• Journal of Korea Water Resources Association
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• v.46 no.11
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• pp.1079-1088
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• 2013

Groundwater pumping from a well has different impacts on streamflow depletion because hydraulic properties of the aquifer and the stream bed differ depending on its location. Therefore, quantitative assessment of streamflow depletion due to each groundwater pumping with different well locations is needed for the effective groundwater development and streamflow management. In this study, a watershed-based surface water and groundwater integrated model, SWAT-MODFLOW was used to assess the streamflow depletion near stream reach due to groundwater pumping from a well located within the Sinduncheon watershed. The arbitrary 50 wells among the currently used groundwater pumping wells were selected within the study area and the streamflow responses to each groundwater pumping were simulated at nearby and downstream reaches. In particular, the applicability of the Stream Depletion Factor (SDF) and Stream Bed Factor (SBF), which are widely used for evaluating the degree of streamflow depletion due to groundwater pumping, was evaluated. The simulated results demonstrated that the streamflow depletion rate divided by the pumping rate significantly differ depending on well locations and distance between well and stream, showing a wide range of values from below 20% to above 90%. From the simulated results, it was found out that the SDF or the SBF can be a partial referred value but not an absolute criterion in determining whether a pumping well has a great impact on streamflow depletion or not.

• Clinical and Experimental Reproductive Medicine
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• v.26 no.2
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• pp.239-249
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• 1999

The role of amino acids in culture media for IVF-ET was examined in a total of 76 cycles. Patients received clomiphene citrate (CC) followed by hMG or GnRH-a combined with gonadotropins (FSH/hMG) for controlled ovarian hyperstimulation. Severe male (<$4{\times}10^6$ motile sperm) or age factor (>39 y) patients were excluded in this study. Pregnancy was classified as clinical if a gestational sac or fetal cardiac activity was seen on ultrasound. No significant differences were found in age, duration of infertility, follicle size, the level of $E_2$ on the day of hCG injection, the mean number of oocytes retrieved, total motile sperm count, fertilization rate and the mean number of embryos transferred between bHTF (without amino acids) and mHTF (with amino acids) groups. However, total ampules of gonadotropins were higher (p<0.01) in mHTF group than bHTF group. Significantly (p<0.05) more clinical pregnancies were recorded in mHTF group (13/30) compared with bHTF group (9/46). The multiple pregnancy rates were 11.1% in bHTF group and 7.7% in mHTF group. There were one ectopic pregnancy in mHTF group and one heterotopic pregnancy in bHTF group. Abortion rates were 22.2% in bHTF group and 7.7% in mHTF, respectively. The ongoing pregnancy or livebirth rate was significantly (p<0.05) higher in mHTF group (12/30) than bHTF group (7/46). These results suggest that the addition of amino acids in culture media is essential for culture of zygotes in vitro and adjustment of energy substrates in phosphate-free culture media appears to be beneficial for human IVF-ET procedure.

• Korean Journal of Clinical Pharmacy
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• v.10 no.1
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• pp.13-18
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• 2000

The bioequivalence of two clarithromycin tablets, the $Klaricid^{TM}$ (Ciba-Geigy Korea Ltd.) and the $Pylocin^{TM}$ (Kyungdong Pharmaceutical Co., Ltd.), was evaluated according to the Korean Guidelines for Bioequivalence Test (KGBT 1998). Sixteen healthy male volunteers ($20\sim26$ years old) were randomly divided into two groups and a randomized $2\times2$ cross-over study was employed. After one tablet containing 250 mg of clarithromycin was orally administered, blood sample was taken at predetermined time intervals, and the concentrations of clarithromycin in serum were determined using high-performance liquid chromatographic method with electrochemical detector. The pharmaco-kinetic parameters (area under the concentration-time curve: $AUC_t$, maximum concentration; $C_{max}$ and time to maximum concentration; $T_{max}$) were calculated and analysis of variance (ANOVA) was utilized for the statistical analysis of parameters. The results showed that the differences in $AUC_t,\;C_{max}\;and\;T_{max}$ between two tablets based on $Klaricid^{TM}$ tablet were $-0.22\%,\;-0.48\%\;and\;-1.63\%$, respectively. The powers $(1-\beta)\;for\;AUC_t,\;C_{max}\;and\;T_{max}\;were\;99.07\%,\;88.15\%\;and\;99.99\%$, respectively. Detectable differences $(\Delta)\;and\;90\%$ confidence intervals ($\alpha$=0.10) were all less than $\pm20\%$ All the parameters above met the criteria of KGBT 1998, indicating that $Pylocin^{TM}$ tablet is bioequivalent to $Klaricid^{TM}$ tablet.

