• Journal of Pharmaceutical Investigation
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• v.13 no.3
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• pp.115-125
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• 1983

제제설계란 제형의 설계 및 그에 따른 처방설정(formulation)을 의미하며 경험적인 제제방법 및 그 기술측면에서의 제제화는 주악 및 첨가물의 종류와 배합비율의 설정등 비교적 단순한 내용을 의미하지만 의약품은 실제적으로 인체에 적용되므로 치료설계상의 연구와 생물약제학적 검토에 의한 유효정과 안전성을 발휘할 수 있도록 설계가 되어야 한다. 또한 약물의 효력은 체내 특정부위에 특정농도의 약물분포가 필요하고, 일정시간 지속되는 것이 요구되므로 약용량도 중요하지만 약물투여 후의 흡수, 체내이행, 대사, 배설등의 상태를 파악하고 이에 미치는 부형제의 영향도 검토하여야 한다. 제제물리학적 측면에서 품질보증을 위하여 preformulation단계에서 주약의 물성검토, 첨가제의 사용량, interaction 및 혼합순서 등과 처방설정 단계에서 제제화에 사용되는 기계장치의 특성 및 능력, 제제화 후의 포장용기 및 포장상태에서의 안정성 등도 면밀히 검토하여야한다. 제제설계란 단순한 dosage form의 design만이 아니고 유효성이 높고, 부작용이 적은 제제를 합리적으로 만드는 기술과 정보의 종합관리로 scale up과정에서 원료, 기계장치, 제조방법, 작업자 등에 의한 품질변동 요인을 극소화하고, 공정의 초기단계에서 즉시 조정될 수 있는 종합관리 system이 필요하다.

• Proceedings of the Korean Institute of Surface Engineering Conference
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• 2008.11a
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• pp.43-44
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• 2008

실리콘 웨이퍼 위에 마이크로웨이브 플라즈마 화학증착법으로 나노결정질 다이아몬드 박막을 형성하고 그 위에 RF 마그네트론 스퍼터로 ZnO 박막을 적층한 후 SAW(Surface Acoustic Wave) 필터를 제작하여 평가하였다. 기판온도, 작업압력, Ar/$CH_4$ 비율을 변화시켜 최적공정 조건에서 30nm 수준의 결정립을 갖는 $4{\mu}m$ 두께의 다이아몬드 박막을 얻었고, RF 인가전력, 기판온도, Ar/$O_2$ 비율을 조정하여 결정성이 우수하고, 표면 거칠기가 좋으며, 높은 비저항을 갖는 $2.2{\mu}m$ 두께의 ZnO 박막을 얻었다. 박막의 특성은 FESEM과 XRD로 평가하였다. Lift-off 식각공정을 이용하여 일정한 선폭과 간격(Line/Space : 1.5/$1.5{\mu}m$)을 갖는 구리 전극 패턴을 형성하였다. Network Analyzer를 이용하여 측정한 SAW 필터의 중심주파수는 1.67GHz이었다.

• Proceedings of the Korea Multimedia Society Conference
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• 2003.05b
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• pp.641-645
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• 2003

본 논문은 일반적으로 차량의 번호판이 차종에 따라 녹색계통과 노란색계통 등 일정한 색상을 가지고 있다는 특징을 이용하여, 복합 칼라 좌표계의 성분을 결합한 차량 번호판 영역 추출에 대한 방법을 제안하였다. LUV와 HSI 및 YIQ 칼라 좌표계에서 번호판 영역을 검출하기 위해 사용한 색상은 U, H, Q영역이고 이진화 작업을 위한 임계치 조정의 효율성을 높이기 위해 각 영역의 평균 자기 값을 기준이 되는 값으로 보정하는 방법을 사용하였다. 처리과정의 효율성을 높이기 위해 번호판 후보 영역을 선정하여 번호판 크기의 마스크영역을 수직, 수평 라인으로 검색하여 추출하는 방법을 사용하였다. 실험 결과 H와 Q성분으로만 실험대상에 대하여 결합한 경우는 72.58％의 추출률을 보인 반면, 제안한 방법인 U와 H 및 Q성분의 결합에 의한 경우는 100％의 추출률을 보였다.

