• Title/Summary/Keyword: 자기비드

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Magnetic Bio-Sensor Using Planar Hall Effect (평면홀 효과를 이용한 자기 바이오센서)

  • Oh, Sun-Jong;Hung, Tran Quang;Kumar., S. Ananda;Kim, Cheol-Gi;Kim, Dong-Young
    • Journal of the Korean Society for Nondestructive Testing
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    • v.28 no.5
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    • pp.421-426
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    • 2008
  • The magnetic bio-sensor used the PHR (planar hall resistance) effect generated by the free layer in spin-valve giant magnetoresistance structure of Ta/NiFe/CoFe/Cu/NiFe/IrMn/Ta. The PHR element with micrometer size was fabricated through the photolithograph and dry etching process. The PHR signal with magnetic field was measured under the conditions of with and without single magnetic bead. A single magnetic bead of diameter $2.8\;{\mu}m$ was successfully detected using the PHR sensor. Therefore, the high resolution PHR sensor can be applied to bio-sensor application utilizing the output voltage variation of the PHR signals in the presence and absence of a single magnetic bead.

Fabrication and Characteristics of a Highly Sensitive GMR-SV Biosensor for Detecting of Micron Magnetic Beads (미크론 자성비드 검출용 바이오센서에 대한 고감도 GMR-SV 소자의 제작과 특성 연구)

  • Choe, Jong-Gu;Park, Gwang-Jun;Lee, Ju-Hyeong;Lee, Sang-Seok;Lee, Jang-Ro
    • Proceedings of the Korean Magnestics Society Conference
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    • 2012.11a
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    • pp.146-148
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    • 2012
  • 미크론 자성비드 검출용 바이오센서에 활용하는 GMR-SV 박막을 이온빔 스퍼터링 증착법으로 glass/Ta(5.8 nm)/NiFe(5 nm)/Cu(t nm)/NiFe(3 nm)/FeMn(12 nm)/Ta(5.8 nm)의 구조를 갖도록 증착하였다. 비자성체 Cu의 두께가 3.0 nm에서 2.2 nm까지 얇아질수록 교환결합력은 증가하였으며 자기저항비는 다소 낮았다. 비자성체의 두께가 얇으면 반강자성체의 층간 교환작용이 강자성체의 고정층 뿐만 아니라 자유층의 스핀배열에도 영향을 주고 있음을 확인할 수 있었다. 또한 리소그래피 공정 과정을 거쳐 GMR-SV 소자를 제작하여 미트론 자기비드를 검출하였다. 여기서 자기비드를 떨어뜨리기 전과 후의 자기저항비, 교환결합력, 보자력은 각각 0.9%, 3 Oe, 2 Oe의 값을 나타내었다. 이것으로 미크론단위의 바이오센서로서 활용할 수 있는 가능성을 보여주었다.

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Detection Property of Red Blood Cell-Magnetic Beads Using Micro Coil-Channeland GMR-SV Device (마이크로 코일-채널과 GMR-SV 소자를 이용한 적혈구-자성비드 검출 특성연구)

  • Park, Ji-Soo;Kim, Nu-Ri;Jung, Hyun-Jun;Lee, Sang-Suk
    • Journal of the Korean Magnetics Society
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    • v.25 no.1
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    • pp.16-21
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    • 2015
  • The micro device, coil, and channel for the biosensor integrated with the GMR-SV device based on the antiferromagnetic IrMn layer was fabricated by the light lithography process. When RBCs coupled with several magnetic beads with a diameter of $1{\mu}m$ passed on the micro channel, the movement of $RBC+{\mu}Beads$ is controlled by the electrical AC input signal. The $RBC+{\mu}Beads$ having a micro-magnetic field captured above the GMR-SV device is changed as the output signals for detection status. From these results, the GMR-SV device having the width magnitude of a few micron size can be applied as the biosensor for the analysis of a new magnetic property as the membrane's deformation of RBC coupled to magnetic beads.

