• The Korean Journal of Applied Statistics
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• v.29 no.4
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• pp.595-611
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• 2016

We use nonlinear regression models (such as the Hill Model) when we analyze data in toxicology and/or pharmacology. In nonlinear regression models an estimator of parameters and estimation of measurement about uncertainty of the estimator are influenced by the variance structure of the error. Thus, estimation methods should be different depending on whether the data are homoscedastic or heteroscedastic. However, we do not know the variance structure of the error until we actually analyze the data. Therefore, developing estimation methods robust to the variance structure of the error is an important problem. In this paper we propose a method to estimate parameters in nonlinear regression models based on a preliminary test. We define an estimator which uses either the ordinary least square estimation method or the iterative weighted least square estimation method according to the results of a simple preliminary test for the equality of the error variance. The performance of the proposed estimator is compared to those of existing estimators by simulation studies. We also compare estimation methods using real data obtained from the National Toxicology program of the United States.

• Journal of the Korean Society of Groundwater Environment
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• v.6 no.3
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• pp.152-157
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• 1999

Oil leaked from underwound storage tanks and leachate from sanitary landfills have been known as contaminant sources of the high-quality groundwater resources. The mobility of contaminants in the aquifer largely depends on the groundwater flow and the determination of associated hydraulic parameters is essential for a proper remediation of contaminated grnundwater. This study aimed at determining an optimum set of hydraulic parameters for an unconfined sandy aquifer of a laboratory scale through comparison of various methods. Results showed that the specific yield obtained from gravity drainage experiment was an average of 0.20 with minor variations in aquifer depths. and the permeabilities obtained from Dupuit approximation and slug test gave similar values of 5.33 cm/min and 5.85 cm/min but the constant head method gave 0.17 cm/min, which is much ion than the other methods. This experimental evidence reveals that the permeability of the unconfined sandy aquifer could be accurately determined by Dupuit assumption or slug tut rather than by constant head method conducted for a disturbed separate soil column.

• Journal of Korean Society of Transportation
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• v.30 no.6
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• pp.27-36
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• 2012

In Korea, 28,641 cases of traffic accidents were caused by drunk driving in 2010. These statistics accounted for 12.62% of total number of traffic accidents. Moreover, the percentages of deaths and injuries from them were nearly 15% of those from whole traffic accidents. While police has emphasized enforcement efforts in order to reduce drunk driving, culture generous to drunk driving in addition to the absence of an appropriate intervention system for habitual drunk drivers have contributed to the increasing number of the drunk driving accidents in Korea. This study examined specific behavioral changes in drunk driving by comparing drivers' behavior pattern in non-alcoholic condition to those in alcoholic condition, using a psychomotor test and a driving simulator. In the psychomotor test measuring participants' reactions to the target stimulus, it was revealed that participants' correct responses were decreased, false responses were increased, and no responses also were increased after drinking. Furthermore, in the driving simulator performance after drinking, not only driving speed was faster but also the deviation of an accelerator pedal pressure and of the vehicle's lateral position were much increased. These results indicated that alcohol consumption would impair visio-cognitive ability and deteriorate driving safety. Finally, the implications and limitations of our findings and suggestions for the future research were discussed.

• The Korean Journal of Mycology
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• v.29 no.2
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• pp.86-90
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• 2001

This study was conducted to investigate the effects of Pleurotus eryngii fruiting body on blood glucose and cholesterol levels in streptozotocin-induced diabetic rats. Male Sprague-Dawley rats were used as experimental animals and experimental groups were divided into three groups, consisting of two control groups (diabetic and non-diabetic) and one P. eryngii group. Animals were fed experimental diets for 2 weeks. The values of died and water intake of P. eryngii group were lower than those of diabetic control group. The body weights of both groups after 2 weeks decreased by 18% as compared with initial values. The level of blood glucose decreased significantly by 16.9% in P. eryngii group as compared with diabetic control group, and there was a significant difference in glycosylated hemoglobin (GHb) level between both groups. The levels of total-cholesterol, LDL-cholesterol in plasma and atherosclerotic index were not significantly different between both groups. However the level of HDL-cholesterol increased significantly by 28% in P. eryngii group as compared with diabetic control group. These results suggested that fruiting bodies of P. eryngii exert blood glucose-lowering effect in streptozotocin-induced diabetic rats.

