• Journal of Physiology & Pathology in Korean Medicine
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• v.32 no.4
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• pp.226-231
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• 2018

Chijabaegpi-tang (CHG) is an oriental herbal medicine that has been used for its various pharmacological effects, which include anti-inflammatory, anti-oxidant and immunoregulation activities. In the present study, we investigated which skin inflammations are involved in the $TNF-{\alpha}/IFN{\gamma}$-induced HaCaT cells. We investigated the suppressive effect of CHG on $TNF-{\alpha}/IFN{\gamma}$-induced HaCaT cell production of the following chemokines: macrophage-derived chemokine (MDC)/CCL22; regulated on activation, normal T-cell expressed and secreted (RANTES)/CCL5; and interleukin-8 (IL-8); thymus and activation-regulated chemokine (TARC)/CCL17. The pre-treatment of HaCaT cells with CHG suppressed $TNF-{\alpha}/IFN{\gamma}$-induced nuclear transcription factor kappa-B ($NF-{\kappa}B$). In addition, CHG inhibited $TNF-{\alpha}/IFN{\gamma}$-induced phosphorylation of ERK and p38. $TNF-{\alpha}/IFN{\gamma}$ suppressed the expression of skin barrier proteins, including filaggrin (FLG), Involucrin (IVL) and loricrin (LOR). By contrast, CHG restored the expression of FLG, IVL and LOR. Taken together, our findings suggest that CHG could be a therapeutic agent for prevention of skin disease, including atopic dermatitis.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.12
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• pp.8691-8699
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• 2015

With the technology of our time growing sophisticated everyday, softwares advance rapidly in accordance. Reflecting this trend, researches on Usability of S/W GUI(Graphical User Interface) is actively taking place. However, despite the active researches on such topic, Usability study of S/W GUI for weapon system remains insufficient. For such reason, this paper intends to focus on drawing evaluation factors as well as priority of design factors for Usability of S/W GUI for weapon system. For an accurate and reliable result, Usability evaluation attributes & design factors were assessed by professionals. Moreover, by incorporating AHP(Analytical Hierarchy Process) and Matrix analysis, each evaluation attributes' level of importance and relation between design factors & usability attributes were assessed to draw final design priority. As a result, the importance of Informativity, Accessibility, and Visibility were derived as 0.127, 0.121, 0.108, and selected to be the foremost priority for evaluating. This research could be utilized as foundation for usability evaluation of S/W GUI on weapon system.

• The Journal of the Korea Contents Association
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• v.9 no.12
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• pp.459-466
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• 2009

While Korean allows the same consonants at the coda of the preceding syllable and at the onset of the following syllable, English does not allow the geminate consonants in the same intervocalic position. Due to this difference between Korean and English, Korean learners of English tend to incorrectly produce geminate consonants for English geminate graphemes as in $su\underline{mm}er$. Based on this observation, a pilot study was designed to investigate how Korean learners of English perceive and produce English doubleton graphemes and singleton graphemes. Twenty Korean college students were asked to perform a forced-choice perception test as well as a production test for the 36 real word stimuli which consist of (near) minimal pairs of singleton and doubleton graphemes. The result showed that the accuracy rates for the words with singleton graphemes were higher than those for the words with doubleton graphemes both in perception and production because the subjects misperceived and misproduced the doubleton graphemes as geminates due to orthographic influence. In addition, the low error rates of the word with voiced stops were accounted for by Korean language transfer. Further, spectrographic analyses were provided where more production errors were witnessed in doubleton grapheme words than singleton grapheme words. Finally, pedagogical implications are provided.

• Clinical and Experimental Reproductive Medicine
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• v.36 no.4
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• pp.293-300
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• 2009

Objective: This study was aimed to investigate whether uterine blood flow on the day of embryo transfer can be a predictor of pregnancy outcome in human IVF. Methods: Fifty-one patients undergoing IVF program were included in this study. Serum estradiol levels were measured on the day of hCG administration and uterine pulsatility index (PI) and resistance index (RI) was examined for at embryo transfer of day 3. Results: Of 51 cycles, 22 cycles were clinically pregnant (43.1%) and the implantation rate was 14.7%. Uterine PI and RI had a significant inverse correlation with serum estradiol levels (p<0.05). These uterine blood flows were not significantly different between pregnant and nonpregnant groups. The pregnancy rate was slightly higher in patients with PI more than 3.0 compared to those with PI of 3.0 or less, but there was no significant difference. Conclusion: These results suggest that uterine PI and RI at the day of embryo transfer could not be a good predictor of pregnancy in IVF treatment. But they had an inverse correlation with serum estradiol levels on the day of hCG administration.

• Journal of Korea Spatial Information System Society
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• v.1 no.2 s.2
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• pp.63-80
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• 1999

This study presents NGDM(National Geospatial Information Distribution Model) in order to effectively utilize and differently apply geospatial information which is important in the dispersion of GIS. In order to establish the NGDM, this study draws the guideline of NGDM in Korea by analyzing its present condition of domestic and foreign geospatial information distribution. It also investigates some major factors forming the infrastructure of NGDM in regulative, technical, physical, and social aspects. Based on these factors, this study presents a three-staged NGDM that is applicable in Korea. The NGDM consists of four components that are the consumer, supplier, gateway for the clearinghouse and the clearinghouse of the geospatial information. According to the management form of geospatial information, the types of NGDM are classified as the concentration type, the distribution type, and compound type. Also, this study explains the mutual relationship between the NGDM's components and suggests a three-staged NGDM of planting, growth, and maturity period considering comparison results of classified models and development direction of regulation, protocol, communication network, electronic commerce, and etc.

