• Food Science and Preservation
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• v.17 no.5
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• pp.752-756
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• 2010

Lepidoptera (butterflies) extracts, traditionally employed as medicines, have various biological activities. Five species of Lepidoptera (Papilio maackii, Papilio xuthus, Pieris rapae, Eurema hecabe, and Sasakia charonda) were extracted with distilled water (DW), dimethyl sulfoxide (DMSO), ethanol (EtOH), and methanol (MeOH). Each extract was analyzed for anti-oxidant and anti-inflammatory activities using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay method, the ferric reducing ability of plasma (FRAP) test, and a cyclooxygenase-2 (COX-2) promoter assay. The results suggest that Lepidoptera extracts have valuable anti-oxidant and anti-inflammatory properties, supporting the idea that the extracts may serve as a food biomaterial(s) preventing oxidative processes and inflammatory damage.

• Korean Chemical Engineering Research
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• v.43 no.2
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• pp.187-201
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• 2005

Bioprocessing technologies utilizing 'biorecognition' between a solid matrix and a protein is being widely experimented as a means to replacing the conventional, solution-based technology. Frequently the matrices are chromatographic resins with specific functional groups exposed outside. Since the reactions of and interactions with the proteins occur as they are attached to the solid matrix, this 'solid-phase' processing has distinct advantages over the solution-phase technology. Solid-phase refolding of inclusion body proteins uses ion exchange resins to adsorb denaturant-dissolved inclusion body. As the denaturant is slowly removed from the micromoiety around the protein, it is refolded into a native, three-dimensional structure. Once the refolding is complete, the folded protein can be eluted by a conventional elution technique such as the salt-gradient. This concept was successfully extended to 'EBA (expanded bed adsorption)-mediated refolding,' in which the denaturant-dissolved inclusion body in whole cell homogenate is adsorbed to a Streamline resin while cell debris and other impurity proteins are removed by the EBA action. The adsorbed protein follows the same refolding steps. This solid-phase refolding process shows the potential to improve the refolding yield, reduce the number of processing steps and the processing volume and time, and thus improve the overall process economics significantly. In this paper, the experimental results of the solid-phase refolding technology applied to several biopharmaceutical proteins of various types are presented.

• Korean Journal of Oriental Medicine
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• v.17 no.2
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• pp.17-28
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• 2011

This study was conducted to analyze the status of the traditional medicines registered by the Chinese state as intangible cultural heritages, and of Chinese acupuncture and moxibustion registered by UNESCO as world intangible cultural heritages in 2010, in connection with the need to have Traditional Korean Medicine skills similarly registered as world intangible cultural heritage items. Since UNESCO's adoption of the Convention on the Safeguarding of Intangible Cultural Heritages in 2003, the Chinese government has pushed ahead with efforts to explore and protect intangible cultural heritage items and have them registered as world intangible cultural heritages. Thus, Benchaogangmu (本草綱目) and Huangdineijing (黃帝內經) were listed on UNESCO's Memory of the World Register while Chinese acupuncture and moxibustion were registered as world intangible cultural heritage properties. For Traditional Korean Medicine skills to be listed as world intangible cultural heritage properties, steps should be taken first to include the skills in the list of domestic intangible cultural heritage items and to make further explorations in the sector. Such efforts are also important in terms of the need to establish the legitimacy of Traditional Korean Medicines.

• The Science & Technology
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• v.35 no.4 s.395
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• pp.43-70
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• 2002

BT산업의 새시대 - BT산업은 21세기 국가성장 동력, IT와 같이 경쟁력 확보 전망 밝아/우리나라 BT산업현황[의약분야] - 신약 연구와 결과 내용 아직 걸음마 단계, 기반시설 확충ㆍ투자ㆍ우수인력 확보 시급/우리나라 BT산업현황[미생물 분야] - 생물정보학 전문가ㆍ전산시스템 취약, 유전체 정보관련 산업 활로 모색 활발/우리나라 BT산업현황[농업분야] - 지원 취약, 소비자 거부감 겹쳐 발전 애로/우리나라 BT산업현황[축산분야] - 전통육종기술 접목 가축개량 극대화/우리나라 BT산업현황[생물정보(BT+IT) 분야] - 인프라구축단계, 벤처중심 연구 활기/BT와 윤리 - 의식없이 문제제기 불안감 조성은 곤란, BT시대 맞는 새로운 윤리관 확립 필요/선진국의 BT산업 - 의약품 제조분야 치열한 연구개발 경쟁, 대형 제약회사 앞다퉈 BT기업과 연대

