• Title/Summary/Keyword: 장기 안정성

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Analysis of the 2015 reform plan of government employees pension system (GEPS) through monte carlo simulations (모의실험을 통한 2015년 공무원 연금제도 개정안의 효과분석)

  • Lee, Jieun;Song, Seongjoo
    • Journal of the Korean Data and Information Science Society
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    • v.27 no.1
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    • pp.19-32
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    • 2016
  • Due to the increasing fiscal burden and structural unbalanced premium/benefit costs, the new reform on the government employees pension system (GEPS) was considered even after the recent reform in 2009. This article examines the various effects of recent amendment in 2015 on GEPS using a simple probabilistic model. We consider effects on both sides, the pensioners and the government. First of all, the expected net value of pension payment for an individual employee was calculated based on the supposed survival distribution. The fairness of individual pension holders was compared using the benefit-cost ratio. Secondly, from pension system users' point of view, the default probability and the government subsidy were examined by Monte-carlo simulation. From the simulation experiment, we could see that the 2015 reform plan indeed reduces the default probability and the size of the fiscal burden of government by increasing the premium and decreasing the benefit. However, the size of the effect is not very standout at this moment because the number of new employees who are fully subject to the reform will be much smaller than the number of previous employees for a while. Thus, the effect of the reform is expected to appear in a slow manner.

Development of a Pacemaker with a Ventricular Assist Device for End-Stage Heart Failure Patients (말기 심질환 환자를 위한 심실보조장치용 심박조율기의 개발)

  • Kim, Yoo-Seok;Park, Sung-Min;Choi, Seong-Wook
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.35 no.11
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    • pp.1205-1211
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    • 2011
  • In this paper, we developed a pacemaker that can increase the efficacy of a left ventricular assist device (LVAD) and increase the survival rate for patients suffering end-stage heart failure. Because LVAD patients can experience arrhythmia, the pacemaker incorporated into the LVAD has the important role of sustaining sufficient blood circulation during arrhythmia. The electrode of the pacemaker is located at the apex of the left ventricle, where the VAD's inlet cannula is connected. This is efficient placement, in that the electrode can transmit electrical stimulation directly to the Purkinje fibers of the myocardium. The pacemaker can change the stimulation rate from 0 bpm to 191.4 bpm when a button is pressed on the external control module, and the pacemaker normally stimulates the heart at 60 bpm with 0.25 J of energy. We performed animal experiments to evaluate the performance and reliability of the combination of the LVAD and pacemaker. At pacemaker stimulation rates of 86.4 bpm, 100.2 bpm, 126.6 bpm, we recorded the ECGs, aortic pressures, and flow rates to analyze the heart loads.

A study on the changes of the posterior segments between before, after treatment and postretention period through maxillary expansion therapy (상악궁 확장술을 통한 치료전, 후 및 보정후 상악 구치부 변화에 관한 연구)

  • Park, Tae-Seo;Lee, Jin-Woo;Cha, Kyung-Suk
    • The korean journal of orthodontics
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    • v.27 no.1
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    • pp.55-63
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    • 1997
  • The purpose of thus study was to measure the changes of arch and dentition of maxillary posterior teeth before and after treatment and postretentios in patients treated with Quad-helix. Measurements and analysis were performed on study model with carlipers. Seventeen cases, eight boys and nine girls, were selected with average ages of 12.7 years. Mean retention period was 4 months, and mean wearing time was. 127 days. The result were as follows 1. The interpremolar widths and intermolar width were significantly increased in maxillary first piennolar and molar when compared between before and after treatment and postretention. The maxillary second premolar resulted in significant increase in interpremolar between after tretment and post retention. 2. The long axis of maxillary first premolar and first molar accompaning buccal tipping was significant increased before and after Tx and post retention. Significant increase of the lingual inclination of maxillary second premolar was obsered both in before and after Tx, and before Tx and post retention. 3. The distance between the height of tooth contour was significantly increased in the first and second premolar before and after Tx, and was significant increased in the first molar before and after Tx and post retention. 4. Intermolar width at the palatal groove was increased in before and after Tx. and post retention. The palatal depth was significant increased in before and after Tx. In conclusion expansion of maxillary dental arch showed no relapse and results were stable retention

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Analysis of an Immobilized β-Galactosidase Reactor with Competitive Product Inhibition Kinetics (경쟁적 저해를 갖는 고정화 β-galactosidase 반응기의 해석)

