• Tuberculosis and Respiratory Diseases
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• v.60 no.5
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• pp.523-531
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• 2006

Background : Cervical tuberculous lymphadenopathy is a very common disease with a similar incidence to pulmonary tuberculosis. Dendritic cells play a role of initial antigen presentation of this illness. Nevertheless, the precise role of these antigen-presenting cells according to the clinical features in unclear. The aim of this study was to determine the clinical implication of dendritic cell infiltration in the cervical lymph nodes. Methods : A review of the clinical characteristics was carried out retrospectively based on the clinical records and radiography. Immunohistochemical staining was performed on the available histology specimens of 72 cases using the S-100b polyclonal antibody for dendritic cells. The number of dendritic cells with tuberculous granuloma were determined. A $X^2$ test, unpaired T test and multiple logistic regression analysis were performed. Results : Thirty percent of subjects had previous or concurrent pulmonary TB. Twenty one percent of cases showed a positive reaction on the AFB stain. Within a granuloma, the number of infiltrated dendritic cells was $113.0{\pm}7.0$. The incidence of fever and cough decreased with increasing infiltration of dendritic cells Multivariate regression analysis showed that the infiltration of dendritic cells could significantly contribute to fever. Conclusion : Overall, dendritic cells can control a Mycobacterium tuberculosis infection and modulate the immune response, as well as resolve the clinical manifestations of TB lymphadenopathy.

• Pediatric Infection and Vaccine
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• v.16 no.2
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• pp.167-174
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• 2009

Purpose : Pertussis was very common in the past, but reported cases have dramatically decreased. The improvement of vaccination programs and unreadiness of laboratory confirmation seems to have developed this situation. This study investigated the frequency of pertussis among infants with a paroxysmal cough and compared the clinical characteristics between infants with and without pertussis. Methods : Between June and November 2006, 27 infants admitted to the hospital that were 15-90 days old with a history of a cough for more than seven days were enrolled. The cough was described as: paroxysmal, whooping, and post-tussive vomiting. PCR and cultures for Bordetella pertussis with nasopharyngeal aspirates were obtained. The patients were divided into two groups: (1) the pertussis group that had positive results by PCR or culture; (2) the control group that had negative results by PCR and culture. Clinical and laboratory characteristics were compared between the two groups. Results : Among the 27 cases, five (18.5%) were finally diagnosed with pertussis. Only one out of the five pertussis cases was initially diagnosed with a pertussis-like syndrome on admission. Compared to the group without pertussis, the pertussis group had a significantly higher frequency of: no fever (P =0.043), a paroxysmal cough (P =0.040), cyanosis (P =0.001), non-immunized status for DTaP (P =0.047), normal auscultation (P =0.028), normal chest X-ray findings (P =0.027), high absolute lymphocyte count (P =0.039), and low CRP (P =0.046). The patients with the diagnosis of pertussis had a significantly longer duration of coughing (27.2${\pm}$10.6 vs. 12.6${\pm}$5.6 days, P =0.039). Conclusion : Pertussis should be suspected in any infant with typical symptoms of pertussis in addition to: a persistent cough without fever, accompanied by paroxysms or cyanosis prior to the age of DTaP immunization. Active laboratory confirmation should be carried out to confirm more cases with pertussis.

• Annals of Clinical Neurophysiology
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• v.6 no.1
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• pp.61-63
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• 2004

The copy numbers of the CTG repeats are known to relate to the severity of clinical symptoms for myotonic dystrophy. The positive correlation between clinical manifestations and CTG repeat size has been demonstrated previously. A genetically confirmed myotonic dystrophy patient with 90 CTG repeat number had more severe clinical manifestation than brother with 120 CTG repeats, in adulthood.

