• Journal of Life Science
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• v.21 no.5
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• pp.647-655
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• 2011

The neurotoxicity of aggregated amyloid ${\beta}$ ($A{\beta}$) has been implicated as a critical cause in the pathogenesis of Alzheimer's disease (AD). It can cause neurotoxicity in AD by evoking a cascade of apoptosis to neuron. Here, we investigated the neuroprotective effects of cilostazol, which acts as a phosphodiesterase III inhibitor, on $A{\beta}_{25-35}$-induced cytotoxicity in mouse neuronal cells and cognitive decline in the C57BL/6J AD mouse model via peroxisome proliferator-activated receptor (PPAR)-${\gamma}$ activation. $A{\beta}_{25-35}$ significantly reduced cell viability and increased the number of apoptotic-like cells. Cilostazol treatment recovered cells from $A{\beta}$-induced cell death as well as rosiglitazone, a PPAR-${\gamma}$ activator. These effects were suppressed by GW9662, an antagonist of PPAR-${\gamma}$ activity, indicative of a PPAR-${\gamma}$-mediated signaling. In addition, cilostazol and rosiglitazone also restored PPAR-${\gamma}$ activity levels that had been altered as a result of $A{\beta}_{25-35}$ treatment, which were antagonized by GW9662. Furthermore, cilostazol also markedly decreased the number of apoptotic-like cells and decreased the Bax/Bcl-2 ratio. Intracerebroventricular injection of $A{\beta}_{25-35}$ in C57BL/6J mice resulted in impaired cognitive function. Oral administration of cilostazol (20 mg/kg) for 2 weeks before $A{\beta}_{25-35}$ injection and once a day for 4 weeks post-surgery almost completely prevented the $A{\beta}_{25-35}$-induced cognitive deficits, as did rosiglitazone. Taken together, our findings suggest that cilostazol could attenuate $A{\beta}_{25-35}$-induced neuronal cell injury and apoptosis as well as promote the survival of neuronal cells, subsequently improving cognitive decline in AD, partly because of PPAR-${\gamma}$ activation. The phosphodiesterase III inhibitor cilostazol may be the basis of a novel strategy for the therapy of AD.

• Management & Information Systems Review
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• v.29 no.4
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• pp.225-244
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• 2010

In the information society, characterized by knowledge and network economy, standards and standardization became a very important factor in determining the competitiveness of nations and firms. This paper defines the concept of standards and standardization and reconstructs the theory on the relationship between standards and technological innovation. The findings and policy implications are as follows. First, the effect of standards on technological innovation differs according to its function(compatibility, minimum quality, information, and variety reduction) and types(product-related and non-product). On the other hand, standards can impede technological innovation. Second, in terms of national innovation system(NIS), standards are an infra-technology, which is a public good. Therefore, government should decide the optimal level of investment on standards and standardization. Third, since standards foster firms' innovation over the all stages of business activities company, industry, and government should connect standardization activities with R&D, manufacturing, marketing, supply chain, and technology transfer, Fourth, standards play an important role in product innovation as well as process innovation. Based on these theoretical background and hypotheses, the empirical study of the Korean firms is needed.

• Proceedings of The Korean Society of Health Promotion Conference
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• 2005.09a
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• pp.33-51
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• 2005