  • Kang, Byung Chul
    • Journal of Life Science
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    • v.23 no.12
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    • pp.1471-1476
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    • 2013
  • The present study deals with the immobilization of Kluyveromyces lactis ${\beta}$-galactosidase on a weak ionic exchange resin (Duolite A568) as polymer support. ${\beta}$-Galactosidase was immobilized using the adsorption method. A kinetic study of the immobilized enzyme was performed in a packed-bed reactor. The adsorption of the enzyme followed a typical Freundlich adsorption isotherm. The adsorption parameters of k and n were 14.6 and 1.74, respectively. The initial rates method was used to characterize the kinetic parameters of the free and immobilized enzymes. The Michaelis-Menten constant ($K_m$) for the immobilized enzyme (120 mM) was higher than it was for the free enzyme (79 mM). The effect of competitive inhibition kinetics was studied by changing the concentration of galactose in a recycling packed-bed reactor. The kinetic model with competitive inhibition by galactose was best fitted to the experimental results with $V_m$, $K_m$, and $K_I$ values of 46.3 $mmolmin^{-1}mg^{-1}$, 120 mM, and 24.4 mM, respectively. In a continuous packed-bed reactor, increasing the flow rate of the lactose solution decreased the conversion efficiency of lactose at different input lactose concentrations. Continuous operation of 11 days was conducted to investigate the stability of a long-term operation. The retained activity of the immobilized enzymes was 63% and the half-life of the immobilized enzyme was found to be 15 days.

Electrical Conductivity of ZrO2 Doped with Sc2O3 and CeO2 (Sc2O3와 CeO2가 첨가된 ZrO2의 전기전도도)

  • Lee, Dong-Suek;Heo, Jang-Weon;Kim, Jae-Dong;Kim, Joo-Sun;Lee, Hae-Weon;Kim, Gyeung-Ho;Kim, Dae-Jun;Lee, Jong-Ho
    • Journal of the Korean Ceramic Society
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    • v.39 no.4
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    • pp.346-351
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    • 2002
  • The electrical conductivity and phase stability of $ZrO_2$ doped with $Sc_2O_3$ and $CeO_2$ were investigated in order to search for better solid electrolyte material for solid oxide fuel cell. Present study showed that $ZrO_2$ doped with $Sc_2O_3$ and $CeO_2$ exhibited no phase transition during the heat treatment up to $1350^{Circ}C∼1550^{Circ}C$ and was stable as a cubic phase in whole temperature ranges. The $ZrO_2$ doped with $Sc_2O_3$ and $CeO_2$ showed much higher electrical conductivity than YSZ in the temperature range of $300∼^{Circ}C$ and better long term stability than other sc-$ZrO_2$ based electrolyte that showed the possibility as a strong candidate electrolyte material for intermediate-or low-temperature SOFC.

Biochemical Characterization of a Protease with Fibrinolytic Activity from Maggots of Protaetia brevitarsis (Protaetia brevitarsis의 maggot로부터 fibrinolytic activity을 가진 protease의 생화학적 특성 연구)

  • Chang, Jeong-Hyun;Jo, Ji-Young;Kim, Yeong-Jin;Lee, Sun-Yi;Cho, Hyo-Jin;You, Sun-Nyoung;Kim, Kwang-Youn;Park, Byoung-Keun;Ahn, Soon-Cheol;Kwon, Heun-Young
    • Journal of Life Science
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    • v.17 no.5 s.85
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    • pp.606-612
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    • 2007
  • Fibrin clots remained in blood vessels can be one of the serious factor caused cardiovascular disease, such as ischemia, infarction and necrosis The development of an antithrombotic and thrombolysis solvent is necessary to prevent and treat these diseases. In this study, the fibirinolytic protease was prepared from the maggots of Protaetia brevitarsis using ammonium sulfate fractionation and desalting column. The optimum pH and temperature for the enzyme activity were pH 9.0 and $50^{\circ}C$, respectively. The enzyme activity was relatively stable at pH 7.0-9.0 and temperature below $60^{\circ}C$. The activity of the enzyme was strongly inhibited by phenylmethanesulfonyl fluoride. And the activity of the enzyme was inhibited by $Ca^{2+}\;and\;Zn^{2+}$, but it was not by $Mg^{2+}\;and\;Fe^{2+}$ ions. In these experimental results, we have speculated that the enzyme derived from maggots of Protaetia hrevitarsis is a serine protease with a strong fibrinolytic activity.

