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A Study on Glomerular Filtration Rate Comparisons between Gates Method and Modified Gates Method used in Dynamic Renal Scintigraphy (동적 신장 신티그래피 검사 시 사용되는 Gates 법과 Modified Gates 법의 사구체 여과율 비교에 관한 고찰)

  • Ham, Jun-Cheol;Bahn, Young-Kag;Park, Min-Soo;Cho, Seok-Won;Lim, Han-Sang;Kim, Jae-Sam;Lee, Chang-Ho
    • The Korean Journal of Nuclear Medicine Technology
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    • v.16 no.1
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    • pp.96-101
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    • 2012
  • Purpose: Glomerular filtration rate is an important index for assessment of renal function, early discovery of renal disease, and progress observation of chronic renal disease patients. In the present study, the objective is to conduct a comparative analysis of differences between Gates and Modified Gates method in dynamic renal scintigraphy based on MDRD (Modification of Diet Renal Disease) formula using blood collection. Materials and Methods: Renal scintigraphy was performed for 45 patients who visited our hospital between November 2010 and August 2011. For 20 patients of those tested, glomerular filtration rates from Gates method and MDRD formula using AGUS equipment, were compared. For the other 20 patients, glomerular filtration rates from Modified Gates method and MDRD formula using INFINIA equipment. Finally, Gates and Modified Gates method were compared for 5 patients who indicated no change in glomerular filtration rates from MDRD formula during progress observation. Results: Glomerular filtration rates from both Gates and Modified Gates method showed a high correlation with those from MDRD formula ($p$<0.01, r=0.903, r=0.867), with a paired difference mean for Gates method of $2.05{\pm}2.54mL/min/1.73m$, and that for Modified Gates method of $25.2{\pm}3.71mL/min/1.73m$. Finally, the values for Gates method and those for Modified Gates method showed a high correlation for the five patients ($p$<0.05, r=0.949), with a paired difference mean of $20.4{\pm}8.84mL/min/1.73m$. Conclusion: Glomerular filtration rates from Gates method, Modified Gates method and MDRD formula showed mutually high correlations. If the tests are performed with recognition for the correlations between Gates and Modified Gates method used in a dynamic renal scintigraphy, then an accurate assessment of renal function is considered possible with an improved diagnostic ability.

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A Study on the Structure and the owners of the Royal Tombs of the Goryeo Dynasty (고려왕릉의 구조 및 능주(陵主) 검토)

  • Lee, Sang June
    • Korean Journal of Heritage: History & Science
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    • v.45 no.2
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    • pp.4-19
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    • 2012
  • There remain many royal tombs of the Goryeo Dynasty in Gaeseong and Ganghwa. During the Goryeo Dynasty, these royal tombs were taken over tradition of tomb construction style from previous generation, and they completed their own inventive style. Furthermore they handed down those style to the Joseon Dynasty. The area of tomb was divided into 3 or 4 steps, and stone figures and T-shaped houses for sacrifice were arranged on each steps. It was the stone chamber of lateral opening style which had an entrance to southward, and it was formed as a rectangular box-shaped with a pile of stone walls and a flat ceiling. There was a coffin stand in the middle of floor, and traditional bricks were around them. The wall side and ceiling had been whitewashed and painted pictures. These are general characteristics for the tomb construction style of the Goryeo Dynasty. By the way, we can notice a number of features except those general things with inspection in detail. In early days, we confirmed 1step-parallel fulcrum ceiling, coffin stand of all in one stone, bier of burial artifact, and mural of plant material as a set, but they were changed as flat ceiling, Red-stone wall with rectangular stone, coffin stand set as stone pillar through the period of transitional form as of in the late 12th century. In case of several royal tombs, the fragments of king's epitaph which were confirmed from tombs could be defined owners clearly, and there were considerable timing difference between the large numbers of celadons which were excavated with the fragments of king's epitaph and recording chronologically of stone chamber structure. The reason for timing difference is that posterity artifacts were buried through repairing courses by occasion of destruction caused by robbing of the royal tombs. Meanwhile I inferred the existing hypothesis about owners of royal tombs and autonym ones in comparison the burial spot direction of hypothesis ones and outcomes of excavation. Therethrough, some hypothesis about owners of royal tombs such as Myung-neung which was assumed as tomb of the King Choongmok were not correct.