• Proceedings of the KSRS Conference
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• 2006.03a
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• pp.210-213
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• 2006

이 연구에서는 다중시기 Landsat 영상을 이용하여 강원도 일대 임상의 변화를 살펴보고 상록수의 영급을 구분하는 알고리즘을 개발하여 적용하였다. 1980년대에서 현재까지 축적된 Landsat-5와 Landsat-7영상 중에서, 대부분 지역에 활잡목 및 활엽수가 낙엽이 지고 눈이 아직 쌓이지 않을 시기인 11월에 촬영된 영상만을 이용하였다. 각 영상에서 양지바른 상록수, 활엽수, 그늘진 지역, 도시 및 바다 등을 클래스로 지정하여 감돌분류를 하였다. 분류 결과에서 양지바른 상록수만 추출하여 5개의 영상을 이진 분류체계로 조합한 후 임상의 시기적 변화 양상을 관찰한 결과, 강원대 연습림의 조림 기록 및 현황도와 상당히 일치함을 확인하였으며, Path 115, Row 34에 해당하는 강원도 일대로 연구지역을 확대하였다. 향후 Kompsat-2를 비롯한 고해상도 11월 영상이 지속적으로 촬영된다면, 이 연구에서 개발된 이진 분류체계 방법을 통하여 산림변화의 모니터링을 보다 용이하고 효율적으로 할 수 있을 것으로 기대된다.

• The Journal of the Korean dental association
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• v.26 no.5 s.228
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• pp.441-456
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• 1988

지난 수 십년간 기계적인 측면에서의 교정장치나 치료술식은 급속한 발전을 하여왔으나 생물학적 관점에서의 현대 교정학은 아직도 낙후된 수준에 머물러 있다. 이러한 관점에서 기초의학을 기반으로 세포의 생물학적 잠재력을 극대화시켜 임상적 효율성을 증진시키기 위한 일련의 연구들이 진행되고 있다. 그중에서 전기적 자극에 의한 골성장기전의 개념을 이용하는 분야는 가장 활발히 연구되고 있는 분야 중의 하나이다. 전기자극 중 가장 유용한 수단인 전자기장 이용법의 발달과정에 대해 알아보고 전기적 자극에 의한 골세포 반응의 작용기전에 대한 많은 자료를 종합, 분석하여 그 가설적인 모형을 세우고 아울러 교정 임상에서 이러한 개념의 적용가능성과 그 범위에 대해 조명해 본다. 앞으로 이 분야에 대한 계속적인 연구로 머지않아 실제 임상에 활용되는 단계에 이르게 되길 기대한다.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1991.06a
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• pp.38-38
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• 1991

콜레스테롤 육아종은 콜레스테롤 결정이 주위조직에 이물질로 작용하여 육아성 반응 및 골파괴 반응을 유발시키는 질환으로 병리조직학적으로 많은 콜레스테롤 결정이 거대세포를 가진 만성적인 염증성 침윤속에 나타나는것을 특징으로 한다. 이 병변은 아주 드물지만 특징적인 방사선적소견, 병리조직학적 소견과 임상양상으로 쉽게 진단이 된다. 두부에서는 다양한 위치에서 발견되는데 특히 함기화가 잘 된 측두골, 유양동, 고실강에서 많이 보이며 전두골, 상악골, 협골, 인상측두골 및 후두개와에서도 보고되고 있으나 부비동에 발생하는것은 특히 드물다. 부비동에서 발생한 콜레스테롤 육아종의 발생기전은 환기장애설, 배출장애설 및 출혈설 등으로 보고되고 있다. 저자들은 최근 복시와 측두통을 호소하는 50세 여자환자에서 접형동에 발생한 콜레스테롤 육아종이 우측 상안와열 (superior orbital fissure)과 경사대(clivus)를 파괴하며 전교조 (Prepontine cistern)로 확장된 1례를 경험하였기에 임상 증세, 특징적인 전산화단층 및 핵자기공명소견과 병리조직학적인 소견을 문헌 고찰과 함께 보고하는 바이다.

• Journal of Veterinary Clinics
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• v.21 no.1
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• pp.15-19
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• 2004

The emergence of bacterial resistance to antibiotics during therapy is a matter of great problem in clinical medicine. This may be because many veterinarians have used inappropriate antibiotics without bacteriological culture. Therefore, the purpose of this study is to determine isolation of anaerobic bacteria as pathogens from veterinary clinical specimens as well as susceptibility pattern for choosing antibiotics. Various anaerobic bacteria were isolated from clinical specimens of dogs, cats, rabbits at Veterinary Medical Teaching Hospital of Seoul National University from May 2001 to October 2002. The total number of isolated anaerobic bacteria was 13 isolates; Bacteroides spp. (3 isolates), Fusobacterium spp. (2 isolates), Peptostreptococcus spp. (2 isolates), Porphyromonas gingivalis (2 isolates), Prevotella spp. (3 isolates), and Propionibacterium acnes (1 isolate). For evaluating the antibiotic susceptibility patterns of the isolates disk diffusion method was used. All isolates were susceptable to all tested antibiotics except only one Fusobacterium varium was resistant to norfloxacin.

