• Journal of Life Science
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• v.32 no.4
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• pp.298-302
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• 2022

Sulforaphane is a sulfur-containing substance found in large amounts in cruciferous plants and has been reported in several studies to have anticancer effects. Kale is a representative cruciferous plant known as a superfood and is widely used as an ingredient in various dishes. In this study, in order to investigate a cultivation method for increasing kale's content of sulforaphane, kale was treated with geraniol or methyl jasmonate and water stressed during cultivation using a aeroponic culture system in a fully enclosed plant factory. Geraniol or methyl jasmonate were sprayed on the kale's leaf surface once a day for 2 days, and water deprivation stress was conducted for 3 days after 7 days from first treatment day. No difference in growth between control, geraniol, methyl jasmonate treated groups were observed during cultivation. The study results showed that the kale sulforaphane content increased by 60% in the group treated with geraniol compared to the control group and that the group treated with water deprivation stress in addition to geraniol showed a significant increase of 414%. These results show that kale with an increased content of sulforaphane can be grown and that geraniol can be a good research material for increasing the content of functional substances in plants.

• Journal of Society of Preventive Korean Medicine
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• v.2 no.1
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• pp.13-30
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• 1998

Geraniol (1), olivetol (2), cannabinoids (3 and 4) and 5-fluorou.a.il (5). were tested for their growth inhibitory effects against SK-MEL-3 cell lines using two different 3-(4,5-dimethylthiazol- 2yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay and sulforhodamine B protein (SRB) assay. These compounds showed inhibitory activity in vitro in the micromolar range against SK-MEL-3 cell lines. In general, the antitumor activity of these compounds (1, 2, 3, 4 and 5) was in a dose-dependent over the micromolar concentration range $1\;to\;100{\mu}M$. The comparison of $IC_{50}$ values of these compounds in tumor cell lines shows that their susceptibility to these compounds decrease in the following order : OLVTL > CBG > CBD > 5-FU > CRNL in MTT assay, CBG > OLVTL > CBD > GRNL > 5-FU in SRB assay. Cannabinoids (3 and 4) and 5-fluorouracil (5) were tested for their cytotoxic effects on NIH 373 fibroblasts using two different MTT assay and SRB assay. These compounds exhibited potent cytotoxic activities in vitro in the micromolar range against NIH 373 fibroblasts. In general, the cytotoxic activities of these compounds (3, 4 and 5) were in a dose-dependent over the micromolar concentration range $1\;to\;100{\mu}M$. The comparison of $CD_{50}$ values of these compounds on NIH 373 fibroblasts shows that their susceptibility to these compounds decrease on the following order ; CBD > 5-FU > CBG in MTT assay and SRB assay. Cannabigerol (3) was shown the least cytotoxic activity on NIH 373 fibroblasts. Cannabigerol (3) exhibited the most growth-inhibitory activity against SK-MEL-3 cell lines.

• The Korean Journal of Pesticide Science
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• v.19 no.4
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• pp.399-401
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• 2015

This study investigated the plant growth promoting activity of geraniol on Chinese cabbage (Brasscia campestris ssp. Pekinensis Rupr.), Pak Choi (Brassica rapa L.), Crown daisy (Chrysanthemum coronarium L.), Iceberg lettuce (Lactuca sativa L.) and Leaf perilla (Perilla frutescens Britt.). Geraniol at 0.5 to $10mg\;L^{-1}$ promoted radical growth of Chinese cabbage Pak Choi, Crown daisy, Iceberg lettuce and leaf perilla by >30%. In the pot experiments, geraniol treatment at $20mg\;L^{-1}$ by drenching increased up to 190% of the aerial part growth promotion. By comparison, foliar application showed 124% promoting activity only at $100mg\;L^{-1}$.