• Journal of Korea Fair Competition Federation
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• no.162
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• pp.68-85
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• 2012

이 글은 2012년 3월 9일 '무역 및 경쟁 정책에 관한 국제 원탁회의(International Roundtable on Trade and Competition Policy) 비공개전문가회의'에서 Shanker A. Singham이 발표한 자료와 참석자들의 토의내용을 발표 이후 정리, 이를 요약문 형식으로 번역(의역)한 것이다. 이 글의 주요 논지는 경쟁당국의 지식재산권에 대한 전통적 관점에 대한 재고찰로서, 필자는 "지식재산권 보호가 반드시 경쟁정책에 반하는 것은 아니고, 오히려 지식재산권 보호가 경쟁을 촉진하는 효과를 가진다"는 점을 강조하고 있다. 저자는 자신의 논지를 설명하면서 의약산업의 예시를 상당부분 들고 있다. 이 글 중에는 국내 사정과 정서에 일부 부합하지 않는 내용도 있을 수 있지만, 국내외 경쟁정책에 대한 다양한 관점을 경험할 수 있다는 점에서 의미가 있다고 생각한다.

• Journal of Ginseng Research
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• v.15 no.3
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• pp.224-230
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• 1991

The seven traditional quality factors including age and root weight ect. were reviewed in relation to the chemical components as a new quality factor and pharmacological data. The other important factor, production place, appeared to be sum of the eight factors. The important of production place indicated that the best quality ginseng is produced in the optimum environment. The description of ginseng for medicinal use in present materia medica missed most traditional quality factors only indicating the change by processing. Such phenomena do not mean the significant of raw$.$ ginseng quality. since appropriate raw ginseng was supplied in traditional way. For the generation with analytical attitude the description of raw ginseng quality to the processed ginseng products is recommendable. For the quality control with biologically active or index compound, the composition of various compounds seems to be the best. The establishment of physical and chemical quality creteria that will match with the traditional mothod it needed and will accomplished by comparative research on raw ginseng from various production sites and growth conditions. The description of production-place, grade and quantity of raw ginseng to the processed products will give better information and higher popularity of products to consumers.

• Food Science and Industry
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• v.49 no.2
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• pp.25-33
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• 2016

우리나라의 발효식품 산업의 규모는 2010년 약 4조 원으로 식품 산업 전체의 4.0%정도이며, 이 중 전통 발효식품이 50.0% 수준으로 전체 식품 산업 대비 비중은 2.0%에 불과하지만, 발효제품의 세계 시장 규모는 2000년 152억 달러, 2010년 730억 달러로 급속한 성장으로 확대되고 있다. 국내 소금시장의 규모는 2010년 기준 1,300억 원이며, 전 세계적으로 나트륨 대체 염미제의 시장수요는 절실히 필요한 실정으로, 최근 2,000억 원대 규모를 유지하고 있는 간장 시장에서 염도를 낮춘 '저염 간장'매출 성장세를 보이고 있어 소금을 줄이는 식생활 개선에 대한 교육 홍보와 더불어 '나트륨 저감화 식품 개발의 필요성'이 국민건강증진, 경제성 측면에서 날로 커지고 있다. 또한, 2007년부터 웰빙 열풍으로 자연조미료 제품의 비중이 크게 늘어나는 추세이며, 100% 천연재료로 사용하여 소비자용 제품 출시 등 다양한 변화를 가져온 결과, 자연조미료 시장은 2008년 151억 3,200만 원의 매출규모에서 215억 2,600만원으로 무려 42.3%를 차지했으며, 저염을 위하여 활용하는 저염 소금도 연령대가 높아질수록 선호도가 높아지는 있다는 보고가 있다. 식품의약안전처의 '나트륨 저감화 사업'은 2012년부터 연차별로 가공식품의 나트륨 저감화 가이드라인을 개발하여 가공식품 생산업체들의 참여를 유도하며, 다양한 홍보를 펼쳐 2014년 6월 기준으로 165개 제품의 나트륨이 저감화 되었으며, 2015년에는 95종의 면류제품의 나트륨 함량이 약 20% 이상 저감되는 실적을 보여주었다. 여러 지역자체 단체들은 지역의 특성을 최대한 살려 다양한 발효산업 육성을 진행하고 있음에 영남권의 장류 업체를 대상으로 나트륨 섭취량을 줄일 수 있도록 '경북 발효식품 수출농업기술지원단'은 식품의약품안전처와 연계하여 지속적으로 가공식품 중 나트륨 저감화에 노력을 할 것이며 이에 대기업과 함께 중소기업들의 참여도를 높이기 위해 현장 컨설팅을 지역적으로 실시할 계획으로 각 지역별 업체들의 참여도를 높일 계획이다. 이를 통해 전통 발효식품이 기능성을 유지하면서 나트륨 함량을 줄인 건강식품으로 우리나라 식품산업 발전에 기여하고자 노력할 것이다. 향후 발효산업 중 한류의 매운맛, 김치 등을 시작으로 고성장이 기대되는 세계화 전략 품목이며 지역 농산물을 활용한 발효식품 세계화를 위하여 나트륨 저감화는 반드시 선행되어야 할 것으로 생각된다.

