• Polymer(Korea)
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• 제30권4호
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• pp.279-285
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• 2006

Non-viral gene carriers continue to attract a great deal of interest due to advantageous safety profile. Among the non-viral gene carriers, cationic liposomes or synthetic gene carriers are efficient DNA carriers in vitro. but their in vivo applications are greatly hampered because of low biocompatibility. On the other hand, chitosan, a natural cationic polysaccharide, is a candidate non-viral vector for gene delivery because of its low cytotoxicity and high positive charges. In this work, targeted gene carrier was synthesized to target artery wall cells using low molecular water-soluble chitosan (LMWSC). The molecular weight $(M_W)$ and degree of de acetylation (DDA) of LMWSC were measured by relative viscometer and Kina titration. respectively. The structure of LMWSC was analyzed by measuring FTIR, $^1H-NMR,\;and\;^{13}C-NMR$. AWBP-PEG-g-LMWSC was synthesized by conjugation of the artery wall binding peptide (AWBP), a specific targeting peptide, to the end of pegylated LMWSC as a gene carrier to target artery wall cells. The synthesized AWBP-PEG-g-LMWSC were analyzed by measuring FTIR, $^1H-NMR$, zeta -potentiometer, and atomic force microscopy (AFM).

• Proceedings of the KIEE Conference
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• 대한전기학회 2001년도 하계학술대회 논문집 C
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• pp.1820-1822
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• 2001

광파이버 패브리페로 간섭계에서 동작영역을 넓히기 위해 공진기의 길이를 1mm보다 짧은 초소형 간섭계를 구성하고자 하였을 경우, 광출력의 위상변화에 대한 감도가 낮아 전달함수로부터 변화된 위상을 복원하는 과정이 까다로워진다. 이러한 신호복원 과정에는 대부분 신호잡음비를 높여주는 신호처리 수단을 포함하게 되므로 간섭계가 겪은 위상변화를 보다 높은 신뢰성으로 검출하고자 할 때 어떠한 신호처리 방법이 적절한가하는 선택의 문제가 발생된다. 이는 각각의 신호처리방법이 장단점을 가지므로 응용목적에 따른 trade-off가 필요하기 때문이다. 본 연구에서는 참조 간섭계와 센서 간섭계 간의 correlation으로부터 위상을 검출하여 시스템의 잡음을 common mode 잡음으로 처리할 수 있었으며, 디지털 신호처리기법을 응용하여 짧은 공진기로 구성된 센서 간섭계의 위상변화분을 보다 안정적으로 검출하게 되었다.

• Journal of the Korean Society of Safety
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• 제16권4호
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• pp.200-207
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• 2001

The transmission of harmonic vibratory power form a vibrating rigid body into a supporting plate through passive and active isolators is investigated theoretically and experimentally. The theoretical model allows for the transmission of vertical and horizontal harmonic forces and moments about all three coordinate sun. The experiment is to use vibration actuators attached to the intermediate mass of the two-stage mount to minimize the rotational and translational vibration of the intermediate mass. The performance is done by measuring the vibration at the error sensors due to the primary vibration source and measuring the transfer functions from the control sources to the error sensors. Results show that over a frequence range from 1 to 100Hz, transmission into the supporting plate can be reduced substantially by employing in parallel with existing passive isolators, active isolators adjusted to provide appropriate control force amplitudes.

• Journal of the Korean Magnetics Society
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• 제22권4호
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• pp.136-141
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• 2012

In the this research, two simultaneous peaks of radial artery pulse wave and ECG pulse wave measured by using clip-type pulsimeter and ECG were investigated in order to analyze pulse wave velocity. The measured value of a pulse wave velocity is about 5~7 m/s, it is proved one new method to measure an exact value of pulse wave velocity more than the typical biomedical signal monitoring system. This result implies that data measured by the oriental medical diagnosis apparatus as pulsimeter is clinically used in future.

