• Journal of Life Science
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• v.31 no.2
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• pp.237-247
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• 2021

Immune responses in the central nervous system (CNS) function as the host's defense system against pathogens and usually help with repair and regeneration. However, chronic and exaggerated neuroinflammation is detrimental and may create neuronal damage in many cases. The NOD-, LRR-, and pyrin domain―containing 3 (NLRP3) inflammasome, a kind of NOD-like receptor, is a cytosolic multiprotein complex that consists of sensors (NLRP3), adaptors (apoptosis-associated speck like protein containing a caspase recruitment domain, ASC) and effectors (caspase 1). It can detect a broad range of microbial pathogens along with foreign and host-derived danger signals, resulting in the assembly and activation of the NLRP3 inflammasome. Upon activation, NLRP3 inflammasome leads to caspase 1-dependent secretion of the pro-inflammatory cytokines IL-1β and IL-18, as well as to gasdermin D-mediated pyroptotic cell death. NLRP3 inflammasome is highly expressed in CNS-resident cell types, including microglia and astrocytes, and growing evidence suggests that NLRP3 inflammasome is a crucial player in the pathophysiology of several neuroinflammatory and psychiatric diseases, such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, stroke, traumatic brain injury, amyotrophic lateral sclerosis, and major depressive disorder. Thus, this review describes the molecular mechanisms of NLRP3 inflammasome activation and its crucial roles in the pathogenesis of neurological disorders.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.1
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• pp.251-256
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• 2021

This study analyzed the most frequently used navigation cases in a desktop environment. As a result of the research, GNB induces users' search as the top element of the search structure and can place color, text, icon, and image elements. LNB could be classified in the form of a dropdown, flyout, dropline and mega menu. In this study, the navigation structure of Interpark and Interpark among open markets used by users was analyzed. G-Market's GNB has a two-tier structure with color, text, image, and icon elements, and Interpark has a three-tiered horizontal label. Interpark's GNB drew attention by placing a badge on the seasonal label, which is a temporary content section, unlike G-market. It can be seen that the LNBs of both shopping malls have flyout menus that protrude when you mouse over the category menu arranged in a vertical text form under the logo placed on the left. The flyout menu has a complex structure consisting of the layout of the mega menu. This study is meaningful in revealing user experience elements by analyzing the GNB and LNB of shopping malls these days where internet shopping is increasing.

• Tunnel and Underground Space
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• v.30 no.6
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• pp.540-550
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• 2020

Machine learning has been actively used in the field of automation due to the development and establishment of AI technology. The important thing in utilizing machine learning is that appropriate algorithms exist depending on data characteristics, and it is needed to analysis the datasets for applying machine learning techniques. In this study, advance rate is predicted using geotechnical and machine data of TBM tunnel section passing through the soil ground below the stream. Although there were no problems of application of statistical technology in the linear regression model, the coefficient of determination was 0.76. While, the ensemble model and support vector machine showed the predicted performance of 0.88 or higher. it is indicating that the model suitable for predicting advance rate of the EPB Shield TBM was the support vector machine in the analyzed dataset. As a result, it is judged that the suitability of the prediction model using data including mechanical data and ground information is high. In addition, research is needed to increase the diversity of ground conditions and the amount of data.

• (The)Study of the Eastern Classic
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• no.72
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• pp.127-156
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• 2018

Kim Yoo-shin was highly evaluated in Silla, not only when he was alive, but also after his death. When he was alive, he was regarded as one of the best servants who accomplished the task of 'Iltong-Samhan' by supporting KiIng Tae-jong and King Mun-mu. Kim Yoo-shin was recognized as 'good servant' or 'sacred servant' who helped King Tae-jong even after he died. In addition, he was revered as 'two adults' with King Mun-moo. He was awarded the title of 'The Great King Heung-mu'. In the Goryeo period, it was supported as a national sacrifice in the shrine of Mt. Taeryeng of Jinchon. Kim Yoo-shin was regarded as a person who achieved great success with the absolute trust of King Tae-jong and King Mun-mu. In addition, Yoon-gwan recognized Kim Yoo-shin as a general who caused many miracles. Lee Seung-hyeo said that Kim Yoo-shin had a mysterious Military-Strategy Book and excelled in martial arts. Even during the Joseon Dynasty, the evaluation of Kim Yu-shin's success had been continued due to the absolute trusting relationship between King Taejong or King Mun-moo and his retainer Kim Yoo-shin. Kim Yoo-shin was either the representative of Silla's martial or the most outstanding figure in the entire history of the Silla Dynasty. Furthermore, he was recognized as a person with competence and aptitude comparable to Chinese characters. Kim Yoo-shin was superior in military strategy. Kim Yoo-shin was evaluated as a representative of martial in Korea's history. From a neo-Confucian point of view, they evaluated him as a loyal person through Kim's achievements.

