• Proceedings of the Korean Information Science Society Conference
• /
• 2001.04b
• /
• pp.283-285
• /
• 2001

유전자 프로그래밍은 프로그램 자동생성 도구이다. 문제를 해결하는 프로그램코드를 프로그래머가 직접 구현하는 것이 아니라, 적절한 초기값만을 입력하여 컴퓨터가 스스로 적합한 해를 찾아내도록 하는 방법이다. 유전자 프로그래밍은 생물의 진화개념에서 얻어진 여러 아이디어를 사용하여 최적화된 해를 찾아낸다. 본 논문에서는 세포영상인식 문제를 해결하기 위하여 유전자 프로그래밍을 사용하였다. 실험에 사용된 영상은 자궁경부세포진 영상이다. 여러 가지 종류와 상태의 세포들이 뒤섞여 있어 분석하기에 힘들다는 것이 이 영상의 특징이다. 주어진 문제는 샘플 영상이 암인가 아닌가를 판별하는 것이다. 유전자 프로그래밍을 적용하기 위하여 사용한 특징값들은 영상에서 찾을 수 있는 가장 단순한 대표값들과, 산술 및 논리연산자들이다. 실험결과 실제 인식기 제작에 바로 적용하기엔 무리가 있지만, 80%정도를 제대로 판별해 낼수 있었다. 인식률이 낮은 이유는 사용한 특징들이 영상의 정보를 잘 흡수하지 못했기 때문이라 여겨지고, 앞으로 지나치게 복잡하지 않으면서 여상의 특징을 잘 표현하는 특징값들을 찾는 것이 향후과제이다.

• Proceedings of the Korea Multimedia Society Conference
• /
• 2003.05b
• /
• pp.242-245
• /
• 2003

현미경을 통해 획득한 세포영상이나 조직영상은 질병의 유무나 암의 진행 정도를 파악하여 환자를 치료하기 위한 매우 중요한 요소이다. 하지만 현재 세포나 조직영상에 대한 분석은 광학현미경을 통해 얻어진 2차원 영상분석방법을 주로 이용하고 있으므로 잘린 단면의 각도나 두께에 따라 서로 다른 분석결과를 나타내는 문제점을 가지고 있다 따라서 본 연구에서는 콘포컬 현미경을 사용하여 50nm 두께의 연속적 섹션 영상을 획득한 후, 이를 바탕으로 자궁경부암세포를 3차원으로 재구성 방법을 제안한다. 본 연구의 결과는 2차원 정량분석에 대한 한계를 극복하고 정확한 진단과 예후 추정으로 환자에게 최적의 임상적 치료를 제공할 수 있는 기반을 마련하는데 활용하고자 한다

• Journal of Korean Biological Nursing Science
• /
• v.14 no.4
• /
• pp.239-248
• /
• 2012

Purpose: The purpose of this study was to identify the relationships among knowledge, cancer information seeking behavior, and Willingness for education about Human Papillomavirus (HPV) vaccination among school teachers. Methods: The subjects were 135 teachers who had were working in the middle or high school in Korea. Data were collected by a self-report questionnaire, 2011. Data were analyzed by using the SPSS WIN 18.0 program. Results: There was a positive relationship between information seeking behavior and Willingness for education about HPV vaccination. There were differences in Willingness for education according to necessity of HPV vaccination for premarital women above 16-year old and marital women below 45-year old, and necessity of education for students. The Willingness for education were predicted by information seeking behavior, groups who HPV vaccination is necessary to premarital women above 16-year old, and HPV vaccination education for student is necessary. These variables explained 25.0% of the variance of the Willingness for education about HPV vaccination. Conclusion: The Willingness for education about HPV vaccination among middle or high school teachers could be improved by the emphasis of the preception that HPV vaccination is necessary to middle or high school students and is related to the prevention of cervical cancer.