• Journal of the korean academy of Pediatric Dentistry
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• v.33 no.1
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• pp.139-145
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• 2006

Ranula is a mucocele which occurs at the mouth floor and is mostly related to sublingual gland. In other words ranula is definded as a pseudocyst which occurs as the secretion duct of sublingual gland is destructed there as the saliva from the secretion duct flows out and retention in the soft tissue. The cause of ranula is destruction or obstruction of the duct. The clinical findings of ranula is a painless, unilateral bluish transparent swelling around the frenum and shows fluctuation when palpated. Histological finding represent a formation of cavity inside the connective tissue, but a pseudo-cyst can be seen which the wall of the cyst is composed of granulation tissue rather than epithelial cells. The first treatment of ranula can be considered as marsupialization. which induces the inner wall of the Ranula to be a part of oral mucosa. This case report shows a treatment of marsupialization with gauze packing in a young patient representing a clinical finding of characteristic ranula.

• Journal of The Korean Association For Science Education
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• v.31 no.6
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• pp.942-957
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• 2011

The purpose of this research was to examine the concept of elementary school teachers of combustion. The participants were selected from the elementary school teachers who had various career experiences, 6th grade science teaching experiences, and academic backgrounds on science. For the purpose of this study, 12 elementary school teachers took the concept-test formed five questions on combustion and were interviewed. The concept-test was composed with 'The definition of combustion', 'The reason that the candle was blown out when glass was closed.', 'The existence of oxygen and carbon dioxide of before and after combustion in glass', 'Combustion of iron', 'Combustion products'. And the collected data by semi-structured interviews based on responses to the concept-test. During the analysis of the data, additional interviews by phone, e-mail and Internet messenger were conducted if necessary. The answers to each question were classified into three levels: (Scientific-concept(S), Partial-concept(P), Misconcept(M)). The research results showed that all teachers had misconceptions or partial-concept of more than 50 percent of each question. Teachers who had the 6th grade science teaching experience acquired scientific concepts of the combustion more than teachers who did not have the 6th grade science teaching experience. We should develop visualization materials about the change of gases during combustion and use these materials for implementation of the scientific concept.

• Electrical & Electronic Materials
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• v.7 no.4
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• pp.317-324
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• 1994

In this study, new preparation method of LiCoO$_{2}$ was applied to develop cathode active material for Li rechargeable cell, and followed by X-ray diffraction analysis, electrochemical properties and initial charge/discharge characteristics as function of current density. HC8A72- and CC9A24-LiCoO$_{2}$ were prepared by heating treatment of the mixture of LiOH H$_{2}$O/CoCO$_{3}$(1:1 mole ratio) and the mixture of Li$_{2}$CO$_{3}$/CoCO$_{3}$(1:2 mole ratio) at 850 and 900.deg. C, respectively. Two prepared LiCoO$_{2}$s were identified as same structure by X-ray diffraction analysis. a and c lattice constant were 2.816.angs. and 14.046.angs., respectively. The electrochemical potential of CFM-LiCoO$_{2}$(Cyprus Foote Mineral Co.'s product), HC8A72-LiCoO$_{2}$ and CC9A24 LiCoO$_{2}$ electrode were approximately between 3.32V and 3.42V vs. Li/Li reference electrode. Stable cycling behavior was obtained during the cyclic voltammetry of LiCoO$_{2}$ electrode. According as scan rate increases, cathodic capacity decreases, but redox coulombic efficiency was about 100% at potential range between 3.6V and 4.2V vs. Li/Li reference electrode. Cathodic capacity of HC8A72-LiCoO$_{2}$ was 32% higher than that of CFM-LiCoO$_{2}$ and that of CC9A24-LiCoO$_{2}$ was 47% lower than that of CFM-LiCoO$_{2}$ at 130th cycle in the condition of lmV/sec scan rate. Constant cur-rent charge/discharge characteristics of LiCoO$_{2}$/Li cell showed increasing Ah efficiency with initial charge/discharge cycle. Specific discharge capacities of CFM and HC8A72-LiCoO$_{2}$ cathode active materials were about 93mAh/g correspondent to 34% of theretical value, 110mAh/g correspondent to 40% of theretical value, respectively. In the view of reversibility, HC8A72-LiCoO$_{2}$ was also more excellent than CFM- and CC9A24-LiCoO$_{2}$.

