• Journal of Yeungnam Medical Science
• /
• v.9 no.2
• /
• pp.382-395
• /
• 1992

GABA is an inhibitory neurotransmitter in central nervous system and produce sedative, antianxiety and muscle reaxing effects via $GABA_A$ receptor or $GABA_B$ receptor. Recently it is known that GABA is widely distributed throughout peripheral organs and may playa physiological role in certain organ. The vas deferens is innervated by species-difference. These study, therefore, was performed to investigate the mode and the mechanism of action of GABA on the norepiniphrine-, ATP- and electric stimulation-induced contraction of vas deferens of rat. Sprague-Dawley rats were sacrificed by cervical dislocation. The smooth muscle strips were isolated from the prostastic portion and were mounted in the isolated muscle bath. PSS in the bath was aerated with 95/5%-$O_2/CO_2$ at $33^{\circ}C$. Muscle tensions were measured by isometric tension transducer and were recorded by biological recording system. 1. GABA, muscimol, a $GAB_A$ agonist, and baclofen, a $GABA_B$ agonist inhibited the electric field stimulation(EFS, 0.2Hz, 1mSec, 80 V, monophasic square wave)-induced contraction with a rank order of potency of GABA greater than baclofen greater than muscimol. 2. The inhibitory effect of GABA was antagonized by delta aminovaleric acid(DAVA), a $GABA_B$ antagonist, but not by bicuculline, a $GABA_A$ mtagonist. 3. The inhibitory effect of baclofen was antagonized by DAVA, but the effect of muscimol was not antagonized by bicuculline. 4. Exogenous norepinephrine(NE) and ATP contracted muscle strip concentration dependently, but the effect of acetylcholine was negligible : and GABA did not affect the NE-and ATP-induced contractions. 5. GABA, baclofen and muscimol did not affect basal tone, and GABA did not affect the NE-and ATP-induced contractionsm 6. EFS-induced contraction was including 2 distinctable components. The first phasic component was inhibited by beta gamma-methylene ATP(mATP), a desensitizing agent of APT receptor and the second tonic component was reduced by pretreatment of reserpine(3 mg/Kg, IP). 7. GABA inhibited the EFS-induced contraction of reserpinized strips, but not the mATP-treated strips. These results suggest that in the prostatic portion of the rat vas deferens, adrenergic and purinergic neurotransmissions are exist, and GABA inhibits the release of ATP via presynaptic $GABA_B$ receptor on the excitatory neurons.

• 한국인삼전략화협의회:학술대회논문집
• /
• v.2003 no.09
• /
• pp.29-53
• /
• 2003

"[ $cdot$ ]브랜드 전략 - 정관장 쌀(?) $ ightarrow$ 이천쌀, 여주쌀 - 정관장, 한삼인, 금산인삼 $ ightarrow$ 고려인삼(안성인삼, 강원이삼, 풍기인삼, 등) $cdot$정보전략 - 마케팅과 연계한 정보전략 $cdot$상품전략 - 생산자별로 차별화 할 수 있는 지"

• Journal of Yeungnam Medical Science
• /
• v.10 no.1
• /
• pp.144-156
• /
• 1993

This study was performed to investigate the effect of octreotide on the contractility of rat vas deferens. The smooth muscle strips isolated from the prostatic portion were myographied in isolated organ bath, Electric field stimulation (monophasic square wave, duration: 1 mSec, voltage : 50 V, frequency : 5 Hz or 30 Hz, train: 10 Sec) produced reproducible contraction. The contraction was composed of two component, first phasic component (FPC) and second tonic component (STC). These contractions were abolished by tetrodotoxin ($1{\mu}M$). Octreotide inhibited the field stimulation induced contractions both FPC and STC concentration-dependently. The FPC was decreased by a desentization of purinergic receptor by pretreatment of mATP, and the STC was decreased by pretreatment of reserpine(3 mg/kg, IP) 24 hours before experiments. Octreotide reduced the field stimulation induced contraction in the presence of mATP and of reserpinized muscle strips. The inhibitory effect of octreotide was more potent at 5 Hz than at 30 Hz. Octreotide did not affect basal ton and exogenous norepinephrine- or ATP-induced contraction. These results suggest that octreotide inhibit the contractility of the isolated rat vas deferens by inhibition of the release of neurotransmitters, both ATP and norepinephrine from adrenergic nerve terminal.