• The Korean Chronic Disease News
• /
• no.307
• /
• pp.1-18
• /
• 2006

경기도 의왕시 보건소 임인동 소장/의료비지출 OECD국가 중 최하위/“암환자 96%가 정상활동 못해”/MRI 진료비 18.2% 환불조치/“진료비 부당 청구 심사 강화”/대형병원 환자 집중현상 심화/제왕절개 분만율 평가결과 공개/KGMP 국제적 수준 높인다/완제의약품 생산국가 표기‘명확’/“국내 제약산업 희생양”안 된다/‘산디문 뉴오랄’당뇨 발현억제/지역사회정신보건사업 선도적 추진/지역보건의료계획 어떻게 추진되고 있나/버섯, 항암 등 15가지 약리효과 입증/자궁경부암은 HPV가 주원인이다/증상 없다고 대장암 안심은‘금물’/1급발암 물질 석면 사용 금지/고지혈증/당뇨병과 비만/

• Radiation Oncology Journal
• /
• v.21 no.2
• /
• pp.143-148
• /
• 2003

Purpose: The purpose of this study was to evaluate treatment results in terms of the survival and failure patterns subsequent to radiation therapy in recurrent cervical cancer, fellowing primary surgery. Material and Methods: Between January 1990 and December 1999, 27 patients, with recurrent cervical cancer following primary surgery, were subsequently treated with radiation in the Department of Radiation Oncology, at the Keimyung University Dongsan Medical Center. Their median age was 48, ranging from 31 to 70 years old. With regard to the Initial FIGO stage on presentation, 20 and 7 patients were stages I and II, respectively. Twenty three patients had squamous cell carcinomas and 4 had adenocarcinomas. The time interval from the primary surgery to the recurrence ranged from 2 to 90 months with a median of 29 months. The recurrent sites were the vaginal cuff alone, the pelvic cavity and combined recurrence in 14, 9 and 4 patients, respectively. Radiation was peformed, with external and vaginal intracavitary radiation in 13 patients, external radiation alone in 13 and vaginal intracavitary radiation alone in another one. The median follow-up period was 55 months, ranging from 6 to 128 months. Results: The five year disease free survival (5y DFS) and five year overall survival (5y OS) rates were 68.2 and 71.9$\%$, respectively. There was a marginal statistically significant difference in the 5y DFS in relation to the recurrent site (5y DFS, 85.7$\%$ in vaginal cuff recurrence alone, 53.3$\%$ in pelvic cavity recurrence, p=0.09). There was no difference in the survival according to the time interval between the primary surgery and a recurrence. There was only a 7$\%$ local failure rate in the patients with a vaginal cuff recurrence. The major failure patterns were local failure in the patients with pelvic cavity recurrence, and distant failure in the patients with a combined recurrence. There were no complications above grade 3 after the radiation therapy. Conclusion: Radiation therapy was safe and effective treatment for a recurrent carcinoma of the uterine cervix following primary surgery, especially the external beam radiation and vaginal intracavitary irradiation achieved the best results in the patients with a vaginal cuff recurrence following primary surgery.

• Radiation Oncology Journal
• /
• v.22 no.2
• /
• pp.124-129
• /
• 2004

Purpose : To evaluate the clinical findings, prognosis and treatment strategy of patients with neuroendocrine carcinoma of cervix. Materials and Methods: Thirteen patients with neuroendocrine carcinoma of cervix were included in this study, as confirmed histologically and immunohistochemically at the Dongsan Medical Center, Keimyung University, between May 1944 and October 2001. The mean age of patients was 56 years with a range of 32 to 78 years of age. According to the FIGO staging system, there were 5 patients with stage IB carcinoma, 5 patients with IIA, and 3 patients with stage IIB. Four patients underwent radical hysterectomy with pelvic lymphadenectomy, 3 of these patients also received postoperative radiotherapy, and one patient underwent extrafascial hysterectomy after radiotherapy. Primary radiotherapy was done in 9 patients, and 3 were irradiated postoperatively. Nine patients received chemotherapy, 7 received neoadjuvant and 2 received concurrent chemoradiotherapy. The radical purpose of radiotherapy consisted of external irradiation to the whole pelvis (4,500 $\~$5,400 cGy) and intracavitary irradiation (3,000 $\~$ 3,500 cGy). Results : The mean follow up duration was 36 months with a range of 3 to 104 months. The overall 5-year survival rate was 61.5$\%$ and the 5-year survival rates for stage IB, IIA, IIB were 60.0$\%$, 60.0$\%$, and 66.7$\%$ respectively (p=0.99). Eight patients are still alive without disease, and all of the 5 patients with recurrence are dead due to distant metastasis. Conclusion : Neuroendocrine carcinoma of cervix is highly aggressive, with early lymphatic dissemination and a high rate of distant recurrence. Therefore, an aggressive therapeutic strategy Is required to obtain pelvic and distant disease control. Multimodal therapy should be considered at the time of Initial diagnosis.

