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Inhibitory Effects of a Herbal Composition (HemoHIM) on the Activation of Human Mast Cell Line (HMC-1) (생약복합조성물(HemoHIM)의 사람 비만세포주 활성 억제 효과)

  • Kim, Jong-Jin;Jo, Sung-Kee;Jung, U-Hee;Park, Hae-Ran;Yee, Sung-Tae
    • Journal of Life Science
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    • v.19 no.12
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    • pp.1808-1814
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    • 2009
  • In our previous study, a new herbal preparation (HemoHIM) was developed as a functional food for the radioprotection and immunomodulatory agents. In order elucidate the mechanism involved, we examined the effect of HemoHIM on the compound 48/80-induced histamine release, and on the phorbol 12-myristate 13-acetate (PMA)/calcium ionophore (A23187)-induced inflammatory cytokine secretion in HMC-1. The cell culture supernatants were harvested, and the cytokines (IL-4, IL-6, IL-8, TNF-$\alpha$, GM-CSF) in the supernatants were measured by enzyme-linked immunosorbent assay. The total RNA of the cells was extracted, and the cytokines or c-kit/tryptase/Fc$\varepsilon$RI's messenger RNA expressions were examined using reverse transcriptase polymerase chain reaction. Under low concentrations, HemoHIM inhibited histamine release in HMC-1 stimulated compound 48/80. Furthermore HemoHIM inhibited PMA/A23187-induced inflammatory cytokines' secreation or mRNA expression in a dose-dependent manner. But IL-8 secretion was not inhibited by low concentrayion of HemoHIM, respectively. The mRNA expression of c-kit and Fc$\varepsilon$RI were also inhibited in a dose-dependent manner. Tryptase mRNA expression was only inhibited by low concentration of HemoHIM. These results indicated that HemoHIM might be an useful agent for protection against allergy as well as immune modulation, especially since it is a relatively nontoxic natural product.

A Study on the Construction and Application of Administrative Boundary (행정경계 구축 및 활용방안에 관한 연구)

  • Choi Yun-Soo;Kwon Jay-Hyoun;Lee Im-Pyeong;Park Ji-Hye
    • Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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    • v.24 no.2
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    • pp.201-208
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    • 2006
  • Currently, 1/5,000 Digital Topographic Map covers the whole country with administrative boundary of Gu, while some region has already been constructed with 1/1,000 digital topographic map has legal boundary of Dong. Here, Dong in 1/1,000 scale represents the legal boundary which is used in the address most of time. Therefore, there is no administrative-Dong yet although it is very useful in various fields. In this study, we suggested a method to construct the administrative boundary extending to the level of Dong empirically. In addition, the practical application of the administrative boundary in GIS is discussed. Two methods are applied to construct the administrative boundary to the level of administration-Dong; using the edited cadastral map and the digital topographic map. When the edited cadastral map is used, some problems such as boundary discordance to superordinate administrative area is appeared. On the other hand, using digital topographic map showed simple construction processes and easy connection with other framework data. Therefore, it is recommended that the digital topographic map should be used in the construction of the administrative boundary. It would be useful as framework data in various industries and public operations.

Studies on the Current Epidemiological Situation of Brugian Filariasis in Endemic Areas of Korea (최근 국내 사상충증의 역학적 상황에 관한 조사)

  • 백영한;조유정
    • Parasites, Hosts and Diseases
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    • v.26 no.4
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    • pp.255-262
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    • 1988
  • An epidemiological study on brugian filariasis was carried out in endemic areas including Cheju Island in Korea, with a brief review of literatures. The results showed that the incidence among residents has remarkably decreased in Cheju Island, which was the main endemic area. Reviewing available informations on the prevalence of filariasis reported in recent years and also judging from the present socio·economic conditions which enable people to practice personal protection against mosquitos, it can be said with confidence that alariasis has almost disappeared from Cheju Island and inland areas. The disease is considered to remain at a low level of endemicity in Hugsan Islands. Certainly mass diethylcarbamasine (DEC) treatment carried out in Cheju Island in the 1960s and 1970s and remarkable economic growth followed by improved living standard and altered life-style of inhabitants could all have combined effects on the disappearance of this mosquito-borne disease in this island. If the present trends go on, the possibility of resurgence of filariasis in Cheju Island is hardly postulated.