Construct of uncontaminated underground reservoir test facility (청정지하저수지 시험시설의 구축)

  • Lee, Chang Seob;Park, Nam Sik;Jeong, Jae Hoon
    • Proceedings of the Korea Water Resources Association Conference
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    • 2016.05a
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    • pp.328-328
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    • 2016
  • 우리나라는 생활용수의 대부분을 지표수에 의존하고 있는 실정이다. 그러나 지표수는 가뭄과 같은 기상변화, 수질사고 등으로 물 공급의 안정성에 문제가 되기도 한다. 향후 기후변화는 가뭄의 빈도와 강도를 증대시킬 것으로 파악되므로 수질 및 수량의 문제를 더욱 악화시킬 것으로 예상된다. 이러한 문제점을 해결하기 위해 지표수를 대수층 내에 인공적으로 함양한 뒤 대수층의 자연정화 기능에 의해 여과된 양질의 청정원수를 생산하는 기술을 본 연구에서 현장에 실증 적용하는 시설을 구축하였다. 이러한 기술은 기존의 지하 대수층을 이용하는 강변여과 등이 갖는 장점을 취하고 단점을 보완하였으며 친환경적이며 지속가능한 용수공급뿐만 아니라 청정 원수 확보를 통해 정수처리비용을 절감, 장기간의 가뭄이나 지표수 수질사고 시에 비상용수 공급 등 기존 취수원들과 달리 많은 장점을 갖고 있는 대규모 청정지하저수지 시험시설이다. 청정 지하저수지 기술이 주로 적용되는 지역은 해안지역 또는 하구 델타지역을 대상으로 한다. 해안 또는 델타지역은 해수침투로 인하여 염지하수가 부존되어 있기 때문에 지하수자원 활용에 매우 제한적이다. 따라서 지표수(담수)를 전처리하여 대수층에 인공적으로 함양을 하여 염지하수 대수층 안에 담지하수(담수체)를 형성할 수 있다. 이는 염수와 담수의 밀도차에 의해 희석되지 않는 특성을 이용한 기술이다. 청정 지하저수지 시험시설은 크게 지표수 취수시설, 전처리시설, 주입정, 양수정, 운영시스템으로 나눌 수 있다. 주입정 및 양수정은 원형의 형태로 지하저수지 조성범위 중심부에 9개의 주입정과 외각에 8개의 양수정을 설치하였다. 시험시설의 운영 과정은 하천수를 취수하여 전처리시설에서 탁도를 제거한 후, 피압대수층 염지하수에 동력으로 주입을 한다. 이때 기존에 부존되어 있던 염지하수를 밀어내고 담수체 지하수 형성을 유도한다. 일정기간 주입을 통해 목표 담수체를 만들어 내면 양수정에서 담수를 취수하되, 대수층의 모래자갈층을 일정거리 이동하여 취수하는 방식이다. 즉, 하천수를 대수층에 함양하고, 일정거리를 이동하여 취수하는 ASTR 방식의 대체수자원 확보 기술이다. 시험시설은 통합운영센터를 통해 원격감시 및 각종 제어/계측을 실시하며, 모니터링된 자료는 운영시스템에서 관리한다. 본 연구시설에서는 대수층 주입, 관정폐색, 미생물/지화학 수질반응, 지하수모니터링, 지반변형 등이 주요 핵심 연구를 진행하고 있도록 시설을 구성하였다. 본 시험시설은 2015년 8월 착공하여 2016년 4월에 완공 예정이며, 2016년 3월부터 주입을 시작하여 6개월간 피압대수층에 주입을 실시하고 이후부터 주입과 양수를 병행할 계획이다.

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Predictive analysis of minimum inflow using synthetic inflow in reservoir management: a case study of Seomjingang Dam (자료 발생 기법을 활용한 저수지 최소유입량 예측 기법 개발 : 섬진강댐을 대상으로)

  • Lee, Chulhee;Lee, Seonmi;Lee, Eunkyung;Ji, Jungwon;Yoon, Jeongin;Yi, Jaeeung
    • Journal of Korea Water Resources Association
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    • v.57 no.5
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    • pp.311-320
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    • 2024
  • Climate change has been intensifying drought frequency and severity. Such prolonged droughts reduce reservoir levels, thereby exacerbating drought impacts. While previous studies have focused on optimizing reservoir operations using historical data to mitigate these impacts, their scope is limited to analyzing past events, highlighting the need for predictive methods for future droughts. This research introduces a novel approach for predicting minimum inflow at the Seomjingang dam which has experienced significant droughts. This study utilized the Stochastic Analysis Modeling and Simulation (SAMS) 2007 to generate inflow sequences for the same period of observed inflow. Then we simulate reservoir operations to assess firm yield and predict minimum inflow through synthetic inflow analysis. Minimum inflow is defined as the inflow where firm yield is less than 95% of the synthetic inflow in many sequences during periods matching observed inflow. The results for each case indicated the firm yield for the minimum inflow is on average 9.44 m3/s, approximately 1.07 m3/s lower than the observed inflow's firm yield of 10.51 m3/s. The minimum inflow estimation can inform reservoir operation standards, facilitate multi-reservoir system reviews, and assess supplementary capabilities. Estimating minimum inflow emerges as an effective strategy for enhancing water supply reliability and mitigating shortages.

