• Korean Journal of Clinical Laboratory Science
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• v.47 no.4
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• pp.251-258
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• 2015

Curcumin, a major polyphenolic compound of turmeric, is well known to prevent non-alcoholic steatohepatitis (NASH) related to obesity. The aim of the study was to investigate the effect of curcumin on hepatic fibrosis induced by carbon tetrachloride ($CCl_4$) in obese mice. $CCl_4$ was administrated in mice fed a normal diet (ND) or a high fat diet (HFD) for 7 weeks together with or without curcumin. It was conducted to examine for metabolic profiles, adipocyte size, and liver fibrosis by serum biochemistry, histology and immunohistochemistry. Also, Apoptosis of hepatic cells was determined by the TUNEL method. Treatment with curcumin significantly lowered the body weight, fasting glucose, serum AST and ALT, and decreased the adipocyte size, the number of macrophage and mast cells in adipose tissue, and collagen deposition in liver tissue in the HFD+$CCl_4$ group compared with the findings of the HFD+$CCl_4$ group. In contrast, treatment with curcumin on the ND+$CCl_4$ group did not show a significant difference except the body weight and mast cell number when compared with the ND+$CCl_4$ group. Furthermore, curcumin significantly reduced the number of parenchymal apoptotic cells, whereas it increased the number of non-parenchymal apoptotic cells, especially resembling an activated hepatic stellate cell in the liver. Taken together, this data suggests that curcumin might be an effective antifibrotic drug for the prevention of liver disease progression in obese mice. Thus, the development of curcumin as a therapy for obesity and liver fibrosis is supported.

• Journal of the Korea Society of Computer and Information
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• v.12 no.1 s.45
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• pp.161-168
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• 2007

Web attack uses structural, logical and coding error or web application rather than vulnerability to Web server itself. According to the Open Web Application Security Project (OWASP) published about ten types of the web application vulnerability to show the causes of hacking, the risk of hacking and the severity of damage are well known. The detection ability and response is important to deal with web hacking. Filtering methods like pattern matching and code modification are used for defense but these methods can not detect new types of attacks. Also though the security unit product like IDS or web application firewall can be used, these require a lot of money and efforts to operate and maintain, and security unit product is likely to generate false positive detection. In this research profiling method that attracts the structure of web application and the attributes of input parameters such as types and length is used, and by installing structural database of web application in advance it is possible that the lack of the validation of user input value check and the verification and attack detection is solved through using profiling identifier of database against illegal request. Integral security management system has been used in most institutes. Therefore even if additional unit security product is not applied, attacks against the web application will be able to be detected by showing the model, which the security monitoring log gathering agent of the integral security management system and the function of the detection of web application attack are combined.

• Korean Journal of Acupuncture
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• v.24 no.2
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• pp.129-139
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• 2007

목적 : Signal transducers and activators of transcription 6 (Stat 6) 유전자는 면역세포의 발달에 있어서 중요한 유전인자이며, IL-4와 같은 사이토카인에 의해 유전자 발현이 조절된다. 본 연구에서는 Stat 6 유전자 제거 생쥐와 정상 (wild type, W/T) 생쥐에 carrageenan으로 염증을 유도한 후 족삼리에 침치료를 시행하여 시상하부에서의 유전자 발현 양상을 분석하고자 하였다. 방 법 : BALB/c (W/T, n=12) and BALB/c-Stat 6 유전자 제거 생쥐 (n=12)의 발뒤꿈치 표피에 1% carrageenan을 30 ul 주사하여 염증을 유도하였다. 침은 염증 유도 30분 후에 족삼리(ST36)에 시침하였으며, 염증유도에 의한 부종 증가율을 매 시간마다 측정하여 총 5시간동안 측정하였다. 마이크로에러이는 Stat 6 유전자 제거 생쥐를 염증 유발 군과 염증유발 후 침을 처치한 군으로 나누고, 시상하부를 적출하여 RNA를 분리한뒤 마이크로어레이 프로파일을 분석하였다. 결 과 : 염증에 의한 부종증가율을 비교한 결과, Stat 6 유전자 제거 생쥐 그룹의 부종증가율이 W/T 생쥐의 부종 증가율보다 약 50 % 정도 감소하였으며, 각 3, 4, 5시간째에 유의한 차이를 나타내었다. (각 p<0.05). W.T생쥐군과 Stat 6 유전자 제거 생쥐군 모두에서, 침 처치군이 염증 유발 군에 비해, 염증 유발 2시간 후부터 유의한 감소를 나타내었다. 시상하부의 유전자 발현을 관찰한 결과, 39개의 유전자가 3배 이상 감소하였으며, 19개의 유전자는 3배 이상 증가하였다. 결 론 : W/T 생쥐군과 Stat 6 유전자 제거 생쥐 모두에서 침의 진통효과는 나타나며, 이의 기전에는 시상하부에서의 침 치료에 의한 염증관련 유전자들의 감소와, 항염증과 관련된 유전자들이 증가가 관여하는 것으로 보인다., 10, 11), 내측전완피신경(TE5, 6, 7, 8, 9, 10, 11), 후상완피신경(TE12, 13), 상외측상완피신경(TE13), 외측쇄골상신경(TE14, 15),대이개신경(TE16, 17, 18, 19), 소후두신경(TE19, 20), 이개측두신경(TE20, 21, 22), 안면신경측두지(TE22, 23), 관골측두신경(TE23), 중층에 견갑상신경(TE15), 견갑배신경(TE15), 경상설골근신경(TE17), 후이개신경(TE18, 19, 20), 안면신경측두지(TE20, 21, 22), 심층에 후골간신경(TE5, 6, 7), 요골신경심지(TE8, 9, 12, 13), 견갑상신경(TE14), 액와신경가지(TE14), 부신경(TE16), 안면신경과 부신경가지(TE17), 설인신경(TE17), 설하신경(TE17), 경신경고리(TE17), 미주신경(TE17), 안면신경 (TE18). 3) 혈(血) 관(管) : 천층에 척측정맥배측지(TE1, 2), 고유수장지동맥배측지(TE1), 배측중수골동맥배측지(TE2), 배측중수골정맥(TE3), 척측피정맥(TE4, 5, 6, 7, 8, 9, 10, 11), 배측정맥궁(TE4), 부요측피정맥(TE6, 8, 9),요측피정맥(TE10, 11), 후견봉정맥가지(TE13, 14), 후이개동 ${\cdot}$ 정맥(TE16, 17, 18, 19, 20), 전이개동 ${\cdot}$ 정맥(TE20), 천측두동 ${\cdot}$ 정맥(TE22, 23), 중층에 후상완회선동맥(TE14), 견갑배동맥(TE15), 견갑상동맥(TE15),천측두동 ${\cdot}$ 정맥(TE21), 관골측두동 ${\cdot}$ 정맥(TE23), 심층에 배측중수골동맥(TE3), 배측수근동맥궁(TE4), 후골간동맥(TE4, 5, 6, 7, 8, 9), 전골간동맥(TE6, 7, 9)

