• Title/Summary/Keyword: 임상특징

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Pathological Laughing and Crying : Pathophysiology and Treatment (병적 웃음과 울음 : 병태 생리와 치료)

  • Kim, Ji Hyun;Nam, Beom Woo;Choi, Jin-Yong
    • Korean Journal of Psychosomatic Medicine
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    • v.21 no.2
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    • pp.93-98
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    • 2013
  • Pathological laughing and crying(PLC) is a condition that is characterized by episodic, brief, contextually inappropriate, uncontrollable outbursts of laughing and/or crying. It can be observed in patients with various neurological disorders. PLC often causes distress in interpersonal functioning and activities for patients and their families. PLC can be recognized easily with proper understanding of the condition and its nature. Also it generally shows good response to various pharmacological treatments. This review aims to encourage the diagnosis and treatment of PLC by providing definition and clinical presentation of PLC, analysis of its pathophysiology and various current treatment options.

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The clinical phenotype of the derivative (8)t(7;8)(q22;p23.3) in two siblings (오누이에서 발생한 derivative (8)t(7;8)(q22;p23.3) 염색체 이상 증후군의 임상 증상)

  • Kim, Young Ok;Cho, Young Kuk;Song, En Song;Han, Dong Kyun;Choi, Ic Sun;Baek, Hee Jo;Kim, Chan Jong;Woo, Young Jong;Choi, Young Youn
    • Clinical and Experimental Pediatrics
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    • v.51 no.11
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    • pp.1241-1244
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    • 2008
  • We report on 2 siblings with a partial trisomy of 7q ($7q22{\rightarrow}qter$) and concomitant partial monosomy of 8p ($8p23.3{\rightarrow}pter$), which were shown by FISH using probes located at the telomere region of each chromosome. All the balanced translocation carriers (father and a sister) in this family had a normal phenotype. The 2 siblings with the same abnormal karyotype had similar multiple congenital anomalies and dysmorphic features. During the follow-up, the first male patient died in the neonatal period, but the female sibling is still alive at 2 years and 6 months of age.

Primary Hypoparathyroidism in a Miniature Schnauzer Dog (미니어처 슈나우저에서 발생한 원발성 부갑상선기능저하증)

  • Kang, Min-Hee;Park, Hee-Myung
    • Journal of Veterinary Clinics
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    • v.26 no.6
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    • pp.603-605
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    • 2009
  • A 7-year-old intact female, Miniature Schnauzer dog was presented with an acute seizure episode and tremors. Fever and panting were noted when presented. Physical examination revealed apparent forelimb muscle rigidity, fasciculations and stiff gait. Characteristic laboratory findings in this dog were severe hypocalcemia with hyperphosphatemia. The low serum concentration of intact parathyroid hormone and ionized calcium levels were consistent with the diagnosis of primary hypoparathyroidism. In addition, there were increased urinary excretion of calcium and decreased urinary excretion of phosphorus in this case. Urgent treatment was initiated with 10% calcium gluconate. The dog remained healthy with vitamin D analogue and oral calcium supplementation. A transient hyperphosphatemia was controlled well with sevelamer hydrochloride. To the author's knowledge, this is the first case report describing the clinical and laboratory characteristic features of canine primary hypoparathyroidism and its clinical outcome in Korea.

Correlation of motor and non-motor symptoms in Parkinson's disease: a factor-analytic convergence study (파킨슨병 환자의 운동과 비운동 증상의 상관관계: 요인 분석 융합 연구)

  • Gang, Miyeong
    • Journal of the Korea Convergence Society
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    • v.13 no.4
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    • pp.71-78
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    • 2022
  • Parkinson's disease (PD) is clinically characterized by a variety of motor and non-motor symptoms, including cognitive and neuropsychiatric symptoms. Integrating a large variety of symptoms into a small number of clinical subtypes could be valuable for appropriate and early therapeutic intervention. As a first step toward this aim, this study attempted to identify correlation patterns among motor, cognitive and neuropsychiatric symptoms in PD without dementia. One hundred four non-demented patients with PD underwent a comprehensive motor, neuropsychological, and neuropsychiatric assessments. Factor analysis was performed to identify correlation patterns among demographic, motor, cognitive and neuropsychiatric variables. The eight factors were extracted: 1 motor-related, 3 cognitive-related and 4 neuropsychiatric factors. We indentified that characteristics of correlation can have associated symptom pattern in the disease process of Parkinson's disease. The current results suggest that a broad range of motor and non-motor symptoms in PD may be reducible to a small number of clinical parameters, which may be useful for identifying clinical subtypes of PD for individual patients.

