• Journal of the Korean Society of Radiology
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• v.17 no.1
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• pp.11-16
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• 2023

In preclinical positron emisson tomography(PET), spatial resolution degradation occurs outside the field of view(FOV). To solve this problem, a depth of interaction(DOI) detector was developed that measures the position where gamma rays and the scintillator interact. There are a method in which a scintillation pixel array is composed of multiple layers, a method in which photosensors are arranged at both ends of a single layer, a method in which a scintillation pixel array is constituted in several layers and a photosensor is arranged in each layer. In this study, a new type of DOI detector was designed by analyzing the characteristics of the previously developed detectors. In the two-layer detector, different sizes of scintillation pixels were used for each layer, and the array size was configured differently. When configured in this form, the positions of the scintillation pixels for each layer are arranged to be shifted from each other, so that they are imaged at different positions in a flood image. DETECT2000 simulation was performed to confirm the possibility of measuring the depth of interaction of the designed detector. A flood image was reconstructed from a light signal acquired by a gamma-ray event generated at the center of each scintillation pixel. As a result, it was confirmed that all scintillation pixels for each layer were separated from the reconstructed flood image and imaged to measure the interaction depth. When this detector is applied to preclinical PET, it is considered that excellent images can be obtained by improving spatial resolution.

• Journal of the Korean Society of Radiology
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• v.16 no.2
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• pp.157-162
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• 2022

Since preclinical positron emission tomography imaging is performed on small animals that are very small compared to the human body, a detector with excellent spatial resolution is required. For this purpose, a system was constructed using a detector using small scintillation pixels. Since the size of the currently developed and used photosensors is limited, excellent spatial resolution can be obtained when the minimum scintillation pixel and maximum array are used. In this study, the size of the photosensor is fixed and various scintillation pixel arrays are configured to match the size of the scintillation pixels, so that no overlap occurs in the flood image and the maximum scintillation pixel array in which all scintillation pixels are distinguished. For this purpose, DETECT2000, which can simulate a detector module composed of a scintillator and an photosensor, was used. A photosensor consisting of a 4 × 4 array of 3 mm × 3 mm pixels was used, and the scintillation pixel array was configured from 8 × 8 to 13 × 13, and simulations were performed. A flood image was constructed using the data obtained from the photosensor pixel, and the maximum scintillation pixel array that does not overlap the image was found through the flood image and the profile. As a result, the size of the scintillation pixel array in which all scintillation pixels are imaged without overlapping each other in the flood image was 11 × 11.

• Journal of the Korean Society of Radiology
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• v.12 no.5
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• pp.637-643
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• 2018

A depth of interaction(DOI) detector module using a block scintillator and a pixellated scintillator was designed, and layer discrimination ability was calculated using DETECT2000. The block scintillator was used to improve the sensitivity and the spatial resolution was improved by measuring the DOI. The DOI was measured by analyzing the signal characteristics of each channel of the changed distribution of light. The detector module was composed to the block scintillator in the top layer and the pixellated scintillator in the bottom layer, which changes the distribution of light generated from a scintillator interacting with a gamma ray. In the flood image, the top layer was able to acquire the image at the position similar to the position of the bottom layer because the bottom layer consist of the pixellated scintillator. By using the Anger algorithm, the 16 channel signal was reduced to 4 channels to facilitate the analysis of the signal characteristics. The layer discrimination was measured using a simple algorithm and the accuracy was about 84% for each layer. When this detector module is used in preclinical PET, the spatial resolution at the outside of the field of view can be improved by measuring the DOI.

• Journal of the Korean Society of Radiology
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• v.13 no.3
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• pp.319-324
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• 2019

A depth-encoding detector module with silicon photomultipliers(SiPMs) using two layers of scintillation crystal array was designed, and the position measurement capability was verified using DETECT2000. The depth of interaction of the crystal pixels with the gamma rays was tracked through the image acquired with the combination of surface treatment of the crystal pixels and reflectors. The bottom layer was treated as a reflector except for the optically coupled surfaces, and the crystals of top layer were optically coupled each other except for the outer surfaces so that the light sharing was made easier than the bottom layer. Flood images were obtained through the combination of specular reflectors and random reflectors, grounded and polished surfaces of crystal pixels, and the positions at which layer images were generated were measured and analyzed. The images were reconstructed using the Anger algorithm, whose the SiPM signals were reduced as the 16-channels to 4-channels. In the combination of the grounded surface and all reflectors, the depth positions were discriminated into two layers, whereas it was impossible to separate the two layers in the all polished surface combinations. Therefore, using the combination of grounded surface crystal pixels and reflectors could improve the spatial resolution at the outside of the field of view by measuring the depth position in preclinical positron emission tomography.

