• The Korean Journal of Nuclear Medicine
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• v.19 no.2
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• pp.25-41
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• 1985

간흡충증은 한국 및 동남아세아에 널리 분포되어 있는 중요한 풍토병의 하나로서 진단은 전통적으로 분변검사에 의존하여 오고 있다. 최근 들어 담관내 간흡충 및 이의 합병증의 진단을 위해 ERCP 및 contrast cholangiogram등이 시도되었으나 실제에 이용하기에는 많은 제약이 있다 하겠다. 저자는 간흡충증에 있어서 최근 소개된 $^{99m}Tc-DISIDA$ hepatobiliary scintigraphy의 진단적 의의를 규명하고자 1982년부터 1983년까지 고신의대 부속 복음병원에서 검진한 간흡충증 환자 90명을 대상으로 하여 $^{99m}Tc-DISIDA$ hepatobiliary scintigraphy와 formalin-ether 원침법에 의한 분변검사를 시행하였다. $^{99m}Tc-DISIDA$ scintigram소견은 간내 담관 bile flow 및 총수담관 bile flow defect, 그리고 간세포기능의 정도에 따라 자료를 분석하였고 그외 합병증의 진단은 병록 기록, 수술 소견, ERCP 등에 의존하여 결론을 얻었다. $^{99m}Tc-DISIDA$ scintigraphy는 특이한 양상의 bile flow dynamics를 나타내었으며 간내 주담관의 intermittent irregular focal bile flow defect 및 tile flow stasis를 나타내고 말초담관의 bile flow defect는 경미하고 60분 내에 담관 bile flow activity의 완전한 배설을 나타내는 경우를 mild pattern, 간내 담관의 심한 irregular bile flow dynamics 및 간내담관의 심한 irregularity (담관내벽의 심한 불규칙성), 총수담관, 간내 주담관 및 말초 담관까지 심하게 irregular bile flow stasis를 나타내며 bile flow activity의 완전 베설이 $60\sim90$분사이 혹은 90분이상까지 인지된 경우를 moderate-severe pattern으로 분류하였다. 1) 분변검사상 간흡충증은 95검사중 70검사(환자 86명중 67명)에서 양성을 보여 분변 충난검사의 양성율은 73.7%였고 음성율은 26.3%였다. 2) $^{99m}Tc-DISIDA$ hepatobiliary scintigraphy는 90명중 70명에서 특이한 Cs-bile flow양성을 보였으며 양성율은 77.8%였으며 음성율은 22.2%였다. 3) $^{99m}Tc-DISIDA$ hepatobiliary scintigram양성율을 나타낸 환자 70명중 11명은 mild pattern, 59명은 moderate-severe pattern을 나타냈으며 그중 21명은 여러가지 간세포 기능 및 담관에 영향을 미치는 질환과 합병했지만 특이한 Cs-bile flow pattern을 dominent하게 나타내었으며 합병된 여러 질환들도 bile flow pattern상 인지 할 수 있었다. 4) $^{99m}Tc-DISIDA$ hepatobiliary scintigram 음성율을 나타낸 환자 20명중 8명은 만성간염, 5명은 간경변증, 3명은 재발성 농양성담관염(recurrent pyogenic cholangitis)과 간내담도의 stricture 및 담관담석증이 합병되었으며 scintigram상 합병증의 pattern을 나타냈고 4명에서는 low CBD obstruction을 나타내었으며 후에 CBD stone, CBD carcinoma, gall bladder Ca.의 porta hepatis 전이 및 clonorchis worms의 cluster에 의한 obstruction이 operation 및 ERCP로서 진단 되었다. 5) $^{99m}Tc-DISIDA$ hepatobiliary scintigraphy pattern은 현재의 자각증상과 관계된 dominent disease를 나타내었으며, 공간 점유병소도 multiple project images를 시행하므로서 쉽게 발견할 수 있었다. 이와 같이 간흡충증에 있어서 $^{99m}Tc-DISIDA$ hepatobiliary scintigram은 환자의 자각증상과 관계된 질환을 규명하는 데 필요한 정보를 얻었을 수 있었으며 간내담관의 damage정도를 규명하는데 필요한 procedure임이 판명되었다.