• The Journal of Korean Society for Radiation Therapy
• /
• v.13 no.1
• /
• pp.122-125
• /
• 2001

I. 목적 : Primus의 Multi Leaf Collimator는 X측이 29쌍으로 이루어 져 있으며 그중27쌍의 leaf은 1cm이고 2쌍은 6.5cm의 leaf으로 구성되어있다. 이러한 이유로 Paraaortic node를 포함하는 자궁경부암 치료시 현재는 Y가 27cm 이상인 경우는 차폐블럭을 제작하여 치료를 시행하나 차폐 블럭의 제작에 따른 업무의 지연과 차폐 블럭이 무거워져 치료시 환자에게 떨어질 위험을 제거 하기 위해 Asymmetric Field로 Multi Leaf Collimator를 사용한 결과를 보고하고자 한다. II. 재료 및 방법 : 모의 치료(Ximatron, Varian, USA)시 $Y_1$측을 15cm을 기준으로 하여 $Y_2$측을 변경하면서 Field size를 결정한다. ($Y_2$측은 20cm가 최대, 즉 Y측은 35cm까지 적용) 이러한 방법으로 Multi Leaf Collimator를 사용한 환자와 기존의 차폐블럭을 제작하여 치료한 환자와의 업무 개선사항을 확인하기 위하여 실제 공작실 업무 담당자의 블럭 제작 시간과 Beam Shaper를 이 용해 Multi Leaf Collimator를 입력하는 시간을 상호 비교하여 단축된 시간을 조사하였다. III. 결과 : 차폐블럭을 대신해 Multi Leaf Collimator를 이용함으로써 치료실에서 환자에 대한 위험요소(차폐블럭이 무겁다)를 사전에 제거 할 수 있었고 공작실에서 블럭 제작 시간과 LANTIS를 이용해 MLC를 입력하는 시간을 실측 한 결과업무의 시간이 120분에서 5분으로 단축되는 효과가 있었다. 전산화 계획 실에서 선량 계산시 OAR Factor값을 고려하여야 한다. IV. 결론 : Paraaortic node를 포함한 자궁경부암 환자의 차폐부위는 모양이 거의 일직선이기 때문에 Mu]ti Leaf Collimator를 사용하기에 용이 한 치료 부위이다. 하지만 큰 Field size로 인한 불편함이 있었다. 이러한 제 약성을 Asymmetric Field를 이용해서 Multi Leaf Collimator의 사용을 가능하게 하고 차폐 블록의 제작과정과 치료 시에 발생되는 근무자의 업무의 손실을 줄이고 환자에 대한 위험성 을 해결하였다.

• Korean Journal of Health Education and Promotion
• /
• v.24 no.5
• /
• pp.23-37
• /
• 2007

Background: Even though cervical cancer poses a significant global cancer burden, successful implementations for early detection offer an opportunity to prevent deaths and reduce the cancer burden. In Korea, cervical cancer is the most prevalent type of cancer among adult women, but it is one of the few cancers in which a consensus-approved screening test exists for early diagnosis, Pap test, that can be combined with highly efficacious treatment regimens for early-stage disease. Purpose: This study was carried out to identify the cognitive-behavioral factors associated with cervical cancer screening behavior among adult women, aged 40 to 59, and to develop tailored messages and to evaluate the effectiveness of stage-matched educational program. Method: A total of 283 women who aged 40 years or older was recruited in Seoul, from September, 1st to November, 14th, 2003. The intervention group (N=162) and the control group (N=121) were selected from five sub-districts in Seocho-gu, Seoul. Building on the TTM, a quasi-experimental study was conducted to test the effectiveness of stages-matched intervention addressed at the five stages of cervical cancer screening behavior. Women in the intervention group were randomly assigned to one of two conditions, internet or postal services. Results: In our results, 88.9% of participants had received a Pap test at least once in their life-time, and 65.4% had got it in the past two years. With regard to cognitive-behavioral factors, the stages-matched educational program increased attitude and process of change for cervical cancer screening. The percentage changed was the largest in maintenance stage. With regard to delivery methods for tailored messages, the print materials were more effective at increasing screening adherence than the e-mail. Whereas the postal service group showed remarkable the change of behavior stage, the internet service group did not. Also it was not shown any difference of the satisfaction with stages-matched educational program between internet and postal service groups. Conclusion: This study suggested that cervical cancer screening behavior could be changed by tailored messages which had developed with cognitive-behavioral factors. The stages-matched educational program was effective to promote the screening adherence for cervical cancer.

