• Childhood Kidney Diseases
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• v.6 no.1
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• pp.120-122
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• 2002

A 9-year-old boy of B blood group with end-stage renal disease due to IgA nephropathy received group O kidney transplantation from his father On day 9, he developed intravascular hemolysis, and anti-B autoantibody formation was confirmed. We diagnosed as immune hemolytic anemia due to passenger lymphocyte from donor, and cyclosporine withdrawl was done. Anemia resolved spontaneously, but on day 18, graft dysfunction developed, and graft biopsy revealed acute allograft rejection. Although hemolysis due to autoantibody is very rare and often mild, and the role of hemoglobinuria on acute rejection in this case is not certain, we recommend consideration of aggressive management on severe hemolysis after minor mismatched kidney transplantation. (J Korean Soc Pediatr Nephrol 2002 ; 6 : 120-2)

• Membrane Journal
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• v.26 no.4
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• pp.291-300
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• 2016

Techniques for selectively separating molecules of gas and liquid states using various separation membranes have been widely used in variety of applications such as chemical, biological, pharmaceutical, and petrochemical industries. As the nanochannel diameter, inter-channel distance and length of the nanochannel of the anodic aluminum oxide (AAO) membranes can be precisely controlled, various studies to effectively separate mixture of various molecules using AAO membrane have been widely carried out. In this study, we fabricated AAO membranes of cylindrical nanochannels of various diameter sizes and of through-hole structure, that is, nanochannels of which both ends of each nanochannel are open. Using those AAO membranes of through-hole nanochannel structure, we studied the selective permeation polymer chains dissolved in a solvent based on hydraulic volume of the polymer chains. We found a precise, quantitative relationship between the radius of gyration of polymer chains that permeated through nanochannels inside AAO membrane and the diameter of nanochannels. In addition, we demonstrate that the behavior of the polymer solution flowing through nanochannel of the AAO membrane can be successfully described with the Hagen-Poiseuille relationship. It is, therefore, possible to theoretically interpret the nanoflow of the solution flowing inside the cylindrical nanochannel.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2006.02a
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• pp.91-96
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• 2006

현대의학의 발전으로 많은 질병들의 치료율이 개선되고 있으나, 암은 여전히 낮은 치료율과 약제 내성 및 부작용으로 많은 환자들이 의학적 고통 뿐 아니라 정신적, 경제적 문제점들을 호소하고있다. 이와같은 문제점은 동일한 병리학적 특성을 가지는 종양이라도 사람마다 그 생물학적 특성이 다르며, 동일한 환자안에서도 종양의 시기에 따라 다양한 특성의 세포들이 공존하며 다양한 문제를 발생하는 tumor heterogeneity에서 기인하게된다. 다행히 최근의 분자생물학의 발전과 인간유전체연구들의 활성화로 이와같은 다양한 암의 특성과 환자들의 특성을 이해하는 연구 방법들의 개발로 환자의 특성에 맞는 항암제를 효율적으로 투여하는 맞춤치료를 향한 노력을 지속하고 있다. 이와같은 맞춤치료의 일환으로 약제의 환자에서의 반응과 부작용을 예측하고자 최신의 high-throughput 기법을 도입한 것이 Pharmacogenomics이다. 즉, 지금까지의 항암치료는 암의 종류에 따라 임상연구 결과에 근거한 항암제를 선택하고 있다. 그러나 앞서 설명한 것처럼 암의 특성과 환자 반응의 다양화로 실제 항암효과는 기대에 미치지 못하여 많은 수의 환자들이 치료에 내성을 보일 뿐 아니라 치명적인 부작용으로 새로운 문제에 대면하게 되었다. 따라서 각 항암제011 최대의 효과를 보이며 최소의 부작용을 나타내는 최선의 치료책을 선정하는 것이 중요한 과제이다. 이를 위해서 암환자의 치료 단계에서 정확한 진단 및 병기 설정, 생물학적 특성 이해 뿐 아니라, 치료 반응을 예측할 수 있는 생물학적 표지자를 찾고자 하는 노력의 결과로 현재 임상에 사용되는 몇 가지 종양표지자를 포함하여 다양한 유전자 칩들이 연구단계에 있다. 특히 다양한 생물학적 현상이 많은 유전자들의 변화에 의한다는 근거하여 약제의 효과와 부작용을 예측할 수 있는 표지자 발굴도 DNA chip 등의 high-throughput technology를 사용하여 그 특이도와 민감도가 향상된 표지자 발굴이 시도되고 있다. 아직은 시작단계이고 많은 검증이 필요하나 여러 가지 가능성의 증거들로 멀지않은 시기에 맞춤치료가 가능하리라 기대하며, 암 연구에 있어서 pharmacogenomics의 현황을 소개하고자 한다.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2005.07a
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• pp.526-528
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• 2005