• Clinical and Experimental Reproductive Medicine
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• v.26 no.3
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• pp.389-398
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• 1999

Objective: This study was designed to evaluate the effects of endogenous LH surge, GnRH agonist (GnRH-a) or human chorionic gonadotropin (hCG) as ovulation trigger on pregnancy rate by intrauterine insemination (IUI). Method: Patients received daily 100 mg of clomiphene citrate (CC) for 5 days starting on the third day of the menstrual cycle followed by human menopausal gonadotropin (hMG) for ovulation induction. Follicles larger than >16 mm in diameter were present in the ovary, frequent LH tests in urine were introduced to detect an endogenous LH surge. Final follicular maturation and ovulation were induced by GnRH-a 0.1 mg (s.c.) or hCG $5,000{\sim}10,000$ IU (i.m.) administration except natural ovulation. Pregnancy was classified as clinical if a gestational sac or fetal cardiac activity was seen on ultrasound. Results: There were no differences in age, duration of infertility and follicle size, but more ampules of hMG were used in GnRH-a group compared to hCG 10,000 IU treated group (p<0.05). Lower level of estradiol ($E_2$) on the day of hCG or GnRH-a injection was observed in hCG 10,000 IU group than other treatment groups (p<0.01). The overall clinical pregnancy rate was 19.8% per cycle (32/162) and 22.2% per patient (32/144). Pregnancy rate was higher in natural-endogenous LH surge group (37.5%, 9/24) than GnRH-a (18.8%) or hCG treated group (20.9% & 13.9%), but this difference was not statistically significant. No patient developed ovarian hyperstimulation. Abortion rate was 22.2% (2/9) in hCG 5,000 IU group. Delivery or ongoing pregnancy rate was 37.5% (9/24), 18.8% (3/16), 16.3% (7/43) and 13.9% (11/79) in endogenous LH surge, GnRH-a, hCG 5,000 IU and hCG 10,000 IU treatment groups, respectively. Conclusion: These results support the concept that use of natural-endogenous LH surge in stimulated cycles may be more effective to obtain pregnancies by IUI than GnRH-a or hCG administration.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.48 no.4
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• pp.47-53
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• 2011

The Electric Multiple Unit (EMU) has many types of door system such as sliding door, plug door etc.al. according to customer's requirements. The sliding door is widely used in Korea but has weak point in the noise problem. In the low operation speed, the noise coming from outer side of the EMU is not an important factor. As the speed is higher than before, noise is increased and make a problem. The main cause of noise is the imperfect air tightness in the EMU. The plug door system has advantages for the noise reduction characteristic in the high speed area. We have been developing electric plug-in door. The door is controlled by Door Control Unit(DCU) following the order of Automatic Train Protection (ATP) that is a kind of train signalling system. DCU has to simultaneously open and close the doors and the operation of it is related to the passengers safety. So DCU is a safety device that is important to reliability and safety. DCU is composed of several devices of control, motor driving, Input/Output, communication and power. In this paper, we will describe the functions, characteristic, requirement, subsystem and test results of DCU used for the electric plug-in door.

• Journal of Korea Water Resources Association
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• v.48 no.9
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• pp.729-741
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• 2015

This study examined the applicability of MBLRP (Modified Bartlett-Lewis Rectangular Pulse) rainfall generation model for an urban flood simulation which is a type of Poisson cluster rainfall generation model. This study constructed XP-SWMM model for Namgajwa area of Hongjecheon basin, which is a two-dimensional pipe network-surface flood simulation program and computed a flood discharge and a flooded area with input data of synthetic rainfall time series of 200 years that were generated by the MBLRP model. This study compared the data of flood with synthetic rainfall and flood with corresponding values which were based on design rainfall. The results showed that the flooded area computed with MBLRP model was somewhat smaller than the corresponding values on the basis of the design. A degree of underestimation was from 8% (5 year) to 34% (200 year) and the degree of underestimation increased as a return period increased. This study is meaningful in that it proposes methodology that enables quantifiability of uncertain variables which are related to a flooding through Monte Carlo analysis of urban flooding simulation and applicability and limitations thereof.

• YAKHAK HOEJI
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• v.54 no.5
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• pp.348-353
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• 2010

The dissolution test method and an analytical procedure by HPLC were developed and validated for viquidil hydrochloride capsules and alibendol tablets. These drugs were not yet characterized by the dissolution specifications in Korean Pharmaceutical Codex. So, with each reference and test drugs, we did the preliminary and standard experiments based on the Korean Pharmacopeia Guideline of dissolution testing for solid oral dosage forms. The dissolution test for viquidil hydrochloride capsules was carried out under sink conditions as follows: dissolution medium water, paddle rotation speed 50 rpm and vessel volume 900 ml. More than 90% of its label amount was released within 30 min in this method. Also the dissolution test for alibendol tablets was carried out under sink conditions as follows: dissolution medium water, paddle rotation speed 100 rpm and vessel volume 900 ml. More than 90% of its label amount was released within 45 min in this method. The dissolution samples were analyzed with a precise and accurate HPLC method. The developed dissolution test showed specificity, linearity, precision and accuracy within the acceptable range. The dissolution testing method described above was adequate for the purpose and may be proposed as a pharmacopeial standard to assess the performance of viquidil hydrochloride capsules and alibendol tablets.