• 한국노년학
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• v.36 no.3
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• pp.611-632
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• 2016

Solutions for elderly health issues need to be found that take into account not only a medical perspective, but also interactions with social conditions such as socioeconomic status. With this in mind, this study aims to understand how socioeconomic status leads to health inequalities for the elderly. Specifically, this study investigates the mediating effects of socioeconomic status(income and education levels), health activities as an intermediary of the three dimensions of physical health(medical health, functional health, subjective health), accessibility of medical facilities, social participation, and social network. To test the research model, a secondary data analysis was conducted on the 2014 National Survey of Senior Citizens. The participants of the study were 10,451 elderly men and women aged 65 and above. To test the mediated model, hierarchical multiple regression analysis was conducted following the procedures suggested by Baron and Kenny(1986). In addition, a Sobel test was conducted to test the mediated model's significance. According to the analysis, the effects of income and educational levels on the health of the elderly were not the same. Additionally, different results were found depending on health dimensions. However, the overall direction of the results showed that the socioeconomic status of the elderly creates health disparities, and health behaviors, accessibility of medical facilities, social participation, and social network had significant mediation effects between socioeconomic status and physical health. Study findings especially worth noting are as follows: education was shown to have a stronger effect on health than income; effects of social integration factors such as social participation were highlighted; and significant mediating effects on the accessibility of medical facilities remained even after taking residential area into account. Results of this study shed light on health inequality mechanisms due to socioeconomic conditions and the need to find alternatives to alleviate these problems.

• The Journal of Korean Philosophical History
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• no.39
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• pp.143-168
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• 2013

The purpose of this paper is to study the succession and method of five-masters of southern school in transmitting the internal alchemy in Taoism which is established by Zhang Bo-duan. In history, the internal alchemy is divided into a few schools but all of them are under the umbrella of Zhang Bo-duan's alchemy. The five master's method has been consistent from Zhang Bo-duan to Seok Tae to Seol Do Gwang based on three reasons. First, they lived long while practicing the method. Second, they learned the method from their direct master secretly. Third, they kept practicing the individual method while staying in the secular world rather than in a religious body. I limit three of them Zhang Bo-Dan, Seok Tae, Seol Do Gwang as figures who practiced the pure internal alchemy. Thus I argue that the method stayed only for 200 years, arising from the late Dang Dynasty and disappearing in 1911, when Seol Do-Gwang was dead. This method can be instructed only to the appropriate figure, and the specific steps of method are taught through the oral instruction so that this method cannot be wide spread. Based on the fact that the time of practicing method is quite long and it needs intensive and constant efforts, it is difficult for a mundane person to practice and cope with the training. Jin Nam and Baek Ok Seom are believed that they belonged to the school of Shin So. Baek Ok Seom is regarded as a figure that made efforts to unite the school of Wei and the internal alchemy. However, he made lots of fabrication and discrepancy. Thus I state that Jin Nam and Baek Ok Seom need to be out in the succession and method of five masters of southern school in Taoism. Their changed method in quality needs to be organized in a new genealogy.