• The Korean Journal of Pharmacology
• /
• v.10 no.1 s.15
• /
• pp.31-40
• /
• 1974

1. The authors investigated the effects of $PGE_1$ on the action of sympathomimetics in the vas deferens of guinea-pig, comparing with those in the rat vas deferens, and also the action of $PGE_1$ on the motility of nerve-free smooth muscle of chick amnion. 2. In the isolated guinea-pig vas deferens, the actions of phenylephrine and norepinephrine were much potentiated by pretreatment with $PGE_1$. Futher, in the isolated hypogastric nerve-vas deferens preparation of guinea-pig, effects of phenylephrine, norepinephrine and tyramine on the contractile response of vas to the hypogastric nerve stimulation and to the transmural stimulation were also augumented especially in tension by $PGE_1$-pretreatment. 3. In the isolated hypogastric nerve-vas preparation of rat, both contractile responses to hypogastric nerve and transmural stimulation were slowly reduced by treatment with $PGE_1$ and the potentiated effect of phenylephrine or norepinephrine was not observed in spite of pretreatment with $PGE_1$. 4. The actions of phenylephrine and norepinephrine on the denervated vas deferens of guinea-pig were also enhanced by $PGE_1$ as it were in the intact vas deferens, but there was no significant effect by $PGE_1$ on the action of norepinephrine in the denervated rat vas deferens. 5. $PGE_1$ in low concentration $(10^{-8}g/ml)$ did not affect the spontaneous motility of nerve-free smooth muscle of chick amnion ($9{\sim}11$ th day incubated chick), but in large concentration $(5{\times}10^{-8}g/ml)$ it caused irregular and slightly inhibitory movement. Pretreatment with $PGE_1$ on chick amnion did not exert any change on the action of phenylephrine applied. However, the stimulatory action of physostigmine on the chick amnion was a little antagonized by the low concentration of $PGE_1$. 6. It might be summarized that there is species difference between the actions of $PGE_1$ on the vas deferens of guinea-pig and that of rat, and the action of $PGE_1$ on the guinea-pig vas deferens might be mediated by the other mechanism rather than by direct action on the vas musculature.

• Korean Journal of Animal Reproduction
• /
• v.27 no.1
• /
• pp.61-67
• /
• 2003

This study was conducted to investigate the effect of infusion of sterile boar and their semen as pregnancy antigen factor for improvement of production in gilts. We observed 160 gilts between 7 to 8 months of age that were divided into 4 treatment groups vie. A group-epidimetomized boar, B group-no sperm semen infusion, C group-vasectomized boar, and D group-control in a completely randomized design. The number of total pigs born(NT) of A, B, C, and D groups were 10.05, 10.44, 11.63, and 9.97 pigs, respectively(P<0.05). And the NT of C g.cup was the highest among treatment. The number of live pigs born(NB) was similar to NT The NB of C group (10.70) was higher than that of A(9.12) and control(9.11)(P<0.05). However, there was not significant between B and C groups. The progesterone concentration of C group was the highest compare to other group at the 6th day after breeding. However, the progesterone concentration of C was lower than other groups after 8th day. There were not significant among cortisol of A, B, C and D groups. According of the results of this study, the infusion with vasectomized boar and semen at estrus before gestation can be improved reproductive efficiency because of more litter size in gilts.

