• The Journal of Pediatrics of Korean Medicine
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• v.28 no.2
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• pp.23-39
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• 2014

Objectives PRAL (Prunus armniaca Linne Var) is a herbal formula in Oriental Medicine, known for its anti-inflammatory and anti-allergenic properties. However, its mechanism of action and the cellular targets have not yet been found enough. The purpose of this study is to investigate the effects of PRAL on Th2 cytokines expression in MC/9 mast cells. Methods The effect of PRAL was analyzed by ELISA, Real-time PCR, Western blot in MC/9 mast cells. mRNA levels of GM-CSF, IL-4, IL-5, IL-6, IL-13, TNF-${\alpha}$ were analyzed with Real-time PCR. Levels of IL-13, MIP-$1{\alpha}$ were measured using enzyme-linked immunosorbent assays (ELISA). NFAT, AP-1 and NF-${\kappa}B$ p65 were examined by Western blot analysis. Results PRAL inhibited GM-CSF, IL-4, IL-5, IL-6, IL-13, TNF-${\alpha}$ mRNA expression in a dose dependent manner. GM-CSF, IL-4, IL-5 mRNA expression were inhibited significantly in comparison to DNP-IgE control group at concentration of 100 ${\mu}g/ml$ and IL-6, IL-13, TNF-${\alpha}$ mRNA expression were inhibited at concentration of 50 ${\mu}g/ml$, 100 ${\mu}g/ml$. PRAL also inhibited the IL-13, MIP-$1{\alpha}$ production significantly in comparison to DNP-IgE control group in a dose dependent manner. IL-13 production was inhibited at a concentration of 200 ${\mu}g/ml$, 400 ${\mu}g/ml$ and MIP-$1{\alpha}$ was inhibited at a concentration of 100 ${\mu}g/ml$, 200 ${\mu}g/ml$, 400 ${\mu}g/ml$. Western blot analysis of transcription factors involving Th2 cytokines expression revealed prominent decrease of the mast cell specific transcription factors including NFAT-1, c-Jun as well as NF-${\kappa}B$ p65 but not NFAT-2 and c-Fos. Conclusion These results indicate that PRAL has the effect of suppressing Th2 cytokines production in the MC/9 mast cells. These data represent that PRAL potentiates therapeutic activities to the allergic disease by regulating Th2 cytokines in the MC/9 mast cells.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.33 no.2
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• pp.87-92
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• 2007

To develop the skin whitening agent, we investigated the effects of Acanthopeltis japonica, a rhodophyta on the coast of Jeju island, on melanogenesis. Dried A. japonica was refluxed with 70 % aqueous ethanol and the extract was evaporated to dryness. To validate the activity as a depigmenting agent, various in vitro tests, polyphenol contents, and free radical scavenging activity were performed. In addition, cellular tyrosinase activity and protein expression of p-ERT, tyrosinase, TRP-1, and TRP-2 were measured in B16/F10 murine melanoma cells. A. japonica had low polyphenol contents and low free radicals scavenging activities against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical. A. japonica suppressed cellular tyrosinase activity up to 86.9 % at $100{\mu}g/mL$ with inhibition or tyrosinase and TRP-1 expression in ${\alpha}$-melanocyte stimulating hormone (${\alpha}$-MSH)-treated B16/F10 melanoma cells. Our results suggest that inhibitory effects of A. japonica on melanogenesis are due to inhibiting the pathways involving ${\alpha}$-MSH-induced ERK activation. Therefore, A. japonica nay be useful as a skin whitening agent associated with the suppressive effect of melanotrophin-induced signaling pathway to inhibit melanin synthesis.

• International Union of Geodesy and Geophysics Korean Journal of Geophysical Research
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• v.21 no.1
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• pp.31-46
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• 1993