파장 분할 다중화 방식 (WDM)의 광통신은 중앙 기지국에서 각 가입자에게 서로 다른 파장을 할당하여 동시에 데이터를 전송하는 방식으로서 각 가입자는 할당된 파장을 이용하여 항상 데이터를 송/수신할 수 있고 각 가입자에게 대용량의 데이터를 전송할 수 있을 뿐만 아니라 통신의 보안성이 뛰어나고 성능 향상이 용이하다 따라서 상, 하향(양방향, bidirectional) 3 파장 WDM-필터 소자(Flat band-path filter)는 광 가입자망 구축에서 통신 방송을 융합한 양방향 고화질 멀티미디어 서비스 사업에 반드시 필요로 하는 원천 부품이다. 본 연구에서는 1차원 광자결정을 이용한 저 손실 양방향 3 파장 WDM-필터를 얻을 수 있는 이론적 모델을 설계하고 그에 따라 2-cavity $Ta_2O_5/SiO_2$ 1차원 광자결정체를 제작하고 그 특성을 고찰 하였다. 파장에 따른 투과도 측정 결과 1550nm파장에서 투과되고 1310nm 및 1490nm파장에 대한 차단이 이론값과 일치하였다. 1550nm 파장 대에서 손실이 매우 낮은 flat-투과 밴드가 생성되었다. 특히 입사각도에 따라 flat-band 중심 파장의 변화를 이용하므로 새로운 개념의 WDM 소자로의 응용이 가능하다.

• Polymer(Korea)
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• v.35 no.4
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• pp.296-301
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• 2011

This study focuses on the investigation of the impregnation of poly (vinyl alcohol) (PVA) crosslinked with poly(styrene sulfonic acid-co-maleic acid) (PSSA-MA) to porous polyethylene membrane for the fuel cell application. The membranes were characterized by the measurements of the water content, contact angle, FTIR spectra, thermal gravimetric analysis, ion exchange capacity, proton conductivity, methanol permeability and elastic modulus. The existence of hydrophilic moieties in the impregnated membranes was confirmed by contact angle and FTIR measurements. The impregnated PVA/PSSAMA(90:10) membrane exhibited a higher ion exchange capacity (1.2 meq./g dry membrane) than Nafion membrane (0.91 meq./g dry membrane). Through the elastic modulus measurement, the dimensional stability of the resulting membranes was expected to increase higher than the polyethylene membranes. The methanol crossover and water content decreased even if the PSSA-MA content increased due to the reduction of the free volume.

• Membrane Journal
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• v.25 no.6
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• pp.547-557
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• 2015

In this study, we synthesized polyimide with high carbon dioxide gas transport property using 2,2-bis(3,4-carboxylphenyl) hexafluoropropane, 2,3,5,6-tetramethyl-1,4-phenylenediamine and poly(ethylene glycol) bis(3-aminopropyl) terminated and then we calculated solubility parameter of synthesized polymer and non-solvent phase separation coefficient to determine proper solvent for preparation of asymmetric membrane, also we measured the viscosity of the polymer solution to check polymer contents in membrane solution and prepare asymmetric membrane with $LiNO_3$ additives. The morphology and gas separation property of membrane prepared by phase separation method was confirmed using Field Emission Scanning Electron Microsope and the single gas permeation measurement apparatus. We confirmed that the carbon dioxide permeance of the membrane increased and the selectivity showed little change with decreasing of the volatile solvent contents.

• Korea journal of population studies
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• v.28 no.2
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• pp.1-32
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• 2005

The optimum population of a society or country can be defined as 'the population growth path that maximizes the welfare level of the society over the whole generations of both the present and the future, under the paths allowed by its endowments of production factors such as technology, capital and labor'. Thus, the optimum size or growth rate of population depends on: (i) the social welfare function, (ii) the production function, and (iii)demographic economic interrelationship which defines how the national income is disposed into consumption(birth and education of children included) and savings on the one hand and how the demographic and economic change induced thereby, in turn, affect production capacities on the other. The optimum population growth path can, then, be derived in the process of dynamic optimization of (i) under the constraints of (ii) and (iii), which will give us the optimum population growth rate defined as a function of parameters thereof. This paper estimates the optimum population growth rate of Korea by: specifying (i), (ii), and (iii) based on the recent development of economic theories, solving the dynamic optimization problem and inserting empirical estimates in Korea as the parametric values. The result shows that the optimum path of population growth in Korea is around TFR=1.81, which is affected most sensitively, in terms of the size of the partial elasticity around the optimum path, by the cost of children, share of capital income, consumption rate, time preference, population elasticity of utility function, etc. According to a survey implemented as a follow up study, there are quite a significant variations in the perceived cost of children, time preference rate, population elasticity of utility across different socio-economic classes in Korea, which implied that, compared to their counterparts, older generation and more highly educated classes prefer higher growth path for the population of Korea.

