• Korean Journal of Psychosomatic Medicine
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• v.21 no.2
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• pp.140-146
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• 2013

Objectives: We compared the characteristics of the pain threshold and pain experience between demented group and non-demented group. Methods: This study was part of Gangwon projects for early detection of dementia in 2010. We recruited 8302 local resident ages over 65 years old. Of theses, 1259 people who scored low MMSE were selected and 365 of them completed CERAD-K(Consortium to Establish a Registry for Alzheimer's disease). Finally, 90 in non-demented group and 57 in demented group(mild to moderate Alzheimer's disease) were analyzed. Pain threshold was experimentally measured by pressure algometer and we investigated the pain experience, by Brief pain inventory (BPI), a self-report test. Results: In the demographic characteristics, there are more female, higher ages, lower education in the demented group. There was no significant difference between the two groups in the pain threshold. On the BPI results, 'shoulder pain', 'the number of pain' and 'interference of working' were significantly more prevalent in non-demented group. However, there are no significant differences between the groups in the 'pain severity', 'prevalence of pain' and 'pain treatment'. Conclusions: Demented group report less pain experience but, still perceived pain. It support previous studies that patient with dementia have increased pain tolerance but preserved pain threshold. Thus, active pain assessment and treatment for patients with dementia is needed.

• Korean Journal of Food Science and Technology
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• v.48 no.6
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• pp.604-609
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• 2016

In postmenopausal women, estrogen deficiency can be associated with metabolic diseases, such as obesity, diabetes, and cardiovascular diseases. The purpose of this study was to investigate factors related to lipid, glucose and antioxidnat metabolism. Sprague-Dawley female rats were subjected to either bilateral ovariectomy or sham operation and randomly divided into 3 dietary groups, (n=8) sham-operated fed with normal diet (SHAM), ovariectomized fed with normal diet (OVX), and ovariectomized fed with normal diet supplemented with Eucommia ulmoides extract (OVX-EU). The OVX-EU group showed significantly lower body weight, triacylglycerol, and total cholesterol than that showed by the OVX group. In addition, the OVX-EU group showed improved lipogenesis, glucose-regulating enzyme activities, adipokine and antioxidant enzyme activities. These findings demonstrate that extracts from E. ulmoides extract can be used as a functional food.

• Journal of Life Science
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• v.19 no.12
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• pp.1841-1846
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• 2009

Menopause is often associated with the incidence of several chronic diseases including osteoporosis, cardiovascular disease, and obesity. Hormone replacement therapy (HRT) is an effective regimen that has been found to prevent these diseases in postmenopausal women. However, HRT is accompanied by an increased risk of unfavorable outcomes. Therefore, this study was conducted to evaluate the effects of Ecklonia cava, a kind of seaweed, extract on bone turnover markers in symptomatic menopausal women. For this study, the following four groups of 9-week-old Sprague-Dawley rats were evaluated over 6 weeks: normal rats (SHAM), ovariectomized rats (OVX-CON) and ovariectomized rats that were treated with Ecklonia cava extracts. The optimum extraction temperature and solvent of Ecklonia cava were found to be $80^{\circ}C$ and 80% ethanol. We measured the osteocalcin and CTx content, enzyme ALP activity in serum and collagen content in the cartilage, bone, skin and lungs. We found that the levels of indicators of bone metabolism such as ALP, osteocalcin and CTx were lower in rats in the Ecklonia cava extract group than the OVX-CON group. In addition, the collagen contents in the bone, cartilage, skin and lungs decreased in response to ovariectomy, but the levels of collagen were greater in the bone of rats that were treated with Ecklonia cava extract than in the bone of rats in the OVX-CON group. According to these results, we were able to know the effects of Ecklonia cava extract on bone aging in ovariectomized rats. Consequently, we expect Ecklonia cava extract to have an effect on bone aging in postmenopausal women.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.1
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• pp.183-188
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• 2008

Osteoporosis is one of the major health problem affecting postmenopausal women. Estrogen deficiency results in an increase in bone turnover, lead to bone resorption and an increase risk of fracture. The aim of this study was to evaluate the effects of Platycodon grandiflorum A. extract (PG) in bone metabolism in ovariectomized estrogen-deficient rats. Two groups were surgically ovariectomized (OVX). The third group was sham operated. Sprague-Dawley female rats were randomly assigned to the following groups : sham-operated rats (Sham), ovariectomized control rats (OVX-control), ovariectomized rats supplemented with PG at 50mg/kg body wt (OVX-PG50) The Platycodon grandiflorum extracts were orally administrated at 1mL per day. The ovariectomy caused a decreasing in the levels of collagen content in bone, cartilage and skin tissues. However PG group, supplementation with Platycodon grandiflorum extract, were increased the level of collagen content in bone, cartilage and skin tissues than OVX-control group. PG group had a higher content of pyridinoline in collagen than OVX-control group. Alkaline phosphatase activity on serum were decreased after supplemented with the PG extract. These results might be expected that Platycodon grandiflorum is believed to be possible protective effects in postmenopausal bone loss.