• Journal of Korean Ophthalmic Optics Society
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• v.20 no.4
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• pp.477-484
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• 2015

Purpose: This study was investigated to evaluate the effect of the variation of the face form angle(FFA) of spectacle frame on the visual acuity and the visual function. Methods: The visual acuity, the contrast sensitivity, the stereopsis, and the phoria were measured with the spectacle frame whose the FFA is at $5^{\circ}$ and $25^{\circ}$ and the surveys were conducted on subjective symptoms. Here, 30 adults (14 men and 16 women, average age:$25.46{\pm}3.9$), who did not have ocular diseases and were fully corrected in case of having had refractive error, were to act as experimental subjects for this measurement. Results: The visual acuity and the contrast sensitivity was decreased and the phoria was tended to increase to the esophoria direction at the FFA $25^{\circ}$ than at the FFA $5^{\circ}$. The stereopsis was significantly reduced at the FFA $25^{\circ}$ than at the FFA $5^{\circ}$. Also when the FFA was larger, the higher the degree of refractive error was, the more the increase of the subjective symptoms such as being blurred characters, being disturbed head, and having sore eyes was, which reveals a statistically significant correlation between them. Conclusions: If the FFA increases, the visual acuity, the contrast sensitivity and the stereopsis was found to decrease and the phoria to increase to the esophoria direction. Therefore it shows that the variation of the FFA of spectacle frame can influence the visual acuity and the visual function.

• Journal of Acupuncture Research
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• v.22 no.1
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• pp.177-190
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• 2005

Objective : This study intends to identify the effects of the Doin Gigong Exercise on the shoulder-arm pain in Women. Methods : The study was performed with nonequivalent control group pretest-posttest design. A total of 45 subjects were divided into 25 persons in experimental groups and 20 persons in contrastive group by convenience sampling. The data were collected by using questionnaires and measured values from June, 2004, to August, 2004. Results : The results of the study are as follows: 1. The homogeneity testing revealed that most study variables were equally distributed between experimental and control groups. 2. The first hypothesis: The experimental group who performed the Doin Gigong Exercise and who decreased on the subjective symptom scale was supported(t=10.245, p=.000). 3. The scond hypothesis : The experimental group who received Doin Gigong Exercise and who decreased on the subjective pain(VAS) was supported(t=6.816, p=.000). 4. The third hypothesis: The experimental group who received Doin Gigong Exercise and who decreased on the muscular stiffness measured techniques(UNIQUE) was supported (t=7.114, p.000). Conclusions : Based on the results described above, it is considered that the Doin Gigon Exercise is clearly effective in all an values of the 5 measured. Therefore, the Doin Gigong Exercise can be thought of as effective nursing intervention for the reduction of shoulder-arm pain in women.

• Tuberculosis and Respiratory Diseases
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• v.41 no.2
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• pp.127-134
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• 1994

Background : Diffuse panbronchiolitis(DPB) is a chronic inflammatory lung disease of unknown etiology which has characteristic clinical, radiological and pathological features, and is distinguished from bronchial asthma, chronic bronchitis, pulmonary emphysema, bronchiectasis, or alveolitis. Clinically, patients with DPB have chronic cough, purulent sputum, exertional dyspnea, and finally respiratory failure. Until a few years ago, the prognosis of DPB had been thought to be very grave, because there had been no effective treatment for the disease. But recent1y, low-dose long-term erythromycin was found to be very effective on DPB. Even though DPB is prevalent in Japan, and is known to be rare outside of Japan, we have a1ready reported the clinical features of 16 DPB cases in Korea. We tried low-dose long-term erythromycin on DPB patients and analyzed the clinical effect of erythromycin. Methods : We analyzed the changes of subjective symptoms, physical signs, pulmonary function tests and chest X-rays on 14 DPB patients with more than 6 months erythromycin treatment during the period from September 1989 to August 1992 in Seoul National University Hospital. Results : 1) Subjective symptoms improved in all patients within 2-3 months, and 54.5% of the patients showed no symptom after one year of treatment. 2) Crackles and wheezing decreased in 92.9% of the patients after 3 months and completely disapppeared in 63.5% of the patients after one year of treatment. 3) FVC and FEV1 increased remarkably during the first 3 months, and slowly increased thereafter, reaching normal level after one year of treatment. 4) Small nodular lesions on chest X-ray decreased in all patients, and chest PA was normal in 36.4% of the patients after one year of treatment. 5) There was side effect in one patient, stopping medication because of dyspepsia. One patient stopped medication because of no symptom after 16 months of treatment, but her symptom recurring after one month, improving again after retreatment. Conclusion: Low-dose long-term erythromycin showed ramarkable effectiveness on DPB. Further studies are needed on the mechanism of the drug and the duration of the treatment.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.9
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• pp.3999-4008
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• 2012

