• The Korean Journal of Medicine
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• v.93 no.6
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• pp.548-555
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• 2018

Background/Aims: Assessment of fluid status in hemodialysis patents is very important. Overhydration in hemodialysis is associated with generalized edema, cardiovascular complications, and hypertension. The aim of this study was to determine the factors correlated with mortality of hemodialysis patients, assessing body muscle mass and fluid status using bioelectrical impedance analysis (BIA). Methods: This study enrolled 93 patients who underwent hemodialysis between January 2010 and May 2015 at CHA Bundang Medical Center. Medical records of enrollees up to June 2017 were reviewed retrospectively. These included laboratory results (serum albumin, C-reactive protein [CRP], lipid profile, etc.) and BIA data (extracellular water, intracellular water, total body water, soft lean mass, fat free mass, skeletal muscle mass, etc.). Results: Eleven of 93 patients had expired by May 2017. Among the surviving subjects, mean age was younger, CRP levels were lower, albumin levels were higher, and extracellular water/total body water (ECW/TBW) ratios were lower than in the expired patient group. Kaplan-Meier survival analysis revealed that overhydration (ECW/TBW > 0.4) was associated with higher mortality. Conclusions: In hemodialysis patients, overhydration is an important factor in mortality, and BIA could be a reliable modality in its assessment. We suggest that, for hemodialysis patients, overhydration is more of a risk factor for mortality than is muscle wasting.

• Journal of the korean academy of Pediatric Dentistry
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• v.29 no.1
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• pp.107-114
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• 2002

The purpose of this study was to determine and compare the shear bond strength of two self-etching primer systems to primary teeth contaminated with saliva and blood. Clearfil SE Bond and AQ Bond were evaluated. One hundred specimens were made by seventy-five deciduous teeth(fifty anterior and twenty-five posterior teeth) and divided randomly into ten groups. Small flat dentinal surfaces were prepared by grinding the buccal, lingual and labial areas. Specific surface treatments were applied to each group: (1) a self-etching primer application(control group), (2) saliva contamination followed by primer(Group I), (3) primer curing followed by saliva contamination (Group II), (4) blood contamination followed by primer(Group III), (5) primer curing followed by blood contamination(Group IV). After bonding of composite resin(Z100, 3M, USA) to contaminated sample surfaces and thermocycling(1,000 cycles), shear bond strengths were measured using Universal Testing Machine(Zwick Z020, Zwick Co., Germany). The results were as follows; 1. Group I showed lower shear bond strength than control group but no statistically significant difference was found(P>0.05). 2. Group II and blood contamination group(Group III & IV) showed significantly lower shear bond strength than control group(P<0.01). 3. The shear bond strength of Clearfil SE Bond was significantly higher than that of AQ Bond(P<0.05).

• Proceedings of the KSCN Conference
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• 2004.05a
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• pp.410-410
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• 2004

전문체육인을 육성하는 체육고등학교의 학생들을 대상으로 영양교육을 실시하기 전 대상 진단용 기초자료로 활용하고자 학생들의 식습관, 영양상태 및 영양지식도를 평가하였다. 연구대상은 대구체육고등학교 1학년생 59명(남학생 47명, 여학생 12명)을 대상으로 하였으며, 신체계측은 체성분 분석기(DX-200/100)를 이용하여 계측하였고 혈액생화학치는 kite법(영동제약)으로 분석하였으며, 대상자의 일반사항 및 식습관과 영양지식도는 설문지로 평가하였다.(중략)

• Journal of Digital Convergence
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• v.11 no.12
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• pp.607-614
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• 2013

This study has been conducted to investigate the effect of self awareness of halitosis on the quality of life related to oral health in patients with chronic renal failure undergoing hemodialysis and use basic data related to oral health of patients with chronic renal failure which is very rare in Korea. In terms of oral symptoms based on awareness of halitosis, there were significant differences in symptoms of teeth pain in the past one month, bleeding gums, symptoms of tongue or cheek pain, dry mouth, In terms of status of oral functions, there were significant differences in discomfort upon chewing foods, difficulty of pronunciation and presence of lost teeth. As the results of analysis of effect of self awareness of halitosis on the quality of life related to oral health in patients with chronic renal failure, it was shown that there were significant effects in psychological discomfort(B=-2.028, p<.01), poor social skills(B=2.596, p<.01) and social disadvantage(B=-2.173, p<.01). Thus, because self awareness of halitosis gives psychologically and socially negative effects, it could be an important factor to patients with renal failure whose number is rapidly increasing.