역량(capacity)이란 진술된 목표를 수행할 수 있는 능력을 의미하므로, 목표란 그 목표를 성취하기 위해서 요구되는 역량의 구체적 요소, 양, 질, 그리고 역량의 소재를 결정한다. 건강증진이란 문제를 파악하고 해결하기 위한, 그리고 조직이나 사람들이 그들의 목표를 성취하기 위한 응용과학으로 발전되어 왔다. 문제를 분석하고, 문제의 원인이나 결정요인들을 파악하고, 그리고 해결책을 제시하고 이를 실행하는데 있어 효과적인 방법론이 중요하다는 점도 또한 밝혀졌다. 그러므로 효과적인 건강증진의 토대가 되는 방법론은 건강을 증진을 위한 역량으로 정의될 수 있을 것이다. 목표는 매우 중요한 역할을 한다. 평균 기대수명을 향상시키는데 요구되는 능력은 생물학적인 그리고 행동적 건강위험을 감소시키는데 필요한 능력과는 다르다. 그리고 질병의 발생을 예방하고, 또는 상해를 예방하거나 모든 사람들이 좋은 건강상태를 얻고 유지하는데 동등한 기회를 갖는 환경을 조성하는 능력도 다른 특성을 지닌다. 방콕헌장은 현 단계의 건강증진을 위하여 건강에 대한 사회적 결정요인에 대한 해결책과 더불어 건강에 도움이 되는 사회적, 경제적, 그리고 물리적 환경을 조성하여 건강형평성을 달성하고자 하는 목표를 설정하고 있다. 지난 30년간 건강증진을 위한 역량에 대하여 많은 것들을 배울 수 있었다. 이러한 역량을 기르고 확대하는 것이 미래를 위한 도전과제가 되며, 비록 우리가 성취한 것이 많지는 않을지라도, 더 많은 것들이 필요하다는 점은 명백해졌다. 우리는 좀 더 야심 찬 목적을 가져야 하며, 이러한 목적달성을 위하려 좀더 의욕적인 노력을 해야 할 것이다. 전문분야로서 건강증진은 다른 사람들에 의하여 발생된 문제에 대한 대책이나 반응에만 중점을 둔 이방인으로서의 역할을 해왔다. 그러나 우리가 도전해야 할 과제는 좀 더 새롭고, 더욱 야심 찬 활동계획을 설정하고 우리가 건강해지고 건강을 유지하는데 필요한 생활환경, 작업환경, 여가환경, 영적 환경을 모든 사람들에게 제공할 수 있는 가족, 지역사회, 그리고 국가가 있는 세계를 만드는 우리사회의 능력들을 신장하는 것이다. 방콕 헌장은 건강증진을 위한 새로운 일련의 목표들을 제시하고 있다. 이제 이러한 목표를 성취할 수 있도록 역량을 기르는 것은 우리의 책임이 되었다. 이는 원하는 활동수준을 달성하기 위한 역량을 조율하고 확장시키는 것을 의미할 것이다. 구체적으로 기존의 건강증진효과성에 관한 증거들을 좀더 큰 규모의 사업으로 확대시키는 것, 공공정책을 개발하고 건강증진 상태를 평가하는 데 다양한 지역사회의 참여를 촉진시키는 능력, 언어, 인종, 성, 종교, 장애 등과 관련된 건강형평성의 문제를 파악하고 제거하는 노력, 그리고 정책결정과 인구집단의 건강과의 관련성에 대한 증거수집, 국가와 지역차원에서 사회적 의사결정 과정에의 적극적 참여, 다른 부문과의 건강증진을 위한 협력 등이 포함된다고 볼 수 있다. 본 논문은 방콕헌장을 분석함으로써 이러한 역량이란 무엇인가에 대한 본인의 의견을 제시하였다. 이러한 아이디어는 토론과 논쟁을 위하여 제시된 것이다. 명백한 것은 건강증진을 위한 역량은 전략이나 기술적인 능력 뿐 만이 아니라 정치적 능력이나 개인적인 능력도 포함된다는 점이다. 가치와 증거들이 정책이나 권력과 함께 결합되어야하며, 정치적인 논쟁 속에서 연마되어야 한다. 우리세계의 미래는 역량에 의존하기 때문이다.

• 재활복지
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• v.21 no.1
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• pp.47-70
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• 2017

The aim of this study was to explore the effects of the epidemiological factor (depression), the behavioral factor (activities of daily living), the predisposing factor (self-efficacy), reinforcing factors (family support, professional support), and enabling factor (resource availability, accessibility) on quality of life in home-dwelling disabled people in rural areas. The conceptual model for this study was established on the basis of the PRECEDE model which was developed by Green and Kreuter. Data were drawn from the "Preliminary Investigation for Community-centered rehabilitation" conducted by a public health center located in the O province in 2011 and 186 of 190 disabled people who participated in the survey were included in the final analysis. Data were analyzed using Direct effects on quality of life arose from latent variables depicting the epidemiological factor (depression)and reinforcing factor (family support, professional support), while indirect effects arose from the behavioral factor (activities of daily living), the predisposing factor (self-efficacy), and enabling support (resource availability, accessibility). This model explained 85.5% of the variance in quality of life among rural disabled individuals. These findings may have shed some light on the necessity of including strategies to reduce depression and to strengthen supports from family and healthcare professionals when performing rehabilitation programs to improve quality of life in home-dwelling disabled people in rural areas. Furthermore, it suggested that it would be useful to develop specific strategies and tactics which might increase self-efficacy and to expand linkages between public health centers and other professional institutions such as hospitals for community-centered rehabilitation services for individuals with disabilities.

