• KSBB Journal
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• v.10 no.2
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• pp.191-195
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• 1995

Using Pseudomonas sp. CH-414, the optimum culture conditions were investigated for the cell growth and the phospholipid production in batch culture by varying pH and aeration rate. With starting the cultivation under the conditions of pH 7.0 and 1vvm, pH was controlled to 6 or 8 at 30 hours of culture time. In the case of changing into pH 6.0, the phospholipid production was increased by ca. 20% with comparison to the case of pH 7.0. However, the biomass and the phospholipld concentration were rapidly decreased after 30 hours of culture time when pH was controlled to 8.0. As the aeration rate was increased, the biomass was increased while the phospholipid concentration was considerably varied and unstable. Especially, the concentration of phospholipid was rapidly decreased with 3vvm of aeration rate. Finally, under the culture conditions of pH 7.0 and 3vvm until 30 hours for the cell growth, which were controlled to pH 6.0 and 1vvm for the stable production of phospholipid beyond that time, the dry cell weight was $18.5g/\ell$ and the phospholipid concentration was $\0.83g/ell$ (45mg/g cell).

• Journal of Korean Society of Neurocognitive Rehabilitation
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• v.10 no.2
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• pp.35-44
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• 2018

This study was conducted to explore the effects of semi-structured $DIRFloortime^{(R)}$ treatment on the enhancement of language comprehension and information processing of children with high-performance autistic spectrum disabilities. We measured the general characteristics of the test subjects, which are level of autism, total intelligence, language comprehension and information processing indicators. The intervention method used was a semi-structured $DIRFloortime^{(R)}$ therapy using board game intervention program after revising and supplementing the expert content validity. A pre/post-test for a group was designed as a similar experiment and the pre/post test was initiated with the t certification at .05 of significance level. After initiating the program, the post test has shown that the language comprehension indicators showed statistically significant levels of difference (p<.001) and the information processing indicator also had a statistically significant effect (p<.001). There was a statistically significant difference (p<.001) in the level of verbal comprehension index after the program implementation, and statistically significant differences in the information processing index (p<.001). The semi-structured $DIRFloortime^{(R)}$ treatment using boardgames for enhancing the language comprehension and information processing indicators of children with high performance autistic spectrum disorder had a significant effect.

• Korean Journal of Plant Resources
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• v.26 no.4
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• pp.417-425
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• 2013

The aim of this study was to examine improving effect of Platycodon extracts (PE) and/or Platycodon extracts jelly (PEJ) on cognitive impairment in vitro and in vivo. PC12 (Pheochromocytoma) cells were pretreated with PE for 1hr and than incubated with $50{\mu}M$ amyloid ${\beta}(A{\beta})_{25-35}$ for additional 48hr. Cell viability was assessed by WST-1. Animals for Morris water test and passive avoidance test were divided into normal, control and two Platycodon extracts treated groups that were named Normal (n=7), Control (0 mg/kg, n=7), PE (300 mg/kg, n=7), PEJ (10 g/kg, n=7). Cognitive impairment was induced by scopolamine (1 mg/kg/body weight, i.p.) in the three experimental groups but not the normal group. Pretretment of PE (0.01-1 mg/mL) were not induced cytotoxicity but observed in high dose-treated group (5 and 10 mg/mL) in PC12 cells. Protective effects of PE against $A{\beta}$-induced cytotoxicity were increased in dose dependent manner in PC12 cells. Administration of PE and PEJ were significantly reduced escape latency time on Morris water maze test and passive avoidance test in copolamine-induced cognitive impairment animal model. These results suggest that Platycodon extracts and its related product available to ameliorative purpose for cognitive ability impairments.