• Journal of Chest Surgery
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• v.37 no.4
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• pp.342-348
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• 2004

It is very important for hemodialysis in patients with end stage renal disease to obtain vascular access that resists repeated punctures and maintains adequate blood flow. This study was designed to indentify factors that may influence early patency rate of autogenous arteriovenous fistula. Material and Method: 49 cases in 47 patients who underwent radiocephalic fistula formation in our hospital from June 2002 through May 2003 were reviewed and analyzed. Result: The early patency rate was 79.6%. Age, sex, hypertension, and diabetes mellitus were not significant factors for patency. Body mass index and duration of hypertension and diabetes did not influence the early results either. Cephalic vein diameter measured preoperatively and blood flow at radio-cephalic fistula were significantly positive correlative factors. Groups with the vein diameter less than 2.7mm, or with the blood flow less than 100 mL/min had significantly lower early patency rate than the other groups. Conclusion: To improve early patency rate of radiocephalic fistula, large sized cephalic vein should be selected and if the intraoperative flow at radiocephalic fistula is less than 100 mL/min, another arteriovenous fistula formation should be considered.

• Clinical and Experimental Pediatrics
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• v.45 no.8
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• pp.1000-1006
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• 2002

Purpose : In the course of treatment, patients with hematological or oncological disorders often develop pulmonary complication. The patients who develop a severe pulmonary complication have a poor outlook. The causes of pulmonary complication are either infectious or non-infectious in origin. We have analyzed the etiology and outcome of these patients admitted to the pediatric intensive care unit of Asan Medical Center. Methods : Medical records of 95 patients on Pediatric oncology service who were admitted to pediatric intensive care unit(PICU) of Asan Medical Center from Jan 1997 to May 2000 were retrospectively reviewed. Results : The mean age of the patients was 8.5 years(2 months-18 years). The underlying malignancies of these 95 patients were as following; acute lymphoblastic leukemia(31 cases), lymphoma (11 cases), acute myeloid leukemia(nine cases), brain tumor(eight cases) and other solid tumors(25 cases). Pulmonary complications included pneumonia, acute respiratory failure, pneumothorax and pleural effusion. The most common cause of pulmonary complication was infection(88%) in etiology. The overall mortality rate was 56.8%. Pulmonary complications in these patients carried high rates of mortality regardless of whether they were immune compromised(76%) or not(69%). Even without pulmonary complications, the hematological or oncological patients admitted to PICU had high mortality rates of 43%. Conclusion : Pulmonary complications are frequent finding in the hematological or oncological patients admitted to Intensive Care Unit. The main etiology of these pulmonary complications was infection, which carried a high mortality rate regardless of their immune status at the time when they were admitted to PICU.

• Journal of Life Science
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• v.24 no.2
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• pp.105-111
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• 2014

The purpose of this study was to characterize equine heat-shock protein (Hsp) genes and analyze their expression pattern in various horse tissues and blood leukocytes after exercise. In a previous study, RNA sequencing of blood and skeletal muscles of thoroughbreds before and after exercise was performed using differently expressed gene (DEG) analysis. Three Hsp genes (HspH1, Hsp90${\alpha}$ and Hsp70) were selected by DEG analysis and were found to be differentially expressed in either blood or muscle. To validate and extend previous observations on these genes, we performed RT-PCR analyses of horse tissue as well as real-time qPCR analyses of blood leukocytes after exercise. mRNA expression of these Hsp genes was found to be ubiquitous in the analyzed tissues (including thyroid, colon, skeletal muscle, cecum, kidney, spinal cord, heart, and lung). In addition, Hsp mRNA expression of these genes in extracted whole blood increased after 120 minutes of exercise compared to the baseline condition. These results are in agreement with the results of human and other experimental animals, suggesting that regulatory mechanisms that are responsible for upregulation of Hsp gene transcription may be conserved among species. Further investigations to correlate Hsp gene expression patterns with athletic performance or recovery processes after exercise are warranted.

• Biomedical Science Letters
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• v.1 no.1
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• pp.73-79
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• 1995

The effect of prior cumulative mixing was evaluated by means of a simple regression model which used as a dependent variable percentage(%) change of each repeated observed value for the initial value. The red blood cell count (RBC), hematocrit (Hct), and mean corpuscular volume(MCV) showed a significant decrease (p<.01), but % of basophils had a significant increase (p<.05). The ratios of rate of change (regression coefficient/SD) were .0012 for RBC, .0020 for Hct, .0024 for MCV, and .0011 for % of basophils. Of the 19 parameters evaluated, 21% changed.

• Proceedings of the Korean Aquaculture Society Conference
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• 2003.10a
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• pp.103-104
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• 2003