A radiative transfer model with two-stream/delta-Eddington approximation has been developed to calculate the vertical distributions of atmospheric heating rates and radiative fluxes. The performance of the model has been evaluated by comparison with the results of ICRCCM (Intercomparison of radiative codes in climate models). It has been demonstrated that the presented model has a capability to calculate the solar radiation not only accurately but also economically. The characteristics of ultraviolet-B radiation (UV-B; 280-320nm) are examined by comparison of relation between the flux at the top of atmosphere and that at the surface. The relation of UV-B is quadratic due to the strong ozone absorption in this band. Also, the dependence of the UV-B radiation on the stratospheric ozone depletion and stratospheric aerosol haze due to volcanic eruption on the stratospheric ozone depletion and stratospheric aerosol haze due to volcanic eruption has been tested with various solar zenith angles. The surface UV-B increases as the solar zenith angle increases. The existence of stratospheric aerosols causes an increase in the planetary albedo due to the aerosols' backscattering. The planetary albedo with aerosol's effect has been increases as the solar zenith angle is not sensitive. It may be caused by the fact that the aerosols' scattering effect becomes saturated with the relatively long path length in a large solar zenith angle. Finally, the regional impact of stratospheric aerosols due to volcanic eruption on the intensity of UV-B radiation at the surface has been estimated. A direct effect is that the flux is diminished at the low latitudes, while it is enhanced in the high latitudes by the aerosols' photon trap or twilight effect. In the high latitudes, both aerosols' scattering and ozone absorption have strong and opposite impacts to the surface UV-B radiation is located at the mid-latitudes during spring season in both hemispheres.

• Journal of the Korean Chemical Society
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• v.44 no.6
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• pp.533-540
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• 2000

Melanization of B16 melanoma cells was comparatively studied by the aqueous extract of Epimedium koreanum Nakai(EK) and $\alpha$-MSH. In addition, inhibitory effects of RA was investigated. B16 melanoma cells(about 1${\times}10_5$) have been shown an increase in tyrosinase activity and melanin contents in proportion to concentration of $\alpha$-MSH when treated with $\alpha$-MSH and incubated for 72 hrs. They indicated a 350% increase in tyrosinase activity and a 290% increase in melanin contents at 8 ng/mL. In case of EK, they have been shown a 200% increase in tyrosinase activity and a 180% increase in melanin contents at 100 ${\mu}g$/mL. In addition of RA to the above condition, they have been shown an inhibition from 350% to 210% in tyrosinase activity and from 290% to 250% in melanin contents in $\alpha$-MSH, and inhibition from 200% to 100% in tyrosinase activity and from 180% to 120% in melanin contents in EK. From the above results, it is suggested that EK promotes melanization of B16 melanoma cells through cAMP pathway, whereas RA inhibits it.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2002.11a
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• pp.560-565
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• 2002

In this paper, we implemented the sign board system that displays user's image, user's sentence, the information from DARC an[1 information based position by GPS module for vehicle. The existing sign board is displaying only user's image and sentence. Or other existing sign board is displaying the information via CDMA network. However, our system is also able to display the user's message like other system and gain the information more cheap by DARC. This system consists of 6 parts. The DARC control part classes the DARC information - news, weather, stock and time. The GPS control part gains moment and item to display with calculating the information of global position, direction, speed and satellite. The LED control part has two buffers to store and handle the image. The buffers help the system display various effected images on LED board. An external memory card includes the location based data, the option file and the displayed data files. The data files are stored by FAT 16 with the folder structure on external memory card. The USB controls the communication with PC. PC programs can control and monitor this system. This system is using G72l voice file format, for casting the information. This system was established at the vehicle and we monitored this system. The system displayed the DARC data , user's data and the location based data on the LED board, successfully.

• Journal of Navigation and Port Research
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• v.27 no.2
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• pp.233-238
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• 2003

Due to the impermeability of outer wall facilities such as Breakwaters which dissipates the wave energy and keeps harbor tranquility, the enclosed area of harbor becomes partially blocked and the water exchange can be reduced. Recent trends of port development protect water quality and emphasize Water-Front, so the method which enhances the circulation of harbor waters and the dilution of the water pollutants are studied. The best improvement of water quality is a remove of pollutant source on land, but an enclosed port must be enhanced the tidal exchange. For this end, the best improvement may be made a drain-route on the existing outer wall facilities. In this study, the numerical computations were carried out to predict the circulation of harbor waters and the tidal exchange through the drain-rout in the polluted harbor(Samchonpo-guhang) located at the east coast of South Sea. Computational models adopting FDM(Finite Difference Method) were used here and were already verified from the previous studies und ocean survey. As a result of this study, circulation and the tidal exchange at the harbor before and after introduction of drain-route were assessed.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.29 no.10A
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• pp.1131-1138
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• 2004