• Journal of Korean Academy of Nursing
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• v.29 no.6
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• pp.1273-1283
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• 1999

This study was done to explore the effects of dance therapy on pulmonary and cognitive functions in the elderly. The design of this study was a non-equivalent pre-post test experiment. The subjects consisted of elderly persons living in a facility located in Kyoungi-Do. Fifty eight subjects had normal cognition, sensory function and resting blood pressure. They underwent tests of pulmonary and cognitive function as baseline data before dance therapy, and at 6th week and at the end of 12nd week after following dance therapy. Twenty seven elderly persons were assigned to the experimental group and participated with the dance therapy. This therapy was based on the Marian Chace's dance therapy and Korean traditional dance with music. The dance therapy consisted of 50 minutes session, 3 times a week for 12 weeks. One session consisted of warming-up, expression, catharsis, sharing and closing stage. the intensity of the dance therapy was at the 40% of age-adjusted maximum heart rates. Data were analyzed with mean, standard deviation, Chi-square test, unpaired t-test, repeated measures ANOVA, and Bonferroni multiple regression using SAS program. The results were as follows : 1. Pulmonary function(forced expiratory volume at one second and forced vital capacity) of the experimental subjects significantly increased over time more than that of the control subjects. 2. The experimental group had significantly higher score for pulmonary function than the control group at the 12nd week after dance therapy. 3. Cognitive function of the experimental subjects significantly increased over time more than that of the control subjects. 4. The experimental group had significantly higher score for cognitive function than the control group at the 6th week and 12nd week after dance therapy. The findings showed the dance therapy could be effective in improving the pulmonary and cognitive function of the elderly.

• Journal of Digital Convergence
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• v.14 no.12
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• pp.583-590
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• 2016

This study aims to suggest a desirable dietary methods based on the oriental medicated dietary effects based on the schema of four qi and five flavors of foods originated from the yin-yang and five phase theory through clear understanding of the theory of oriental medicated dietary in a modern point of view, and through experimental analysis on the nutrient and dietary effect of 4 medicinal plants. We expect it can show us the way for promoting more healthy life styles and for preventing adult diseases by following our own medicated dietary theory. We should develop our own culinary and dietary culture which is suitable for our physical and genetic conditions for our healthy and happy lives. To successfully develop and introduce them, we should analyze their dietary effects scientifically based on both the theory of nutrialogy and the oriental medicated dietary in a modern point of view.

• Korean Journal of Food Science and Technology
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• v.19 no.1
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• pp.66-68
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• 1987

The qualitative and quantitative analyses of phospholipids in chloroform-methanol extracted crude and hexane extracted deodorized soybean oils were carried out by High-Performance Liquid Chromatography (HPLC). The phosphorus contents in hexane extracted crude, degummed, refiend, bleached and deodorized soybean oil were 510, 120, 5, 1.4 and 1 ppm, respectively. The chloroform-methanol extracted crude soybean oil had 800 ppm phosphorus. The phospholipids found in crude oil were phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine and phosphatidic acid. Only phosphatidylchonine and phosphatidylethanolamine were detected in the deodorized soybean oil. The HPLC method described in this report can separate and detect individual phospholipids in soybean oil at 0.1 ppm level in 30 min.

• Journal of the Korean Society of Food Science and Nutrition
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• v.26 no.4
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• pp.662-668
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• 1997

Linoleic acid(LA) was examined to evaluate its potential as a chemotherapeutic agent for MG-63 human osteosarcoma and AZ-521 gastric cancer cells. The treatment of LA(0.005% for 6 days) to the MG-63 and AZ-521 cancer cells inhibited growth of the cancer cells by 54% and 52%, respectively as compared to that of the controls. It also exhibited that LA with 0.01% concentration decreased the [$^3$H] thymidine incorporation by more than 90% in the both cancer cells. In additions we observed morphological changes in MG-63 and AZ-521 cells under inverted microscope, and the changes in membrane fatty acid compositions of the cancer cells when LA was added at the level of 0.005%. The treatment with LA revealed that the contents of 16:0 and 18:0 decreased significantly, but fatty acids that C numbers are more than 20 and unsaturated(20:4, 22:6, and 24:4) increased, concomitantly the morphological changes of the cells were observed.