Study on Analysis of Difference in Preference of Stakeholders in Port Gyeongin Using Conjoint Analysis (컨조인트 분석을 활용한 경인항 이해관계자의 선호도 차이분석에 관한 연구)

  • Park, Jong-Min;YANG, Tae-Hyeon;Park, Sung Hoon;Yeo, Gi-Tae
    • Journal of Navigation and Port Research
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    • v.44 no.1
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    • pp.10-19
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    • 2020
  • Port Gyeongin was developed as a multi-functional port equipped with container and general port facilities and could be linked with nearby tourist attractions. However, it has experienced difficulties from the limitation of being a small port, duplicating functions, and lacking an interlink with nearby ports. Nonetheless, resident companies that need logistics facilities in Port Gyeongin or nearby ports process specific import and export goods such as wood, steel, and industrial products through Port Gyeongin because of the characteristics of the port. From this perspective, it is critical to establish a measure to promote Port Gyeongin through utility analysis of the stakeholders in Port Gyeongin. In this regard, the purpose of this study was to analyze the preference of stakeholders in Port Gyeongin using conjoint analysis and propose a difference in the preference of the stakeholders. Study results show that the terminal group, shippers, and tenant companies considered the berthing capacity, incentive scale, and port logistics cost as the most critical matters, respectively. The stakeholders in Port Gyeongin should recognize the difference in critical matters, and be equipped with shipper discovery and institutional arrangement according to the characteristics of Port Gyeongin such as cooperation with related institutions and inter-collaboration between operating companies to promote Port Gyeongin.

Cellular Protective Effect and Liposome Formulation for Enhanced Transdermal Delivery of Isoquercitrin (Isoquercitrin의 세포 보호 작용과 피부 흡수 증진을 위한 리포좀 제형 연구)

  • Jo, Na-Rae;Gu, Hyun-A;Park, Su-Ah;Han, Seat-Byeol;Park, Soo-Nam
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.38 no.2
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    • pp.103-118
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    • 2012
  • In this study, the cellular protective effect of isoquercitrin against $H_2O_2$ and rose bengal-indued HaCaT cell damage was investigated. The ethosome and elastic liposome for enhanced transdermal delivery were prepared. Particle size, loading efficiency and cumulative permeated amounts of them were evaluated. Isoquercitrin didn't show any characteristic cytotoxicity at 50 ${\mu}M$. When HaCaT cells were treated with 5 mM $H_2O_2$ and 25 ${\mu}M$ rose bengal, isoquercitrin protected the cells against the oxidative damage in a concentration dependent manner (6.25 ~ 50 ${\mu}M$). The size of 0.03 % isoquercitrin loaded ethosome was 222.85 nm and the loading efficiency was 82.26 %. The ethosome loaded with 0.03 % isoquercitrin was stable and maintained the constant particle size for 2 weeks after being prepared. The ethosome exhibited more enhanced skin permeability than general liposome and ethanol solution. The optimal ratio of lipid to surfactant of 0.1 % isoquercitrin loaded elastic liposomes was observed to be 89 : 5 through evaluating particle size (341.2 nm), deformability index (59.89), loading efficiency (54.3 %), and skin permeability (54.4 %).

Design and Implementation of a High-Performance Index Manager in a Main Memory DBMS (주기억장치 DBMS를 위한 고성능 인덱스 관리자의 설계 및 구현)

  • Kim, Sang-Wook;Lee, Kyung-Tae;Choi, Wan
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.28 no.7B
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    • pp.605-619
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    • 2003
  • The main memory DBMS(MMDBMS) efficiently supports various database applications that require high performance since it employs main memory rather than disk as a primary storage. In this paper, we discuss the index manager of the Tachyon, a next-generation MMDBMS. Recently, the gap between the CPU processing and main memory access times is becoming much wider due to rapid advance of CPU technology. By devising data structures and algorithms that utilize the behavior of the cache in CPU, we are able to enhance the overall performance of MMDBMSs considerably. In this paper, we address the practical implementation issues and our solutions for them obtained in developing the cache-conscious index manager of the Tachyon. The main issues touched are (1) consideration of the cache behavior, (2) compact representation of the index entry and the index node, (3) support of variable-length keys, (4) support of multiple-attribute keys, (5) support of duplicated keys, (6) definition of the system catalog for indexes, (7) definition of external APIs, (8) concurrency control, and (9) backup and recovery. We also show the effectiveness of our approach through extensive experiments.

