• The Journal of the Korea Contents Association
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• v.18 no.11
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• pp.655-664
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• 2018

Retina transforms the external light into electrical signal that stimulates visual cortex of the brain. Electrical modeling of the retina is useful to understand its structure and action that is a prerequisite to implement the retina as a hardware device. This paper introduces a 2-D electrical network model of vertebrate's retina considering signal pathway of retinal cells and synapses. We implemented a simulator of the retina based on the electrical network model to analyze its operation under various circumstances. Compared to the prior studies, It might contribute designing of artificial retina device in terms of that this study specifically observed input and output reactions of each cell and synapse node under various light intensity on the retina.

• 한국지형공간정보학회:학술대회논문집
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• 2002.11a
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• pp.111-116
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• 2002

우리나라 응급의료체계의 구축은 선진국이 1960년대 초 시작한 반면 1980년 이후 구축되기 시작하여 아직까지 미흡한 편이다. 사고 및 재해 발생시 응급환자에 대한 적절한 처치는 관련정보가 빠르게 전달되고, 적절하게 사용되어 응급환자로 하여금 지체시간내에 얼마나 적합한 응급의료서비스를 수혜토록 하느냐가 가장 중요하다. 이를 위해 본 연구는 의료기관, 소방서 등 의료체계의 실태조사를 통하여 현재의 응급의료체계의 현황과 문제점을 분석하였다. GIS를 이용하여 119구급차 등 응급차량이 가는 경로와 일반 시민들이 이용할 수 있는 응급경로탐색에서 많은 영향을 미치는 교통요소, 좌회전, 우회전, 경유지, 시간대별 교통량을 고려하였다. 그리고 환자의 상태에 따른 병원을 찾도록 정보를 제공하였다. 이러한 교통요소 및 병원에 대한 정보를 제공함으로서 보다 나은 환자이송에 최적경로를 제시하고자 하였다.

• Journal of Life Science
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• v.32 no.11
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• pp.833-840
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• 2022

Chronic inflammation has been shown to be closely associated with tumor development and progression. Nuclear factor kappa B (NF-κB) is composed of a family of five transcription factors. NF-κB signaling plays a crucial role in the inflammatory response and is often found to be dysregulated in various types of cancer, making it an attractive target in cancer therapeutics. In this study, CDC-like kinase 3 (CLK3) was identified as a novel kinase that regulates the NF-κB signaling pathway. Our data demonstrate that CLK3 inhibits the canonical and non-canonical NF-κB pathways. Luciferase assays following the transient or stable expression of CLK3 indicated that this kinase inhibited NF-κB activation mediated by Tumor necrosis factor-alpha (TNFα) and Phorbol 12-myristate 13-acetate (PMA), which are known to activate NF-κB signaling via the canonical pathway. Consistent with data on the ectopic expression of CLK3, CLK3 knockdown using shRNA constructs increased NF-κB activity 1.5-fold upon stimulation with TNFα in HEK293 cells compared with the control cells. Additionally, overexpression of CLK3 suppressed the activation of this signaling pathway induced by NF-κB-inducing kinase (NIK) or CD40, which are well-established activators of the non-canonical pathway. To further examine the negative impact of CLK3 on NF-κB signaling, we performed Western blotting following the TNFα treatment to directly identify the molecular components of the NF-κB pathway that are affected by this kinase. Our results revealed that CLK3 mitigated the phosphorylation/activation of transforming growth factor-α-activated kinase 1 (TAK1), inhibitor of NF-κB kinase alpha/beta (IKKα/α), NF-κB p65 (RelA), NF-κB inhibitor alpha (IκBα), and Extracellular signal-regulated kinase 1/2-Mitogen-activated protein kinase (ERK1/2-MAPK), suggesting that CLK3 inhibits both the NF-κB and MAPK signaling activated by TNFα exposure. Further studies are required to elucidate the mechanism by which CLK3 inhibits the canonical and non-canonical NF-κB pathways. Collectively, these findings reveal CLK3 as a novel negative regulator of NF-κB signaling.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.18 no.2_spc
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• pp.275-289
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• 2020

In 2017, multimodal transportation tests for evaluating road, sea, and rail transport were performed by research institutes in the US, Spain, and the Republic of Korea. In this study, acceleration and strain data determined through road and sea tests were analyzed. It was investigated whether the load generated for each transport mode was amplified or attenuated according to the load transfer path. From the results, it was confirmed that the load transfer characteristics differed according to the transportation mode and loading path. The effects of strain determined through each test on the structural integrity of the spent nuclear fuel were also investigated. It was found that the magnitude of the measured strain had a negligible effect on the structural integrity of the spent nuclear fuel, considering its fatigue strength. The results for the acceleration and strain data analyses obtained in this study will be useful for scheduled domestic transportation tests under normal transport conditions.