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Study on the Basic Survey and Materials Properties for Conservation of Plastic Artifacts: 'A Bag of Alice - a Fish without Eyes' (플라스틱 작품의 기초조사 및 보존처리 재료 연구: 이인희 '앨리스의 가방 - 눈 없는 물고기'를 중심으로)

  • Han, Ye Bin;Kim, Jung Heum;Beom, Dae Geon
    • Journal of Conservation Science
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    • v.34 no.5
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    • pp.379-385
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    • 2018
  • This study examined the condition of degraded plastic artifacts and conducted materials assessments for conservation treatment. The properties and bond characteristics of five types of adhesives(EVA, PVAc, Cyanoacrylate) were evaluated to select the adhesive most suitable for conservation treatment. The degradation of plastic artifacts caused cracks, peelings, and surface warping. According to the FT-IR analysis, the synthetic resin used in the artifact was estimated to EVA type. The properties of the adhesives were evaluated through acidity, and hardness measurements. The results showed that acidity varies with the type of adhesive, and that the hardness of PVAc was higher than those of EVA. On comparing the bond characteristics of the samples after artificial degradation, it was found that PVAc and Cyanoacrylate increased the chromaticity and hardness of the samples, while EVA was the most stable with relatively little change. Thus, EVA was confirmed to be the most suitable materials for conservation treatment of degraded plastic artifacts. In this study, as the experiment of treatment materials based on actual artifact, it is expected that it could be used a basis research for conservation treatment of plastic artifacts.

The Study on the Internet-based Virtual Apartment Remodeling and Auto Estimation Simulator (인터넷 기반의 아파트 리모델링 및 자동 내역산출을 위한 시뮬레이터 디자인 연구)

  • 서재은;김성곤
    • Archives of design research
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    • v.15 no.1
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    • pp.191-202
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    • 2002
  • As family types have been diverse, patterns of living and living space became diverse as much as users are. Therefore, it is needed to provide various remodeled design of living space corresponding to changes of users'living patterns, and to provide these remodeling process to users directly on the web. In this paper, use scenario for the Internet-based Virtual Apartment Remodeling Simulator is researched as an export system to remodel space in accordance with users diverse lifestyle paradigm and the website is developed. The study consists of four parts. First, the general concept of remodeling, including the range and types of remodeling, are defined, and the misleading terms in this field are reviewed and organized by secondary research Second, fixed factors and variable factors are differentiated in the complex building for residence and business that was decided as a basic building type in this study. Third, there needed a database for consulting, final material, pre-estimation real estimation for simulation of remodeling. This database was introduced along with floor plan and elevation. Finally, the remodeling simulator is presented by the case study developed on the web. The system structure and use scenario are also presented. In order to present and inspect design alternatives, prototype was produced. The Final simulator was enhanced by defeating problems regarding interface efficiency and missing information of existing online site.

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Implementation of Annotation-Based and Content-Based Image Retrieval System using (영상의 에지 특징정보를 이용한 주석기반 및 내용기반 영상 검색 시스템의 구현)

  • Lee, Tae-Dong;Kim, Min-Koo
    • Journal of KIISE:Computing Practices and Letters
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    • v.7 no.5
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    • pp.510-521
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    • 2001
  • Image retrieval system should be construct for searching fast, efficient image be extract the accurate feature information of image with more massive and more complex characteristics. Image retrieval system are essential differences between image databases and traditional databases. These differences lead to interesting new issues in searching of image, data modeling. So, cause us to consider new generation method of database, efficient retrieval method of image. In this paper, To extract feature information of edge using in searching from input image, we was performed to extract the edge by convolution Laplacian mask and input image, and we implemented the annotation-based and content-based image retrieval system for searching fast, efficient image by generation image database from extracting feature information of edge and metadata. We can improve the performance of the image contents retrieval, because the annotation-based and content-based image retrieval system is using image index which is made up of the content-based edge feature extract information represented in the low level of image and annotation-based edge feature information represented in the high level of image. As a conclusion, image retrieval system proposed in this paper is possible the accurate management of the accumulated information for the image contents and the information sharing and reuse of image because the proposed method do construct the image database by metadata.