• Clinical and Experimental Pediatrics
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• v.50 no.1
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• pp.74-78
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• 2007

Purpose : Systemic lupus erythematosus (SLE) is a chronic multisystemic autoimmune disease with complex clinical manifestations. It probably involves genetic, environmental and immunologic factors. In this study, we investigated the clinical manifestations, laboratory findings and prognosis of pediatric SLE to aid clinical care of pediatric SLE. Methods : The data of 45 patients who were diagnosed as pediatric SLE in Severance Children's Hospital from Jan. 1996 to Dec. 2005 were analysed retrospectively. Results : The mean age at diagnosis was 10.8 (0-15) years old. And the ratio of male to female patients was 1:4. The initial manifestations were facial edema (51.1 percent), malar rash (44.4 percent), and fever (28.9 percent). The ANA (97.8 percent), anti-ds DNA antibody (82.2 percent), lupus nephritis (71.1 percent), malar rash (71.1 percent), and cytopenia (66.7 percent) were the most common findings among the classification criteria by ACR (American College of Rhematology, 1997). Conclusion : Clinical manifestations and prognosis are various in pediatric SLE. Intensive studies of SLE in children should be continued for more effective treatment.

• Clinical and Experimental Pediatrics
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• v.49 no.10
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• pp.1067-1072
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• 2006

Purpose : The purpose of this study was to examine the clinical courses and long-term outcomes of children with Allagille syndrome in Korea, and to evaluate the prognostic potentials of identified variables. Methods : We reviewed the clinical manifestations and outcomes of 30 children with Alagille syndrome, investigated from 1984 to 2006 until the end of this study (defined as death or last visit; mean follow-up : 5 years). Results : Cholestasis occurred in 100 percent, cardiovascular abnormalities in 83.3 percent, butterfly vertebrae in 30.0 percent, posterior embryotoxon in 43.3 percent, and a characteristic facial appearance in 100 percent. At study conclusion, of these 30 patients, eight had died (26.7 percent); six related to Alagille syndrome. Five patients died of a liver disease complication. Liver transplantation was carried out in five of the 30 patients (16.7 percent) and one of these died due to hyperacute rejection. At age two, cholestasis improved in 17 of the 30 patients. Those who had severe cholestasis at 2 years of age tended to have a complication, such as liver cirrhosis or liver transplantation, or to have died. Conclusion : Hepatic complications account for the most mortalities in patients with Alagille syndrome. Careful and complete assessments should be made in children who have cholestasis at 2 years of age. Further investigations of more cases are required.

• Journal of Oral Medicine and Pain
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• v.32 no.1
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• pp.113-120
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• 2007

Although most cases of tension-type headache(TTH) are myogenic headache, in some cases, arthralgia appears, such as the disorder of the temporamandibular joint. This study is designed to compare the clinical patterns of arthralgia to those of myalgia, when both symptoms are co-existing. Among 167 patients who visit our clinic during a certain period, whose chief complaint was TTH, 18 patients were the arthralgia group, 50 patients were the myalgia group, and 99 patients who have both arthralgia and myalgia were the arthromyalgia group. Three groups were asked to answer the questionnaires about their age, gender, and oral parafunction such as bruxism or clenching. Then we gathered statistics on the data from the accomplished questionnaires. 1. There was statistical significance in age among the three groups(p=0.02). 2. There was no statistical significance in sex and oral parafunction among the three groups. 3. There was statistical significance the myalgia group was older than the arthromyalgia group(p<0.03). The results of the study show that as patients become older, TTH with myalgia happens more frequently than TTH with arthralgia and myalgia does.