This study investigated the symptoms of work-related musculoskeletal disorder(WMSDs) for physical therapists who have different work duties. We analyzed the symptoms in the musculoskeletal system and the degree of work-harmfulness by the survey of the symptom in the musculoskeletal system and rapid upper limb assessment(RULA) for pain control group(n=56), adult exercise group(n=53), and pediatric exercise group(n=22). As a result, 69.6% of the pain control group, 84.9% of the adult exercise group, 81.8% of the pediatric exercise group show the observable symptom. The adult exercise group has the biggest work load per hour in the final wrist & arm score of the ergonomic risk assessment using RULA. The action level of the pain control group is $3.0{\pm}0.9$; the Action Level of adult exercise group is $3.3{\pm}0.6$; the Action Level of the pediatric exercise group is $3.2{\pm}0.8$, and so it is shown that the adult exercise group has a problem of working posture. It is considered that devices and education system for preventing from WMSDs should come into wide use.

• Journal of Yeungnam Medical Science
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• v.23 no.2
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• pp.171-181
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• 2006

Background: $Clonorchis$ $sinensis$ is an important human parasite that is usually found in the biliary tract. It is widely distributed in East Asia in Taiwan, Japan, China and Korea. About 2 million people are estimated to be infected with $C.$ $sinensis$ in Korea. This study was conducted to evaluate the state of infestation and clinical aspects of $C.$ $sinensis$. Material and Methods: We evaluate 1,063 patients with clonorchiasis retrospectively at Yeungnam University Hospital and Health Promotion Center from January 2001 to December 2003. All patients were diagnosed by a positive stool test for $C.$ $sinensis$ eggs. Clinical features, laboratory data and imaging studies were evaluated. Results: The ratio between affected males and females was 3.6 : 1. The highest infection rate was noted in the 40-60 age groups regardless of sex. The infection rate of $C.$ $sinensis$ among the residents of urban areas was higher than in rural areas. There were 813 (76.5%) patients who were asymptomatic. Common symptoms included right upper abdominal pain in 7.6% and epigastric pain in 7.2%. For the laboratory studies, serum ALP and GGT levels were within normal limits in 85.2% and 56.0% respectively. Peripheral eosinophilia was noted in 66.1% of cases. Of the 83 cases undergoing ERCP, 27 cases (32.5%) showed peripheral dilatation of the intrahepatic duct. Conclusion: This study suggests that $C.$ $sinensis$ infection is still endemic even in rural areas of Korea and that asymptomatic infections are common. Further work should be focused on the early diagnosis and treatment of patients with subclinical infection.

• Journal of Korean Ophthalmic Optics Society
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• v.6 no.2
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• pp.99-104
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• 2001

This study surveyed common sense of testing eye vision, feeling of own vision and wearing glasses, and method of wearing glasses using questionnaire for 625 primary student(male 322, female 303) live in Iksan city, Jeon buk Province. The question about the selection of testing vision office answered ophthalmic optics only 12.6% by common sense but 38.8% among testing vision students had been checked the visual acuity in ophthalmic optics. 40% student of all answerer have a poor vision by self-evaluation testing and realized when they look far vision is 46.4% among the poor vision answerer, look black board is 26.0%, look monitor is 18.4%, and reading is 9.9%. 46% answerer of the subjective poor vision who tested eye vision by self-evaluation did not correct eye vision. 48.7% answerer among uncorrect eye vision is because of having no chance to test. The question of effect in wearing glasses answered that the 48% of a1l answerer will be worse the visual acuity, the other is getting better and unchanged eye vision by common sense. The question about how looks like glasses wearer answered that the 45.8% answerer is uncomfortable appearance by common sense. 32.3% answerer of the glasses wearer became a failure wearer because glasses was uncomfortable to fit primary student.

• Tuberculosis and Respiratory Diseases
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• v.44 no.6
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• pp.1296-1307
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• 1997