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유기농 이유식 제품 제조 기술 현황과 소비 전망

  • Sin, Hyeon-Ho
    • 한국유가공학회:학술대회논문집
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    • 2006.06a
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    • pp.29-45
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    • 2006
  • 최근에 들어 웰빙(well-being)과 함께 로하스(LOHAS: Lifestyle of Health and Sustainability)란 개념이 급속도로 확산되고 있으며, 이를 만족하는 식품으로 친환경 농산물과 유기 가공 식품이 대두되고 있다. 여러 마케팅 조사에서도 친환경 농산물과 유기 가공 식품의 소비자 선호도는 상당히 높게 나타난다. 이러한 다양한 소비자의 요구에 맞춰 우리의 2세에게 더욱 안전하고 좋은 품질의 이유식을 제공하고 나아가 한계에 이른 '지구와 환경을 해치지 않는 지속가능 한 소비'를 유도하고자 업체들은 유기농 이유식을 개발하고 있다. 유기농 소비자 10명 가운데 7명은 최근의 웰빙 붐 때문에 유기농에 관심을 가지게 됐으며, 가격이 다소 비싸더라도 가족의 건강을 위해 친환경 농산물을 구입하는 것으로 나타났으며, 국내외를 막론하고 친환경 농산물과 유피 가공 식품의 시장 동향을 살펴보면 지속적으로 증가하고 있으나, 아직까지 일반 제품에 비해 미미한 수준이며, 국내는 인증 제도가 없으나, 유기 가공 식품표시기준에 따라 표시되고 있다. 일반적으로 이유식이라 함은 식품공전에서 영 ${\cdot}$ 유아용 곡류 조제식만을 말하지만 넓게 축산물의 조제유류, 영아용 조제식, 성장기용 조제식, 기타 영 ${\cdot}$ 유아식을 포함할 수 있으며, 유기농 이유식 제조 현황을 살펴보면 동결, 분무, 드럼 등의 건조와 퍼핑이나 Extruder를 통한 알파화로 원료를 가공하여 은 살균, 멸균, 균질, 혼합, 건조, 냉각, 포장 등의 다양한 공정으로 이루어진 분무건조나 유동층이나 연속식 과립기를 사용하여 분말이나 입자형 이유식을 생산하며, 동결 건조를 하여 열수를 가해 죽 상태로 먹을 수 있도록 한 제품, 데워서 떠 먹일 수 있도록 병조림이나 레토르트 유동식 제품, 바로 마실 수 있는 쥬스류, 두유류, 과자 등으로 생산하고 있다. 주된 메이저4사는 일동후디스, 남양유업, 매일유업, 파스퇴르유업으로 다양한 제품들을 생산하고 있으며, 두유를 위주로 한 정식품, 연세우유와 종근당건강, 다양한 다국적 기업들의 제품이 수입되고 있는 실정이다. 이유식 시장도 96년 하반기부터 정체를 보이는 상태다. 2002년도 이유식 시장은 약 1,300억원 규모로 업체들의 고가 신제품과 유기농 이유식 출시로 판매 금액은 소폭 상승하였으나 판매 수량은 큰 변동이 없다. 저출산에 따른 양육비 집중과 유기농 제품에 대한 저변이 크게 확산돼 베이비 웰빙은 어느 정도 예견된 일이거니와 이미 미국 등 선진국에선 유아에 그치지 않고 아동까지 유기농과 고급 원료를 사용한 고가의 웰빙 제품이 봇물을 이루고 있는 상황이어서 유아식 시장은 어느 때보다 경쟁이 치열할 것이며, 국내 식품 업체들이 너도나도 유기농 제품과 매장사업에 뛰어들고 있다. 유기 가공 식품의 지속적인 발전을 위해서 (1) 국내산/수입산 공통으로 인증 제도가 도입되고 원료 농산물뿐만 아니라, 모든 공정이나 공장에 대한 종합적 관리와 동일한 인증 표시가 이루어져야 한다. (2) 정부 부처의 이기를 타파할 수 있는 법정부적 기구나 대책이 필요하다. (3) 유기 가공 식품을 취급하는 업계에서는 기존 3%의 비의도적 혼입치의 고려나 상한선 재설정을 요구하고 진정한 유기 가공 식품으로 공정 경쟁한다. (4) 활발한 인증심사원의 교육과 배출로 인증이나 심사기관의 민간 이양을 적극 장려하고 국가관 상호 신뢰를 구축한다. (5) 각 소비자 단체나 소비자는 환경을 살리고 생명체의 공생이라는 관점에서 최선의 길이 유기농 제품임을 인식하고 소비하여 우리의 다음 세대에게서 빌려온 소중한 환경을 물려준다.