• Proceedings of the KAIS Fall Conference
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• 2009.05a
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• pp.114-118
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• 2009

주요 일간지와 KBS 1 9시 뉴스에서 다루고 있는 건강관련 기사의 내용을 분석하여, 건강관련 정보의 경향을 파악하여, 건강 예보제 실시를 위한 현황 분석을 위해 본 연구를 실시하였다. 1. 일간지 건강정보 내용분석 결과요약: 기사 보도 분야에서는 생활건강(47.8%), 사회(14.6%), 종합(7.7%), 국제(4.7%), 경제(1.5%) 순이었고, 3/4분기에서만 국제와 경제 분야가 종합분야 보다 많이 보도 되었으며, 기타 분야가 22.9%로 많은 비율을 차지하였다. 건강정보를 대상 성별별로 분류 하였을 시 남녀 모두에 해당되는 자료가 대다수였고(87.9%), 여성이 대상인 정보(8.0%)가 남성(4.1%)보다 많았으며, 생애 주기별 대상으로 분류 하였을 시에 역시 특별히 구분되지 않은 모든 연령층에 해당 정보가 가장 많았고(60.8%), 성인(19.8%), 학동기 어린이(7.3%), 청소년 (4.9%), 노인(4.9%), 영유아(3.3%) 순이었다. 일간지별 기사의 주제를 조사한 결과 두 일간지의 총합은 병의 원인 및 위험인자(15.5%)가 가장 많이 보도 되었는데, 조선일보는 건강증진, 치료 및 술기, 투약, 기타의 순이었고, 한겨레신문은 건강증진, 행정, 치료 및 술기, 투약 순이었으며 각 주제별로 분기별로 약간의 차이를 나타내었다. 예측성에 관한 내용분석을 보면 예보성은 있는 경우(76.2%)가 없는 경우보다 많았고, 예보성의 정보는 알림성, 예측성, 행사성의 순이었고 예측성의 경우 건강형태가 가장 많았으나 한겨레 신문의 경우 기타에 속하는 경우가 가장 많았다. 사 ICD-10 체계, 21대 분류로 질병에 관한 기사를 분류한 결과 신생물(14.5%), 특정 감염성 및 기생충성 질환(13.6%), 정신 및 행동장애(9.5%)의 순이었으며 두 일간지간의 차이를 보였다. 2. TV 뉴스 건강정보 내용분석 결과요약: 건강정보의 대상 특징 성별은 모두 해당되는 경우가 265회 중 238회 (89.8%)로 가장 많았고, 생애주기별 대상으로 보면 모든 연령층에 해당 되는 것이 154회(58.1%)로 가장 많았다. 건강정보의 주제에 대해서 조사한 결과 병의 원인 및 위험인자가 73회(27.5%), 역학(역학조사 및 보도성)이 64회 (24.2%), 행정이 30회(11.3%), 증상 및 호소가 27회(10.2%) 등의 빈도순으로 조사 되었다. 건강정보의 내용의 분야를 보면 대분류로는 질병관리 분야가 102회(38.5%), 보건의료제도 및 행정 분야가 52회(19.6%), 보건행태 및 기타 42회(15.8%), 생활환경분야 39회(14.7%)의 빈도순으로 나타났다. 건강정보 내용을 질병의 분류 ICD-10 체계로 분석한 결과는 특정감염성 및 기생충성 질환 48회(26.8%), 소화기계의 질환, 손산, 중독 및 외인에 의한 특정기타 결과, 건강상태 및 보건서비스 접촉에 주는 요인 등의 빈도순으로 조사되었다.

• Development and Reproduction
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• v.5 no.1
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• pp.59-71
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• 2001

Since the first radioimmunoassay (RIA) was developed in 1970s, many conventional RIAs and non-isotopic immunoassays (NIA) had been developed in which the degree of precision, accuracy, specificity and practicability have progressively increased. Recently ultrasensitive assay method at femtogram to determine testosterone in serum, saliva and feces is required for the study of sexual dysfunctions in male and female, monitoring the psychological stress and conditions, aging process such as menopause and partial androgen deficiency in aging male, the hormonal changes of small experimental animals etc. This review discussed the recentd evelopments of steroid assay methods, based upon the testosterone assay results of authors far 20 years, and the problems associated the assay set-up, the characterizations and applications of the established procedures, and desifls of assay, reliablity criteria, and the practical aspects of assay set-up and application, based upon the data of the authors. The present study demonstrates the general problems methods to be consider in order to set up the highly sensitive assay methods and to increase the assay quality and the necessity of assay quality control program. To improve the assay quality of each laboratory and to compare the assay results in homeland, the national QC programs should be organized.