• Journal of Haehwa Medicine
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• v.12 no.2
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• pp.235-244
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• 2004

WIPO international government committee will finish to develop toolkit for making documentation on discussions of intellectual property protection with TK, GR until the late 2003. As they construct DB of TK, GR, it becomes in a hurry to construct DB of TK information in Korea. We looked into application of copyright in force and a lot of problems in terms of analyzing medical books in the resent condition or protecting them in Korea. There are 29 kinds which have been lost, 12 kinds which could have read in parts, 136 kinds which have been existed of Korean medical books before 1900. There are also a lot of medical books which have been published after 1900 and still are unpublished. It would be 406 medical books from China totally, 111 kinds from Chosun Dynasty version, 134 kinds from Euybangeuchui, 225 kinds from Hyangyackjibsungbang, 78 kinds from Dongeuybogam. We consider to know whether Korean medical books could been applied to the copyright in force or not in accordance with discussions of WIPO on the period, subject(author), contents of protection. If it is applied to the copyright in force, it will be decided to revise according to discussions of WIPO. On the other hand, the problem which is occurred to protect Korean medical books is friction with China as importing their medical books, to find our medical books actively which has been unpublished. Finally, We have to revise administration and intellectual property standards or protect our medical books by making new administration laws.

• Korean Journal of Oriental Medicine
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• v.8 no.2 s.9
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• pp.47-65
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• 2002

This project is planned to grasp the present situation of traditional medicine part in our country and to study protection method about this by the intellectual property which is the international concerning point recently. Through this, we will be able to devise means to deal with protection method of traditional medicine being developed by WIPO now. Traditional medicine field In our country Is organized with specific condition separated into the part of institution and the part of non-institution. So, because of the closed peculiarity, we have experienced the difficulties to understand the real facts about traditional medicine. We cannot be indifferent to the matter anymore. Because the expectation of object people is high, we could expect the realization of research content. In 1 detail project, we investigated the situation of traditional medicine in our country through various collecting methods for excavation of oriental treatment technique and herb medicine which is worth protecting. With it, we sorted again into 56 kinds of 11 parts through analysis of validity in the way of oriental medicine. And we tried to link this up 2 detail project which is about legal and institutional guarantee concerning protection. furthermore, we tried to find approach ways for security of objectivity into 4 steps with the example of model disease. we could complete practical classification of traditional medicine in our country. In 2 detail project, we studied the protection method by the intellectual property through research result in 1 detail project. For this, we observed an outline of the intellectual property including a patent application analysis in folk traditional medicine part, and problems of traditional medicine protection and world trend by traditional knowledge protection tendency and the patent law In domestic traditional medicines, the aspects unprotectable with the patent law now were remained. So, we suggested supplementary plan. And we also suggested the freedom of utilization between traditional medicine possession countries (in-situ utilization) and the demand compensation payment for a third country (ex-situ utilization) in connection with international movement.

• Journal of Agricultural Extension & Community Development
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• v.7 no.1
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• pp.193-208
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• 2000

The purpose of this study was carried out to investigate medicinal resources herb plants that using through the ages in Korea among the spontaneous and naturalized flavor or frangrant plants and to discuss some way of utilizations of their products to promote human health. Another goal of this study was to collect and systematically synthesize those materials connected with fragrant medicinal plants to serve useful informations on this problems for following researchers. The major findings of this study were as follows ; In Korea, many species of fragrant plants were used for medicinal purpose through the ages. And most of the everyday`s common drugs in Korea's traditional medicine were contained fragrant resources plants as major medicinal material. Therefore, We can find that mast of the fragrant resources plants are very excellent material for traditional medicinal use. At the same time, we should reveal to fragrant material's activity for human health and to investigate the effect of aromatherapy in the future.