• Tuberculosis and Respiratory Diseases
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• v.52 no.5
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• pp.441-452
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• 2002

Background : Anti-apoptotic proteins may be involved in tumor development, progression and the response to treatment, Bcl-2 is by far the most studied anti-apoptotic protein. A novel inhibitor of apoptosis, designated survivin, and the heat shock proteins (HSPs) have recently been found in many human cancers. Immunohistochemical methods were used to determine the expression level of survivin, HSP70 and bcl-2 in non-small cell lung cancer (NSCLC) to evaluate their clinical significance. Materials and Methods : Tissue array slides were obtained from 99 surgically resected NSCLCs. Immunohistochemical staining was performed by an immuno-peroxidase technique using an avidin-biotinylated horseradish peroxidase complex. Anti-survivin rabbit polyclonal antibodies, anti-HSP70 mouse monoclonal antibodies and anti-bcl-2 mouse monoclonal antibodies were used as the primary antibodies. Results : Positive staining of survivin was detected in 33.3% of the cases. Survivin positivity is associated with to females and recurrence. A nonstatistically significant trend toward increased survivin expression was observed in non-smokers, and its expression inversely correlated with the number of cigarettes smoked in smokers. HSP70 was detected in 84.8% but this did not correlated with the clinicopathologic characteristics. Bcl-2 was detected in 18.2% and its expression correlated to tumor recurrence. No significant difference in the median survival time was noted in a comparison of all cases with survivin expression and those without. There was no association between HSP70 or bcl-2 expression and survival. Conclusion : Survivin expression was significantly associated with females and tumor recurrence. In addition its expression was inversely associated with the number of cigarettes smoked. However, HSP70 and bcl-2 expression were not associated with the clinical parameters or survival. This suggests that measuring the survivin levels may be useful in identifying patients at high risk for disease recurrence. Therefore, survivin might be a new diagnostic/therapeutic target in cancer.

• The Korean Journal of Nuclear Medicine
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• v.33 no.4
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• pp.381-387
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• 1999

Purpose: The International Labor Organization (ILO) has established an international standard for chest X-ray diagnosis of pneumoconiosis since 1980. However, there is a need for improved diagnosis and staging in occupational disease. We evaluated Ga-67 citrate scintigraphy quantitatively and correlated the scintigraphic findings with pulmonary function tests and chest X-ray results. Materials and Methods: Twenty-five patients underwent whole body scintigraphy with additional chest and abdomen images 48 hrs after intravenous injection of 185 MBq of Ga-67 citrate. Ten normal controls were also studied. Regions of interest (ROI) were drawn on the posterior image to measure counts from the liver and lungs (Lung/Liver Ratio). Results: L/L ratio according to the stages of chest X-ray classification were as follows; stage 0 (normal, n=10): $0.3948{\pm}0.0692$, stage 1 (n=10): $0.5763{\pm}0.1537$, stage 2 (n=11), $0.6849{\pm}0.1459$, stage 3 (n=4) $0.9913{\pm}0.0712$. There was a significant correlation between the scintigraphic L/L ratio and the X-ray stage (r=0.618, p<0.05). However, no significant correlation between L/L ratio and pulmonary function tests were observed (p>0.05). Conclusion: Quantitative Ga-67 scintigraphy can be a useful method for staging of silicosis. However, it is not a method to assess pulmonary functional impairment.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.48 no.4
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• pp.1-9
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• 2011

Hemorrhagic shock is a clinically widespread syndrome characterized by inadequate oxygenation and supply. It is important to diagnose hemorrhagic shock in its early stage for improving treatment effects and survival rate. However, an accurate diagnosis and treatment could be delayed in the early stage of hemorrhagic shock by evaluating only vital signs such as heart rate and blood pressure. There have been many studies for the early diagnosis of hemorrhagic shock, reporting that lactate concentration and perfusion were useful variables for tissue hypoxia and metabolic acidosis. In this study, we measured both perfusion using a laser Doppler flowmeter and lactate concentration from the volume controlled hemorrhagic shock using rats. We also proposed a new shock index which was calculated by dividing lactate concentration by perfusion for early diagnosis. As a result of the survival prediction by the proposed index with the receiver operating characteristic curve method, the sensitivity, specificity, and accuracy of survival were 90.0, 96.7 and 94.0%, respectively. The proposed index showed the fastest significant difference among the other parameters such as blood pressure and heart rate. It could offer early diagnosis and effective treatment for human hemorrhagic shock if it is applicable to humans.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.2
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• pp.124-132
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• 2020