• Korean Journal of Clinical Laboratory Science
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• v.55 no.4
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• pp.298-305
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• 2023

Burkitt's lymphoma is a distinct subtype of non-Hodgkin's lymphoma originating from B-cells that is notorious for its aggressive growth and association with immune system impairments, potentially resulting in rapid and fatal outcomes if not addressed promptly. Optimizing the use of Food and Drug Administration-approved medications, such as combining known safe drugs, can lead to time and cost savings. This method holds promise in accelerating the progress of novel treatments, ultimately facilitating swifter access for patients. This study explores the potential of a dual-targeted therapeutic strategy, combining the bruton tyrosine kinase-targeting drug Ibrutinib and the epidermal growth factor receptor/human epidermal growth factor receptor-2-targeting drug Lapatinib. Ramos and Daudi cell lines, well-established models of Burkitt's lymphoma, were used to examine the impact of this combination therapy. The combination of Ibrutinib and Lapatinib inhibited cell proliferation more than using each drug individually. A combination treatment induced apoptosis and caused cell cycle arrest at the S and G2/M phases. This approach is multifaceted in its benefits. It enhances the efficiency of the drug development timeline and maximizes the utility of currently available resources, ensuring a more streamlined and resource-effective research process.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.16 no.6
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• pp.17-29
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• 2021

Recently, as social distancing have been raised due to the re-spread of COVID-19, the number of serial entrepreneurs who are closing their business is rapidly increasing. Learning from failure is a source of success, but business failure can result in psychological and economic losses and negative emotions of the serial entrepreneur. At this point, it is very important to find a way to recover the negative emotions caused by business failures of serial entrepreneurs. Recently, a strategic model has emerged to deal with the negative emotions of grief caused by business failures of serial entrepreneurs. This study identified the recovery factors from the grief of business failures of serial entrepreneurs and analyzed Shepherd's(2003) three areas: loss orientation, restoration orientation, and dual process. To this end, individual in-depth interviews were conducted with 12 small business serial entrepreneurs who challenged re-startup to identify the attributes of recovery factors that were not identified with quantitative data. As a result of the study, first, recovery factors were investigated in three areas: individual orientation, family orientation, and network orientation. It was found to help improve recovery in nine categories: self-esteem, persistence, personal competence, hobbies, self-confidence, family support, networks, religion, and social support. Second, recovery obstacle factors were investigated in three areas: psychological, economic, and environmental factors. Nine categories including family, health, social network, business partner, competitor, partner, fund, external environment, and government policy were found to persist negative emotions. Third, the emotional processing process for grief was investigated in three areas: loss orientation, restoration orientation, and dual process. Ten categories such as family, partner support, social member support, government support, hobbies, networks, change of business field, moving, third-party perspective, and meditation were confirmed to enhance rapid recovery in the emotional processing process for grief. The implications of this study are as follows. The process of recovering from the grief caused by business failures of serial entrepreneurs was attempted by a qualitative study. By extending the theory of Shepherd(2003), This study can be applied to help with recovery research. In addition, conceptual models and propositions for future empirical research were presented, which can be discussed in carious academic ways.

• Journal of agricultural medicine and community health
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• v.29 no.2
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• pp.287-301
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• 2004

Objectives: The development of internet programs for smoking cessation was motivated to quit smoking in the large group of smokers. This personalized program consisted of tailored message to consider the smokers characteristics, and contain the informations on the outcomes of smoking cessation and the skills to be used in the quit attempts. The purpose of this study was to develop the internet management program and information push-delivery system for smoking cessation to encourage the personal intention to quit smoking. Methods: We conducted in 3 steps as developing push service to encourage intention of smoking cessation, analyzing problems of smoking cessation program through the pilot test and suggesting improvements by implication stages. Results: This program is delivered for 30 days. if the participants do not fail to quit smoking. The contents consisted of 13 stages which were divided on starting period. practical period, maintenance period and success period. And push service afforded the tailored message to participants using their e-mail. According to the evaluation of pilot test, the problems of internet information push-delivery service for smoking cessation were the over-tasks per visiting time, recording style of participants, difficulty of terms and sentences, lack of visual effects, absence of follow-up module and unsuitable link with main homepage. Improvements were divided on 3 stages by implication period. The first stage included the immediate improvements as improving link with homepage, modifying menu of smoking information and upload file of notice part. The second stage included the short term improvements as alleviating condition of withdrawal, coordinating start stage of retrial, modifying errors of information push-delivery service and addition of educational materials. The third stage included the long term improvements as development of follow-up module, cost-effectiveness evaluation, reducing contents quantity, introduction of checking style, compensation of graphics effect and review for SMS utilization. Conclusions: This program contribute to improving smoking cessation rate. Therefore this program should be tested in a community to evaluate the effectiveness. To promote the effectiveness, this program should be developed the contents and the strategies for various targets, and established the follow-up system for ex-smokers.