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Evaluation of Two Levels and Types of Acorn Powder on Product Quality of Low-fat Sausages as a Fat Replacer (도토리 가루의 첨가량과 첨가 형태가 지방대체제로서 저지방 소시지의 품질에 미치는 효과)

  • Chin, Koo-Bok;Ban, Gwang-Hoon
    • Journal of Animal Science and Technology
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    • v.50 no.2
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    • pp.217-226
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    • 2008
  • Product quality of low-fat sausages(LFSs) manufactured with two types(powder and hydrated) and two levels(0.5 and 1.0%) of Acorn powder was evaluated as a potential fat replacer. The addition of Acorn powder did not affect the product quality of LFSs (P>0.05), however 0.5% and hydrated Acorn was better sensory flavor than 1.0% and powder counterparts. The addition of Acorn into the LFSs decreased the expressible moisture(%) except for 0.5% powder type and decreased Hunter L-values in LFSs. The addition of 1.0% hydrated Acorn lowered sensory saltiness than those of other LFSs and regular-fat control. These results indicated that Acorn powder can be used to manufacture LFSs as a fat replacer and 0.5% with hydrated form had better characteristics than 1.0% and powder counterparts. Future research will be performed to prevent the color change with the addition of Arcon powder in LFSs.

A Study on the Success Factors of Port Operation for New International Passenger Terminal Using Fuzzy Theory (퍼지이론을 이용한 인천항 신국제여객터미널의 항만운영 성공요인에 관한 연구)

  • Yoo, Sung-Jai;Cha, Young-Doo;Yeo, Gi-Tae
    • Journal of Digital Convergence
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    • v.14 no.11
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    • pp.91-100
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    • 2016
  • The purpose of this study was to draw out success factors of port operation for New International Passenger Terminal(NIPT) in Incheon Port using the fuzzy method. In this study, the success factors of port operation were firstly selected by literature review and finally adopted them by in-depth interview with experts who had working experiences over 15 years in the field of Korea-China Carferry shipping business and stevedoring business. Success factors of port operation of the NIPT have been classified into four principal factors such as 'land's use side', 'productivity side', 'cost side' and 'services side', and the comparative analysis was conducted among success factors of port operation. According to the results of analysis, in terms of "land's use side", securing CY space of full-empty containers(0.857) was the most important factor. Among detailed factors of "productivity side", building terminal automation system(0.806) was significantly needed. In the factors of "cost side" and "service side", land rental costs(0.861) and schedule management of berth operation(0.798) were selected as the most important factors. Consequently, new international passenger terminal has implications that the main port operations should focus on reasonable rents calculation, ensuring proper space of CY, and building automation system of terminal, There is a need to proceed to conduct a comparative study of the same operating mode of an international passenger terminal.

Design and Implementation of Distributed Active Object System(DAOS) for Manufacturing Control Applications (공정 제어 응용을 위한 분산 능동 객체 시스템(DAOS)의 설계 및 구현)

  • Eum, Doo-Hun;Yoo, Eun-Ja
    • Journal of KIISE:Computing Practices and Letters
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    • v.7 no.2
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    • pp.141-150
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    • 2001
  • Manufacturing conb'ol applications consist of concurrent active components such as robots, AGV's (Automatic Guided Vehicles), and conveyors. Running of manufacturing control programs is interactions among those components. We can enhance the productivity and extendability of manufacturing control applications by using the object-oriented teclmology that models those components as reusable objects. But the objects in current object-oriented technology that encapsulate state and behavior infonnation are passive in a sense that those respond only when messages are sent to them. In this paper, we introduce the Distributed Active Object Systems (DAGS) approach that SUPPOltS active objects. Since active objects encapsulate control infonnation in addition to state and behavior information under COREA/Java-based distributed environment, they can represent manufacturing control components better than the objects in ordimuy object-oriented technology. TIus control infonnation provides an object with a featme that can monitor its own status as well as other object's status connected by intelface valiables. Active objects can initiate a behavior according to the change of those status. Therefore, we can sb-uctmally assemble self-initiating active objects by using intelface variables to construct a system without describing bow to control distributed objects by using message passing. As the DAOS approach supports object composability, we can enhal1ce the productivity and extendability of disbibuted manufactming control applications even better than the ordil1alY object-oriented approach. Also, the DAOS approach supports better component reusability with active objects that encapsulate control information .

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