• Journal of dental hygiene science
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• v.15 no.2
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• pp.182-189
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• 2015

The purpose of this study was to investigate the relationship between degree of satisfaction and experience on performance in accordance with the characteristics for the dental hygiene students. Dental hygiene students to 480 people from November to December 2014 and analyzed by conducting a survey. The higher grade students were more satisfied with the degree of satisfaction on experience for clinical test performance and clinical practice organization rather than the lower grade students. Also, the degree of satisfaction on major for the higher grade students has been shown as relatively higher than the lower grade students. The factors that affecting the experience for clinical performance and the degree of satisfaction for clinical practice were shown as grade, satisfaction for major and period for practice. In order to enhance the degree of satisfaction on the clinical performance for students, it should be established the system for practice management considering the characteristics of clinical practice by relevant organizations. Also, the dental hygienist who is responsible for dental education should manage his/her practice for students actively. Meanwhile, the practice organization should improve and update the content of education through the consistent alliance with colleges continuously.

• The Journal of the Convergence on Culture Technology
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• v.6 no.1
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• pp.223-229
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• 2020

The study was to understand the meaning and nature of clinical practice by examining the clinical experience of male nursing college students who have experienced clinical practice and to obtain basic data on how male nurses influence the career setting in clinical practice. to be. Participants in this study were male students who are currently in the Department of Nursing at H University, and three snowmen were selected as 3rd grade students and 3rd grade male students who had clinical practice, and analyzed meaningful statements according to Colaizzi data analysis To understand the meaning of students' clinical experience. The findings were divided into three categories, with six themes and 14 meaningful statements. The male nursing students experienced discrimination on the grounds of 'negative nursing image experienced in ward practice', 'the burden of self to be handled', and 'the charm of nursing found in the special part training experience'. Conflict and confusion over the profession were causing. However, among them, the professionalism of the nurses was confirmed and the pleasure of learning was found, and the results of this study can provide a holistic view of the clinical practice experience of male nursing students. In addition, it can be used as a basic data useful for counseling and guidance on academic adaptation and clinical practice adaptation of male nursing college students, and is expected to be useful for counseling career decision after graduation of male nursing students.

• Communications for Statistical Applications and Methods
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• v.16 no.1
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• pp.51-65
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• 2009

The purpose of a phase I clinical trial is to determine the maximum tolerated dose(MTD) of a new drug. This paper investigates the performance of standard method, continual reassessment method and accelerated titration designs in phase I clinical trials. Especially we study the precision and safety at the MTD of these methods. We utilize hyperbolic tangent function and power function to define dose-toxicity model. For each method, expected toxicity rate at MTD is computed and compared with target toxicity probability. We also suggest some modifications of these methods and show some improvements in performance.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.330-330
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• 1994

항암화학요법후 가장 심각한 부작용의 하나는 중성구 감소에 의한 감염이다. 본원에서는 rhGM-CSF을 이용한 제 I상 임상연구에서 150-500$\mu$g/M$^2$/day가 biologically active dose임을 보고한 바 있다. 연자들은 연세암센터에 내원하여 진행성 악성종양으로 병리조직학적 진단을 받고 항암화학요법 시행후 골수억제가 예상되는 환자를 대상으로 GM-CSF 용량에 따른 안전성 및 독성을 검토하고 백혈구 감소증 및 감염의 예방, 치료효과를 분석하여 임상사용권장량을 결정하기위한 2상 연구덜 대상환자의 동의를 얻은후 시행하였다. 대상환자는 37명 (여 26, 남 11)이었고, 항암제는 Adriamycin, Cisplatin, VP-l6 이 주로 사용되었다. 최적임상사용권장량을 결정하기 위하여 1500$\mu\textrm{g}$/M$^2$/day을 12명, 250$\mu\textrm{g}$/M$^2$/day을 12명, 350$\mu\textrm{g}$/M$^2$/day을 13명의 환자에게 투여하였다. 첫번째 항암요법에는 rhGM-CSF을 투여하지않고 (비투여기) 두번째 항암요법에서는 항암요법후 익일부터 10일간 연속, 매일 1회 피하주사하여 (투여기), rhGM-CSF 투여기와 비투여기의 백혈구 감소중 정도의 차이를 비교하였다.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.306-306
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• 1994

항암화학요법후 가장 심각한 부작용의 하나는 중성구 감소에 의한 감염이다. 본원에서는 rhGM-CSF을 이용한 제 I상 임상연구에서 150-500$\mu$g/M$^2$/day가 biologically active dose임을 보고한 바 있다. 연자들은 연세암센터에 내원하여 진행성 악성종양으로 병리조직학적 진단을 받고 항암화학요법시행후 골수억제가 예상되는 환자를 대상으로 GM-CSF 용량에 따른 안전성 및 독성을 검토하고 백혈구 감소증 및 감염의 예방, 치료효과를 분석하여 임상사용권장량을 결정하기위한 2상 연구를 대상환자의 동의를 얻은후 시행하였다. 대상환자는 37명 (여 26, 남 11)이었고, 항암제는 Adriamycin, Cisplatin, VP-16이 주로 사용되었다. 최적임상사용권장량을 결정하기 위하여 1500$\mu\textrm{g}$/M$^2$/day을 12명, 250$\mu\textrm{g}$/M$^2$/day을 12명, 350$\mu\textrm{g}$/M$^2$/day을 13명의 환자에게 투여하였다. 첫번째 항암 요법에는 rhGM-CSF을 투여하지않고 (비투여기) 두 번째 항암요법에서는 항암요법후 익일부터 10일간 연속, 매일 1회 피하주사하여 (투여기), rhGM-CSF 투여기와 비투여기의 백혈구 감소증 정도의 차이를 비교하였다.