• Korean Journal of Acupuncture
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• v.30 no.2
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• pp.135-142
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• 2013

Objectives : This study aimed to investigate the general effects of low-frequency electrical stimulation of the ankle joint acupuncture points(BL62 and KI6) on the brain waves of elderly women as a pilot study to figure out the possibility of candidate non-invasive and non-chemical stimulation method for the enhancing the brain function. Methods : A randomized, controlled, double-blinded clinical trial was performed in 31 healthy women(mean age, 54.5 years) within a treatment duration of 12 sessions. In the experimental group, low-frequency electrical stimulation was applied using the maximum range of the individual insensible strength(mean current, $0.04{\mu}A$). The control group received sham stimulation. The background electroencephalographic activity was measured before and after the12 sessions. Results : After 12 sessions of stimulation, the relative power of the alpha wave increased(32 of 32 channels: significant difference in 11 channels, p<0.05); the theta(30 of 32 channels: significant difference in 10 channels, p<0.05), beta(31 of 32 channels), and gamma(30 of 32 channels: significant difference in 7 channels, p<0.05) powers were also decreased compared with the sham group. Conclusions : Electrical stimulation on the ankle joint acupuncture points(BL62 and KI6) seemed to stabilize the elderly women brain by inducing the alpha power and reducing beta, theta, and gamma powers. These results provide insight into the action mechanism of the stimulation and can assist the future developement of a non-invasive and non-chemical treatment technique for stressor related cognitive problems.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.6
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• pp.728-735
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• 2017

With the proliferation of digital devices, the devices have generated considerable additive white Gaussian noise while acquiring digital images. The most well-known denoising methods focused on eliminating the noise, so detailed components that include image information were removed proportionally while eliminating the image noise. The proposed algorithm provides a method that preserves the details and effectively removes the noise. In this proposed method, the goal is to separate meaningful detail information in image noise environment using the edge strength and edge connectivity. Consequently, even as the noise level increases, it shows denoising results better than the other benchmark methods because proposed method extracts the connected detail component information. In addition, the proposed method effectively eliminated the noise for various noise levels; compared to the benchmark algorithms, the proposed algorithm shows a highly structural similarity index(SSIM) value and peak signal-to-noise ratio(PSNR) value, respectively. As shown the result of high SSIMs, it was confirmed that the SSIMs of the denoising results includes a human visual system(HVS).

• Restorative Dentistry and Endodontics
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• v.23 no.1
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• pp.357-365
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• 1998

목적: 치과용 수복재료의 방사선 불투과성은 매우 다양하다. 따라서 다양한 수복재료의 방사선 불투과성을 인지하여 치질과 비교하면 이차우식의 진단에 도움이 될 수 있다. 도재의 방사선 불투과성에 따라 적절한 luting cement의 선택이 가농해진다. 수복재료의 방사선 불투과성은 알루미늄 step wedge 의 후경과 방사선 불투과성과의 상관관계 의해 측정된다. 본 연구의 목적은 CAD/CAM용 도재와 이틀의 접착에 쓰이는 접착재료의 방사선 불투과성을 조사해 적절한 재료의 선택과 이차우식 진단의 효율결정에 도움이 되게 하는데 있다. 방법: 본 실험에서는 CAD/CAM용 도재인 Vita MarkII, Dicor MGC와 이의 접착에 사용되는 Z-100, 그리고 luting cement인 Duo cement, Scotchbond resin cement를 사용해 방사선 불투과성을 측정하였다. 시편 제작을 위해 도재를 저속절단기로 두께 2mm, 3mm로 절단하였으며 Z-100과 cement시편은 두께 2mm와 3mm, 직경 7.0mm의 금속 주형을 제작한 후 재료를 양쪽 면에 유리판을 대고 조임쇠로 압접하였으며 광조사기를 사용하여 각 재료마다 두 가지 두께로 10개씩 100개의 시편을 제작하였다. 치질의 시편을 얻기 위해 교정 목적으로 최근에 발거된 정상적인 상악 소구치를 저속 절단기를 사용하여 협설측 교두정을 기준 삼아 2mm, 3mm 두께로 절단하였으며 방사선 불투과성의 기준을 위해 12개의 step으로 구성된 12mm두께의 aluminum step wedge를 사용하였다. Kodak E-Speed occlusal film에 aluminum step wedge와 시편들을 위치시킨 후 70kVp, 7mA, 2.16mm aluminum filtration으로 고정된 dental X-ray unit을 사용하여 target과 film 사이의 거리는 25cm, 노출시간은 0.2초로 하여 방사선 촬영을 한 다음, 현상된 방사선 사진상에 나타난 방사선 불투과성을 X-rite 301 densitometer를 이용하여 측정한 값들의 평균을 냈다. 얻어진 결과는 one-way ANOVA Duncan test(P<0.01)로 검증하였다. 결론: 1. Dicor MGC의 방사선 불투과성은 법랑질보다 약간 높게 나타났다.(P<0.01) 2. Vita Mark Il는 상아질보다 낮은 방사선 불투과성을 보였다.(P<0.01) 3. Z-100과 Luting cement들의 방사선 불투과성은 법랑질보다 높았다. Duo cement가 방사선 불투과성이 가장 높았고 그 다음이 Z-100, 그리고 Scotchbond resin cement 순이었다. 4. Z-100과 2종류의 방사선 불투과성 luting cement들은 Vita Mark II 와 같이 사용하면 2차우식 진단에 도움이 된다.

