. specular screen, dynamic screen) and propose effective solutions (i.e. multiple overlapping projectors, complementary pattern embedding) for thor And the usefulness of the solutions is verified through experimental results and user evaluation. Notice that the environments are considered not simultaneously but independently because it is impossible to consider them simultaneously by simply combining the solutions for each. Acually, a totally different solution would be necessary to consider them simultaneously. Therefore, we expect that the proposed methods would largely extend the application area of intelligent projection systems except for severely arbitrary environment.

• Journal of KIISE:Software and Applications
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• v.27 no.7
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• pp.769-783
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• 2000

In this paper, in order to disambiguate Korean noun word sense, we define a local context and explain how to extract it from a raw corpus. Following the intuition that two different nouns are likely to have similar meanings if they occur in the same local context, we use, as a clue, the word that occurs in the same local context where the target noun occurs. This method increases the usability of extracted knowledge and makes it possible to disambiguate the sense of infrequent words. And we can overcome the data sparseness problem by extending the verbs in a local context. The sense of a target noun is decided by the maximum similarity to the clues learned previously. The similarity between two words is computed by their concept distance in the sense hierarchy borrowed from WordNet. By reducing the multiplicity of clues gradually in the process of computing maximum similarity, we can speed up for next time calculation. When a target noun has more than two local contexts, we assign a weight according to the type of each local context to implement the differences according to the strength of semantic restriction of local contexts. As another knowledge source, we get a co-occurrence information from dictionary definitions and example sentences about the target noun. This is used to support local contexts and helps to select the most appropriate sense of the target noun. Through experiments using the proposed method, we discovered that the applicability of local contexts is very high and the co-occurrence information can supplement the local context for the precision. In spite of the high multiplicity of the target nouns used in our experiments, we can achieve higher performance (89.8%) than the supervised methods which use a sense-tagged corpus.

• KIPS Transactions on Software and Data Engineering
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• v.3 no.6
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• pp.219-230
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• 2014

An analysis of dependency relation is a job that determines the governor and the dependent between words in sentence. The dependency relation of predicate is established by patterns and selectional restriction of subcategorization of the predicate. This paper proposes a method of analysis of Korean dependency relation using homograph predicate disambiguated in morphology analysis phase. The disambiguated homograph predicates has each different pattern. Especially reusing a stage transition training dictionary used during tagging POS and homograph, we propose a method of fixing the dependency relation of {noun+postposition, predicate}, and we analyze the accuracy and an effect of homograph for analysis of dependency relation. We used the Sejong Phrase Structured Corpus for experiment. We transformed the phrase structured corpus to dependency relation structure and tagged homograph. From the experiment, the accuracy of dependency relation by disambiguating homograph is 80.38%, the accuracy is increased by 0.42% compared with one of undisambiguated homograph. The Z-values in statistical hypothesis testing with significance level 1% is ${\mid}Z{\mid}=4.63{\geq}z_{0.01}=2.33$. So we can conclude that the homograph affects on analysis of dependency relation, and the stage transition training dictionary used in tagging POS and homograph affects 7.14% on the accuracy of dependency relation.

• Journal of Korean Ophthalmic Optics Society
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• v.17 no.3
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• pp.293-298
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• 2012

Purpose: We compared static retinoscopy in eyes opened with cycloplegic refraction depending on the hyperopia for school-aged children. Methods: There were 59 eyes (30 patients) who were divided into 3 groups - the mild hyperopia (+0.25 D ~ +1.00 D), moderate hyperopia (+1.25 D ~ +2.00 D) and high hyperopia (+2.25 D or more). They all had 0.8 visual acuity or more. Autorefraction and retinoscopy were performed prior to cycloplegic refraction, and then copmared with manifest refraction and cycloplegic refraction. Results: Hyperopia measured with static retinoscopy tends to be measured higher than manifest refraction for school-aged children. Changes of spherical power was statistically significant (p < 0.001). Changes of astigmatism was not statistically significant (p > 0.05). Conclusions: The difference between cycloplegic refraction and static retinoscopy was not significant for hyperopic school-aged children. The use of retinoscopy was limited for opticians because of legal constraints. The usage of static retinoscopy in eyes opened for optician should be generalized under the conditions not using the cycloplegic.