This study examines the clinical availability of alpha amplitude, asymmetry and mean frequency in old age as EEG indexes reflecting brain health condition. The EEGs of prefrontal lobes in eye closure state were measured for 4 minutes with 72 male and female elderly people aged 73. Subjects were divided into higher and lower groups based on average values of alpha amplitude, asymmetry and mean frequency. The results of correlations and t-test among EEG indexes were as follows. First, the higher Alpha altitude was, the higher physical and mental stress resistance and left-to-right brain communication were, and the lower mean Alpha mean frequency location was. The higher Alpha asymmetry was, the lower left-to-right communication level was. Second, as Alpha power of right brain was higher than that of left brain, Alpha amplitude and mental stress resistance and left-to-right brain communication level were higher. Third, as Alpha mean frequency location was higher, Alpha amplitude and mental anti-stress level were lowered and arousal level was enhanced. These high correlations and complementary meaning among quantitative EEG indicators demonstrated the possibility of biomarkers reflecting brain health state in old age.

• Korean Journal of Clinical Laboratory Science
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• v.50 no.4
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• pp.477-483
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• 2018

Transcranial doppler is a non-invasive method that measures the blood flow velocity and the direction of cerebral blood vessels through the doppler principle. The pulsatility index is an index for measuring the transcranial doppler that reflects the distal vascular resistance and is used as an index for the presence and diffusion of cerebral small vessel diseases. The purpose of this study was to evaluate the risk factors affecting the basilar artery pulsatility index in ischemic stroke patients. From January 2014 to May 2015, 422 patients were selected by measuring the transcranial doppler pulsatility index, considering their basilar artery pulsatility index. Univariate analysis was performed using the basilar artery pulsatility index as a dependent variable. Multiple regression analysis was performed considering the factors affecting the pulsatility index as variables. Univariate analysis revealed age, presence of hypertension, presence of diabetes mellitus, presence of hyperlipidemia, and hematocrit (P<0.1) as factors. Multiple regression analysis showed statistically significant results with age (P<0.001), presence of diabetes (P=0.004), and presence of hyperlipidemia (P=0.041). The risk factors affecting the basilar artery pulsatility index of transcranial doppler were age, diabetes, and hyperlipidemia. Further research will be needed to increase the cerebral pulsatility index as a surrogate marker of the elderly, diabetes, and hyperlipidemia.

• Korean Journal of Psychosomatic Medicine
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• v.12 no.1
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• pp.3-14
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• 2004

In this article, the effects of stress on central nerve system and heart function and the concept of heart rate variability were reviewed. HRV(Heart Rate Variability), the periodical change of the heart rate, is indicated larger in the healthier because they respond flexibly to various sorts of facts influencing on HR. HRV analysis is largely composed of the time domain analysis and the frequency analysis. In the former the flexibility of heart function is analysed, while in the latter autonomic nerve function is examined, which is the degree of sympathetic and parasympathetic nerve activity and the state of balance. Furthermore, existence or nonexistence of disease and/or level of stress can be estimated by measuring the variability and normality of heart rate, and balance of autonomic nerve system, and through HRV biofeedback the symptoms of anxiety disorder or asthma can be reduced.