Fabrication and Characteristics of a Highly Sensitive GMR-SV Biosensor for Detecting of Micron Magnetic Beads (미크론 자성비드 검출용 바이오센서에 대한 고감도 GMR-SV 소자의 제작과 특성 연구)

  • Choi, Jong-Gu;Lee, Sang-Suk;Park, Young-Seok
    • Journal of the Korean Magnetics Society
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    • v.22 no.5
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    • pp.173-177
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    • 2012
  • The multilayer structure of glass/Ta(5.8 nm)/NiFe(5 nm)/Cu(t nm)/NiFe(3 nm)/FeMn(12 nm)/Ta(5.8 nm) as typical GMR-SV (giant magnetoresistance-spin valve) films is prepared by ion beam sputtering deposition (IBD). The coercivity and magnetoresiatance ratio are increased and decreased for the decrease of Cu thickness when the thickness of nonmagnetic Cu layer from is varied 2.2 nm to 3.0 nm. It means that the decrease of non-magntic layer is effected to the interlayer exchange coupling of pinned layer and the spin configuration array of free layer. For experiment of detecting and dropping of magnetic beads we used the GMR-SV sensor with glass/Ta/NiFe/Cu/NiFe/FeMn/Ta structure. From the comparison of before and after for the dropping status of magnetic bead, the variations of MR ratio, $H_{ex}$, and $H_c$ are showed 0.9 %, 3 Oe, and 2 Oe, respectively. The fabrication of GMR-SV sensor was included in the process of film deposition, photo-lithography, ion milling, and MR measurement. Further, GMR-SV device can be easily integrated so that detecting biosensor on a single chip becomes possible.

Investigation of Crack Healing and Optimization of Microbe Carrier for Microbial Self-healing of Concrete Crack (미생물 기반 콘크리트 자기치유를 위한 미생물 담체 최적화 및 균열치유성능 분석)

  • Yun Lee
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.28 no.4
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    • pp.62-67
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    • 2024
  • In this paper, we developed and optimized a chitosan-based polymer microbial bead carrier that is cell-friendly, has a high moisture absorption rate, and effectively provides the conditions for microbial biomineral formation as an optimal microbial carrier that protects microorganisms in concrete, and evaluated the self-healing performance of mortar using it. In order to incorporate circular-shaped microbial endospores, a circular-shaped microbial bead carrier was developed by combining chitosan and alginate polymers, and the amount of calcium carbonate produced could be actively controlled by adjusting the composition of the carrier. The amount of biominerals formed and the size of crystals were maximized in the hydrogel bead carrier containing chitosan, and in the case of mortar cracks using this, it was confirmed that self-healing of cracks with a maximum crack width of 0.3mm was achieved within 96 hours after crack generation.

Detection Characteristics of a Red Blood Cell Coupled with Micron Magnetic Beads by Using GMR-SV Device (GMR-SV 소자를 이용한 미크론 자성비드와 결합된 적혈구 검출 특성 연구)

  • Lee, Jae-Yeon;Kim, Moon-Jong;Lee, Sang-Suk;Rhee, Jin-Kyu
    • Journal of the Korean Magnetics Society
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    • v.24 no.4
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    • pp.101-106
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    • 2014
  • The glass/Ta(5.8 nm)/NiFe(5 nm)/Cu(2.3 nm)/NiFe(3 nm)/IrMn(12 nm)/Ta(5.8 nm) GMR-SV (giantmagneto-resistance-spin valve) multilayer structure films with a magnetoresistance ratio (MR) of 5.0 % and a magnetic sensitivity (MS) of 1.5%/Oe was deposited by dc magnetron sputtering method. Also, GMR-SV device having a width of $7{\mu}m{\sim}8{\mu}m$ similar to the diameter of RBC (red blood cell) was fabricated by the light lithography process. When RBCs coupled with several magnetic beads with a diameter of $1{\mu}m$ dropped upon the GMR-SV device having MR = 1.06% and MS = 0.3 %/Oe, there is observed the variation of about included of a resistance value of ${\Delta}R=0.4{\Omega}$ and ${\Delta}MR=0.15%$ around a external magnetic field of -0.6 Oe. From these results, the GMR-SV device having the width magnitude of a few micron size can be applied as the biosensor for the analysis of a new magnetic property of hemoglobin inside of RBC combined to magnetic beads.