• Journal of KIISE:Software and Applications
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• v.32 no.7
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• pp.683-692
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• 2005

Java specification states that all accesses to an object must be checked at runtime if object refers to null. Since Java is an object-oriented language, object accesses are frequent enough to make null pointer checks affect the performance significantly. In order to reduce the performance degradation, there have been attempts to remove redundant null pointer checks. For example, in a Java environment where a just-in-time (JIT) compiler is used, the JIT compiler removes redundant null pointer check code via code analysis. This paper proposes a technique to remove additional null pointer check code that could not be removed by previous JIT compilation techniques, via early null pointer check using an architectural feature called predication. Generally, null point check code consists of two instructions: a compare and a branch. Our idea is moving the compare instruction that is usually located just before an use of an object, to the point right after the object is defined so that the total number of compare instructions is reduced. This results in reduction of dynamic and static compare instructions by 3.21$\%$ and 1.98$\%$. respectively, in SPECjvm98 bechmarks, compared to the code that has already been optimized by previous null pointer check elimination techniques. Its performance impact on an Itanium machine is an improvement of 0.32$\%$.

• Journal of the Korean Society of Food Science and Nutrition
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• v.33 no.5
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• pp.821-826
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• 2004

The effects of the fruiting body of Agaricus blazei Murill on the weight gains, food intakes, food efficiency ratios, serum and hepatic lipids concentrations were investigated in male rats. Sprague-Dawley rats, 21 weeks old, were given four different types of diets for a succeeding period of 10 weeks: either a normal diet (5% corn oil), a high fat diet (high fat; 20% lard), a 3% or 5% Agaricus diet (high fat diet+3% or 5% Agaricus powder). The body weight gains and food efficiency ratios of the rats fed 5% Agaricus diet were significantly lower than those of the rats fed high fat diet. The hepatic and kidney weights of the rats fed Agaricus diets were similar to those of the rats fed high fat diet. The epididymal fat pad weights of the rats fed 3% or 5% Agaricus diets were significantly lower than those of the rats fed high fat diet. The concentrations of hepatic and serum triglyceride in the rats fed 5% Agaricus diet were significantly lower than those in the rats fed high fat diet. But the hepatic total cholesterol of rats fed the 3% or 5% Agaricus diets were similar to those of rats fed the high fat diet. The concentrations of serum total cholesterol, LDL-cholesterol and atherogenic index in rats fed the 3% or 5% Agaricus diets were significantly decreased compared with those of rats fed the high fat diet. The HDL-cholesterol/total- cholesterol ratios of the rat fed 3% or 5% Agaricus diet were significantly increased compared with those of rats fed the high fat diet. There were no differences in serum concentrations of HDL-cholesterol and phospholipid among the experimental groups. These results showed that the 5% Agaricus diet feeding decreased the total cholesterol, the triglyceride, the LDL-cholesterol and the atherogenic index, and increased the HDL-cholesterol/total-cholesterol ratio in serum of rats.

• Journal of the Korean Society of Food Science and Nutrition
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• v.26 no.4
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• pp.743-750
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• 1997

Direct measurement of the kinetics of free fatty acid transfer between phospholipid model membrane is technically limited by the rapid nature of the transfer process. Separation of membrane-bound fatty acid by centrifugation has shown that although the equilibrium distribution of free fatty acid is determined by this method, fatty acid transfer occurs too rapidly for accurate kinetic measurements. Recently fluorescence resonance energy transfer(FRET) assay has been developed to examine transfer of fatty acids between membranes. Donor membranes which has fluorescent fatty acid, anthroyloxy fatty acid(AOFA), is mixed with acceptor membranes which has non-interchangeable fluorescent quencher, nitrobenzo-xadiazol(NBD), using stopped flow apparatus. As the fluorescent fatty acids transfer from donor membrane to acceptor membrane, fluorescence intensity would be decreased and the rate and degree of fatty acid transfer can be analyzed. Fatty acid transfer between micelles is more complicated because of bile salt. Therefore in experiments with micelles, fluorescence self quenching assay is used. At high concentrations, a fluorophore tends to quench its own fluorescence causing a reduction in fluorescence intensity. Donor micelles contained self quenching concentrations of fluorophore and acceptor micelles had no fluorophore. Upon mixing of donor and acceptor micelles, the rate of transfer of the fluorophore from the donor to the acceptor was measured by monitoring the release in self quenching when its concentration in donor decreased over time.