• Journal of Korean Medicine Rehabilitation
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• v.18 no.2
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• pp.143-156
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• 2008

목적 : 갱년기 여성은 내장비만의 위험이 높으며 또한 심리적 변화를 겪는 시기이다. 갱년기 여성의 복부지방, 내장지방, 피하지방 및 이와 관련된 단순비만지표, 간울증, 스트레스, 우울, 자존감 등을 조사하여 갱년기 건강의 위협이 되는 신체 심리 인자를 알아보고자 이 연구를 시행하였다. 방법 : 병원공고를 통해 체질량지수 $23kg/m^2$ 이상 비흡연자인 만 45세 이상 55세 이하의 폐경 전후의 갱년기 여성 환자를 모집하여 2007년 8월 20일부터 24일까지 47명이 모집되었으며 이중 체질량지수 $25kg/m^2$ 이상이면서 복부 전산화 단층촬영 상 내장지방이 $100cm^2$ 이상인 20명의 단순비만지표, 체성분검사, 혈액검사, 복부 전산화 단층촬영 및 한방비만변증 (간울) 및 스트레스, 우울, 자존감 설문검사 결과의 상관성을 분석하였다. 본 연구는 경희대학교 동서신의학병원의 임상연구심사위원회의 승인을 받았다. 결과 : 1. 갱년기 비만여성에서 복부지방 면적, 피하지방 면적은 체질량지수, 체지방률, 허리둘레/신장비 등의 단순비만지표와 유의한 상관성을 보인 반면 (p < 0.01), 내장지방 면적은 단순비만지표와 상관성을 보이지 않았다. 2. 내장지방 면적은 사회 재적응 평가척도 (${\gamma}=0.577$, p < 0.01)와 유의한 상관성이 있었고, 선형회귀분석에서 유의한 결과를 나타냈다. $VAT(cm^2)=116.1+0.101{\times}(SRRS\;score)$ (${\gamma}^2=0.332$) 3. 피하지방은 식이태도 점수와, 총복부지방은 식이태도 점수 및 갱년기지수 중 혈관운동증상과 상관성이 있었다. 4. 간울증은 스트레스 반응척도, 우울지수, 갱년기지수 및 그 하부항목 중 혈관운동, 정신, 운동, 소화, 전신증상과 양의 상관성을, 자존감척도와는 음의 상관성을 나타냈으며, 내장지방과 직접적인 상관성을 보이지 않았다. 결론 : 간울증은 높은 스트레스, 우울, 갱년기 증상 및 낮은 자존감과 관련되는 것으로 나타났다. 폐경전후 비만여성에서 내장지방 면적은 간울증과 유의한 상관성을 보이지 않았으나, 생활 스트레스 사건이 많을수록 높아지는 것으로 나타나 갱년기 여성 내장비만에서 스트레스에 대한 대처가 중요할 것으로 사료된다. 추후 임상적 연계성 및 설문 보완에 대한 연구가 필요하리라 생각된다.

• Herbal Formula Science
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• v.17 no.2
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• pp.99-110
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• 2009

목 적 : 한약 또는 한약제제의 아토피성 피부염에 대한 치료효과를 조사하고 향후 연구방향을 제시하기 위하여 고찰연구를 시행하였다. 방 법 : PubMed에 한약과 아토피성 피부염과 관련된 검색어의 조합을 넣어 포함기준에 맞는 무작위배정 대조군 임상연구만 포함하였다. 연구설계, 치료방법, 대조군, 평가지표, 결과, 부작용 관련 정보를 미리 정해놓은 자료 추출 형식에 맞추어 추출하고 방법론적 질 평가는 옥스포드 질 평가 척도와 그룹 할당 은닉(allocation concealment) 여부를 평가하였다. 연구들이 임상적 및 통계적으로 상이하여 메타분석은 이루어지지 않고 기술적 고찰만 실시하였다. 결 과 : 모두 8편의 연구가 고찰기준을 만족시켰다. 다양한 복합한약제제와 한약이 포함된 외용제가 평가되었는데 8편 가운데 5편에서 아토피성 피부염의 증상을 호전시키는 것으로 나타났다. 방법론적 질은 대체로 양호한 것으로 나타났으며 일부 효과적인 것으로 나타난 한약복합제제에서 간손상 등의 부작용도 보고되었다. 결 론 : 한약 또는 한약제제를 이용한 치료는 아토피성 피부염의 증상개선에 도움이 되는 것으로 보이나 현재 근거는 부족하다. 우리나라에서 많이 쓰이는 한약제제들 역시 엄정한 임상연구를 거쳐 그 효과를 평가하고 근거를 구축해야 할 것이다.