Background : Erdosteine is a thiol derivative developed for the treatement of chronic obstructive bronchitis, including acute infective exacerbation of chronic bronchitis. Erdosteine has mucomodulating and antioxidant properties and especially exhibits excellent gastrointestinal tolerability. Methods : The study was conducted as a prospective evaluation, with 2 comparative groups orally treated with erdosteine 300mg (bid.) or ambroxol 30mg (b.i.d.) for 7 days and the design of trial was double-blind. The treatments have been assigned randomly to patients (n=80) with acute or chronic bronchitis. The primary end-point used to determine efficacy in this study was subjective symptoms including expectorating frequence, expectoration volume, expectorating difficulty, expectoration viscosity, cough intensity and dyspnea. The secondary end-points of efficacy was the result of arterial blood gas analysis and pulmonary function test. Safety was evaluated with adverse drug reactions and laboratory tests monitoring. 61 patients was included in the efficacy analysis, due to the fact that 19 patients drop-out for different reasons. The obtained values have been analyzed with paired Hest., ANOVA test., multivariate $t^2$-test, repeated measures analysis of covariance, two sample t-test, loglinear-logit model analysis, Fisher's exact test. Results : 1) There was no significant difference on demographic data and vital signs between erdosteine and ambroxol treated groups. 2) The comparison between erdosteine and ambroxol treated groups showed no significant difference in improvement of each symptom in spite of the more favorable efficacy obtained with erdosteine. No difference on the contrary was observed for arterial blood gas analysis and pulmonary function test. 3) As safety is concerned, no clinical significant changes in laboratory test and symptom were induced in erdosteine and ambroxol treated group and two patients in ambroxol treated group drop-out for adverse reactions in symptom. 4) In the evaluation of final clinical efficacy, erdosteine improved more effectively patient's overall symptoms {very good effect (11/31), good effect (12/31), moderate effect (6/31), no effect (2/31), aggravation (0/31)} than ambroxol {very good effect (6/30), good effect (14/30), moderate effect (5/30), no effect (4/30), aggravation (2/30)}. And the probability of symptomatic improvement by erdosteine compared to ambroxol was 2.5 times. (p<0.05). Conclusion : This study showed that erdosteine was clinically effective and safe drug for treatment of acute and chronic bronchitis.

• Journal of Preventive Medicine and Public Health
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• v.24 no.1 s.33
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• pp.37-44
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• 1991

In the plywood manufacturing factory established in 1979, female 3 workers who had exposed to adhesives containing formaldehyde for more than 48 months of duration suffered from eye, nasal, oral, throat and skin irritation and dyspnea as chief complaints. The actual level of the exposure to formaldehyde were not estimated when the exposed workers started to have above symptoms. The environmental monitoring of workplace was measured on April 25, 1990, and the concentration of formaldehyde revealed 0.2 ppm, however the exhaustive ventilatory system was already installed at that time. Twenty six subjects from entire factory were examined by questionnaire, physical examination and spirometry, etc. on August 22, 1990. Significant difference was observed in symptoms and signs of nasal, oral and throat irritation between the exposed group with longer duration and that with short duration. When the exposed group with longer duration was compared to the group of nonexposed, symptoms and signs of nasal, oral, throat and skin irritaion, chest tightness and dullness were significantly increased in the former group. The results of the spirometric test showed that the forced vital capacity and the forced expiratory volume at 1 second were decreased among the exposed group with longer duration but not significant.

• Journal of Korean Ophthalmic Optics Society
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• v.21 no.1
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• pp.1-10
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• 2016

Purpose: The study was aimed to suggest the most effective color of the tinted lenses by evaluating the effect of the prescription with tinted lenses on the visual quality of the elderly at the age of the sixty or more. Methods: The visual acuity of fifty subjects at the age of sixty or more (17 males, 33 females with the averaged age of $71.0{\pm}6.3$) were corrected to have the visual acuity at a far distance of 0.5 or more using a trial lens frame, and non-tinted, brown-tinted, and gray-tinted lenses were randomly applied on the trial frame. The minimum legibility and minimum separability were measured at a far distance in the aspect of the visual acuity and calculated as LogMAR and then, the visual acuity was compared. The stereopsis and contrast sensitivity were also estimated at a near distance in the aspect of the visual function. The participants' preference for tinted lenses and their subjective symptoms of the visual perception and the movement were further surveyed. Results: The best minimum legibility and minimum separability was shown when wearing non-tinted lenses, and brown-tinted and gray-tinted lenses were in the next. The stereopsis and the contrast sensitivity at a near distance and the visual perception was the best when wearing brown-tinted lenses. It was surveyed that the subjective discomfort was the biggest when wearing gray-tinted lenses, and brown-tinted lenses were the best in the aspect of the subjective preference. Conclusions: As the result of this study, it was revealed that the visual acuity and visual function could be improved by the use of tinted ophthalmic lenses however, its change of visual acuity and visual function was not completely correlated with the subjective satisfaction. Therefore, the appropriate color of ophthalmic lenses should be selected in accordance with the individual visual perception and the main vision lifestyle in the elderly generation. From the present study, the use of non- or brown-tinted lens and brown- or gray-tinted lens can be recommended for distance work and near work, respectively, in the elderly generation under the illumination of about 1,000 lux.