• Proceedings of the Korea Information Processing Society Conference
• /
• 한국정보처리학회 2011년도 춘계학술발표대회
• /
• pp.1039-1042
• /
• 2011

스트레스는 다양한 질병의 원인이 되며 스트레스의 해소는 질병 예방에 중요한 요인이라 할 수 있을 것이다. 스트레스를 해소시키는 방법 중 한 가지는 청각이나 시각을 이용하는 방법이다. 청각과 시각을 동시에 이용할 수 있다면 그 효과를 극대화 할 수 있을 것이다. 본 논문에서는 음악의 분위기를 자동으로 파악하고, 파악한 음악의 분위기를 표현할 수 있는 감성조명 시스템을 제안하였다. 본 논문에서 제시한 감성조명을 공원이나 가정집 등에 제공할 수 있을 것이고, 음악과 조명을 동시에 제공함으로 현대인 질병의 원인이라 할 수 있는 스트레스 해소가 가능 할 것이다. 또한 본 논문의 시스템을 이용하여 임상실험을 실시하여 임상데이터를 확보한다면 심리 치료를 목적으로 하는 의학적 도구로 발전 할 수 있을 것으로 보인다.

• Clinics in Shoulder and Elbow
• /
• 제16권1호
• /
• pp.63-72
• /
• 2013

In medical research, multivariate analysis, especially multiple regression analysis, is used to analyze the influence of multiple variables on the result. Multiple regression analysis should include variables in the model and the problem of multi-collinearity as there are many variables as well as the basic assumption of regression analysis. The multiple regression model is expressed as the coefficient of determination, $R^2$ and the influence of independent variables on result as a regression coefficient, ${\beta}$. Multiple regression analysis can be divided into multiple linear regression analysis, multiple logistic regression analysis, and Cox regression analysis according to the type of dependent variables (continuous variable, categorical variable (binary logit), and state variable, respectively), and the influence of variables on the result is evaluated by regression coefficient${\beta}$, odds ratio, and hazard ratio, respectively. The knowledge of multivariate analysis enables clinicians to analyze the result accurately and to design the further research efficiently.

• Journal of Veterinary Clinics
• /
• 제27권2호
• /
• pp.147-153
• /
• 2010

Bio-integration of cartilage grafts with subchondral bone is a significant clinical challenge. To date, the use of demineralized bone matrix (DBM) has been one of the most effective strategies for bone cell proliferation in vivo. Here, we investigated whether coculture of chondrocytes and DBM could serve as a single-platform system containing all the essential elements for purposive bone and cartilage induction. The aim of this study was to evaluate and compare the phenotype and proliferation of bovine chondrocytes cocultured with DBM in two different culture systems, pellet and alginate bead culture. In alginate bead culture, we observed an increase in chondrocyte number and formation of cell clusters. Typical chondrocytic phenotype was maintained for entire eight weeks. Histological analysis showed that chondrocytes maintained a typical round, plump morphology and there was a gradual increase in lacunae. Both coculture systems yielded an expanded cell population as compared to the controls (chondrocytes alone). The production of glycosaminoglycans was also increased in the coculture systems as compared to controls.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• 제11권9호
• /
• pp.3330-3335
• /
• 2010

Due to the acceleration of medical information age, the semantic interoperability of clinical information is rising up as a major issue. The laboratory results are known as the best significant area among clinical information to be required for exchanging and sharing. The aim of this research is to develop the clinical contents model for exchange laboratory results. This research was conducted from March 2008 to September 2008. Firstly, the method is to get the attributes and codes from LOINC which is one of the standard medical terminology system related to laboratory and the Reference Information Model(RIM) of Health Level 7(HL7). Secondly, the attributes from each work process around orders and reports of laboratory was analyzed. We evaluated the attributes whether they could be represented into the attributes contained in HL7's RIM. Thirdly, the prototype for hemoglobin case using the structure of clinical contents model and defined attribute. Fourthly, the face validity was done by one laboratory physician with four clinicians. The assessment contents were for the suitability involved in representation and exchange with proposed model. The results shows that the model corresponds with the aim of the research. Eventually the proposed model for the exchange of laboratory results could contributes to information interchange according to laboratory area for the future.

