• The Science & Technology
• /
• v.21 no.10 s.233
• /
• pp.80-83
• /
• 1988

• Proceedings of the Korean Society of Potoscience Conference
• /
• spring
• /
• pp.9-9
• /
• 1995

• The Korean Journal of Nuclear Medicine
• /
• v.28 no.3
• /
• pp.343-349
• /
• 1994

The study was taken to analyze the laboratory findings of the 161 patients with autoimmune thyroiditis treated at Kyungpook University Hospital from January 1992 to July 1993. They were all female and mean age was 33 years ranging from 10 to 73 years. Mean radioactive iodine uptake(RAIU) of the thyroid was $30.90{\pm}21.80(mean{\pm}SD)%$ at 6 hours and $37.97{\pm}23.25%$ at 24 hours. Mean serum levels of thyroid hormones were $1.41{\pm}0.48$(ng/ml) of T3, $7.26{\pm}3.23$(ug/dl) of T4, and $1.11{\pm}0.66$(ng/dl) of free T4, while mean serum level of TSH was $17.99{\pm}30.72$(uIU/ml). Mean levels of serum autoantibodies were 24. $43{\pm}31.91$(U/ml) of antithyroglobulin antibody and $55.32{\pm}41.97$(U/ml) of antimicrosomal antibody. The correlation between RAIU and serum thyroid hormone levels was significantly negative, but the positive correlation between RAIU and serum TSH was noted. The correlation between thyroid hormones and TSH was significantly negative, but the positive correlation between RAIU and serum TSH was noted. The correlation between thyroid hormones and TSH was significantly negative, while antimicrosomal antibody titer revealed significantly positive correlation with TSH. The RAIU and free T4 showed negatively correlated with the increasing age. The Initial clinical findings of the patients with autoimmune thyroiditis revealed euthyroidism in 83.2%, hypothyroidism in 14.9%, and hyperthyroidism in 1.9%. The incidence of abnormally increased serum thyroglobulin, antithyroglobulin antibody, and antimicrosomal antibody were 21.3%, 97.5%, and 87.6%, respectively and these abnormalities were more frequent in the patients with documented clinical thyroid functional disturbances.

• The Microorganisms and Industry
• /
• v.16 no.3
• /
• pp.20-25
• /
• 1990

면역계에는 조력T세포(helper T cell)와는 반대로 면역반응을 억제적으로 조절하는 것이 주 기능인 억제성 T세포(suppressor T cell)가 존배한다는 것이 아려져 있다. 이 억제성 T세포가 존재한다는 개념이 면역학및 임상의학에 준 영향은 매우 지대하여, 앨러지나 자가 면역질환 같은 질병은 억제성 T세포의 결핍으로, 그리고 면역 결핍증같은 질병은 T세포가 지나치게 활성화된 것으로 설명되기에 이르렀다. 한마디로 거의 모든 저하된 면역반응은 억제성 T세포와 연관하여 설명되었다. 그러나 억제성 T세포가 발견된지 근 20년이 되고 그에 관한 논문이 5000여편에 달하는 최근까지도 억제성 T세포 및 이들 세포가 만드는 억제성 T세포 인자에 대한 실체는 정확히 규명되지 못하고 있다. 오히려 억제성 T세포가 조력 T세포처럼 별개의 세포군으로 존재한다는 것을 부인하는 학자도 최근 나오게 되었다.(이 분야의 연구에서 나타난 문제점들이 정리되어 있음). 그러나 억제성 T세포의 존재를 부인하는 학자들도 T세포가 면역 반응의 억제에 관여한다는 사실, 적어도 그 현상 자체를 부인하지는 않았다. 다시말하면, 면역반응이 T세포에 의하여 억제되는 현상은 이미 수 천년의 논문을 통하여 입증되고 있다. 면역반응의 억제에 있어서 억제성 T세포및 억제성 T세포 인자의 역할은 앞으로의 연구를 통해 명확히 규명될 것이며, 정말 억제성 T세포가 있느냐 없느냐 하는 것은 이 총설의 주제가 아니다. 다만 여기서는 조력 T세포도 경우에 따라서는 면역반응의 억제에 관여한다는 최근의 연구결과를 간단히 소개하고자 한다.

• Annals of Clinical Neurophysiology
• /
• v.9 no.2
• /
• pp.51-58
• /
• 2007

Autoimmune myasthenia gravis (MG) is the neuromuscular junction disorder mostly caused by antibody against the acetylcholine receptor (AChR antibody) at the muscle endplate. The goal of treatment is to induce and maintain remission, i.e., absence of symptoms, with the least cost-to-benefit ratio. Although corticosteroids are effective in inducing remission in most patients, they have numerous potentially serious adverse effects with their long-term use. In addition, some patients do not respond or are intolerant to the conventional treatment. In this article, we discuss the difficulties encountered in long-term immunosuppressive treatment of MG, and review useful tips for the use of corticosteroids. Long-term immunosuppressive agents that can be used in steroid-refractory or -dependent patients will be reviewed with their safety profiles and efficacy in MG.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• v.10 no.1
• /
• pp.91-97
• /
• 2007

The Overlap syndrome is characterized by a combination of the major hepatobiliary autoimmune diseases such as autoimmune hepatitis, primary biliary cirrhosis and primary sclerosing cholangitis. It is frequently accompanied by inflammatory bowel disease. Chronic lymphoplasmacellular osteomyelitis is characterized by recurrent episodes of bacterial osteomyelitis and is associated with autoimmune diseases (especially inflammatory bowel disease). We report the case of a girl who was diagnosed with ulcerative colitis and autoimmune hepatitis at 4 years of age and with the overlap syndrome with primary sclerosing cholangitis at 6 years. At 9 years, she was diagnosed with chronic lymphoplasmacellular osteomyelitis.