Carotid Web in Duplex Sonography: 4 Cases (이중초음파에서 관찰된 경동맥갈퀴막: 4례)

  • Han, Minho;Seo, Kangsik;Choi, Junghye
    • Korean Journal of Clinical Laboratory Science
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    • v.52 no.1
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    • pp.78-82
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    • 2020
  • Carotid web is a disease that is rarely found in patients with ischemic stroke, whereas it is more frequently observed in cryptogenic stroke patients. Fibromuscular dysplasia is known as the cause of carotid web, and it has been reported that carotid web causes blood flow disturbance, resulting in both thrombus and embolic stroke. Carotid web is confused with carotid dissection because fibromuscular dysplasia causes relatively rigid fibrous structures to grow into the lumen of the carotid artery and this creates a double lumen that is seen on duplex sonography. In addition, carotid web is web-shaped and may be confused with other carotid artery diseases such as ulcerative plaque. However, carotid web tends to be thicker at the beginning and thinner at the end, and it also has no flutter. Therefore, this study reports on four cases of carotid web with the overall description of the carotid web and the characteristic findings of duplex sonography in patients with carotid web.

Study on Dongkyung-i Dog Characterized as Anury and Brachyury (무미와 단미로 특징되는 동경이에 대한 연구)

  • Cho, Sung-Jin;Park, Young-Seok;Lee, Eun-Soo;Lee, Hyun-A;Kim, Ok-Jin
    • Journal of Veterinary Clinics
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    • v.25 no.1
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    • pp.15-18
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    • 2008
  • Until now, there are no scientific studies for Dongkyung-i(DKI) dog, which is recently called as Deng-Kyun. This study is aimed to investigate the characteristics of DKI. According to visiting studies, DKI is an active, live and muscular dog. The dog is willing to announce the approach of strangers friendly. As the results of morphological studies, DKI is medium sized and the average weight is 22.6 kg. Its coat has mainly yellowish brown color and short hair. Morphologically, the dog showed vestigial tail and muscular and sturdy pelvic limbs. As the results of radiological studies, DKI is characterized as the absence of coccygeal vertebrae or the coccygeal agenesis. We concluded that DKI may be a Korean native canine breed characterized as short or non-tail dog. Also, we suggested that this characteristic dog is valuable to develop as a Korean native breed.

Effect of Light on the Vegetative Growth of Viola rossii, V. japonica, and V. dissecta var. chaerophylloides Populations (고깔제비꽃, 왜제비꽃, 남산제비꽃 집단의 광조건에 따른 영양생장적 특징)

  • Im, Hyoung-Tak;Hong, Hang-Hwa
    • Korean Journal of Environmental Biology
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    • v.31 no.4
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    • pp.333-339
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    • 2013
  • In this study we investigated the relationship between characteristics of vegetative growth of three species of Viola (V. rossii, V. japonica, and V. dissecta var. chaerophylloides) and light in order to explain how these three species could live together under a closed space in a forest. This studywas carried out at five sites in Mudeung-san (Mt.) on 1994, 1995, and 2000 and additional investigations were performed on 2007 and 2010 at the same sites. In order to find the relationship, three main investigations were conducted: counting number of individuals for each investigated year, measuring dry mass and counting developed leaves per plant, and finding presenting patterns of each species with reference to incidence of light. As a result, we found that three species could share the closed space in a forest because of their different adaptive strategies like V. rossii as Kstrategist, V. japonica as r-strategist, and V. dissecta var. chaerophylloides as an intermediator between two species.

Tubing Wear and Spallation Induced by Roller pumps in Cardiopulmonary Bypass (심폐바이패스 롤러펌프에 의한 튜브 마모 및 폐쇄)