• Journal of the Korean Crystal Growth and Crystal Technology
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• 제1권1호
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• pp.74-81
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• 1991

The temperature profile of Czochralski single crystal growth system was simulated considering the fluid flow and surface radiation heat transfer. View factors of surface elements were calculated for radiation heat transfer. Two phases(solid and liquid) were treated as a continuous phase by assigning artificial large viscosity to the solid phase and latent heat was accounted by iterative heat revolution method. The solidification model was applied to solid front of the pure Ga during the melting to verify the model. The whole simulation model of CZ system was applied to the growth Al single crystal.

• Journal of the Korean Society for Railway
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• 제11권2호
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• pp.176-181
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• 2008

This paper presents results from experimental analysis of a friction-driven wheel responsible for generating wheel squeal noise. Squeal noise generating mechanism has been examined under the laboratory condition by the model rig on a small scale. Creep characteristics and squeal noise were observed by changing the possible variables, such as relative velocities and friction coefficients in time- and frequency-domain.

• Journal of the Korean Society for Precision Engineering
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• 제21권2호
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• pp.100-107
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• 2004

The development of a Web-based powertrain performance simulation system is introduced. The development approach of system architecture and each module is introduced along with the H/W and S/W used. The interface with all users is developed via a JAVA Applet. The powertrain modeling and other job history data of a user is managed systematically on the server by database to increase the reusability of the data. A self-developed program using object-oriented programming is used as a solver for the performance simulation. The graph tool for the analysis of simulation results has the collaboration support developed based on JAVA so that synchronous users can view the same result. As a result, the powertrain simulation is possible only with Web-browser for the user and the collaboration support among the relevant engineers is possible.

• Journal of Power System Engineering
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• 제16권1호
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• pp.78-83
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• 2012

The authors suggest the algorithm for the static analysis of a three dimensional solid structure by using the finite element-transfer stiffness coefficient method (FE-TSCM) and the hexahedral element of the finite element method (FEM). MATLAB codes were made by both FE-TSCM and FEM for the static analysis of three dimensional solid structure. They were applied to the static analyses of a very thick plate structure and a three dimensional solid structure. In this paper, as we compare the results of FE-TSCM with those of FEM, we confirm that FE-TSCM introducing the hexahedral element for the static analysis of a three dimensional solid structure is very effective from the viewpoint of the computational accuracy, speed, and storage.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 한국소음진동공학회 2002년도 추계학술대회논문집
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• pp.715-718
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• 2002

자동차 및 유체기계의 흡기계나 배기계에 사용되는 소음기의 음향성능은 전달손실로 기계성능은 배압으로 표현된다.유체가 흐르는 관 사이의 임피던스 부정합을 이용하는 반사형 소음기의 경우, 내부 유로에 천공을 주어 음향감쇠를 시키거나 유동을 안정시키는 경우가 많다.본 연구에서는 동심관형 공명기의 내부 관에 존재하는 천공의 분포 양상의 변화가 공명기 내부의 유동장에 미치는 영향을 살펴보고, 그 유동장의 변화에 따라서 소음기의 성능이 어떠한 영향을 받게 되는지를 고찰하였다.또한 유동장에 영향을 미치며, 소음기의 설계 인자 중 하나인 면적 확장비의 변화가 유동장 및 배압에 미치는 영향을 예측하였다.이로부터 유동의 흐름을 제어하여 소음기의 성능을 향상시키는 방법을 찾고자 한다.

• Journal of the korean Society of Automotive Engineers
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• 제14권3호
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• pp.57-70
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• 1992

As automobile industry develope, design techniques to satisfy light weight and high efficiency in automobile parts is demanded. In this study modal analysis is performed using transfer matrix method to identify dynamic characteristics of exhaust system. It is estimated the theoretical transfer function by Pestel-Leckey method and the mode shapes in 3-D graphic. the validity of developed program is verified by comparing with the experimental results of exhaust system. Estimated modal parameters(natural frequency, vibrational mode, transfer function) are in accord with the experimental results. From the developed program, we can predict a location of the hanger which is determined by the lowest RMS value point, when displacement is given as an input at the engine side. We can find that attachment of spring modelled hanger at the hanger location bring vibration level down.