• Journal of Yeungnam Medical Science
• /
• v.5 no.2
• /
• pp.121-128
• /
• 1988

Clinical and histopathological studies were made on 202 cases of malignancy of cervix, that were visited to the Department of Obstertrics and Gynecology, Yeungnam University Hospital, during 5 years from 1983 to 1987. The results were summarised as follows. 1. Malignancies of the uterine cervix were 10% of total female malignancies. 2. Among 202 cases, 195 cases(96.5%) were squamous cell carcinoma, in which 60 cases(30.0%) of carcinoma in situ, 9 cases(4%) of microinvasive, and 126 cases(62.5%) of invasive carcinoma were included. 3. The average age of the patients with squamous cell carcinoma was 49.4 years old. ; In cases of carcinoma in situ, it was 43.8, microinvasive, 40.0, invasive 52.1 years old. 4. Clinical symptoms of the patient with squamous cell carcinoma in order of frequency were as follows. ; vaginal bleeding(47.5%), abnormal cytology(15.4%), and abnormal vaginal discharge(9.4%). 5. Duration of the chief complaints was most commanly less than 6 months(73.2%), and the average duration was 3.8 months. 6. The most common age of marriage was between 19 to 22 years 0Id(46.5%). The average was 21.5 years old. 7. The gravity was 51.5% in 5~8 times, and average 6.2 times. The parity was 61.9% in 1~4 times, and average 3.9 times. 8. The subdivision of 126 cases of invasive carcinoma was made according to FIGO stage classification, stage I, 40 cases(31.8%), stage II, 54 cases(42.9%), stage III, 11 cases(8.7%), and stage IV, 8 cases(6.3%). 9. The histologic subtypes of invasive squamous cell carcinoma were distributed as follows. ; large cell keratinizing type, 25 cases(19.8%), large cell nonkeratinizing type, 101 cases(80.2%). 10. In the cytologic diagnosis, class I was 2 cases(l.9%), class II was 16 cases(15.1%), class III was 33 cases(31.1%), class IV was 31 cases(29.3%), class V was 24 cases(24.6%). 11. The frequency of lymph node metastasis was 7.5% in stage I, and 11.1% in stage II.

• Korean Journal of Clinical Laboratory Science
• /
• v.50 no.4
• /
• pp.449-456
• /
• 2018

Cervical cancer is the fourth most frequently diagnosed cancer in women worldwide. In lower Human Development Index countries, it has the second highest incidence and mortality among cancer in women. Therefore, better diagnosis and treatment systems are needed. Among them, estrogen receptor alpha ($ER-{\alpha}$) mRNA expression has been analyzed with RT-qPCR since several studies reported that $ER-{\alpha}$ is necessary in the maturation of the uterus and is related to cervical cancer. In this study, $ER-{\alpha}$ quantitative analysis was performed on various lesions and normal tissue samples. Based on the receiver operating characteristic (ROC) curve, its sensitivity and specificity were 85% and 75%, respectively, showing higher or similar results to those of conventional HPV tests. In addition, its expression level was analyzed with clinical information. With regression analysis, the R square value between the $ER-{\alpha}$ mRNA expression level and menopause status was 0.5041, indicating a strong correlation. This study was performed as part of a pilot study and suggests that $ER-{\alpha}$ is related to carcinogenesis. Future studies will examine other hormones and menopausal factors with a larger sample size.