• Korean Journal of Biological Psychiatry
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• v.15 no.3
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• pp.147-151
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• 2008

This review briefly summarizes the relevant knowledge of psychoneuroimmunological basis for neuroimmunology, with particular emphasis on bidirectional neural-immune interactions. The immune system and the nervous system maintain extensive communication, including hardwiring of sympathetic and parasympathetic nerves to lymphoid organs. Immune system is modulated by various neurotransmitters such as acetylcholine, norepinephrine, substance P and histamine. Neuroendocrine hormones such as corticotrophin-releasing hormone(CRH) or substance P regulate cytokine balance. The immune system modulates brain activity including sleep and body temperature. Recent studies have revealed that psychological factors which influence immunity and immune-related disease may modulate brain-to -immune interaction. But, we still await the scientific research and evidences to prove whether or how behavioral or treatment intervention of stress can influence the development, progress or prevention of a specific disease.

• Proceedings of the Korean Fiber Society Conference
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• 1998.10a
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• pp.360-364
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• 1998

지금까지, 천의 주관적인 태평가는 역학적인 특성에 의하여 결정된다고 연구되고 있다. 특히 KES-FB 시스템은 천의 역학적인 특성을 통계학적인 방법으로 객관화한 소프트웨어이다[1], 대체적으로 직물에 비해 편성물은 측정의 어려옴, 지역적인 기후특성, 문화적인 차이 때문에 태를 평가하는데 적용하기 난해한 면이 있다[2]. 종합적인 태는 천의 사용 용도와 사람의 정신적인 특성에 대한 반영이 개입되어야 하므로 적용하기에 곤란하지만, 최근에 응용되고 있는 퍼지이론과 신경망이론을 통하여 전체적인 태평가가 가능하리라 본다. (중략)

• Women's Health Nursing
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• v.21 no.2
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• pp.106-114
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• 2015

Purpose: The purpose of this review was to describe a psychoneuroimmunology (PNI) framework for postpartum depression (PPD) and discuss its implications for nursing research and practice for postpartum women. Methods: This study explored the role of hypothalamic-pituitary-adrenal (HPA) axis and inflammation as possible mediators of risk factors for PPD through literature review. Results: From this PNI view, human bodies are designed to respond with the reciprocal interactions among the neuro-endocrine and immune system when they are faced with physical or psychological stressors. Chronic stress induces alterations in the function of HPA axis, and a chronic low-grade inflammatory response is associated with depression. The dysfunctions of cytokines and HPA axis have been observed during the postpartum period. Stress promotes glucocorticoid receptor resistance, which can promote inflammatory responses. This, in turn, can contribute to the pathophysiology of depression. This can especially affect populations at vulnerable time-points, such as women in the postpartum. Conclusion: From a PNI perspective, well-designed prospective research evaluating the role of stress and inflammation as an etiology of PPD and the effect of stress reduction is warranted to prevent PPD.

• Korean Journal of Culture and Social Issue
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• v.11 no.spc
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• pp.85-95
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• 2005

The present article explored the studies on the relational mechanisms between trust and health in terms of psychosomatic medicine or integrative medicine. For this, the research findings of the Quantum physics, psychosomatic medicine, and traditional eastern healing methods on the mind-body problem and then a practical guide to greater physical and mental well-being is presented. In the first section of the Quantum mechanical human body, the body has a mind of its own, the mechanism and cause of disease, the body as objective experienced conscious, and the effects of consciousness and information on the body are includes. The second section is psychosomatic medicine. In this, the thought changing brain, placebo, the power of expectancy, achieving health by active endeavor, psychoneuroimmunology, and the several therapies are included. Finally, Dr. Benson and Proctor's practical guide to well-being in presented. It is emphasized that the four trusts (trust in oneself, one's doctor, one's treatment, and one's spiritual trust) are crucial to recovery from serious illness and to achieve better health.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.16 no.2
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• pp.183-191
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• 2005

Tic disorder including Tourette's disorder is a neurodevelopmental disorder that appears in childhood and characterized by the presence of motor and vocal tics. Childhood-onset obsessive-compulsive disorder (OCD) is suggested to be a phenomenologically and etiologically distinct subtype of OCD, bearing a close genetic relationship to tic-disorders. Tourette's disorder and OCD are comorbid in $40-75\%$ of patients initially diagnosed with either disorder. Basal ganglia and cortico-striato-thalamic circuits are implicated in the pathophysiology of both disorders and these disorders have similar clinical features. Over the past decades, the progress in research on Tourette's disorder and OCD has been extraordinary. This review describes some of important insights from these work, involving these areas : 1) clinical implication 2) genetics and epidemiology 3) brain imaging study 4) neuroche-mistry 5) pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS).

• Korean Journal of Biological Psychiatry
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• v.15 no.3
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• pp.175-185
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• 2008

Accumulating evidence has suggested the existence of reciprocal communication between immune, endocrine, and neurotransmitter system. Cytokine hypothesis of depression implies that increased pro-inflammatory cytokine such as -1, IL-6, IL-12, TNF-${\alpha}$, and IFN-${\gamma}$ in major depression, acting neuromodulators, play a key role in the mediation of behavioral, neuroendocrine, and neurochemical disturbances in depression. Concerning the relation between cytokines and serotonin metabolism, pro-inflammatory cytokines have profound effects on the metabolism of brain serotonin through the enzyme indoleamine-2,3-dioxygenase(IDO) that metabolizes tryptophan, the precursor of 5-HT to neurodegenerative quinolinate and neuroprotective kynurenate. The neurodegeneration process is reinforced by the neurotoxic effect of the hypercortisolemia during depression. From this perspective, it is possible that efficacy of antidepressants in the treatment of depression may, at least in part, rely on downregulation of pro-inflammatory cytokine synthesis. So, the use of cytokine synthesis inhibitors or cytokine antagonists may be a new treatment approach in depression. However, at present the question whether cytokines play a causal role in the onset of depression or are mere epiphenomena sustaining depressive symptoms remains to be elucidated. Nevertheless, cytokine hypothesis has created new perspectives in the study of psychological and pathophysiological mechanism that are associated with major depression, as well as the prospect for developing a new generation antidepressants.