• The Transactions of the Korea Information Processing Society
• /
• 제7권8호
• /
• pp.2349-2360
• /
• 2000

In medical image processing, if new technologies arc developed, they arc applied to real clinical cases. The results are to be analyzed by doctors to improve the new technologies. So, it is important for doctors to have a tool that helps the doctors in applying the new technologies to clinical cases and analyzing the clinical results. In this paper, we design and implement a visual programming environment where non-programming experts, such as medical doctors, can easily compose a medical image processing application program. A set of image processing functions are implemented and represented as icons. Thc user selects functions by clicking correslxmding icons. The users can easily find necessary' functions from the visualized library. A user selects a function from the visualized library and [Jut the function node into a canvas of Visual Programming Interface. The user connects nodes to compose a dataflow diagram. The connected dataflow diagram shows the now of the program. Hyperbolic Tree is helpful in visualizing a set of function icons in a single screen because it provides both the whole stmcture of the function Iihrary and the details of the focused functions at the same time. We also developed a CUI builder where the user interfaces of the medical image processing applications are composed. Therefore. non'programming experts such as physicians can apply new medical image processing algorithms to clinical cases without performing complex computer programming procedures.

• Nuclear Medicine and Molecular Imaging
• /
• 제42권2호
• /
• pp.153-163
• /
• 2008

Medical imaging modalities to image either anatomical structure or functional processes have developed along somewhat independent paths. Functional images with single photon emission computed tomography (SPECT) and positron emission tomography (PET) are playing an increasingly important role in the diagnosis and staging of malignant disease, image-guided therapy planning, and treatment monitoring. SPECT and PET complement the more conventional anatomic imaging modalities of computed tomography (CT) and magnetic resonance (MR) imaging. When the functional imaging modality was combined with the anatomic imaging modality, the multimodality can help both identify and localize functional abnormalities. Combining PET with a high-resolution anatomical imaging modality such as CT can resolve the localization issue as long as the images from the two modalities are accurately coregistered. Software-based registration techniques have difficulty accounting for differences in patient positioning and involuntary movement of internal organs, often necessitating labor-intensive nonlinear mapping that may not converge to a satisfactory result. These challenges have recently been addressed by the introduction of the combined PET/CT scanner and SPECT/CT scanner, a hardware-oriented approach to image fusion. Combined PET/CT and SPECT/CT devices are playing an increasingly important role in the diagnosis and staging of human disease. The paper will review the development of multi modality instrumentations for clinical use from conception to present-day technology and the application software.

• Journal of Korean Society of Forest Science
• /
• 제97권1호
• /
• pp.1-9
• /
• 2008

It is necessary to examine relationship between spatial patterns of forest types and characteristics of forest fires for efficient management of fire and forest. By the ecoregions of South Korea, we computed landscape indices for whole types of forests(landscape level) and pine forests(class level), and analyzed characteristics of forest fires using statistics of forest fires from 1991 to 2006. We performed canonical correlation analysis to model the relationship between the landscape indices and the statistics of forest fires. At landscape level, forest patches were larger and more complex in the ecoregions which had higher percentage of forest area. At class level, pine forest patches were more complex and closer to neighbor patches in the coastal ecoregions. The ecoregions including metropolitan areas and cities had more frequent fire occurrences per 1,000ha, while mountainous coastal ecoregions had more burned areas and faster spread of fire growth rate. The canonical correlation between the landscape indices for pine forests and the statistics of forest fires was statistically significant at the 0.05 level and explained more than 70% of the variation in fire variables. The results showed that combustion time per fire was longer in the ecoregions which had larger and more aggregated pine forest patches.

