• Radiation Oncology Journal
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• v.26 no.2
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• pp.104-112
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• 2008

Purpose: To assess the toxicity and tumor response induced by $DCVac/IR^{(R)}$ dendritic cell(DC) immunotherapy combined with irradiation for refractory colorectal cancer patients with multiple liver metastases. Materials and Methods: Between May 2004 and November 2006, applicants from a pool of refractory colorectal cancer patients with multiple liver metastases were enrolled. The patients were registered after having signed the informed consent form, which had been approved by the Institutional Review Board from the Dong-A University and Busan National University Hospital. DCs were obtained from peripheral blood of each patient, and then cultured in vitro. A total of $6{\times}10^6$ DCs were packed into a vial($DCVac/IR^{(R)}$, 0.5 ml) at the convenience of each patient's schedule. On the day before and on the day of each vaccination, each patient received a 4 Gy radiation dose to the target tumor. On the day of vaccination, the indicated dose of autologous DCs was injected into the irradiated tumor using ultrasound-guided needle injection procedures. A total of four vaccinations were scheduled at three 2-week intervals and one 4 week interval at the Dong-A University and Busan National University Hospital. If the tumor status was deemed to be stable or responding to therapy, an additional vaccination dose or two was approved at 4 week intervals beyond the fourth immunization. A tolerance test for DCs was conducted by injecting a range of doses($3{\times}10^6\;to\;12{\times}10^6$ DCs) after the 3rd injection. Moreover, the maximal tolerable dose was applied to additional patients. Treatment safety was evaluated in all patients who had at least one injection. Treatment feasibility was evaluated by the 10th week by assessing the response of patients having at least 4 injections. For systemic toxicities, the evaluation was performed using the National Cancer Institute Common Toxicity Criteria, whereas adverse effects were recorded using common WHO toxicity criteria. Results: Of the 24 registered patients, 22 received the DCs injections. Moreover, of the 14 patients that applied for the tolerance test, only 11 patients completed it because 3 patients withdrew their testing agreement. A grade 3 or more side effect, which was possibly related to the DC injection, did not occur in additional patients. The $12{\times}10^6$ DC injection was identified as the maximum tolerable dose, and was then injected in an additional 8 patients. Patients tolerated the injection fairly well, with no fatal side effects. In order to assess the feasibility of DC immunotherapy, the response was evaluated in other hepatic lesions outside of the targeted hepatic lesion. The response evaluation was performed in 15 of the 17 patients who received at least 4 injections. Stable and progressive disease was found in 4 and 11 patients, respectively. Conclusion: The DC-based immunotherapy and radiotherapy is theoretically synergistic for the local control and systemic control. The $DCVac/IR^{(R)}$ immunotherapy combined with irradiation was tolerable and safe in the evaluated cases of refractory colorectal cancer with multiple liver metastases. Future work should include well designed a phase II clinical trials.

• Journal of the korean academy of Pediatric Dentistry
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• v.42 no.1
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• pp.1-9
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• 2015

This study was conducted for the purpose of providing basic data that aims to develop the clinical practice education program and improve satisfaction for clerkship by evaluating the satisfaction of students who participated in learning using role-play in the clerkship of the department of pediatric dentistry. 85 senior dental students participated in this study. The students were divided into 17 groups and randomly performed role-plays in their role. After each role-play, a questionnaire designed to evaluate students' satisfaction on interest and appropriacy and satisfaction on usefulness towards role-play were completed by 77 students. The mean score of total satisfaction was 3.38 on a 5 point Likert scale. The mean score satisfaction on interest and appropriacy was 3.99 and the mean score satisfaction on usefulness was 3.79. The satisfaction score in the role group of parents was the highest and there was a significant difference in mean scores by the role groups (p < 0.05). Students evaluated the role-play as an interesting and useful educational tool in clerkship. It is necessary to undergo further trials and complement programs to upgrade the quality of dental clerkship.