• Journal of the korean academy of Pediatric Dentistry
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• v.34 no.2
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• pp.234-246
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• 2007

The combination of chloral hydrate and hydroxyzine is one of the safest and most commonly used drug regimens for sedating young, uncooperative pediatric dental patients. Midazolam IM or IN and $N_2O/O_2$ inhalation is sometimes administered with chloral hydrate and hydroxyzinecombination when deeper and longer sedation is needed. The purpose of this study was to assess the outcome and safety of chloral hydrate, hydroxyzine and $N_2O/O_2$ in the sedation of a large number of uncooperative pediatric dental patients and to identify variables associated with their effectiveness. In a nine-month retrospective study, 171 records of sedation performed in 94 healthy children(male 46, female 48) with mean age of $30{\pm}8$ months were reviewed. The authors analyzed several variables such as age, sex, weight, methods of drug delivery, waiting time after drug delivery, treatment rendered, treatment time, adverse events, sedation outcome. Eighty five percent of sedation had success behavioral outcome. Sedation sessions rated success used more $N_2O/O_2$ administration and had longer treatment duration than sedation sessions rated failure. A children patient under 36 months of age had enough sleep by only oral administration and the mean waiting time of this case was significantly shorter than that of a children patient over 36 months of age. There was a clear correlation between age and $N_2O/O_2$ using tine, but no correlation between weight and $N_2O/O_2$ using time. There was no statistically significant difference among variables of treatment duration, $N_2O/O_2$ administration and adverse event.

• Pediatric Infection and Vaccine
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• v.15 no.2
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• pp.115-120
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• 2008

Purpose : This post-marketing surveillance (PMS) study was conducted in Korea to assess the safety and reactogenicity of hepatitis A vaccine (GlaxoSmithKlineBiologicals'$Havrix^{TM}$) administered to the Korean population. Methods : A total of 1,188 healthy subjects with 1,122 subjects <6 years of age were enrolled to receive one dose of the hepatitis A vaccine from April 2005 to January 2006. Diary cards were provided to the subjects or subjects' parents for reporting solicited and unsolicited symptoms during the 4-day and 31-day post-vaccination follow-up period. Results : The number of subjects who returned diary cards was 568, whereas, 620 subjects did not return diary cards. Among the subjects who returned diary cards, 9.9% and 14.3% reported local and general solicited/unsolicited symptoms. Among the subjects who did not return diary cards, 1.6% and 8.4% reported local and general solicited/unsolicited symptoms. At least one unsolicited symptom was reported by 13.2% of the subjects. Conclusion : Results indicate that the vaccine was well-tolerated and had an acceptable safety profile. The use of diary cards in such a survey provided a prompt and reliable option for recording symptoms.

• Bulletin of Food Technology
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• v.16 no.2
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• pp.78-179
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• 2003

Nature 본지는 1896년에 창간된 이래 130년 이상 과학출판에 있어 지대한 영향력을 끼쳐온 과학잡지로 최근 Nature 본지 이외에도 자매지인 Nature Biotechnology(1983년 창간), Nature Cell Biology(1999), Nature Genetics(1992), Nature Meterials(2002), Nature Immunology(1999), Nature Medicine(1995), Nature Neuroscience(1998), Nature Structural Biology(1994)의 8개의 Nature Reserch Journal이 있으며 6개의 Nature Reviews(Nature Reviews Cancer, Nature Reviews Drug Discovery, Nature Reviews Genetics, Nature Reviews Immunology, Nature Reviews Molecular Cell Biology, Nature Reviews Neuroscience)가 있다. Nature 본지는 Editorials, News, News Feature, Correspondence, Commentary, Books and Arts, Concepts, News and Views, Brief Communications, Review Article, Articles, Letter to Nature, Naturejob 등으로 구성된 주간지로 과학전반에 걸친 중요한 성과를 즉각적으로 출판할 기회 뿐 아니라 과학에 관한 뉴스나 이슈 등에 대한 토론의 장을 제공하기도 한다. Nature 본지의 2002년 ISI impact factor는 30.432로 SCI에 등재된 저널중에서 매우 높은 수위를 차지하고 있다. 따라서 Nature 본지에 게재된 식품 및 유관 분야에 대한 조사 분석 결과를 게재하오니 향후 투고 방향 설정에 참고하시기 바랍니다. 식품기술에서는 계속적으로 update할 예정입니다.