• Journal of Drive and Control
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• v.13 no.2
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• pp.19-25
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• 2016

Recently, drivers have begun to regard comfort in the cabin as one of the most important factors in construction equipment like forklifts. Accordingly, it has become more important to design a forklift cabin with a better sound quality as well as lower sound level, which can make a driver more comfortable. In this paper, the correlation between subjective evaluation and Zwicker's sound quality index was analyzed through a blind test by a few workers in forklifts and other construction equipment in several countries. Correlation analysis showed that Loudness and Sharpness were ranked in sequence, and tendencies were different from country to country. Also, contribution analysis for Loudness and Sharpness using operational transfer path analysis (OTPA), which is widely used in the field of noise, vibration, and harshness (NVH), was performed. However, Loudness and Sharpness cannot be used with OTPA directly because there are no linear relationships between the sources and receivers. In this paper, both are calculated by applying the DIN 45631 method with a contribution rate (%) of 1/3 Octave Sound Pressure Level by OTPA method in addition to considering spectral masking.

• International Area Studies Review
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• v.15 no.3
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• pp.175-188
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• 2011

This study aims to examine how the U.S. economic shocks affect the Japanese economy. It is widely believed that the U.S. economy has a significant effect on the Japanese economy. Actually, the U.S. accounts for a considerable amount of Japan's exports and imports. To the economic policymakers, it is very important to know how economic disturbances generated by the U.S. are transmitted to the Japanese economy. A vector autoregression(VAR) model is employed to investigate the international transmission channel of economic disturbances. The interactions of the U.S.-Japansese economy are investigated by using variance decompositions(VDCs). The results of this study provided the evidence that the U.S. economic shocks were important for the Japanese economy during the sample period. This study supports the notion of economic dependence of smaller open economy such as Japan as compared with larger economy such as the U.S.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2008.11a
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• pp.705-706
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• 2008

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.23 no.2
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• pp.176-184
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• 2013

Quantification of road noise is a challenging issue in the development of tire noise since its transfer paths are complicated. In this paper, a simplified model to estimate the road noise is developed. Transfer path of the model is from wheel to interior. The method uses the wheel excitation force estimated throughout inverse method. In inversion procedure, the Tikhonov regularization method is used to reduce the inversion error. To estimate the wheel excitation force, the vibration of knuckle is measured and transfer function between knuckle and wheel center is also measured. The wheel excitation force is estimated by using the measured knuckle vibration and the inversed transfer function. Finally interior noise due to wheel force is estimated by multiplying wheel excitation force in the vibro-acoustic transfer function. This vibro-acoustic transfer function is obtained throughout measurement. The proposed method is validated by using cleat excitation method. Finally, it is applied to the estimation of interior noise of the vehicle with different types of tires during driving test.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.7 no.3
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• pp.105-116
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• 1997

Routing security is related to the confidentiality of the route taken by the data transmitted over the network. If the route is detected by the adversary, the probability is higher that the data are lost or the data can be intercepted by the adversary. Therefore, the route must be protected. To accomplish this, we select an intermediate node secretly and transmit the data using this intermediate node, instead of sending the data to the destination node using the shortest path. Furthermore, if we use a number of secret routes from the starting node to the destination node, data security is much stronger since we can transmit partial data rather than the entire data along a secret route. In this paper, the routing algorithm for multiple secret paths on MRNS(Mixed Radix Number System) Network, which requires O(1) for the time complexity where is the number of links on a node, is presented employing the HCLS(Hamiltonian Circuit Latin Square) and is analyzed in terms of entropy.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.7 no.1
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• pp.52-56
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• 2006

This paper presents a cross-eye characteristics of multi-path wave scattering. Cross-eye method uses the phase differences of multi signals and is used fur electronic protection. When a signal is propagated from transmitter to receiver on the ground surface, direct wave and reflected wave signals are combined in front of the receiving antenna with different phases. To calculate and control the amplitude and phase of reflected signal, we have developed a cross eye electronic protection method for radar system and studied the variation of electric power density.