• Proceedings of the Korean Society of Disaster Information Conference
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• 2022.10a
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• pp.239-240
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• 2022

공사장에서 발생하고 있는 먼지는 현장 근로자뿐만 아니라 인근 주민들의 건강에 치명적인 영향을 미치고 있다. 공사장 인근 주민들이 환경분쟁조정위원회에 먼지피해에 대한 피해배상을 청구하고 있지만 공사장 먼지피해 수인한도 초과여부를 확인하기 위한 측정, 예측, 평가가 어려워 먼지피해에 대한 보상이 제대로 이루어지지 않고 있다. 공사장 먼지관리의 법적기준이며 먼지 저감에 대한 구체적인 방법을 제시하고 있는"비산먼지 억제조치기준"의 준수 등을 점수로 평가하여 일정 점수 이하인 경우 피해배상액을 차등 적용하는 방안을 제안한다. 본 안이 제도화된다면 건설사는 먼지피해 배상액 지출을 줄이기 위해 현재보다 한층 더 먼지 저감 노력을 강화할 것이기에 먼지 발생을 획기적으로 줄일 수 있어서 현장 근로자 및 인근 주민들의 먼지피해를 최소화할 수 있으며, 먼지로 인한 환경, 보건 법규위반예방과 쾌적한 작업환경으로 노동 생산성 확보와 먼지로 인한 피해 배상액 지급 등 손실을 줄일 수 있을 것이라고 생각한다.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.7 no.4
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• pp.587-593
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• 2006

Development of digital information and internet technology causes the changes of technology environments and companies, and the variety of customers needs has been dynamically changed in terms of integrating information system with customers satisfaction. Moreover a new logistics concept is needed through the sharing information between suppliers and consumers, which maximizes the customers service and its flexibility by changing functional-oriented to process-oriented. Many research papers on transportation studies have focused on the Vehicle Routing Problem (VRP) and Vehicle Scheduling Problem (VSP). However in the real world, it is known that it takes long time to build vehicle scheduling in the process of transporting the amount of orders from the logistics center to the vendors due to the realistic constraints. This paper presents a framework design for each process enabling delivery planning automatically using heuristic algorithm. In addition, an interactive delivery planning system is implemented utilizing the proposed algorithm.

• Journal of Korean Society of Steel Construction
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• v.27 no.4
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• pp.371-376
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• 2015

This study was conducted for the torsional behavior of catwalk system which is a temporary structure on a suspension bridge. The torsional deformation of the catwalk structure has a significant effect on the workability and safety of workers during main cable erection. For this reason, the torsional deformation of catwalk is controlled to be acceptable levels below by adjusting the cross bridge interval in design stage. This study analyzed the effect of separation between cross bridge associated with twist safety of catwalk system. For the analytical approach, a detailed analysis model was created including cross bridge. Both wind load within the wind velocity range that allows the construction and eccentric load of Prefabricated Parallel Wire Strand were analyzed by analysis model. Result of study shows that separation between cross bridges has a significant effect on the torsional behavior of the catwalk.

• Journal of Korean Ophthalmic Optics Society
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• v.18 no.1
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• pp.37-43
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• 2013

Purpose: The present study was conducted to investigate whether the directions of eye movement in playing computer games for certain period affected the change of near point of convergence (NPC) and fusional reserve (FR) or not. Methods: Total 40 subjects in 20s who have the visual acuity of 1.0 or higher without any ocular disease and accommodative dysfunction were asked to successively play computer games. After the subjects were moving eyes in horizontal and vertical directions for 40 and 90 minutes, their horizontal fusional reserves, vertical fusional vergence and near point of convergence were measured. Results: The near point of convergence showed a tendency to be receded after computer gaming in the horizontal and vertical directions, and both of horizontal and vertical fusional reserves were significantly reduced. The range of declined fusional reserves and receded near point of convergence after computer gaming for 90 minutes was smaller than those after computer gaming for 40 minutes. The change of binocular vision was affected by the horizontal eye movement rather than the vertical movement when analyzed by the direction of eye movement. Conclusions: This study revealed that the change in FR and NPC was different along with dominant direction of eye movement during visual display terminal (VDT) tasks. Therefore, the adjustment of VDT working time is required to prevent the dysfunction of binocular vision according to the dominant direction of eye movement during VDT task.