Petrochemistry of the Hongcheon Fe-REE ore deposit in the Hongcheon area, Korea (홍천 철-희토류광상 모암의 암석화학)

  • 박중권;이한영
    • The Journal of the Petrological Society of Korea
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    • v.12 no.3
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    • pp.135-153
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    • 2003
  • In order to understand its origin and petrogenesis, petrochemical studies of major, trace elements, REE, and stable isotopes of oxygen and carbon from the Hongcheon Fe-REE deposits have been investigated. The Hongcheon Fe-REE deposit intruding into Precambrian metasedimentary rocks consists of magnetite, various carbonates such as ankerite, siderite, magnesite and strontianite, monazite, aegirine-augite, Na-amphibole, and sulfides. Compared with major elements abundances of typical ferro-carbonatites, the Hongcheon Fe-REE deposit is enriched in FeO and depleted in CaO with increasing of $SiO_2$, where $TiO_2$and $A1_2O_3$increased and CaO, FeO, MgO and $P_2O_5$ are slightly decreased, but those are rather scattered and their trends are somewhat ambiguous. V Ni, U and Rb slightly increasing with of $SiO_2$increase and scattering or no trends of other detected elements. Nb, Zr and Zn are depleted then the abundances of typical ferro-carbonatites (Woolley and Kempe, 1989). In rare earth elements a large enrichment of total REE (maximum 14.8 wt%) and LREE relative to chondrites and HREE depleted more then the values of ferro-carbontites therefore La/Lu ratios shows large abundances (max. 16,197). The results of stable isotopes of O and C from minerals of ankerite and strontianite and whole rocks represent studied rocks are from igneous carbonatitic melts. Although petrochemical characteristics of the Hongcheon Fe-REE deposits are somewhat different from normal ferro-carbonatites from the world, this discrepancy suggests another conclusion that petrochemical characteristic of the studied Fe-REE mineralized rocks are similar to those of phoscorites from Kovdor, Russia and Sokli, Finland showing the same petrochemical compositions described above.

Physiological Characteristics and GABA Production of Lactobacillus acidophilus RMK567 Isolated from Raw Milk (원유에서 분리한 Lactobacillus acidophilus RMK567의 GABA 생성 및 생리적 특성)

  • Lim, Sang-Dong;Kim, Kee-Sung;Do, Jeong-Ryong
    • Food Science of Animal Resources
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    • v.29 no.1
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    • pp.15-23
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    • 2009
  • In order to develop a new starter for fermented milk, 2082 bacteria were isolated from raw milk. The strain that showed excellent acid forming and ${\gamma}$-aminobutyric acid (GABA) production ($711.40{\mu}g/g$ D.W) characteristics after incubation at $37^{\circ}C$ for 18 hr was selected and identified as Lactobacillus acidophilus by the result of API carbohydrate fermentation pattern and 16S rDNA sequence. L. acidophilus RMK567 was investigated for its physiological characteristics. RMK67 strain showed good GABA production compared with commercial lactic acid bacteria. The optimum growth temperature of L. acidophilus RMK567 was $40^{\circ}C$ and cultures took 15 hr to reach pH 4.3. L. acidophilus RMK567 showed higher sensitivity to penicillin-G, novobiocin, as compared to other 14 different antibiotics. However, it showed more resistance to kanamycin, neomycin, streptomycin. It showed higher leucine arylamidase and ${\beta}$-galactosidase activities compared to 16 other enzymes. It was comparatively tolerant to bile juice and able to survive at pH 2 for 3 hr. It showed resistence to Escherichia coli, Salmonella typhimurium and Staphylococcus aureus with rates of 29.2%, 39.1% and 51.4%, respectively. Based on these and previous results, L. acidophilus RMK567 could be an excellent starter culture for fermented milk with excellent GABA contents.