• The Korean Journal of Pharmacology
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• v.31 no.1 s.57
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• pp.85-93
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• 1995

In order to examine the effect of testosterone of the cell growth, using a primary rabbit kidney proximal tubule cell culture system, we observed the effect of 3 growth factors and testosterone supplementation on the growth of primary rabbit kidney proximal tubule cells in the serum-free medium. 1 nM of testosterone showed a potentiation of the effect on the growth of the proximal tubule cell in serum-free medium, but higher concentration (>10 nM) of testosterone indeed inhibited the growth. In the absence of hydrocortisone as a growth supplement in serum-free medium, testosterone caused to potentiate the growth of the cell. In the presence of hydrocortisone, testosterone also potentiated the grwoth of the proximal tubule cells. According to the Northern analysis, testosterone increased significantly the level of ${\beta}-actin$ mRNA in proximal tubular cells of rabbit kidney. Consequently we may suggest that growth stimulatory effect of testosterone on the primary rabbit kidney proximal tubule cell in serum-free and hormonally defined media ascribed to increase the synthesis of ${\beta}-actin$, which is an important protein consisting of cellular microfilament.

• Journal of the Korean earth science society
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• v.37 no.7
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• pp.398-407
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• 2016

We cooperated with four domestic educational astronomical observatories to construct a baseline and perform simultaneous observations to determine the geocentric parallax, distance, and motion of 1036 Ganymed, an Amor asteroid near the Earth. Observations were made on the day when simultaneous observations were possible from September to November 2011. Measured distances of 1036 Ganymed were 0.394 AU on Sept. 26, 0.365 AU on Oct. 11, and 0.340 AU on Oct. 25, respectively, which were within the error range as compared with the measured distances proposed by the US Jet Propulsion Laboratory. The 1036 Ganymed showed a tilting motion during the observation period, and the tangential angular velocities were measured at $0.037-0.052^{{\prime {\prime}}\;sec^{-1}$. Through this study, it was shown that the simultaneous observations among educational astronomical observations can obtain distance measurements with an error range of about 5% for asteroids near 0.4 AU. And it expected to be used as a research & education program emphasizing collaborative observation activities based on a network between observatories.

• Journal of the Korean earth science society
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• v.37 no.7
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• pp.389-397
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• 2016

In order to investigate the light curve difference in visual and infrared wavelength of ${\delta}$ Scuti variable Bo Lyn, observations were performed using BOAO 1.8m reflecting telescope and an infrared detector, KASINICS, with J, H, and Ks filters. Infrared light curves of total 7 nights were obtained between March and April in 2011, and those were compared to the V-filter light curve to examine the differences in period, time of maximum light, amplitude, and shape. From the periodic analysis of infrared light curve, a single frequency of $f_1=10.712cycle/day$, $P=0.09335{\pm}0.00002days$ was obtained, and there was no difference in the period along different wavelengths. In the infrared light curve, a frequency of $2f_1$ was detected. This frequency well explains the asymmetric shape of light curve, one of the characteristics of high-amplitude ${\delta}$ Scuti variables. We compared the locations of the measured infrared maxima and the predicted maxima of V-filter, finding that the times of maxima were delayed about 0.3 phase at infrared wavelengths. Amplitude ratios were adopted to be ${\Delta}J/{\Delta}V=0.328$, ${\Delta}H/{\Delta}V=0.216$, and ${\Delta}Ks/{\Delta}V=0.211$, with the range of variation being smaller at longer wavelengths. It seems that the differences in the times of maxima and amplitude occurred because the changes in brightness of a pulsating variable star are mainly caused by the change in temperature.

• Journal of the Korean Data and Information Science Society
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• v.27 no.2
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• pp.409-417
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• 2016

The purpose of this study was to demonstrate the effect on the degree of fatigue and accuracy of cardiopulmonary resuscitation according to the different time delays (3 minutes, 4 minutes). Carrying out repeated measures of variance (repeated ANOVA), we have shown that time effect (F = 7.835, p <.01) and group effect (F = 8.695, p<.01) and the interaction effect between time and group (F = 12.582, p<.001) were all statistically significant. It means, in the test of the main effect of group and time (3 minutes, 4 minutes) using the Bonferroni method, it turned out that the amount of lactic acid of the experimental group was larger than that of the control group (p<.01), and there was no difference until 3 minutes, but the difference of the amount of lactic acid was shown between before the experiment and after 4 minutes, and between 3 minutes and 4 minutes (p <.05), respectively. Then, in the result of the corresponding sample t-test, for comparing the according to the measurement time, the accuracy after 3 minutes became higher than the case of 4 minutes (t = 4.584, p <.001). Therefore, before 119 arrives performing cardiopulmonary resuscitation for emergency, rescuers need to perform cardiopulmonary resuscitation alternating with others before 3 minutes.

• KSBB Journal
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• v.23 no.5
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• pp.452-459
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• 2008

To obtain maximal efficacy with minimal systemic side-effects, many studies have been carried out to achieve the controlled release of 5-fluorouracil (5-FU). In this study, biodegradable poly(L-lactide) (L-PLA) microparticles containing 5-FU were prepared by a process, called aerosol solvent extraction system (ASES), utilizing supercritical carbon dioxide. The effects of various organic solvents, drug/polymer feeding ratio, polymer molecular weight, and blending with the same polymers with different molecular weights on the formation of 5-FU loaded microparticles were investigated under a predetermined operating condition from our previous study. The drug recovery, entrapment efficiency, and in vitro drug release kinetics were determined by HPLC assays. The drug recovery obtained from the ASES process was found to be very high, whereas the drug entrapment efficiency was considerably low in all the experiments due to the poor affinity between L-PLA and 5-FU. These results indicated that the precipitation rate of L-PLA might be quite different from that of 5-FU so that there was little chance to form 5-FU loaded L-PLA microparticles.