• Korean Journal of Clinical Laboratory Science
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• v.50 no.3
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• pp.297-303
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• 2018

This study investigated the effect of community-based health intervention program to improve metabolic disease in Jeju island. There were 50 obese local residents in the experimental group (body mass index, $BMI{\geq}25kg/m^2$). They participated in cooking therapy with nutrition education (4 times), exercise program with proprioceptive neuromuscular facilitation (PNF) and stretching training (9 times), and alternative medicine program with healing touch massage (3 times) during a 3-week period. To evaluate the effectiveness of the program, body composition, blood lipid profiles, blood glucose, and waist circumference were assessed before and after the intervention program. After the program, the value of total cholesterol (TC), glycosylated hemoglobin (HbA1C), diastolic blood pressure, percent body fat, and waist circumference were decreased, and became the normal value. Especially, HbA1C, percent body fat, and waist circumference were significantly decreased (P<0.001) in the experimental group, while HbA1C, percent body fat, and waist circumference were significantly increased (P<0.001) in the control group (N=50), who had no intervention. Our results suggest that metabolic syndrome associated markers need intervention program for improving them. In conclusion, although this study did not analyze the effect of the health intervention program and cooking therapy separately, considering the result of this 3-week, short term program, the effect will be more profuse if cooking therapy and exercise program were performed concurrently.

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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• v.17 no.2
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• pp.130-137
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• 2012

The underwater glider using conception of Lagrangian method, is a new observation platform to understand the properties of the ocean vertically. In 2011 March, KORDI made a first successful autonomous trip from Hupo to west coast of Uleungdo piloting Littoral Glider of Alaska Native Technology LLC. The journey considered many environmental variables and route vigilantly selected, the glider covered 177 km horizontally and took approximately 6 days (153 hours). Despite the existence of 1 kt eddy current, Sound velocity sampling was conducted from 5 meters and reaching maximum of 200 meters depth at each dive. It successfully collected sound velocity and temperature profile at every 5 seconds totaling up to 1408 profiles using SVT&P sensor. During the flight it was also a mission to check the diverse modes of the glider i.e. spiral, waypoints, heading, drift and hover could function without a defect in a given situation. These modes were thoroughly monitored and it could be considered that the glider handled it well during the flight. As a result of this test flight, it was evident that the given underwater glider could operate under 2kt current environment with users defined heading and depth, also with the payload up to 5 kg without changing internal buoyancy.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.37 no.8
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• pp.789-798
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• 2013

The procedures and relevant programs developed for analyzing mechanical load data of wind turbine generator systems, which are obtained through type certification tests, are verified. The following issues according to IEC 61400-13 are covered in the developed programs: data validation, time series analysis, summary load statistics, generation of fatigue load spectra, and estimation of equivalent loads. A capture matrix for normal power production is generated to determine whether the collected data sets are sufficient to carry out fatigue analysis. Fatigue load spectra are obtained through the rainflow counting method using 50 load ranges; finally, equivalent loads are calculated using different S-N curve slopes, m, according to the relevant materials. Case studies are performed using aero-elastic simulation data of the NREL 5 MW baseline wind turbine with a monopile foundation.