A Prospective Clinical Trial on the Mg Oxidized Clinical Implants (마그네슘 양극산화 임플란트의 성공률에 관한 전향적 임상연구)

  • Im, So-Min;Kim, Dae-Gon;Park, Chan-Jin;Cho, Lee-Ra;Um, Heung-Sik;Lee, Jae-Kwan
    • Journal of Dental Rehabilitation and Applied Science
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    • v.27 no.1
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    • pp.25-39
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    • 2011
  • In animal studies, Magnesium (Mg) - incorporated oxidized implants showed significant enhancement of the bone response. This prospective clinical trial was performed to investigate the success rate, implant stability and marginal bone loss of Mg oxidized clinical implant. The experimental protocol was approved by Institutional Review Board of the Gangneung-Wonju National University Dental Hospital. Fifty healthy patients had partial edentulism were included in this study. Mg oxidized clinical implants (Implant M, Shinhung, Korea) were installed and restored with conventional protocol. The patients were recalled at 1, 3, 6 months after functional loading. Implant stability quotient (ISQ) was measured and periapical radiographic images were obtained. Amount of marginal bone loss was calculated with calibrated images from periapical radiographs. Repeated measured analysis of variance and post hoc Tukey test were used to compare the mean ISQ and bone level. A total of 101 implants were analyzed. The mean ISQ values increased continuously with time lapse from 68.4 at fixture installation to 71.5 at 6 months after loading. Implant stability was correlated with gender, fixture diameter, bone quality and implant sites. The mean marginal bone loss during 6 months after loading was 0.26 mm. There was no failed implant and six-month success rate was 100%. Within the limitations of this study, the six-month success rate of Mg oxidized implant was satisfactory. The implant stability and marginal bone level were excellent. However, further longer clinical studies will be needed to confirm the success of Mg oxidized clinical implant.

Effects of Additives on Quality Attributes of Minced Ginger During Refrigerated Storage (첨가물이 냉장 중 생강 다대기의 품질특성에 미치는 영향)

  • Choi, Min-Seek;Kim, Dong-Ho;Lee, Kyung-Hae;Lee, Young-Chun
    • Korean Journal of Food Science and Technology
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    • v.34 no.6
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    • pp.1048-1056
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    • 2002
  • Quality of fresh ginger deteriorates rapidly during low temperature storage, and its storage life is short due to sprouting and microbial spoilage. The objectives of this research were to develop, using additives, a minced ginger product, which could maintain acceptable quality for over 30 days, and to investigate its quality changes during the cold storage. Storage stability of minced ginger product was investigated from the standpoint of the inhibition of brown discoloration, gas formation and liquid-solid separation. Fresh ginger was peeled and ground to produce minced ginger (control). Sodium bisulfite, L-cysteine, NaCl, sodium benzoate, modified starch, and/or xanthan gum were added to the control to minimize quality loss during storage, and to develop an optimum formula (A) of minced ginger. Samples were packed in Nylon/PE films, stored at $5^{\circ}C$, sampled at a 30-day interval, and subjected to quality evaluations. Changes in pH, surface color, gas formation, liquid-solid separation, contents of free amino acids, free sugars, organic acids, and fatty acids were determined. Gas formation was effectively inhibited in samples with sodium benzoate and/or NaCl. Samples with xanthan gum did not result in liquid-solid separation. L-Cysteine and sodium bisulfite were effective in controlling discoloration. pH decreased during storage in all samples, except sample A. Organic acid contents of all samples increased during storage, with lactic acid content showing the highest increase. Free amino acid content decreased with increasing storage time. Free sugar content of all samples decreased during storage. Sensory results showed sample A maintained acceptable quality until 90 days of storage. These results suggest that quality of minced ginger could be successfully maintained with the additions of selected additives for up to 90 days.