• Annual Conference on Human and Language Technology
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• 2016.10a
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• pp.51-55
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• 2016

본 논문에서는 임상 의사 결정 지원을 위한 UMLS와 위키피디아를 이용하여 지식 정보를 추출하고 질병 중심 문서 클러스터와 단어 의미 표현을 이용하여 질의 확장 및 문서를 재순위화하는 방법을 제안한다. 질의로는 해당 환자가 겪고 있는 증상들이 주어진다. UMLS와 위키피디아를 사용하여 병명과 병과 관련된 증상, 검사 방법, 치료 방법 정보를 추출하고 의학 인과 관계를 구축한다. 또한, 위키피디아에 나타나는 의학 용어들에 대하여 단어의 효율적인 의미 추정 기법을 이용하여 질병 어휘의 의미 표현 벡터를 구축하고 임상 인과 관계를 이용하여 질병 중심 문서 클러스터를 구축한다. 추출한 의학 정보를 이용하여 질의와 관련된 병명을 추출한다. 이후 질의와 관련된 병명과 단어 의미 표현을 이용하여 확장 질의를 선택한다. 또한, 질병 중심 문서 클러스터를 이용하여 문서 재순위화를 진행한다. 제안 방법의 유효성을 검증하기 위해 TREC Clinical Decision Support(CDS) 2014, 2015 테스트 컬렉션에 대해 비교 평가한다.

• Korean Journal of Occupational Health Nursing
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• v.22 no.4
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• pp.285-294
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• 2013

Purpose: This study aimed to explore professional autonomy, nursing work environment, and clinical decision making ability and to determine predictors of clinical decision making ability among clinical nurses. Methods: A cross-sectional design was used in this study and 263 clinical nurses were selected from advanced-level hospitals with over 500 beds located in D metropolitan city. Independent t-test, ANOVA, Pearson's correlation coefficients and hierarchical multiple regression analyses were done with the SPSS/WIN 20.0 program. Results: Clinical nurses reported moderate levels of professional autonomy, nursing work environment and clinical decision making ability. Marital status, professional autonomy and nursing work environment accounted for 25% of variance in clinical decision making ability required in various clinical settings. Importantly, being married, higher level of professional autonomy, and greater satisfaction with work environment were significantly associated with better decision making ability. Conclusion: Findings indicate that improving the quality of decision making in the healthcare settings requires awareness of the multiple effects of individual, occupational and environmental features. Nurses' ability to make effective clinical decisions may rely on personal characteristics, the degree of autonomy in their job, and nurses' satisfaction with their work environment.

• Journal of Korean Academy of Nursing
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• v.49 no.5
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• pp.601-612
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• 2019

Purpose: The purpose of this study was to construct and test a hypothetical model of clinical decision-making ability of nurses based on the Decision Making Process model and the Cognitive Continuum theory. Methods: The data were collected from nurses working at 11 hospitals in Busan, Daejeon, and South Gyeongsang Province from June 30 to August 1, 2017. Finally, the data from 323 nurses were analyzed. Results: The goodness-of-fit of the final model was at a good level ($x^2/df=2.46$, GFI=.87, AGFI=.84, IFI=.90, CFI=.90, SRMR=.07, RMSEA=.07) and 6 out of 10 paths of the model were supported. The clinical decision-making ability was both directly and indirectly affected by task complexity and indirectly affected by experiences, autonomy, and work environment. Specifically, it was strongly directly affected by analytical competency but was insignificantly affected by intuitive competency. These variables accounted for 66.0% of clinical decision-making ability. Conclusion: The nurses' clinical decision-making ability can be improved by improving their analytical competency. Therefore, it is necessary to organize nursing work, create a supportive work environment, and develop and implement various education programs.

• Communications for Statistical Applications and Methods
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• v.19 no.1
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• pp.57-64
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• 2012

Phase I clinical trials determine the maximum tolerated dose(MTD) of a new drug. In this paper, we proposed a two-stage MTD estimation method by a Stopping rule in a phase I clinical trial. The suggested MTD estimation method is compared to the standard design(SM3) and the continual reassessment method(CRM) using a Monte Carlo simulation study.

• Annual Conference on Human and Language Technology
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• 2015.10a
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• pp.31-34
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• 2015

본 논문에서는 임상 의사 결정 지원을 위한 UMLS와 위키피디아를 이용하여 지식 정보를 추출하고 질의 유형 정보를 이용한 LDA 기반 질의 확장 방법을 제안한다. 질의로는 해당 환자가 겪고 있는 증상들이 주어진다. UMLS와 위키피디아를 사용하여 병명과 병과 관련된 증상, 검사 방법, 치료 방법 정보를 추출한다. UMLS와 위키피디아를 사용하여 추출한 의학 정보를 이용하여 질의와 관련된 병명을 추출한다. 질의와 관련된 병명을 이용하여 추가 증상, 검사 방법, 치료 방법 정보를 확장 질의로 선택한다. 또한, LDA를 실행한 후, Word-Topic 클러스터에서 질의와 관련된 클러스터를 추출하고 Document-Topic 클러스터에서 초기 검색 결과와 관련이 높은 클러스터를 추출한다. 추출한 Word-Topic 클러스터와 Document-Topic 클러스터 중 같은 번호를 가지고 있는 클러스터를 찾는다. 그 후, Word-Topic 클러스터에서 의학 용어를 추출하여 확장 질의로 선택한다. 제안 방법의 유효성을 검증하기 위해 TREC Clinical Decision Support(CDS) 2014 테스트 컬렉션에 대해 비교 평가한다.