• Journal of Preventive Medicine and Public Health
• /
• v.12 no.1
• /
• pp.70-78
• /
• 1979

This study was carried out for the evaluation on the sociomedical characteristics of 1,580 cases who had recieved vasectomy and laparoscopic sterilization at the Busan Family Planning Clinic from January 1975 to December 1973. The results obtained were as follows: 1. In age distribution, the most predominant age group consited of 30.34 years as 44.7%. In regional distribution, the most predominant region was Youngdo Ku in the vasectomy group and Dong Ku in the laparoscopic sterilization group. 2. The educational level showed that the high school graduates(49.2%) in the vasectomy group and the primary school graduates(47.0%) in the laparoscopic sterilization group were the highest each other. 3. The most predominant experienced contraceptive method before accepted permanant sterilization operation was oral pills and non-experienced contraceptive method group was 54.1% of the total. 4. By the span of marital life before accepted permanant sterilization operation, the 5-9 years group was the highest. 5. The average number of living children per family was 2.54 in the vasectomy group and 3.0 in the laparoscopic sterilization group. 6. The average frequency of pregnancy per case was 2 in the vasectomy group and 3 in the laparoscopic sterilization group and the most predominant frequency of induces abortion was 1 per case. 7. The most predominant motive of accepting the sterilization operation were family planning education at the reserve forces training in the vasectomy group and at the mother's club in the laparoscopic sterilization group. 8. By the residing status of the cases, rented room was the highest as 69.4%.

• Journal of the Daesoon Academy of Sciences
• /
• v.49
• /
• pp.365-399
• /
• 2024

Tang Taizong was regarded as the emperor with the idea of cherishing the common people, paying close attention to his subjects' military service, and mobilizing of the people as recorded in Zhenguan Zhengyao (Essentials for Government), from the Zhenguan period during the reign of Tang Taizong. Contrary to the above, in reality, Li Shimin, the name of Tang Taizong, mobilized many subjects in the construction of Luoyang Palace in second capital city called Dongdu and Jiucheng Palace, a summer palace during Sui-Tang dynasty, and he requisitioned the subjects of Guannei Province and Longyou Province to install and protect provisional powers and a county in the Gaochang Kingdom. Given his antinomic behavior, the evaluation of Li Shimin as an ideal Confucian monarch should be reconsidered based on Zhenguan zhengyao and other historical records. Dividing the 19 years before Goguryeo-Tang War in 645 into two periods, from the throne to 637 and from 639-644, the subjects were burdened by the construction of Luoyang Palace and Jiucheng Palace in the former period. In the latter period, after the conquest of the Gaochang Kingdom, there was a requisition for the transport of troops and supplies to be stationed in Xizhou, a reorganized prefecture and counties in the Gaochang Kingdom territory; probably mainly limited to the provinces of Guannei and Lungyou, which were geographically close to the West Regin that is now known as Xinjiang Uygur Autonomous Region. The burden in the latter period was relatively less than in the former period. Even so, the number of households in 639, fourteenth year of Tang Taizong's reign, was only 34.1% and 26.8%, respectively, in 609, the sixth year of Sui Yangdi's reign. In this situation, Taizong's Goguryeo Invasion was not conducted in an economically situation during the early days of the Tang Dynasty.

• 대학교육
• /
• s.160
• /
• pp.67-72
• /
• 2009

2009년 정부가 발표한 대학입학사정관제 3단계 정착방안 중 1단계 입학사정관제 내실화 단계가 진행 중이다. 선택과 집중의 원칙에 따라 선도대학을 육성하고, 입학사정관 전문양성과정을 운영하여 입학사정관 인력풀이 안정적으로 확보될 수 있도록 하는 것이다. 현재 대학입학사정관 전문양성 훈련프로그램 지원기관으로서 5개 대학이 선정되었다. 입학사정관의 전문성과 신뢰성 확보를 위해 입학사정관 양성교육이 추구해야 할 방향을 논하고자 한다.

• Korean Architects
• /
• no.3 s.431
• /
• pp.44-48
• /
• 2005

• The Korea Swine Journal
• /
• v.25 no.5 s.285
• /
• pp.179-183
• /
• 2003