• Journal of Korean Philosophical Society
• /
• no.95
• /
• pp.59-93
• /
• 2011

Die vorliegende Abhandlung beschäftigt sich mit der Frage, ob Jacque Derrida das Problem des Global-Terrorismus im politisch-theologischen Sinne mit seiner Philosophie der Gastfreundschaft lösen kann. Fur Derrida ist der '11. September' das 'Ereignis', und das Symptom einer autoimmunitären Erkrakung der westlichen Welt. Derrida findet im '11. September Ereignis' die Struktur der Aneignung des Eignen und der Enteignung im Heideggerschen Sinne. Das 'major event' wird nicht in einer vergangenen Aggression bestanden haben, die präsent und wirksam ist und noch schlimmer in der Futur sein wird. Derrida versucht einen philosophischen, politisch-theologischen Ansatz zur Bedingungen der Möglichkeit der absoluten, vollkommenen Auflösung des Globalen Terrorismus zu programmieren. Dafür fordert er das Postulat Verwirklichung des 'Messianischen ohne Messianismus'. Die Gegenüberstellung zwei politischer Theologien zwischen der Europäischen Demokratie und der Islamischen Vereinigten Staaten kann erlöst werden, wenn die 'neue religiöse Spiritualität', die gegenüber der dogmatischen Religionswahrheit frei ist, mit der 'Wiederkehr der Religion' im echten Sinne vorkommt. In der 'Neuen Religion' Derridas ist der Begriff der 'Gastfreundschaft' wichtiger als der der 'Toleranz', den er als 'abrahamitisch' definiert. Die von Derrida postulierte neue Religion ist eine offene Religion, in der das Unvergebbare unbedingt zu vergeben ist. Ihre politische Transformation ist der Begriff der 'Neuen Europäischen Gemeinschaft' und des 'Anderen Kaps'. Derrida postuliert diese neue Idee des Kosmopolitismus als die notwendige Bedingung der vollkommenen Auflösung des autoimmunitären Global-Terrorismus.

• 건강소식
• /
• v.10 no.7 s.92
• /
• pp.20-23
• /
• 1986

우리나라 사람들이 여행하거나 진출하는 지역에서 만연되고 있는 질병에 대한 상식(생활사, 전염원, 면역성, 예방법)을 신문, 방송을 통해 범국민적으로 계몽활동을 전개하도록 하여야 하며, 해외에 여행 또는 근무 할 사람에 대해 현지의 환경에 대한 지도교육을 실시해야 한다.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• v.3 no.2
• /
• pp.199-205
• /
• 2000

Autoimmune enteropathy is a rare chronic diarrheal disease of infancy. Clinicopathologically, this entity is characterized by chronic secretory diarrhea, villous atrophy with crypt hypoplasia of a small intestine and/or associated autoimmune disorders, and absence of severe immunodeficiency. For the confirmation of diagnosis, antienterocyte autoantibody should be delineated. The treatment of choice of this disorder is immunosuppression. We has been experienced a case of autoimmune enteropathy without autoimmune disorders in a 10-month-old male infant. He developed protracted diarrhea from 5 months of his age and has been appeared to be failure to thrive. Antienterocyte autoantibody was demonstrated by immunohistochemistry and western blotting. He was successfully treated with corticosteroid and FK506. This is the first case report of autoimmune enteropathy without autoimmune disorders in Korea.

• Tuberculosis and Respiratory Diseases
• /
• v.62 no.1
• /
• pp.67-70
• /
• 2007

A thymic carcinoma is a rare malignant neoplasm of the thymus epithelium, which can be distinguished from a benign or invasive thymoma. Contrary to a thymoma, the association of a thymic carcinoma and autoimmune disease is rare, with only a few cases having been reported. Herein, a case of thymic carcinoma diagnosed concurrently with systemic lupus erythematosus (SLE) is reported. A 49 year-old man presented at our clinic with myalgia. He was diagnosed with SLE, based on an oral ulcer, lymphopenia, and positive ANA and anti-Sm antibodies. Incidentally, a routine chest X-ray showed a large mediastinal mass. Pathological examination of the mediastinal mass revealed an undifferentiated thymic carcinoma, of WHO classification type C. Further work-up for staging showed multiple bone and lung metastases. With a palliative aim, he received systemic chemotherapy, but refused further chemotherapy after the $2^{nd}$ course. Currently, the patient has not been followed up since the chemotherapy.