• The Journal of the Korea Contents Association
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• v.12 no.9
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• pp.250-256
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• 2012

Disease, such as osteopenia, osteoporosis, etc caused by reduced bone density are common to women after menopause and as the social medical cost increases due to osteoporosis fractures the medical interest in bone density reduction has increased. The bone density reduction is observed even for renal failure patients, due to their decreased ability to synthesize vitamin D which leads to bone fibrosis because of deficiency in calcium absorption. Thus renal failure patients not only suffer from kidney dysfunction, but also are exposed to complications, such as osteoporosis, due to reduced bone density. This research observed the change in bone density of patients receiving renal failure treatment and analyzed the change in bone density before and after kidney transplantations. Subjects were 214 renal failure patients at the department of nephrology Busan B General Hospital. The change in bone density was studied for subjects with and without kidney transplantation according to their age and sex. The research showed improvement or maintenance of bone density for subjects that received kidney transplantation, but showed a tendency of consistent decrease in bone density for subjects without kidney transplantation. Kidney transplantation can be considered as the best cure for renal failure patients, and this researched confirmed that bone density can be improved through kidney transplantation. Thus, this study can also be used as data for preventing complications due to renal failures.

• Journal of the korean academy of Pediatric Dentistry
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• v.32 no.2
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• pp.256-261
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• 2005

Scleroderma is a connective tissue disease of unknown etiology, but known as a kind of auto-immune disease. It is most common in women especially in $30{\sim}50$ years, and very rare in childhood. It can be classified into two main classes : localized scleroderma & systemic sclerosis. Localized type has better prognosis, and usually involves skin only, or in some cases, the muscle below, except inner organs. Systemic type involves skin, oral mucosa and major internal organs. Involving facial skin, we can see small and sharp nose, expressionless stare and narrow oral aperture. Usually they have Raynaud's phenomenon, and in progress, show mouth opening limitation and sclerosis of tongue and gingiva. It is called CREST syndrome showing calcinosis cutis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly, and telangioectasia. Treatment of scleroderma is systemic and localized steroid therapy, use of collagen-link inhibitor (D-penicillamine), immune depressor and etc. Mouth opening limitation can be improved by mouth stretching exercise. We report a 6 years old boy, diagnosed with localized scleroderma who had mouth opening limitation. We could get additional mouth opening, and have done successful restorative treatment of mandibular and maxillary 1st and 2nd deciduous molar under deep sedation with nitrous oxide and enflurane.

• Clinical and Experimental Reproductive Medicine
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• v.33 no.2
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• pp.133-138
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• 2006

Female phenotype of a 46,XY male may originates from male pseudohermaphroditism due to $17{\alpha}$-hydroxylase deficiency. Lack of cortisol increases adrenocorticotropic hormone (ACTH) and mineralocorticoid production, leading to low renin hypertention and hypokalemia. A 41-year-old phenotypic female presented primary amenorrhea and hypertension. In the hormonal profile, the levels of serum estradiol, testosterone, rennin, and cortisol were decreased and ACTH and deoxycorticosterone were increased. Laparoscopic bilateral gonadectomy was performed, and corticosteroid, antihypertensive drugs, and estrogen were administered. We report this case with a brief review of the literatures.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1979.05a
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• pp.7.2-8
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• 1979

The tests related to air usage are valuable for evaluating phonatory function of clinical cases having glottic incompetence. Measurement of mean air flow rate, maximum phonation time and phonation quotient are important test for voice disorder. Stroboscopy is very useful for clinical evaluation of abnormality in the mode of vocal cord vibration. Author obtained following clinical result from 56 cases of laryngeal disorders in Kurume medical school in Japan. 1) Unilateral laryngeal lesions, are 35 cases (62.5%) and bilateral laryngeal lesions are 21 cases (37.5%). 2) Sex ratio is 39 cases (69.8%) of male and 17 cases (30.2%) of female. 3) In maximum phonation time below 10 seconds are 26 cases (46.4%) and above 10 seconds are 30 cases (53.6%). 4) In phonation quotient below 300 ml/sec are 33cases (58.9%). and above 300ml/sec are 23 cases (41.0%). 5) In mean air flow rate below 300ml/sec are 37 cases (66.1%) and above 300ml/sec are 19 cases (33.9%). 6) Symmetry of vibratory movement of the vocal cord, regularity of vibration, amplitude of vibration, wave on the mucosa and glottic closures are observed by stroboscopic examination. 7) Postoperative voice test and stroboscopic examination revealed good result in compare pre-operation with post-operation.