In Hierarchical Mobile Ipv6 (HMIPv6) networks, the mobility anchor point (MAP) handles binding update (BU) procedures locally to reduce signaling overhead for mobility. However, as the number of mobile nodes (MNs) handled by the MAP increases, the MAP suffers from the overhead not only to handle signaling traffic but also to Process data tunneling traffic. Therefore, it is important to control the number of MNs serviced by the MAP, in order to mitigate the burden of the MAP. We propose an adaptive load control scheme, which consists of two sub-algorithms: threshold-based admission control algorithm and session-to-mobility ratio (SMR) based replacement algorithm. When the number of MNs at a MAP reaches to the full capacity, the MAP replaces an existing MN at the MAP, whose SMR is high, with an MN that just requests binding update. The replaced MN is redirected to its home agent. We analyze the proposed load control scheme using the .Markov chain model in terms of the new MN and the ongoing MN blocking probabilities. Numerical results indicate that the above probabilities are lowered significantly compared to the threshold-based admission control alone.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.40 no.10
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• pp.1994-2005
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• 2015

Voice over IP (VoIP) is a technology for the delivery of voice communications and multimedia sessions over Internet Protocol (IP) networks. Instead of being transmitted over a circuit-switched network, however, the digital information is packetized, and transmission occurs in the form of IP packets over a packet-switched network which consist of several layers of computers. VoIP Service that used the various techniques has many advantages such as a voice Service, multimedia and additional service with cheap cost and so on. But the various frauds arises using VoIP because VoIP has the existing vulnerabilities at the Internet and based on complex technologies, which in turn, involve different components, protocols, and interfaces. According to research results, during in 2012, 46 % of fraud calls being made in VoIP. The revenue loss is considerable by fraud call. Among we will analyze for Toll Bypass Fraud by the SIM Box that occurs mainly on the international call, and propose the measures that can detect. Typically, proposed solutions to detect Toll Bypass fraud used DPI(Deep Packet Inspection) based on a variety of detection methods that using the Signature or statistical information, but Fraudster has used a number of countermeasures to avoid it as well. Particularly a Fraudster used countermeasure that encrypt VoIP Call Setup/Termination of SIP Signal or voice and both. This paper proposes the solution that is identifying equipment of Toll Bypass fraud using those countermeasures. Through feature of Voice traffic analysis, to detect involved equipment, and those behavior analysis to identifying SIM Box or Service Sever of VoIP Service Providers.

• Journal of Digital Convergence
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• v.12 no.10
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• pp.337-343
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• 2014

The PRT(Personal Rapid Transit) in material or immaterial guided tracks is operated automatically according to the needs of passengers with the optimal non-stop path from the source to the destination. In recent years, the personal rapid transit (PRT) system, which affords superior accessibility and ease of use, has been spotlighted as a new transport system for the future. In this study, a method for vertical lifting of PRT vehicles was proposed to facilitate interlink with other means of transport and thereby improve the efficiency of door-to-door transport. For this purpose, operation control interfaces were designed and experiments were conducted. Programmable Logic Controller (PLC) dedicated for the PRT vertical lift was designed to interface with Operation Control Center (OCC) by Modbus TCP over Ethernet. We implemented a 3D graphical PRT operation simulator which can emulate the mixing operation of the virtual vehicles and the actual vehicles.

• 한국벤처창업학회:학술대회논문집
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• 2010.08a
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• pp.71-89
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• 2010

It is strongly believed that multicast will become one of the most promising services on internet for the next generation. Multicast service can be deployed either on network-layer or application-layer. IP multicast (network-layer multicast) is implemented by network nodes (i.e., routers) and avoids multiple copies of the same datagram on the same link. Despite the conceptual simplicity of IP multicast and its obvious benefits, it has not been widely deployed since there remain many unresolved issues. As an alternative to IP multicast, overlay multicast (application-layer multicast) implements the multicast functionality at end hosts rather than routers. This may require more overall bandwidth than IP multicast because duplicate packets travel the same physical links multiple times, but it provides an inexpensive, deployable method of providing point-to-multipoint group communication. In this paper we develop an efficient method applied greedy algorithm for solving two models of overlay multicast tree building problem that is aimed to construct MDST (Minimum Diameter Spanning Tree : minimum cost path from a source node to all its receivers) and MST (Minimum Spanning Tree : minimum total cost spanning all the members). We also simulate and analyze MDST and MST.