• Journal of KIISE:Software and Applications
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• v.37 no.4
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• pp.311-316
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• 2010

Esterel is an imperative synchronous language that is used to develop memories, cache controllers, bus interfaces, and so on. An Esterel statement is called schizophrenic if it is executed more than once in an instant. A schizophrenic statement may cause problems when it is translated to hardware circuits; a circuit performs more than one reaction in a clock. Previous works claim that only local signal declarations and parallel statements may cause schizophrenic problems. However, control signals produced by a trap statement or data signals used by emit statements can cause schizophrenia. They are new schizophrenic patterns. Especially, schizophrenic problems caused by emit statements cannot be solved by a loop unrolling technique that is the key idea of previous curing techniques for schizophrenic problems. In this paper, we introduce and define the two schizophrenic problems.

• The Journal of Korean Academy of Sensory Integration
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• v.13 no.2
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• pp.43-51
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• 2015

Objective : The purpose of this study was to investigate the correlation between smartphone addiction, sensory processing features and self-efficacy in college students. Methods : From June to August in 2015, a hundred eighty three healthy college students were completed the questionnaire for smartphone addiction (S-scale), sensory processing feature (Adolescent/ Adult Sensory Profile), and self-efficacy (Self-Efficacy Scale) and correlation analyses were applied. Results : There were significant differences on sensory registration and sensory sensitivity in sensory processing features between the addiction group and the non-addiction group. Significant correlations were found between smartphone addiction and sensory seeking, and smartphone addiction and self-efficacy. Conclusion : This study showed smartphone addiction had relationships with high sensory seeking and low self-efficacy. Thus, more studies and interventions focused on preventing smartphone addiction are required for college students.

• The Journal of the Korea Contents Association
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• v.5 no.5
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• pp.172-181
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• 2005

The latest attack type against network traffic appeared by worm and bot that are advanced in DDoS. It is difficult to detect them because they are diversified, intelligent, concealed and automated. The exisiting traffic analysis method using SNMP has a vulnerable problem; it considers normal P2P and other application program to be harmful traffic. It also has limitation that does not analyze advanced programs such as worm and bot to harmful traffic. Therefore, we analyzed harmful traffic out Protocol and Port analysis. We also classified traffic by protocol, well-known port, P2P port, existing attack port, and specification port, apply singularity weight to detect, and analyze attack availability. As a result of simulation, it is proved that it can effectively detect P2P application, worm, bot, and DDoS attack.

• Proceedings of the Korea Water Resources Association Conference
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• 2016.05a
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• pp.70-70
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• 2016

하천시설물 설계, 시공 및 관리에 있어서 바닥전단응력은 매우 중요하다. 예를 들어, 호안 등 시설물의 허용 소류력을 계산하거나, 하천의 유사량을 예측하는 데 있어서 바닥전단응력이 기준으로 쓰인다. 정상 등류의 경우, 수로 내 수체에 작용하는 중력과 수로 바닥 및 측면에 작용하는 마찰력의 평형을 고려함으로써 바닥전단응력을 산정할 수 있다. 본 연구에서는 식생을 제외한 아크릴수로에서의 전단판의 움직임을 이용한 바닥전단응력 측정장치를 설계, 교정 및 검증을 실시하였다. 이 전단판은 수체와 바닥면에서 발생하는 마찰력에 의해 변위가 발생하고 이 변위를 바닥전단 응력으로 산정하였다. 직접 측정한 바닥전단응력은 기존에 연구된 두 가지 방법과 비교하여 검증하였다. 비교 검증을 위한 실험은 폭 0.3 m, 길이 10 m인 고속수로에서 Froude수 1이상, Reynolds수 20000이상의 사류이면서 난류인 상태로 실험을 진행하였으며 유속은 PIV을 이용하여 측정하였다. 비교 검증을 위한 첫 번째방법은 Reach-avrage공식을 기초로 manning의 평균 유속 공식을 이용한 바닥전단응력을 산정하는 방법으로 일반적으로 간단한 경험식을 이용하여 바닥 전단응력을 산정하는 방법이다, 두 번째는 Reynolds stress를 산정하는 방법으로 PIV를 통해 흐름방향의 연직프로파일의 유속을 측정 한 후 레이놀즈 분해법에 의해 산정된 난류 강도를 측정하여 Reynolds stress를 산정한 후 Shear stress를 산정하는 방법을 사용하였다. 마지막으로 본 연구에서 가로 0.14 m, 세로 0.14 m의 전단판으로 구성된 바닥전단응력 측정장치를 개발하여 실험을 진행하면서 앞에서 언급한 두가지 방법을 측정하는 동시에 장치를 이용하여 바닥전단응력을 직접측정하여 총 3가지 바닥전단응력을 비교하였다.