• Journal of Korean Ophthalmic Optics Society
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• v.20 no.2
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• pp.219-228
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• 2015

Purpose: The current study was performed to compare the difference in binocular visual function depending on variable background colors at near work. Method: Fifty four adults (18 males, 34 females) who consented to the present study and had no ocular disease, ocular surgery history, strabismus and amblyopia with normal binocular vision were participated into this study. The subjects were asked to read the novels with black letter printed on white, red, green and blue background for 15 min. Then, their heterophoria, AC/A ratio, near point of convergence, accommodation facility, relative accommodation and vergence were measured before and after reading. The difference of measurements were compared. Result: Overall heterophoria was tended to decrease with regardless of background color. AC/A ratio showed a tendency of increase after reading the novels with all backgrounds except white background. Near point of convergence was significantly increased compared to before reading at all background color. Accommodative facility of dominant and non-dominant eyes were also significantly increased after reading however, binocular accommodative facility showed a tendency of decrease. Negative relative accommodation also decreased at all background colors however, the change of positive relative accommodation was not significantly different. In case of vergence, there was significant difference in break point of far BO and recovery point of far BI by the wavelength of background color. Conclusions: From the results, it was known there is convergence change depending on the wavelength of light even though same amount of accommodation and convergence is required when doing near work for certain period. Thus, it can be suggested that the adjustment of the near working environment which perception of various color was required, should be conducted according to the main wavelength.

• The Journal of Korean Academy of Sensory Integration
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• v.11 no.1
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• pp.11-27
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• 2013

Objective : This is a descriptive study using a program review collaborative group program by special educator and occupational therapist for supporting children's school tasks, and it is designed to explore how changed school performance skills and to analyze how applied intervention methods including sensory integrative approach. Methods : Participants were 6 male elementary students(5 = 1st grade, 1 = 2nd grade). Pilot program had reviewed and its results used as base for planning main program. Main program was implemented by collaborative process with teacher and occupational therapist for 1 year. School AMPS was used to assess school task participants, and informal motor and process skill observation was used to assess self-help activities. Description of records by professions about intervention strategies through assessments was described as qualitative way. Japanese sensory inventory was used by parents. Results : Through the collaborative process, assessing children, planning and modifying program, establishing intervention strategies were implemented. Self-help abilities in group program were increased much more independently. School task abilities were increased slightly but skills changed irregularly and unexpectedly and their reasons became considered more complex from sensory processing reasons to social and emotional reasons. Conclusion : Sensory integration had benefits for primary group program and more complex intervention strategies became to emerge demands for person- environment-task challenges. Collaborative practice with teacher and occupational therapist was supplement and synergic effect for children and group dynamics. More objective and comprehensive methods for measure collaboration and group effect would be needed in further study.

• Korean Journal of Construction Engineering and Management
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• v.17 no.5
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• pp.54-61
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• 2016

The initial planned annual cost is frequently adjusted under the construction process in construction projects. If the annual cost is reduced than the initial planned cost, the number of possible activities is also reduced from initial planned progress schedule. In such cases, project manager need to replan the progress schedule with possible activities within changed annual cost. However, most project manager will proceed as planned schedule without any change. After the project cost has been exhausted, there are many cases to stop the operation of the construction site. This study developed active 5D CAD system that can replan the progress schedule within changed annual cost and simulate the cost status according to the changed schedule for cost visualization. This system can be used as a decision-making tool in the replaning progress schedule and will be able to increase the practical usability of 5D CAD system.