Biochemical and Histological Effects of Phellinus linteus Methanol Extract on Liver Lipid Metabolism of Rats Fed $CCl_4$ and High Fat (상황버섯이 사염화탄소와 고지방을 투여한 흰쥐의 간지질 대사에 미치는 생화학적, 형태학적 연구)

  • 정차권;정명은;함승시;남상명;강일준;김수진
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.30 no.2
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    • pp.331-337
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    • 2001
  • The effect of Phellinus linteus methanol extract on the lipid metabolism in the liver of rat was investigated in this study. Rats were randomly divided into 6 groups including the control, $CCl_4$and high fat group plus sub-groups with Phellinus linteus methanol extract administration. Methanol extracts of Phellinus linteus were fed 50mg/kg B.W daily via drinking water. A 1.2mL of $CCl_4/kg$ body weight was administered by oral intubation twice a week for total six times. The administration of $CCl_4$ increased total cholesterol, TG, LDL and LDL-phospholipid. However, the level of liver cholesterol and triglycerides were significantly decreased while HDL-cholesterol was increased by the extract feeding. The activities of GOT, GPT, AP and LDH were greatly enhanced by the extract feeding. Electronmicrograph showed that $CCl_4$ treatment deteriorated the structure of cytoplasmic matrix with its uneven distribution. However, the extract treatment reconstituted the damaged cytoplasm and stimulated mitochondriagenesis. From these results, it was suggested that Phellinus linteus can help to recover the damaged liver function and further may help to prevent senescence diseases such as fatty liver, hypertension and hyperlipidemia.

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A Novel Fast and High-Performance Image Quality Assessment Metric using a Simple Laplace Operator (단순 라플라스 연산자를 사용한 새로운 고속 및 고성능 영상 화질 측정 척도)

  • Bae, Sung-Ho;Kim, Munchurl
    • Journal of Broadcast Engineering
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    • v.21 no.2
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    • pp.157-168
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    • 2016
  • In image processing and computer vision fields, mean squared error (MSE) has popularly been used as an objective metric in image quality optimization problems due to its desirable mathematical properties such as metricability, differentiability and convexity. However, as known that MSE is not highly correlated with perceived visual quality, much effort has been made to develop new image quality assessment (IQA) metrics having both the desirable mathematical properties aforementioned and high prediction performances for subjective visual quality scores. Although recent IQA metrics having the desirable mathematical properties have shown to give some promising results in prediction performance for visual quality scores, they also have high computation complexities. In order to alleviate this problem, we propose a new fast IQA metric using a simple Laplace operator. Since the Laplace operator used in our IQA metric can not only effectively mimic operations of receptive fields in retina for luminance stimulus but also be simply computed, our IQA metric can yield both very fast processing speed and high prediction performance. In order to verify the effectiveness of the proposed IQA metric, our method is compared to some state-of-the-art IQA metrics. The experimental results showed that the proposed IQA metric has the fastest running speed compared the IQA methods except MSE under comparison. Moreover, our IQA metric achieves the best prediction performance for subjective image quality scores among the state-of-the-art IQA metrics under test.

Physiological Characteristics and ACE Inhibitory Activity of Lactobacillus zeae RMK354 Isolated from Raw Milk (원유에서 분리한 Lactobacillus zeae RMK354의 생리적 특성 및 ACE 억제능)

  • Lim, Sang-Dong;Kim, Kee-Sung;Do, Jeong-Ryong
    • Food Science of Animal Resources
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    • v.28 no.5
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    • pp.587-595
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    • 2008
  • In order to develop a new starter for fermented milk, 1037 bacterial strains were isolated from raw milk. The strain that showed excellent acid producing and angiotensin converting enzyme (ACE) inhibitory activity (88.6%) was selected and identified as a Lactobacillus zeae based on the result of API carbohydrate fermentation pattern and 16S rDNA sequence. Lactobacillus zeae RMK354 was investigated further to study its physiological characteristics. It showed strong ACE inhibitory activity compared with commercial LAB starters tested. The optimum growth temperature of L. zeae RMK354 was $40^{\circ}C$ and it took 10 hr to reach pH 4.3 under this condition. L. zeae RMK354 showed more sensitive to penicillin-G, bacitracin, novobiocin, in a comparison of 14 different antibiotics, and showed most resistance to polymyxin B and vancomycin. It showed higher esterase and leucine arylamidase activities compared with 16 other enzymes. It was comparatively tolerant to bile juice and able to survive at pH 2 for 3 hr. It showed inhibitory activity against Salmonella Typhimurium with the rate of 60%. Based on these and previous results, L. zeae RMK354 could be an excellent starter culture for fermented milk with high level of ACE inhibitory activity.