• Journal of the Earthquake Engineering Society of Korea
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• v.15 no.6
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• pp.55-66
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• 2011

The purpose of this study was to develop an efficient process in the design and construction of a 1:5 scale 10-story R.C. apartment building model for an earthquake simulation test. The reduction ratio of the specimen was determined by the size ($5m{\times}5m$) and pay load (600kN) of the available shaking table and the availability of model reinforcements. For efficiency and quality control of the reinforcement work, prefabrication was used. Construction was conducted in two steps, the wall in one step, and another step for the slab, because it was impossible to remove the formwork of a wall if the walls and slabs in a story were constructed in one step. The slip form construction method was used repetitively for walls. The formwork of a wall was made with veneer and acryl plate on each side, so it was possible to check the quality of the concrete placing. To construct this model, it took roughly six months with five full-time research assistants, for a total of 602 man days of labor in construction.

• Journal of Animal Environmental Science
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• v.6 no.2
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• pp.121-130
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• 2000

Pure voice characteristics of sow were analyzed to predict parturition time. These were analyzed by using oscilloscope and Sound Forge and the results showed that the voice frequency and amplitude of sow were in the range of 30∼2,500Hz and -35∼-75dB. According to the sound analysis results, the frequencies of sound appearance from farrowing sow in the farrowing pen for three days prior to delivery day and eight hours of prior to delivery day and eight hours of prior to time were around 85% and 46%, respectively of the total appearance during eight days to delivery. Forecasting of delivery time of farrowing sow using the number of sound occurrences showed a promising result such that those have been increased whenever the delivery time was approached. The forecasting success rates were 100% for both of one day and six hours prior to the actual delivery.

• Korean Journal of Agricultural Science
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• v.27 no.2
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• pp.107-116
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• 2000

Pure voice characteristics of sow were analyzed to predict parturition time. These were analyzed by using oscilloscope and Sound Forge and the results showed that the voice frequency and amplitude of sow were in the range of 30~2,500Hz and -35~-75dB. According to the sound analysis results, the frequencies of sound appearance from farrowing sow in the farrowing pen for three days prior to delivery day and eight hours of prior to time were around 85% and 46%, respectively of the total appearance during eight days to delivery. Forecasting of delivery time of farrowing sow using the number of sound occurrences showed a promising result such that those have been increased whenever the delivery time was approached. The forecasting success rates were 100% for both of one day and six hours prior to the actual delivery.

• Nuclear Medicine and Molecular Imaging
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• v.41 no.6
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• pp.561-565
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• 2007

Purpose: Lipophilic cations including tetraphenylphosphonium (TPP) salts penetrate the hydrophobic barriers of the plasma and mitochondrial membranes, resulting in accumulation in mitochondria in response to the negative inner transmembrane potentials. The development of radiolabeled phosphonium cations as a noninvasive imaging agent may serve as a new molecular "voltage sensor" probe to investigate the role of mitochondria in the pathophysiology and diagnosis of cancer. Materials and Methods: We have synthesized a reference compound (4-fluorophenyl)triphenylphosphonium (TPP) and a labeled compound $[^{18}F]$TPP via two step nucleophilic substitution of no-carrier-added $[^{18}F]$fluoride with the precursor, 4-iodophenyltrimethylammonium iodide, in the presence of Kryptofix-2.2.2 and $K_2CO_3$. Result: The reference compound (4-fluorophenyl)triphenylphosphonium (TPP) was synthesized in 60% yield. The radiolabeled compound $[^{18}F]$TPP was synthesized in $10\sim15%$ yield. The radiochemical purity of the $[^{18}F]$TPP was $95.57{\pm}0.51%$ (n=11). Conclusion: $[^{18}F]$TPP was successfully synthesized that might have a potential to be utilized as a novel myocardial or cancer imaging agent for PET. However, it is required to improve the radiochemical yield to apply $[^{18}F]$TPP in preclinical or clinical researches.