• Journal of radiological science and technology
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• v.31 no.2
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• pp.135-140
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• 2008

Purpose: Fatty liver is one of the most commonly found disease by abdominal ultrasonography. The status of fatty liver is classified into mild, moderate and severe degrees. The study was conducted to investigate the clinical significance of fatty liver using ultrasonography. Materials and method: Test set consisted of 2,185 patients who visited D healthcare center in Daejeon to receive an abdominal ultrasonic test from January to December 2007. Out of the 2185 patients, 524 patients was diagnosed as fatty liver (290 male and 234 female patients). They were divided into three groups, group I for mild degree. II for moderate degree, and III for severe degree, depending on the echo of liver parenchyma, the sound attenuation, and the visibility of intrahepatic blood vessels and diaphragm. Then the correlation of obesity indices, liver function tests and metabolic syndrome was analyzed for males and females separately. Results : As for the degree of fatty liver, 350 cases (66.8%) were classified as group I, 153 cases (29.2%) as group II, and 21 cases (4.1%) as group III. In addition, severe degree of fatty liver was more frequently found in males than in females. The mean ages of three groups for males were 46.1, 44.5, and 39.1, and those for females were 48.8, 50.2, 52.4, respectively. Males with lower mean ages have severely of fatty liver for both males and females. Conclusion: The results in this study show that the classification into three degrees of fatty liver in ultrasonography practice is helpful to treat and observe the progress of fatty liver. In addition, careful examination is required to measure the severity of fatty liver as well as detection of it. A standardized method to classify the degree of fatty liver is also needed for more objective measurement.

• Journal of Oral Medicine and Pain
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• v.19 no.2
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• pp.7-23
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• 1994

구강내 작열감 증후군은 객관적 징후없이 구강점막에 작열감을 나타내는 만성동통장애이다. 다양한 원인요소들이 제시되어 있지만, 이러한 요소들의 관련성에 대해서는 아직 분명하지 않은 실정이다. 그러므로, 이러한 구강내 기능이상의 근본적이고 효과적인 치료를 위해서는 다양한 임상적 관찰과 원인요소의 분석등이 계속 연구 조사되어져야 할 것이다. 저자는 구강내 작열감 증후군의 증상을 호소하는 112명의 환자의 임상적 특징에 대해 조사하고자, 환자군과 대조군에 대해 구강내 작열감 증후군에 관한 설문조사 및 구강검사와 혈액학적 검사를 시행하였으며, 점도계를 사용하여 구강내 작열감 증후군 환자의 자극이 전타액의 점도를 측정하였다. 또한, 환자의 심리적 요인을 파악하고자 간이정신진단검사를 실시한 결과 다음과 같은 결론을 얻었다. 1. 구강내 작열감 증후군은 주로 페경기 전후의 여성에서 많이 나타났으며, 호발부위는 혀, 치주 및 치조점막, 구개, 협점막의 순이었다. 2. 구강내 작열감 증후군 환자에게서 대조군 비해 구강건조감, 미각 및 수면장애, 빈혈, 소화기 장애, 두통과 기타 다른 신체불편감의 호소 등이 더 많이 나타났다. 3. 혈액학적 검사결과, 구강내 작열감 증후군 환자중의 26%와 12%에서 각각 혈중 엽산농도와 철분농도의 저하를 나타냇다. 4. 자극시 분비된 전타액의 점도는 40대와 50대이상의 연령군에서 구강내 작열감 증후군 환자가 정상인에 비해 높았다.(p<0.01). 5. 구강내 작열감 증후군 환자군의 간이정신진단검사의 각 증상차원 및 전체지표의 T점수의 평균치는 정상범위내에 있었으며, 신체화(SOD)와 우울 (DEP)차원의 평균치가 가장 높았다.