• Korean Journal of Clinical Laboratory Science
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• v.55 no.1
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• pp.45-51
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• 2023

Canine parvovirus type 2 (CPV-2) and canine coronavirus (CCoV) are major pathogens that can induce gastroenteritis in dogs. They are highly contagious and have a high morbidity rate. There are no specific treatments available for them to date. Therefore, rapid and accurate diagnosis becomes essential. The rapid diagnostic test (RDT) for animals can be used widely in the field because it is fast and easy to use for diagnosis. Thus, this study aimed to clinically evaluate and confirm the clinical utility of CPV-2/CCoV RDT. The parameters evaluated included the limit of detection (LoD), cross-reactivity, interference, sensitivity, specificity, negative likelihood ratio (NLR), and kappa value. The results revealed that the LoD values for CPV-2 and CCoV were 9.7×10 50% tissue culture infectious dose (TCID₅₀)/mL and 2.5×10² TCID₅₀/mL, respectively. There was no cross-reactivity with nine pathogens or interference by interfering materials. The RDT showed a sensitivity of 90.0%, a specificity of 100.0%, NLR of 0.1, and a kappa value of 0.90 for diagnosing both viruses. In conclusion, CPV-2/CCoV RDT is useful as a screening test because of its high sensitivity, specificity, kappa value, and low NLR.

• Journal of Veterinary Clinics
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• v.28 no.5
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• pp.506-509
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• 2011

This study was performed to determine a comprehensive anatomic variation and deviation of the nasal septum in clinically normal dogs by use of computed tomography (CT). The nasal septum was evaluated in 36 shihtzu dogs and 16 beagle dogs. A degree of a septal deviation was evaluated by measuring a maximum angle and a distance of the septal deviation. The angle and distance of the septal deviation were significantly higher in shih-tzu dogs than in beagle dogs. There was no significant relationship between body weight and age and all measurements (angle and distance) in both breed dogs. Results of this study suggest that nasal septum deviation and its defect are observed on CT images of clinically normal dogs, especially in shih-tzu dogs.

• Journal of Practical Agriculture & Fisheries Research
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• v.21 no.2
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• pp.71-76
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• 2019

There have been no reports on the laboratory screening of congenital torticollis in equine medicine. The purpose of this study was to evaluate the blood chemistry of a newborn female foal with congenital torticollis. The filly was born after a normal parturition period, and the clinical pathology results were as follows: biochemistry of the plasma showed significantly higher levels of CK, LDH, and Na than those in a normal foal. However, Cl level was remarkably lower than that of the control. In conclusion, the cells in the neck muscles influenced the clinical pathological value in the neonate. A disorder of the muscles as well as the bone problem, such as the cervical vertebrae, may have caused congenital torticollis. To our knowledge, this is the first report detailing the clinical pathology results in a newborn foal with torticollis. These laboratory results can be used as a reference for interpretation of pathology results in foals.

• Journal of the Korean Society of Physical Medicine
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• v.3 no.4
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• pp.301-307
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• 2008

목적 : 노년층의 대부분이 가지고 있는 골관절염이라고도 알려진 퇴행성 관절 질환은 척추에 영향을 끼친다. 그리고 이 질환은 통증과 일상생활에서의 활동 제한을 초래한다. 본 연구는 퇴행성 관절질환 환자의 물리치료 빈도에 따른 효과를 검증하는 데 있다. 방법 : 퇴행성 관절 질환을 가진 30명의 환자가 이 연구에 참여하였고 이들에 취해진 물리치료의 빈도에 따른 효과를 평가하여 그 결과를 물리치료 임상 지침서와 비교분석하였다. 본 연구에 참여한 환자들은 시각적 사상척도(Visual Analog Scale, VAS), 멕길 통증 설문지, 일반적인 설문지에 응했으며 물리치료 전과 후를 물리치료 빈도에 중점을 두어 평가받았다. 결과 : 본 연구에 참여한 환자들은 제시된 치료 빈도와 평가에 근거하여 볼 때 놀랄만한 호전을 보였다. 치료 초기와 물리치료를 시작하기 전의 평가 자료를 비교하여 보았을 때 설문지로 평가된 점수에서 큰 향상을 보였다. 결론 : 본 연구는 물리치료가 퇴행성 관절 질환 환자들에게 효과가 있음을 보여주었다. 또한 물리치료 임상지침서는 따라야 할 좋은 자료가 될 수 있지만 물리치료 처방에는 정해진 기준은 없다는 것을 보여주었다.