• Journal of the Korea Convergence Society
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• v.8 no.7
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• pp.341-348
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• 2017

The aim of this study is to distinguish children with high-functioning autism spectrum disorder (ASD) from the norm group by identifying their Intelligence with Korean Wechsler Intelligence Scale for Children-Fourth Edition (K-WISC-IV) profile analysis. The article were administered to 90 children with high-functioning ASD (6-16) years and has surveyed the average of the Full scale IQ, index scores, and subtest scores of K-WISC-IV. Also, this study has conducted a single-subject T-test in order to verify whether Full scale IQ, index scores, subtest scores are different from those of the norm group. The results show that children with high-functioning ASD achieved significantly lower scores on Processing Speed Index, compared to the norm group. Furthermore, their scores in Comprehension, Picture Concept, Picture completion, Coding, and Symbol Search were significantly lower than those of the norm group. It is likely that what have turned out to be the cognitive weaknesses of high-functioning ASD children by K-WISC-IV analysis, including slow process speed, low social judgement, and difficulty in visual stimuli in everyday life are interrelated to their unique characters.

• 한국HCI학회:학술대회논문집
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• 2007.02b
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• pp.165-170
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• 2007

최근 사용자 중심적 디자인이 제품 설계에 중요한 경영 철학으로 대두되면서, 사용자의 니즈와 요구사항을 제품에 반영하기 위한 다각도의 시도가 이루어지고 있다. 이 중 ethnography 적 조사 방법들은 사용자의 생활 속 경험 데이터에 기반하여 latent 한 니즈를 가시화 하기 위한 도구로써 점차 중요성이 커지고 있는 추세이다. 그리고 이와 관련 조사 방법들은 photo diary, experience sampling method, shadow tracking, contextual inquiry, in-depth interview 등 매우 다양하다. 각각이 조사 방법들은 도출되는 사용자의 생활 데이터 특성, 조사 참가자 조건, 소요 시간, 필요한 조사 참가자의 수 등에 따라 모두 특징이 상이하다. 휴대폰의 시장 cycle을 고려한다면, 휴대폰 도메인에서 이러한 조사 방법을 적용하기 위해서는 조사 목적 및 조사 진행 상황에 맞게 적절히 방법을 선택하여 사용자의 의미 있는 숨은 니즈를 발견하는 것이 매우 중요하다. 그러기 위해서는 각 방법들을 휴대폰의 사용자 조사에 적용하였을 때, 고유의 특징에 의해서 어떤 유용한 정보를 제공할 수 있는지 파악하는 것이 효과적인 조사를 위해 반드시 필요하다. 따라서 본 논문에서는 휴대폰 니즈/신기능 발굴 목적으로 적용된 총 6 가지 조사 방법의 적용 사례를 간략히 소개 하고자 한다. 이를 통하여 기법의 특징을 기술하고, 이에 기반한 기법의 장-단점 비교를 통해 각 방법이 다른 방법 대비 상대적으로 의미있는 데이터를 제공하는 내용은 무엇인지, 어떤 방법들이 함께 쓰였을 때 시너지 효과를 발휘 할 수 있는지, 조사 목적에 따라서 생략될 수 있는 방법과 참가자에게 유용한 데이터를 끌어내기 위해 반드시 수행해야 하는 방법은 무엇인지에 대하여 기술하고자 한다.

• Proceedings of the Korean Information Science Society Conference
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• 2010.06c
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• pp.221-225
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• 2010

본 연구에서는 제한된 온도 영역에서 보통 정밀 온도 측정 소자로 많이 쓰이는 NTC 써미스터를 사용하여 전압 분배 회로(voltage divider circuits)를 구성하였다. 분압 저항이 온도측정 해상도에 미치는 영향을 분석하고, 회로의 분압 저항을 결정하는 방법으로서 측정하고자 하는 온도 구간의 최대 온도와 최저 온도의 NTC 써미스터 저항 값을 조화평균을 사용하여 분압 저항(divider resistance)으로 사용하였다. 선택한 분압 저항이 이상적인 저항인지에 대하여 조화평균으로 계산한 분압 저항과 대조군 저항으로 전압 분배 회로를 병렬로 구성하였다. 센서들을 항온조 넣어 설정온도($50^{\circ}C$, $70^{\circ}C$, $90^{\circ}C$)에서 각각의 온도를 측정한 후 측정 데이터의 표준편차를 구하여 평균 온도 분해능을 비교 하는 실험을 하였다. 실험결과 측정온도 구간의 최대 온도와 최소 온도에서의 NTC 써미스터 저항 값을 조화평균으로 계산한 분압 저항 값이 대조군 저항에 비해 설정온도에서 보다 높은 평균 온도 분해능(sensing resolution)을 보였다.