• Proceedings of the KOR-BRONCHOESO Conference
• /
• 대한기관식도과학회 1993년도 제27차 학술대회 초록집
• /
• pp.83-83
• /
• 1993

The nuclear phosphoprotein p53 is expressed in all normal cells and appears to function in cell cycle regulation. Abnormally high levels of the protein are found in many different types of cancer. In human cancer overexpression of p53 is associated with point mutations within highly conserved regions of p53 gene. These altered genes encode stable p53 proteins that can detected by standard immunocytochemical techniques unable to detect rapidly degraded wild-type protein. Using of a monoclonal antibody to p53 antigen, immunocytochemical analysis of 29 squamous cell carcinomas of tongue(n= 19) and tonsil(n= 10) was performed. Non-tumor nuclei showed all negative reactivity. Positive reactivity was found in 4/29(13.8%)of SCCs of tongue and tonsil. In sizes of primary tumor, the cases over 4cm showed more positive reactivity than the cases under 4cm(p < 0.05). There was no stastical correlation between the reactivity and histopathologic grades, the primary sites of tumor or the presence of cervical metastasis.

• Journal of The Korean Society of Inherited Metabolic disease
• /
• 제21권1호
• /
• pp.7-14
• /
• 2021

Purpose: Pseudohypoparathyroidism (PHP) is caused by genetic and epigenetic alteration in the GNAS locus, and characterized by the resistance to multiple hormones and the Albright's hereditary osteodystrophy (AHO) phenotype. This study investigated the phenotypic characteristics and molecular features of PHP. Methods: Eight patients who diagnosed as PHP were enrolled at Pusan National University Children's hospital and clinical features, biochemical and genetic findings were retrospectively reviewed. Results: Of a total of 8 patients, 5 were diagnosed with PHP1a, and 3 were diagnosed with PHP1b. Patients with PHP1a had three different mutations in the GNAS gene, and patients with PHPIb had imprinting defect in differentially methylated regions (DMRs) of the GNAS locus. Two novel GNAS variants were identified in patients with PHP1a, including c.313-2A>T and c.1094G>A. All patients with PHP1a displayed AHO features; short stature (80%), brachydactyly (80%), a round face (80%), obesity (40%), heterotopic ossification (60%), and intellectual disability (60%), whereas only one patient (33.3%) with PHP1b showed AHO feature such as a round face. When phenotypic features between PHP1a and PHP1b patients were compared, patients with PHP1b showed a tendency of higher current height standard deviation scores (SDS) compared to patients with PHP1a, (-3.2±2.1 vs.-1.1±0.8; P=0.06) Conclusions: This study summarizes the phenotypic and genetic features of the PHP patients. Although we found considerable clinical overlap between PHP1a and PHP1b, further long-term follow-up is needed to evaluate the growth and development of children with PHP, as well as the effects of end-organ resistances to endocrine hormones.

• Archives of design research
• /
• 제19권5호
• /
• pp.85-94
• /
• 2006

In the 2000s, character animation technique is used at domestic TV character animation ads of diverse items displaying new character patterns and expression techniques of a high level. This study intends to identify the characteristics of TV character animation ads based ell character aesthetic theory and advertising rhetoric theory, and based on these findings, analyze trend and stream of expression in TV character animation ads by examining and classifying advertisements released in the past four years by items, character patterns and expression techniques. The results showed that TV character animation ads have been concentrated on confectionery, beverages and foods in the past, but the items have been diversified through the years. With reference to character patterns, personal and animal characters had made the main pattern, but recently product, virtual and composite characters are on the increase. In expression techniques, cell animation technique was found to be the most frequently used technique, which was followed by full-3D, cell and live action, cell and 3D and the clay animation technique. A trend like this suggests that TV character animation advertising items will continue to increase in line with the participation level of targets. In the meantime, personal and animal characters will continue to make the leading character pattern, while virtual and composite character patterns emerge in new forms. In expression techniques, live action combined with 30 technique and techniques using new expression materials will appear with cell animation technique as a central figure. As a whole, Korean character animation advertisement is expected to keep on growing to a new dimension in the aspect of items, character patterns and expression technique.