• Journal of the Korean Society of Radiology
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• v.2 no.2
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• pp.5-10
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• 2008

Most of the diagnostic medical radiography are rapidly replaced by digital imaging systems recently. Although with the current transition of analog to digital most of the exposure conditions and parameters are still on the basis of film-screen analog system. Moreover the evaluation of acquired digital radiographic image is not fulfilled normally because of the difficulties in handling the digital raw data. The user friendly windows program for the evaluations of digital radiographic image was developed on the MatLab platform. The program has functions for the calculation of the contrast profile, NPS(noise power spectrum), MTF(modulation transfer function), and NEQ(noise equivalent quanta).

• Journal of Korea Entertainment Industry Association
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• v.14 no.1
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• pp.137-147
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• 2020

This study is aimed to develop and validate the clinical competence scale of occupational therapy student. The development of clinical competence scale analyzed the definition of clinical performance and previous studies. preliminary examinations were conducted on 203 occupational therapy departments in 3rd and 4th grade to verify item analysis and job validity. After exploratory factor analysis, eight factors of professional consciousness, 11 items of occupational therapy evaluation factors, 4 items of occupational therapy intervention factors, and 4 items of communication factors were extracted into a total of 27 factors. As a result of verifying the reliability of each factor through the internal consistency coefficient Cronbach's α, it was found to be .87~.94 and the overall reliability was .96. The correlation between the total score and the factors of the clinical competence scale was statistically significant. Through the confirmatory factor analysis, the model fit test of the factor structure for 27 items of 4 factors (χ²=.76, df = .31, CFI = .81, TLI = .80, RMSEA = .79) is considered acceptable. Through this study, The clinical competence scale is a valid and reliable scale that can be useful for objectively assessing.

• Journal of radiological science and technology
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• v.33 no.3
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• pp.193-201
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• 2010

This study aimed to develop an open clinical training program to improve radiology graduates' clinical competency in the hospital setting to raise quality of patient-centered medical service. Development of the training program is similar to that of an instructional system design model. The program was developed according to the ADDIE model. Elements of each phase were collected. Draft of the program was constructed from literature review and clinical demands. Preliminary training program was implemented to sample students with the draft. After consultation with related professionals, the program was modified and completed. Professional groups assessed content validity of the program. Five continuous phases of the program - analysis, design, development, implementation, and evaluation - accommodate changes in clinical environment and demands. They also provide adequate learning needs. Effectiveness of the program and appropriateness of contents in each phase achieved a satisfactory level of significance. This program reflected demands from medical fields and effective learning programs. The purpose of the open clinical training program is to train radiological technologists in clinical setting to actively engage in patient-centered medical service and to help utilize their professional knowledge.

• Journal of the Korean Association of Geographic Information Studies
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• v.12 no.3
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• pp.143-151
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• 2009

Forest type map is a main forest thematic map which shows forest type, age class, diameter class and density. This map has been used as a base data in various fields such as forest policy decision-making, land suitability assessment and eco map production etc. But the existing map had many kinds of errors and no metadata because there was no standard for digital map production. On this study, we developed standard for digital forest type map production consisting of 33 unit processes including DB schema design, mapping process, quality control and metadata input process. Based on this standard, country-wide digital forest type map can be produced with consistent quality and standard metadata.