• Journal of the Microelectronics and Packaging Society
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• v.27 no.4
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• pp.119-125
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• 2020

Transition metal dichalcogenides (TMDCs), two-dimensional atomic layered materials with direct bandgap in the range of 1.1-2.1 eV, have attracted a lot of research interest due to their high response to light and capability to build new types of artificial heterostructures. However, the large-area synthesis of high-quality and uniform TMDC films with vertical-stacked heterostructure still remains challenge. In this study, we have developed a metal-organic chemical vapor deposition (MOCVD) system for TMDCs and conducted a systematic study on the growth of single-layer TMDCs and their heterostructures. In particular, using a bubbler-type organometallic compound sources, the concentration and flow rate of each source can be precisely controlled to obtain uniformly single-layered MoS2 and WS2 films over the centimeter scale. In addition, the MoS2/WS2 vertical heterostructure was achieved by growing WS2 film directly on the MoS2 film, as confirmed by electron microscopy, UV-visible spectrophotometer, Raman spectroscopy, and photoluminescence spectroscopy.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.12
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• pp.192-199
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• 2020

The blower erosion phenomenon was investigated to develop a long-life blower with a volume flow rate of 10,000 ㎥/min with the required total pressure efficiency of 83% or more. The blower performance and blower erosion were predicted through numerical analysis by computational fluid dynamics(CFD). The conditions used for numerical analysis were an air volume of 16,200 ㎥/min, a rotation speed of 893 rpm, and a temperature of 330℃. The specific gravity, particle size, and amount of the dust was 3.15, 90 ㎛~212 ㎛, and is 265 kg/min, respectively. To examine the effects of a dust deflector on erosion, erosion analysis was performed by comparing the models with and without a dust deflector. Numerical analysis showed that when the dust deflector is installed, the average tended to decrease by 167% in the impeller and 133% in the boss. CFD using the Finne's model for erosion revealed a parallel restitution coefficient of 1 and a perpendicular restitution coefficient of 0.1. The blower performance of case 5 was 691.7 mmAq, and the efficiency was 83.3% when the rotation speed and the air volume flow rate were 880 rpm and 16,200 ㎥/min, respectively.

• Korean journal of applied entomology
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• v.59 no.4
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• pp.411-416
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• 2020

Whitefly populations found in heated tomato greenhouses were monitored across three locations in Korea (Nonsan and Buyeo, Chungnam Province; Iksan, Jeonbuk Province) from November to May during the 2015 -2018 growing seasons. From May to October, surveys were conducted in Jangsu (Jeonbuk Province), where retarding cultivation was performed. Whitefly populations were classified and quantified by location and year. The dominant species were Trialeurodes vaporariorum (Westwood) and Bemisia tabaci (Gennadius). The species populations were mixed, but the frequency of occurrece of B. tabaci was higher than that of T. vaporariorum. Although whitefly populations started to increase in late March, they sharply increased in May and the highest population density was observed at the end of the harvest season. Therefore, the management of greenhouse tomato whiteflies through monitoring should begin in early March. In the case of retarding cultivation, the management of whitefly populations should be implemented in June, before the density of whitefly populations increases.

• Journal of the Korean BIBLIA Society for library and Information Science
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• v.32 no.2
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• pp.101-123
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• 2021

This study analyses the questions and answers contained in the Knowledge Information Database of the collaborative digital reference service, 'Ask a librarian'. And based on the results of status of user requests, this study draws information usage behavior in the early stages of the service was derived. 1,124 Knowledge Information Database items out of 3,506 cases was analyzed by nine criterion. ① Number of questions and whether to be reference questions, ② Subject and keywords of the question, ③ Purpose of the question, ④ Type of question, ⑤ User's information request, ⑥ Information source and reference services provided by the librarian, ⑦ Number of days to answer, ⑧ Level of the participating library, ⑨ Question type by topic. As a results of analysis, first, users asked for reference questions from various topics as needed, rather than one from a similar topic at a time, but more than half of the total pure reference questions were from the field of library information science. Second, about 71.35% of users were using the 'Ask a librarian' service to recommend a list of information resources related to a particular topic or research problem, and there were also questions that required consultation on the reading situation. Third, the most preferred sources of information for users were bibliography, and in the case of online information sources, users did not relatively prefer them. Fourth, the number of days required to answer was able to confirm significant differences depending on the type of question and the level of the participating library. Fifth, 31.33% of the purpose of the general field question showed that were self-generated.