  • 김원곤;성기익;윤철용;신윤철
    • Journal of Biomedical Engineering Research
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    • v.20 no.5
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    • pp.609-616
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    • 1999
  • 심폐바이패스시 발생할 수 있는 튜브 마모 및 파쇄는 롤러펌프의 반복되는 압박에 의해 롤러펌프에 장착된 튜브 내벽에 균열이 생기고 이로 인해 미세한 비생물적 조각들이 혈액중으로 떨어져 나가는 현상을 말하는데, 임상적으로 치명적인 색전증을 초래할 수 있다. 그러나 아직 롤러펌프 튜브로 사용되는 PVC 및 실리콘 튜브 중 어느 쪽이 마모 및 파쇄 관점에서 더 우수한지는 체계적으로 밝혀지지 않고 있다. 이에 본 연구는 두 종류의 튜브를각각 일정 기간 롤러펌프에 장착하여 작동시킨 뒤 튜브내외면을 육안 및 주사형 전자현미경으로 관찰하였다. 즉 PVC 및 실리콘 튜브 (내경 1/2 인치의)들을 미리 정해진 폐쇄도 조절에 의해 폐쇄 회로 심폐비이패스 롤러펌프 헤드에 장착시키고 4.500ml/min에서 각각 4차례씩 1,2,4,6 시간 작동시켰다. 파쇄에 의한 색전 관찰 실험에서는 회로 중간에 동맥여과기를 설치하고 각각 6,9시간 씩 롤러펌프를 작동시켰다. 실험 후 튜브 및 여과기들을 수거한 후 육안 및 주사형 전자현미경 분석을 시행하였다. 실험후 튜브 및 여과기들을 수거한 후 육안 및 주사형 전자현미경을 분석을 시행하였다. 튜브 외부의 육안 관찰 결과 일반적으로 실라스틱 튜브에서의 외부 마모가 PVC 튜브에 비해 현저하였다. 주사형 전자현미경 관찰에서 PVC 튜브에서의 홈은 좁으면서 경계선이 뚜렷한 특징을 보였고 3시간 이상 롤러와 접촉한 튜브들에게서는 깊은 균열이 간헐적으로 관찰되었다. 반면, 실라스틱에서의 홈은 좁으면서도 경계선이 뚜렷한 특징을 보였고 3시간 이상 롤러와 접촉한 튜브들에게서는 깊은 균열이 간헐적으로 관찰되었다.반면 실라스틱에서의 튜브들에서는 홈이 상대적으로 넓고 경계가 덜 명확했으며, 특징적으로 V 자 모양의 융기부들이 간헐적으로 관찰되었다. 실라스틱 및 PVC 튜브 모두에서 50u 전후의 Craters 가 간헐적으로 관찰되었다. 여과기의 여과망에 대한 주사형 전자현미경 분석 결과 실라스틱과 PVC 튜브 실험군 모두에서 색전입자로 의심되는조각들이 발견되었으나 두군간 정량적 비교는 어려웠다. 결론적으로 롤러펌프에 의한 튜브 마모 및 파쇄현상은 실리콘 및 PVC 튜브의 재질에 따라 그 양상에는 차이가 있으나 임상적인 측면에서는 어느 쪽도 상대적인 우수성이 입증되지 못하였다.

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Malignant Acanthosis Nigricans with Oral Florid Papillomatosis ; A Case Report (구강내 개화성 유두종증을 가진 악성 흑색극세포증의 증례보고)

  • Jung, Jae-Kwang;Shin, Hong-Ihn;Min, Bo-Kyung
    • Journal of Oral Medicine and Pain
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    • v.35 no.4
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    • pp.237-243
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    • 2010
  • Acanthosis nigricans usually has the characteristics that involve the development of darker pigmented patches and thickened skin with velvety texture on the body folds, and papillomatosis on lip and intraoral regions including tongue, gingiva, mucosa, palate. Malignant acanthosis nigricans, a type of acanthosis nigricans, occurs most commonly in association with underlying malignancy and characterically appears with three characteristic mucocutaneous lesion : especially of the lips and eyelids, hyperkeratosis of the palms and soles, the sign of Leser-Trelat. In the present report, the patient had typical clinical and histological findings of oral acanthosis nigricans, as well as past medical history associated with malignant gastric adenocarcinoma.

Characteristic CT Images in Diffuse Lung Disease (미만성 폐질환(肺疾患)에 있어서 특징적(特徵的)인 CT상(像)에 관하여)

  • Ichikawa, Hidel;Kanamori, Isao
    • Journal of radiological science and technology
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    • v.18 no.2
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    • pp.37-48
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    • 1995
  • 1) 천식 기관지 확장증에서는 기종상 음영이나 기관지가 확장된 상이 있고, 또한 미만성 범세기관지염 5예에서는 미세 반점상 음영이 전체 예에서 인정이 되었다. 2) 폐염에서는 기관지의 확장이나 점액이 고여 침윤음영이 전체 예에 나타나고 있었다. 한편, 간질성 폐염 29예에서는 반점상 음영(불균일 CT치의 상승과 내부에 작은 기관지 확장으로 작은 air상)이 보였다. 폐섬유증 19례에서는 기종상 농포상 음영이나 혈관 기관의 부정 확장, 반점상 음영이 15예로 79 %를 차지하고 있다. 만성 폐기종에서는 기종상, 다발성 농포상 음영, 고목상 혈관이 특징적인 소견이었다. 3) 속립성결핵에서는 작은 입상 음영, 폐결핵 15예에서는 공동 음영 7예, 원형의 융합음영 8예, 침윤음영, 다수의 석회화상, 혈관 기관의 부정 확장 등이 특징적이었다. Aspergillus증에서는 공동 음영 내부에 fungus ball이 보였다. 이상은 미만성 폐질환의 특징적인 CT의 이상 소견에 대해서 검토하였으나, 꼭 일치되는 것은 아니며, 기타 기초적 검사나 임상적인 경과관찰이 필요하였다. 끝으로, 대한방사선기술학회의 발전과 학회원 여러분의 건승을 기원합니다. 그리고 한국과 일본의 우호적인 학술교류가 지속되기를 희망합니다.

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