어류의 양식생산 과정중에는 사육중인 어류에게 스트레스로 작용할 수 있는 여러 가지 요인들이 있다. 그 중에서도 생산된 종묘의 양식장 운송, 수확한 어류의 소비지 운반 등은 양식과정중 피할 수 없는 작업이다. 어류의 수송 후에는 혈장 corticosteroid, glucose, 전해질, 삼투질 농도, 적혈구수, hematocrit, hemoglobin 등이 변화하는 것으로 알려지고 있다(Chang et al. 2001; Hur et al., 2002, 2003). 스트레스 요인별 연구로는 염분, 수온, 밀도 및 마취제에 관한 것 등이며, 아울러 이들의 복합적인 요인에 대하여 스트레스 반응을 최소화시키려는 연구가 진행되고 있다. 어류종묘의 수송이나 수확된 어류가 대량으로 수송되고 있으므로, 넙치(Paralichthys olivaceus)와 같은 대량수송 어류의 수송에 따른 스트레스 반응에 대한 연구의 필요성이 제기된다. 그러므로 본 연구에서는 넙치를 사용하여 염분, 수온 및 마취제에 의한 수송이 스트레스 지표로 알려져 있는 혈액학적 요인, cortisol, glucose, lactic acid 및 삼투질 농도 둥에 나타나는 생리학적 반응을 조사하여, 활어수송 과정에서 나타나는 스트레스 반응에 대한 기초자료를 제공하고자 하였다. 실험어는 21.2 cm, 97.4 g인 양식 넙치를 사용하여, 수온은 20℃ (natural water temperature, NWT)와 15℃ (cooling water temperature, CWT), 염분은 해수(35‰)와 15‰해수, 마취제(anesthesia, Anes., MS-222)는 50 ppm의 조건으로 혼합한 실험구를 설정하였다. 실험구는 각각 NWT＋35‰, CWT＋35‰, NWT＋15‰, NWT＋15‰, NWT＋35‰＋Anes., CWT+35‰＋Anes., NWT＋15‰+Anes. 및 CWT+15‰＋Anes.의 8개 실험구를 2반복으로 설정하여 경북울진∼부산까지 약 400 km (6시간)를 차량수송하였다. 수송용기는 스티로폼상자(66×42×20 cnn)로서, 여기에 해수 3 L와 액화산소를 넣은 비닐봉지에 넙치 8마리씩 수용하여 수송하였다. 혈액의 성상 및 분석항목은 수송전ㆍ후에 채혈하여 비교하였다. 수송전 hematocrit는 22.2±3.8%에서 수송후 NWT＋35‰에서 15.3＋3.9%, CWT＋35‰은 16.7±3.0%, NWT+15‰구에서는 19.2±1.8%로 낮아졌으며, CWT+15‰구는 20.9±3.6%로 수송전과 차이가 없었다. 한편 NWT＋15‰＋Anes.구는 17.8±0.9%, CWT＋15‰＋Anes.구는 14.5±1.5%로 낮아졌다. Cortisol은 수송전 2.4±0.1 ng/ml로부터 CWT＋35‰구는 16.7±12.8 ng/ml, NWT＋35‰구는 47.9＋19.8 ng/ml, NWT＋15‰구는 43.5±13.9 ng/ml, CWT＋15‰구는 26.1±8.3 ng/ml, NWT＋15‰+Anes.구는 61.7±3.3 ng/ml, CWT+15‰+Anes.구는 86.1±19.0 ng/ml로 높아졌다. Glucose는 수송전 74.2±32.6 mg/dl로부터 NWT＋35‰구는 197.9±27.5 mg/dl, CWT＋35‰구도 272.1±29.9 mg/dl로 유의하게 높아졌다. Na/sup +/의 수송전 농도는 163.5±0.6 mEq/L로부터 NWT＋35‰구와 CWT＋35‰구는 각각 175.3±1.2 mEq/L, 190.0±5.0 mEq/L로 높아졌으며, 다른 실험구에서는 차이가 없었다. 본 연구 결과, cortisol과 glucose에서 수송전보다는 모든 실험구에서 높게 나타나 수온, 염분 및 마취제를 사용하여도 스트레스를 받고 있는 것으로 나타났다. 특히, cortisol의 경우, 수온과 염분만을 혼합한 실험구보다 마취제를 혼합한 실험구에서 높게 나타났다. 다른 혈액학적 항목에서는 염분과 마취제를 사용하지 않았던 실험구인 NWT＋35‰구와 CWT＋35‰구에서 다른 실험구에 비하여 glucose, Na/sup +/ 및 Cl/sup -/ 등에서는 높게 나타나는 경향을 보였다.

• Journal of Gastric Cancer
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• v.9 no.1
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• pp.26-30
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• 2009

Purpose: The aim of this study was to evaluate the prognostic value of the peripheral blood lymphocyte count before surgery in those patients with gastric cancer. Materials and Methods: The study group was comprised of a series of 1,054 patients who underwent curative gastrectomy. The appropriate lymphocyte count cutoff value was determined. The prognostic factors were evaluated by univariate and multivariate analyses. Results: The lymphocyte count cutoff value was 1,500/ul. The patients were classified into two groups: Group A had a lymphocyte count $\geq$ 1,500/ul (n=765) and Group B had a lymphocyte count <1,500/ul (n=289). There were statistically significant differences between the groups according to their age (P<0.001), the tumor stage (P=0.038) and the tumor size (P<0.001). The 5- and 10-year survival rates of Group A were 80.1% and 76.6%, respectively and those of Group B were 72.4% and 63.5%, respectively (P=0.002). When multivariate analysis was performed by the Cox proportional hazards model, the lymphocyte count was not an independent prognostic factor. Conclusion: Although the prognosis of patients with a high lymphocyte count was better than that of the patients with a low lymphocyte count, our results did not support using the preoperative peripheral blood lymphocyte count as an independent prognostic factor for patients with gastric cancer.